Lymphadenopathy laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Lymphadenopathy}} | {{Lymphadenopathy}} | ||
{{CMG}};{{AE}}{{ADS}} | {{CMG}};{{AE}}{{ADS}}{{DYM}} [[Ogechukwu Hannah Nnabude, MD]] | ||
==Overview== | ==Overview== | ||
[[CBC]] with differential is a simple test and basic screening for regional and generalized [[lymphadenopathy]]. [[Bacterial]], [[viral]], or [[fungal]] [[pathology]] may be suggested by the number and differentiation of [[white blood cells]]. Furthermore, with many [[hematological]] [[neoplasms]] causing [[lymphadenopathy]], typical white blood cell ([[WBC]]) trends are observed. | |||
==Laboratory findings== | ==Laboratory findings== | ||
Laboratory findings consistent with the diagnosis of [[lymphadenopathy]] may include:<ref name="pmid24753638">{{cite journal |vauthors=Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A |title=Peripheral lymphadenopathy: approach and diagnostic tools |journal=Iran J Med Sci |volume=39 |issue=2 Suppl |pages=158–70 |year=2014 |pmid=24753638 |pmc=3993046 |doi= |url=}}</ref><ref name="pmid30020622">{{cite journal |vauthors=Freeman AM, Matto P |title= |journal= |volume= |issue= |pages= |date= |pmid=30020622 |doi= |url=}}</ref> | |||
'''Complete Blood Count''' | |||
*'''Complete Blood Count''' | |||
:*Elevated [[lactate dehydrogenase]] (LDH) | :*Elevated [[lactate dehydrogenase]] (LDH) | ||
:*Mild [[neutropenia]] | :*Mild [[neutropenia]] | ||
:*[[Leukocytosis]] | :*[[Leukocytosis]] | ||
:*Elevated markers of [[inflammation]] and acute phase reactants (e.g. [[ESR]], C-reactive protein, [[ferritin]]) | :*Elevated markers of [[inflammation]] and acute phase reactants (e.g. [[ESR]],[[C-reactive protein]], [[ferritin]]) | ||
*'''CBC with manual differential''': [[CBC]] with differential is a simple test and basic screening for regional and generalized [[lymphadenopathy]]. [[Bacterial]], [[viral]], or [[fungal]] [[pathology]] may be suggested by the number and differentiation of [[white blood cells]]. Furthermore, with many [[hematological]] [[neoplasms]] causing [[lymphadenopathy]], typical white blood cell ([[WBC]]) trends are observed. | |||
*'''[[EBV]] serology''': [[Epstein-Barr]] viral mono is present causing regionalized [[lymphadenopathy|lymphadenopathy.]] | |||
*Sedimentation rate: A measure of inflammation though not diagnostic, can contribute to diagnostic reasoning. | |||
*'''[[Cytomegalovirus]] titers''' | |||
*'''[[HIV]] serology''': This serology can be used to diagnose acute [[HIV]] syndrome-related lymphadenopathy or to infer the diagnosis of secondary HIV-elated pathologies causing lymphadenopathy. | |||
*'''[[Bartonella henselae]] serology''': used for the diagnosis of [[cat-scratch]] [[lymphadenopathy|lymphadenopathy.]] | |||
*'''[[Fluorescent treponemal antibody absorbtion (FTA-ABS) test|FTA]]/[[Rapid plasma reagent|RPR]]''': can be used for [[syphilis]] diagnose as the cause of [[lymphadenopathy|lymphadenopathy.]] | |||
*'''[[Herpes simplex]] serology''': can determine if the [[lymphadenopathy]] is [[herpes]]-related. [[Herpes simplex]] can produce symptoms that are similar to mononucleosis. | |||
*'''[[Toxoplasmosis]] serology''' | |||
*'''[[Hepatitis B]] serology''' | |||
*'''[[ANA]]''': is a screening test for [[SLE]] that can help establish it as a cause for generalized lymphadenopathy | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:Inflammations]] | [[Category:Inflammations]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Physical examination]] | [[Category:Physical examination]] | ||
Latest revision as of 05:21, 9 December 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]Delband Yekta Moazami, M.D.[3] Ogechukwu Hannah Nnabude, MD
Overview
CBC with differential is a simple test and basic screening for regional and generalized lymphadenopathy. Bacterial, viral, or fungal pathology may be suggested by the number and differentiation of white blood cells. Furthermore, with many hematological neoplasms causing lymphadenopathy, typical white blood cell (WBC) trends are observed.
Laboratory findings
Laboratory findings consistent with the diagnosis of lymphadenopathy may include:[1][2]
- Complete Blood Count
- Elevated lactate dehydrogenase (LDH)
- Mild neutropenia
- Leukocytosis
- Elevated markers of inflammation and acute phase reactants (e.g. ESR,C-reactive protein, ferritin)
- CBC with manual differential: CBC with differential is a simple test and basic screening for regional and generalized lymphadenopathy. Bacterial, viral, or fungal pathology may be suggested by the number and differentiation of white blood cells. Furthermore, with many hematological neoplasms causing lymphadenopathy, typical white blood cell (WBC) trends are observed.
- EBV serology: Epstein-Barr viral mono is present causing regionalized lymphadenopathy.
- Sedimentation rate: A measure of inflammation though not diagnostic, can contribute to diagnostic reasoning.
- Cytomegalovirus titers
- HIV serology: This serology can be used to diagnose acute HIV syndrome-related lymphadenopathy or to infer the diagnosis of secondary HIV-elated pathologies causing lymphadenopathy.
- Bartonella henselae serology: used for the diagnosis of cat-scratch lymphadenopathy.
- FTA/RPR: can be used for syphilis diagnose as the cause of lymphadenopathy.
- Herpes simplex serology: can determine if the lymphadenopathy is herpes-related. Herpes simplex can produce symptoms that are similar to mononucleosis.
- Toxoplasmosis serology
- Hepatitis B serology
- ANA: is a screening test for SLE that can help establish it as a cause for generalized lymphadenopathy