Endometrial cancer differential diagnosis: Difference between revisions

Latest revision as of 21:34, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2]; Monalisa Dmello, M.B,B.S., M.D. [3]Roukoz A. Karam, M.D.[4]

Overview

In early stages endometrial cancer must be differentiated from diseases that cause abnormal uterine bleeding and endometrial thickening on ultrasound, such as endometrial hyperplasia, endometrial polyp, and submucosal uterine leiomyoma. In advanced stages endometrial cancer must be differentiated from uterine sarcoma and uterine lymphoma.

Differentiating Endometrial Cancer From Other Diseases

In early stages endometrial cancer must be differentiated from diseases that cause abnormal uterine bleeding and endometrial thickening on ultrasound, such as endometrial hyperplasia, endometrial polyp, and submucosal uterine leiomyoma. In advanced stages endometrial cancer must be differentiated from uterine sarcoma and uterine lymphoma.^[1]

Diseases	Clinical manifestations				Para-clinical findings							Gold standard
	Symptoms			Physical examination	Para-clinical findings
	Symptoms			Physical examination	Lab Findings			Imaging		Pap Smear	Histopathology
	Bleeding	Pelvic Pain/pressure/ discomfort	Other	Abdomino-pelvic examination	Hb	B-HCG	CA-125	Ultrasound	MRI	Pap Smear	Histopathology
Endometrial cancer^[2]^[3]^[4]^[5]	Menorrhagia Metrorrhagia in premenopausal women Postcoital bleeding Intermenstrual bleeding	±	Polyuria and dysuria (due to compression) Fatigue Weight loss	Enlarged fixed uterus Vaginal bleeding Vaginal discharge Lymphadenopathy Mesenteric nodules (metastasis)	↓	–	+	A thickened endometrial lining >4mm	Endometrial thickening Lymph node involvement Pelvic metastasis	Atypical glandular cells	Endometrial malignant cells Low grade Type I High grade Type II	Biopsy
Uterine leiomyosarcoma^[6]^[7]^[8]^[9]	May have menorrhagia Intermenstrual bleeding	±	Abdominal pain Urinary symptoms Abdominal distension Asymptomatic	Abdominal distension Enlarged or normal sized uterus Lymphadenopathy	↓	–	+	Uterine mass Lymph node metastases	Shows details of uterine mass boundaries, extent and spread	Negative	Epithiloid shaped smooth muscle cells showing: High mitotic index Cellular atypia Coagulative necrosis Two variants of leiomyosarcoma: Epithelioid leiomyosarcoma Myxoid leiomyosarcoma (bland features)	Biopsy
Diseases	Bleeding	Pelvic Pain/pressure/ discomfort	Other	Pelvic examination	Hb	B-HCG	CA-125	Ultrasound	MRI	Pap Smear	Histopathology	Gold standard
Uterine leiomyoma^[10]^[11]^[12]	May have menorrhagia May have intermenstrual bleeding	+	Asymptomatic Dysmenorrhea (most common symptoms) Infertility Obstetric complications Obstructive symptoms (due to compression) Dyspareunia Torsion or degeneration	Enlarged mobile uterus Irregular contour Large fibroid uteri may cause abdominal distention	↓ or Nl	–	–	Transvaginal ultrasound shows: Hypoechoic, well-circumscribed round masses Location of fibroid: Submucosal, intramural, subserosal, and cervical fibroids	"Popcorn" calcification in the fibroid (degeneration) Differentiaites between leiomyomas, adenomyosis and adenomyomas	Normal	Normal appearing bundle of epithiloid shape smooth muscle cells with normal mitotic index	Imaging and histologic analysis
Uterine carcinosarcomas (Malignant mixed mullerian tumour (MMMT) of the uterus)^[13]^[14]^[15]^[16]	May have menorrhagia May have intermenstrual bleeding	±	Classical triad: Pain Bleeding Rapidly enlarging uterus	Enlarged uterus Pelvic mass Mass protruding through the cervical os Involvement of the cervix	↓	–	+	Enlarged uterine cavity Hyperechoic mass in uterus and cervix	Heterogenous bulky polypoid mass with intense enhancement		Biphasic: High grade carcinomatous (epithelial) contents Stromal sarcomatous (connective tissue)	Biopsy
Cervical cancer^[17]^[18]	Menorrhagia Intermenstrual bleeding Postcoital bleeding Vaginal passage of bleeding	± Pressure-related bowel and bladder symptoms	Copious malodorous vaginal discharge Hematuria	Enlarged uterus Concomitant cervical lesions Abdominal distention	↓	–	±	To evaluate tumor size, extent and parametrial invasion Usually not needed for diagnosis	To evaluate tumor size, local extent and staging	Squamous cell carcinoma Low-grade squamous intraepithelial lesions (LSILs) High-grade squamous intraepithelial lesions (HSILs) Adenocarcinoma Atypical glandular cells (AGC) Endocervical adenocarcinoma in situ (AIS)	Squamous cell carcinoma Adenocarcinoma Adenosquamous cervical tumors	Colposcopy and biopsy
Diseases	Bleeding	Pelvic Pain/pressure/ discomfort	Other	Pelvic examination	Hb	B-HCG	CA-125	Ultrasound	MRI	Pap Smear	Histopathology	Gold standard
