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| {{CMG}}; {{AE}} {{Preeti}} | | {{CMG}}; {{AE}} {{Preeti}} |
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| {|
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| ! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Category
| |
| ! colspan="2" rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Etiology
| |
| ! colspan="10" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Clinical manifestations
| |
| ! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" + |Paraclinical findings
| |
| ! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Gold standard
| |
| ! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated findings
| |
| |-
| |
| ! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" + |Lab findings
| |
| |-
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Demography
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! colspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Symptoms
| |
| ! colspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Signs
| |
| ! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" + |CBC
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |PBS
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |PT/PTT
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Immunochemistry
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Histopathology
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Other
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Constitutional symptoms
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Rash
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Abdominal pain
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Diarrhea
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |V/S
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mass
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hepatosplenomegaly
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Other
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |WBC
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hb
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| |-
| |
| ! colspan="24" align="left" style="background:#4479BA; color: #FFFFFF;" + |HL
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Hodgkin's Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| ! colspan="24" align="left" style="background:#4479BA; color: #FFFFFF;" + |NHL
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |B Cell Lymphoma
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |B-lymphoblastic leukemia/lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Precursor B-cell Lymphoma
| |
| *Unknown
| |
| *Inherited mutations of PAX5, ETV6, and TP53
| |
|
| |
|
| | align="center" style="background:#F5F5F5;" + |
| | ==References== |
| * Most common in children <6 years old
| | {{Reflist|2}} |
| * Second peak in adults >60 years old
| |
| * M>F
| |
| * More in Whites and Hispanics
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Ionizing radiation
| |
| * Chemotherapy
| |
| | align="center" style="background:#F5F5F5;" + |+
| |
| | align="center" style="background:#F5F5F5;" + |–
| |
| | align="center" style="background:#F5F5F5;" + |–
| |
| | align="center" style="background:#F5F5F5;" + |–
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Fever
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Bleeding
| |
| *[[Dyspnea]]
| |
| *Joint pain
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |Nl to ↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Down syndrome
| |
| |- | |
| !
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |[[Follicular lymphoma]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| * Reciprocal translocation t(14;18)
| |
| * Overexpression of ''BCL2''
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Second most common subtype of NHL
| |
| *Whites>>African-americans or Asians
| |
| *Median age at diagnosis of 65 years
| |
|
| |
|
| | align="center" style="background:#F5F5F5;" + |
| | {{WH}} |
| * Slightly positive family history
| | {{WS}} |
| | align="left" style="background:#F5F5F5;" + |Only in 20% of patients:
| | [[Category: (name of the system)]] |
| *[[Fever]]
| |
| *[[Weight loss]]
| |
| *[[Night sweats]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Painless peripheral adenopathy in the cervical, axillary, inguinal, and/or femoral regions
| |
| * Asymptomatic large abdominal mass
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Seizures]]
| |
| *[[Chest pain]]
| |
| *[[Bone pain]]
| |
| *[[Cough]]
| |
| *[[Dyspnea]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |Nl to ↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Cytopenia
| |
| | align="center" style="background:#F5F5F5;" + |NA
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * CD21
| |
| * CD23
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Nodular growth pattern
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Elevated LDH
| |
| | align="center" style="background:#F5F5F5;" + |Lymph node biopsy
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Most common clinically indolent NHL
| |
| * Peripheral nerve compression
| |
| |-
| |
| !
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Mantle cell lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| * [[CD5 (protein)|CD5]] positive antigen in pregerminal center of B-cell
| |
| * [[Chromosomal translocation]] at '''t(11:14)'''
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Fatigue
| |
| * Night sweats
| |
| * Weight Loss
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |Abdominal distention
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Palpable masses in skin, breast, and salivary glands
| |
| * Generalized lymphadenopathy
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Extranodal involvement of GI tract, lungs, and CNS
| |
| * Mental Retardation
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Lymphocytosis > 4000/µL
| |
| *
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |Nl to ↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * CD5<sup>+</sup>
| |
| * B-cell antigen positive
| |
| * Overexpression of Cyclin D1
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Germinal centers filled by small-to-medium atypical lymphocytes
| |
| * Nodular appearance
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Elevated LDH
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| !
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Diffuse large B cell lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| * 8q24/''MYC'' [[translocations]]
| |
| * Hypermutated immunoglobulin genes
| |
| * Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]'' /''TTFn'', ''[[TP53]]'' genes
| |
| * Translocations involving ''c-MYC'', ''BCL6'', and ''IgH'' gene.
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Fever
| |
| * Night sweats
| |
| * weight loss
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Painless rapidly enlarging [[lymph nodes]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |Nl to ↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| '''Centroblastic'''
| |
| *Medium-to-large-sized [[Lymphocyte|lymphocytes]]
| |
| *Monomorphic
| |
| '''Immunoblastic'''
| |
| *> 90% immunoblasts
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| *Trapezoid shaped large lymphoid cells with significant [[basophilic]] cytoplasm
| |
| '''Anaplastic'''
| |
| *Very large cells with a round, oval, or polygonal shape that may resemble Reed-Sternberg cells
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Hypergammaglobulinemia
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Category
| |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Etiology
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Demography
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Constitutional symptoms
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Rash
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Abdominal pain
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Diarrhea
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |V/S
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mass
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hepatosplenomegaly
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Other
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |WBC
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hb
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PBS
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT/PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Immunochemistry
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Histopathology
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Other lab findings
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Gold standard
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated findings
| |
| |-
| |
| !
