Enteropathy-associated T-cell lymphoma history and symptoms: Difference between revisions
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{{Enteropathy-associated T-cell lymphoma}} | |||
{{CMG}}; {{AE}} {{Nnasiri}} | |||
==Overview== | |||
Enteropathy-associated T-cell Lymphoma (EATL), also enteropathy-type T-cell lymphoma (ETTL), is a type of T-cell non-hodgkin lymphoma that affects the small intestine, it is composed of large lymphoid cells. Enteropathy-associated T-cell lymphoma has two subtypes, type I enteropathy-associated T-cell lymphoma which has a strong association with celiac disease and it is more common in western countries and type II enteropathy-associated T-cell lymphoma which is mostly found among the Asian population. Genes involved in the pathogenesis of this disease include 8q24, T-cell receptor (TCR) beta and gamma, and 16q genes. On gross pathology, multiple intestinal ulcers are characteristic findings of EATL. On microscopic histopathological analysis, monotonous cells, round or angulated vesicular nuclei, and prominent nucleoli are characteristic findings of enteropathy-associated T-cell lymphoma. There are no established causes for enteropathy-associated T-cell lymphoma. EATL must be differentiated from other diseases such as peptic ulcer, poorly-differentiated adenocarcinoma, MALT lymphoma, diffuse large B cell lymphoma, and mantle cell lymphoma. | |||
===History and Symptoms=== | ===History and Symptoms=== | ||
===History=== | |||
Patient with enteropathy-assocoated T cell lymphoma may have positive history of:<ref name="pmid10673521">{{cite journal |vauthors=Gale J, Simmonds PD, Mead GM, Sweetenham JW, Wright DH |title=Enteropathy-type intestinal T-cell lymphoma: clinical features and treatment of 31 patients in a single center |journal=J. Clin. Oncol. |volume=18 |issue=4 |pages=795–803 |date=February 2000 |pmid=10673521 |doi=10.1200/JCO.2000.18.4.795 |url=}}</ref> | |||
*Celiac disease | |||
*Malabsorption | |||
===Symptoms=== | |||
*Symptoms of the enteropathy-associated T-cell lymphoma include:<ref name="cancer.gov">Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 26, 2016</ref> | *Symptoms of the enteropathy-associated T-cell lymphoma include:<ref name="cancer.gov">Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 26, 2016</ref> | ||
**[[Fever]] | **[[Fever]] | ||
| Line 10: | Line 23: | ||
**[[Bone pain]] | **[[Bone pain]] | ||
**Painless swelling in the neck, [[axilla]], [[groin]], [[thorax]], and [[abdomen]] | **Painless swelling in the neck, [[axilla]], [[groin]], [[thorax]], and [[abdomen]] | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 20:50, 9 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]
Overview
Enteropathy-associated T-cell Lymphoma (EATL), also enteropathy-type T-cell lymphoma (ETTL), is a type of T-cell non-hodgkin lymphoma that affects the small intestine, it is composed of large lymphoid cells. Enteropathy-associated T-cell lymphoma has two subtypes, type I enteropathy-associated T-cell lymphoma which has a strong association with celiac disease and it is more common in western countries and type II enteropathy-associated T-cell lymphoma which is mostly found among the Asian population. Genes involved in the pathogenesis of this disease include 8q24, T-cell receptor (TCR) beta and gamma, and 16q genes. On gross pathology, multiple intestinal ulcers are characteristic findings of EATL. On microscopic histopathological analysis, monotonous cells, round or angulated vesicular nuclei, and prominent nucleoli are characteristic findings of enteropathy-associated T-cell lymphoma. There are no established causes for enteropathy-associated T-cell lymphoma. EATL must be differentiated from other diseases such as peptic ulcer, poorly-differentiated adenocarcinoma, MALT lymphoma, diffuse large B cell lymphoma, and mantle cell lymphoma.
History and Symptoms
History
Patient with enteropathy-assocoated T cell lymphoma may have positive history of:[1]
- Celiac disease
- Malabsorption
Symptoms
- Symptoms of the enteropathy-associated T-cell lymphoma include:[2]
- Fever
- Weight loss
- Night sweats
- Diarrhea
- Skin rash
- Chest pain
- Abdominal pain
- Bone pain
- Painless swelling in the neck, axilla, groin, thorax, and abdomen
References
- ↑ Gale J, Simmonds PD, Mead GM, Sweetenham JW, Wright DH (February 2000). "Enteropathy-type intestinal T-cell lymphoma: clinical features and treatment of 31 patients in a single center". J. Clin. Oncol. 18 (4): 795–803. doi:10.1200/JCO.2000.18.4.795. PMID 10673521.
- ↑ Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 26, 2016