Non-Hodgkin lymphoma laboratory tests: Difference between revisions
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{{CMG}} {{shyam}}; {{AE}} {{AS}} | {{CMG}} {{shyam}}; {{AE}} {{AS}} | ||
==Overview== | ==Overview== | ||
Laboratory tests for non-Hodgkin lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[HIV]] blood test, and hepatitis B blood test. | Laboratory tests for non-Hodgkin lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[HIV]] blood test, and [[hepatitis B]] blood test. | ||
==Laboratory Tests== | ==Laboratory Tests== | ||
Laboratory tests for non-Hodgkin lymphoma include the following:<ref name="pmid26174528">{{cite journal| author=Sandlund JT| title=Non-Hodgkin Lymphoma in Children. | journal=Curr Hematol Malig Rep | year= 2015 | volume= 10 | issue= 3 | pages= 237-43 | pmid=26174528 | doi=10.1007/s11899-015-0277-y | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26174528 }} </ref><ref name="pmid22835603">{{cite journal| author=Shankland KR, Armitage JO, Hancock BW| title=Non-Hodgkin lymphoma. | journal=Lancet | year= 2012 | volume= 380 | issue= 9844 | pages= 848-57 | pmid=22835603 | doi=10.1016/S0140-6736(12)60605-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22835603 }} </ref><ref name="pmid19999217">{{cite journal| author=Hingorjo MR, Syed S| title=Presentation, staging and diagnosis of lymphoma: a clinical perspective. | journal=J Ayub Med Coll Abbottabad | year= 2008 | volume= 20 | issue= 4 | pages= 100-3 | pmid=19999217 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19999217 }} </ref> | Laboratory tests for non-Hodgkin lymphoma include the following:<ref name="pmid26174528">{{cite journal| author=Sandlund JT| title=Non-Hodgkin Lymphoma in Children. | journal=Curr Hematol Malig Rep | year= 2015 | volume= 10 | issue= 3 | pages= 237-43 | pmid=26174528 | doi=10.1007/s11899-015-0277-y | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26174528 }} </ref><ref name="pmid22835603">{{cite journal| author=Shankland KR, Armitage JO, Hancock BW| title=Non-Hodgkin lymphoma. | journal=Lancet | year= 2012 | volume= 380 | issue= 9844 | pages= 848-57 | pmid=22835603 | doi=10.1016/S0140-6736(12)60605-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22835603 }} </ref><ref name="pmid19999217">{{cite journal| author=Hingorjo MR, Syed S| title=Presentation, staging and diagnosis of lymphoma: a clinical perspective. | journal=J Ayub Med Coll Abbottabad | year= 2008 | volume= 20 | issue= 4 | pages= 100-3 | pmid=19999217 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19999217 }} </ref> | ||
===Complete Blood Count=== | ===Complete Blood Count=== | ||
* In early stage of the disease the complete blood count (CBC) may be normal. | * In early stage of the disease the [[complete blood count]] (CBC) may be normal. | ||
*Anemia may be seen secondary to involvement of bone marrow, autoimmune hemolysis and bleeding. | *[[Anemia]] may be seen secondary to involvement of [[bone marrow]], [[Autoimmune hemolytic anemia|autoimmune hemolysis]] and bleeding. | ||
*Thrombocytopenia, leukopenia, or pancytopenia may be seen after bone marrow infiltration or autoimmune cytopenias. | *[[Thrombocytopenia]], [[leukopenia]], or [[pancytopenia]] may be seen after bone marrow infiltration or autoimmune cytopenias. | ||
*Lymphocytosis with circulating malignant cells seen in low grade lymphomas. | *[[Lymphocytosis]] with circulating malignant cells seen in low grade lymphomas. | ||
*Thrombocytosis may be seen as a paraneoplastic syndrome. | *[[Thrombocytosis]] may be seen as a [[paraneoplastic syndrome]]. | ||
===Blood Chemistry Studies=== | ===Blood Chemistry Studies=== | ||
*Elevated lactate dehydrogenase (LDH) correlates with poor prognosis. | *Elevated [[lactate dehydrogenase]] (LDH) correlates with poor prognosis. | ||
*Liver function test (LFT) results may be abnormal secondary to hepatic involvement. | *[[Liver function test]] (LFT) results may be abnormal secondary to hepatic involvement. | ||
*Hypercalcemia may be seen in patients with acute form of adult T-cell lymphoma-leukemia (ATLL). | *[[Hypercalcemia]] may be seen in patients with acute form of [[Adult T-cell leukemia|adult T-cell lymphoma-leukemia]] (ATLL). | ||
===Other Studies=== | ===Other Studies=== | ||
*Increased levels of beta2-microglobulin level may be seen, which correlate with a poor prognosis. | *Increased levels of [[beta2-microglobulin]] level may be seen, which correlate with a poor prognosis. | ||
*A positive Coombs test may be positive. | *A positive [[Coombs test]] may be positive. | ||
*Hypogammaglobulinemia may be present. | *[[Hypogammaglobulinemia]] may be present. | ||
*HIV viral load and the antibody titre may be elevated. | *[[Human Immunodeficiency Virus (HIV)|HIV]] viral load and the antibody titre may be elevated. | ||
*HTLV-1 serology should be obtained in patients with ATLL. | *[[HTLV-1]] serology should be obtained in patients with [[Adult T-cell leukemia|ATLL]]. | ||
*HbsAg and Hep B antibody titre must be obtained. | *HbsAg and [[Hepatitis B|Hep B]] antibody titre must be obtained. | ||
==References== | ==References== | ||
Latest revision as of 21:00, 21 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [3]
Overview
Laboratory tests for non-Hodgkin lymphoma include complete blood count (CBC), blood chemistry studies, HIV blood test, and hepatitis B blood test.
Laboratory Tests
Laboratory tests for non-Hodgkin lymphoma include the following:[1][2][3]
Complete Blood Count
- In early stage of the disease the complete blood count (CBC) may be normal.
- Anemia may be seen secondary to involvement of bone marrow, autoimmune hemolysis and bleeding.
- Thrombocytopenia, leukopenia, or pancytopenia may be seen after bone marrow infiltration or autoimmune cytopenias.
- Lymphocytosis with circulating malignant cells seen in low grade lymphomas.
- Thrombocytosis may be seen as a paraneoplastic syndrome.
Blood Chemistry Studies
- Elevated lactate dehydrogenase (LDH) correlates with poor prognosis.
- Liver function test (LFT) results may be abnormal secondary to hepatic involvement.
- Hypercalcemia may be seen in patients with acute form of adult T-cell lymphoma-leukemia (ATLL).
Other Studies
- Increased levels of beta2-microglobulin level may be seen, which correlate with a poor prognosis.
- A positive Coombs test may be positive.
- Hypogammaglobulinemia may be present.
- HIV viral load and the antibody titre may be elevated.
- HTLV-1 serology should be obtained in patients with ATLL.
- HbsAg and Hep B antibody titre must be obtained.
References
- ↑ Sandlund JT (2015). "Non-Hodgkin Lymphoma in Children". Curr Hematol Malig Rep. 10 (3): 237–43. doi:10.1007/s11899-015-0277-y. PMID 26174528.
- ↑ Shankland KR, Armitage JO, Hancock BW (2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.
- ↑ Hingorjo MR, Syed S (2008). "Presentation, staging and diagnosis of lymphoma: a clinical perspective". J Ayub Med Coll Abbottabad. 20 (4): 100–3. PMID 19999217.