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |[[Burkitt lymphoma]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| * Translocation of chromosome 8 ''[[myc]]'' locus such as:
| |
| ** t(8;14)
| |
| ** t(2;8)
| |
| ** t(8;22)
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Fever]]
| |
| * [[Night sweats]]
| |
| * Unexplained [[weight loss]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Swollen lymph nodes]] in the neck, axilla, or groin
| |
| | |
| * Jaw mass
| |
| * [[Abdominal mass|Abdominal masses]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Ascites]]
| |
| * [[Proptosis]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[CD19]]
| |
| * [[CD20]]
| |
| * [[CD22]]
| |
| * [[CD10]]
| |
| * BCL6
| |
| * BCL2 and TdT
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Round and small nucleoli
| |
| * [[basophilic]] cytoplasm
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| * "Starry-sky pattern"
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| !
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |B cell chronic lymphocytic leukemia/small lymphocytic lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| !
| |
| ! rowspan="3" align="center" style="background:#DCDCDC;" + |Marginal zone lymphoma
| |
| ! align="center" style="background:#DCDCDC;" + |Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |[[Splenic marginal zone lymphoma]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| * Clonal rearrangements of the [[immunoglobulin]] genes (heavy and light chains)
| |
| ** Deletion 7q21-32
| |
| ** Translocations of the CDK6 gene located on 7q21
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[CD20]]
| |
| * [[CD79a]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Small [[lymphocytes]]
| |
| * Transformed blasts
| |
| * Epithelial histocytes
| |
| * Plasmacytic differentiation of neoplastic cells
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |[[Nodal marginal zone B-cell lymphoma]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| * Stimulation of antigen receptor by autoantigen and co-stimulatory molecule CD40
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Hemorrhage
| |
| * Dyspepsia
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * AE1/AE3
| |
| * Expression of B-cell markers CD20, CD79a, CD10, CD23, and bcl-2
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Follicular cells in reactive zone
| |
| * Centrocyte like cells in marginal zone lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Chronic infectious conditions or autoimmune processes, such as
| |
| ** ''H pylori'' gastritis
| |
| * Hashimoto thyroiditis
| |
| * Sjögren syndrome
| |
| |-
| |
| |
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia)
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature B-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |[[Hairy cell leukemia]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Production of [[Cytokine|cytokines]], such as [[TNF alpha]] and IL-2R, provide important stimuli for [[malignant]] [[B cell|B cells]] proliferation in hairy cell leukemia.
| |
| ** The ''p38-MAPK-JNK'' cascade
| |
| ** The ''MEK-ERK'' cascade
| |
| ** The ''Phosphatidylinositol 3 kinase (PI3K)-AKT'' cascade
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Fever]]
| |
| * [[Night sweat|Night sweats]]
| |
| * [[Fatigue]]
| |
| * Easy [[bruising]] or [[bleeding]]
| |
| * Generalized weakness
| |
| * [[Weight loss]]
| |
| * Recurrent [[Infection|infections]]
| |
| * Early satiety
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Pallor]],
| |
| * [[Petechiae]]
| |
| * [[Splenomegaly]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Tartrate-resistant acid phosphatase positive
| |
| * CBC
| |
| ** Decreased [[hemoglobin]] concentration
| |
| ** Decreased [[platelets]] count
| |
| **
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Annexin A1]]
| |
| * [[CD20]]
| |
| * [[CD25]]
| |
| * [[CD103]]
| |
| * [[CD19]]
| |
| * [[CD11c]]
| |
| * [[FMC7]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Small cells with "fried egg"-like appearance
| |
| * Well-demarcated thread-like [[cytoplasmic]] extensions
| |
| * Clear cytoplasm
| |
| * Central round [[nucleus]]
| |
| * Peri-nuclear clearing ("water-clear rim" appearance)
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Precursor T-cell lymphoblastic leukemia/lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Precursor T-cell Lymphomas
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Adult T cell leukemia/lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |T cell lymphoma
| |
| ! colspan="2" align="center" style="background:#DCDCDC;" + |Anaplastic large cell lymphoma
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |Cutaneous T-cell lymphoma
| |
| ! align="center" style="background:#DCDCDC;" + |[[Mycosis fungoides]] / [[Sézary syndrome]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| * The [[tumor]] [[Cell (biology)|cells]] originate from [[memory T cells]] or [[skin]] homing [[CD4+ T cells]] expressing [[cutaneous]] [[lymphocyte]] [[antigen]] (CLA) an<nowiki/>d [[chemokine]] [[receptors]] [[CCR4]]<nowiki/>and CCR7.
| |
| * It is understood that cutaneous t cell lymphoma (maycosis fungoides, Sezary sydrome ) is the result of malignant T cell that derived from a mature CD41 CD45RO1 memory T cells.
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * [[Epidermis (skin)|Epidermal]] [[atrophy]] or poikiloderma
| |
| * Generalized [[itching]]([[pruritus]])
| |
| * [[Pain]] in the affected area of the skin.
| |
| * [[Insomnia]]
| |
| * Red ([[erythematous]]) patches scattered over the [[skin]] of the [[trunk]] and the [[extremities]]
| |
| * [[Weight loss]]
| |
| * [[Lymphadenopathy]]
| |
| * [[Malaise]] and [[fatigue]]
| |
| * [[Anemia]]
| |
| * May progress to [[Sezary syndrome]] (Skin involvement plus hematogenous dissemination)
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Cutaneous manifestations
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! rowspan="6" align="center" style="background:#DCDCDC;" + |Peripheral T-cell lymphoma
| |
| ! align="center" style="background:#DCDCDC;" + |Subcutaneous panniculitis-like T-cell lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |Hepatosplenic gamma-delta T-cell lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |Enteropathy-type intestinal T-cell lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |Extranodal T-cell lymphoma, nasal type
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |Angioimmunoblastic T-cell lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |-
| |
| |
| |
| ! align="center" style="background:#DCDCDC;" + |Peripheral T-cell lymphoma, unspecified
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Mature T-cell Lymphoma
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |}
| |
| <references />
| |