Metastasis	Menorrhagia Intermenstrual bleeding	±	Asymptomatic Obstetric complications Dysmenorrhea (most common symptoms) Obstructive symptoms (due to urinary bladder and bowel compression) Dyspareunia	Enlarged uterus Abdominal distention	↓	–	–	Enlarged uterine cavity Hyperechoic mass in uterus and cervix	Shows involvement of uterus, lymph nodes, parmetrial area, and surrounding area	Normal May show malignant metastatic cells	Not recommended It may show the malignant cells of the primary site	Biopsy and histopathology analysis of the primary site of the tumor
Endometrial polyp^[19]^[20]	Menorrhagia Intermenstrual bleeding Postmenopausal bleeding	–	Asymptomatic Endometrial polyp prolapses (visible on speculum examination protruding through cervical os)	Normal sized uterus with smooth surface	↓	–	+ or Nl	Incidentally found on pelvic ultrasound (most common)	MRI will show polyp size and dimension in detail Not required for diagnosis	Normal	Localized hyperplastic growth of endometrial glands and stroma around a vessel	Imaging Histologic evaluation
Endometrial hyperplasia^[21]^[22]^[23]^[24]	Menorrhagia Intermenstrual bleeding Postmenopausal bleeding	–	Asymptomatic	Normal sized uterus with smooth surface	↓	–	+	Determines endometrial thickness Rules out other abnormalities	Thick endometrial lining	Abnormal glandular or endometrial cells on pap smear	Non-neoplastic changes: Disordered endometrial growth Benign hyperplasia Simple hyperplasia Complex hyperplasia without atypia Precancerous changes: Endometrial intraepithelial neoplasms Atypical complex hyperplasia	Endometrial sampling
Uterine adenomyosis^[25]^[26]^[27]	–	±	Dysmenorrhea Subfertility	Diffusely enlarged tender boggy uterus with smooth surface Uterus may develop masses	↓	–	+	Snow storm appearance in diffuse adenomyosis Shows a uterine mass in case of adenoma	Identifies diffuse or focal adenomyosis from leiomyoma	Mostly normal may show glandular cells in cervical cytology	Endometrial glands in myometrium of uterus	Imaging Histologic diagnosis
Diseases	Bleeding	Pelvic Pain/pressure/ discomfort	Other	Pelvic examination	Hb	B-HCG	CA-125	Ultrasound	MRI	Pap Smear	Histopathology	Gold standard
Hematometra (blood within the uterine cavity) ^[28]^[29]	–	+ Cramping cyclic pain	Dysmenorrhea Amenorrhea Hypotension Vasovagal syncope	Firm and enlarged uterus Adenaxal tenderness Pelvic examination may be restricted due to pain	↓	–	–	Echogenic fluid in the uterine cavity occluding cervical os	Not required	Normal	Biopsy is not required for diagnosis	Ultrasound
Gestational trophoblastic disease^[30]^[31]	May have menorrhagia May have intermenstrual bleeding	+	Pulmonary metastasis: Dyspnea Chest pain Cough Hemoptysis Vaginal metastasis: Vaginal bleeding Purulent vaginal discharge Central nervous system metastasis: Asymptomatic Neurologic signs	Irregularly sized boggy enlarged uterus Adnexal fullness Abdominal distention	↓	±	+	Dilated grape like structures Diffuse hydropic swelling Multiples echoes Cystic spaces invading edometrium and myometrium (in case of invasive disease)	MRI defines the extent of primary lesion, invasion and distant metastasis	Trophoblastic cells	Dilated grape like villous structures Invasive malignant lesions	Imaging Histologic diagnosis
Incomplete abortion	Intermenstrual bleeding Vaginal bleeding	+	Abdominal pain/cramps	Enlarges uterus Abdominal distention	N/↓	±	+↓	Uterus shows fetus with absent cardiac activity in lower part of uterus	Not required for the diagnosis	Not required for the diagnosis	Suction biopsy and histology shows fetal and placental tissues	Imaging Histologic diagnosis
Pregnancy	Absent menstrual cycle May have intermenstrual bleeding	+	Nausea Fatigue	Enlarged gravid uterus Abdominal distention	–	+	–	Fetus inside uterine cavity	Not needed once ultrasound determines pregnancy	Normal or may show cervical cells	Not needed once ultrasound determines pregnancy	Transvaginal ultrasound
Uterine lymphoma^[1]^[32]^[33]^[34]	Menorrhagia Abnormal uterine bleeding Post-coital bleeding Intermenstrual bleeding Postmenopausal bleeding	+	Bladder obstruction Abdominal pain	Abdominal distension Abdominal mass protruding into abdomen	↓	-	-	Show pelvic mass	Shows pelvic mass , its extent in the uterus, and involvement of surrounding lymph nodes	May show malignant cells mostly non-specific	Histology may show primary malignant lymphomas Non-Hodgkin lymphomas, diffuse large B-cell lymphomas (most common)	Laparoscopy and biopsy
Diseases	Bleeding	Pelvic Pain/pressure/ discomfort	Other	Pelvic examination	Hb	B-HCG	CA-125	Ultrasound	MRI	Pap Smear	Histopathology	Gold standard

References

↑ ^1.0 ^1.1 Hippisley-Cox J, Coupland C (2011). "Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm". BMJ. 344: d8009. doi:10.1136/bmj.d8009. PMC 3251328. PMID 22217630.
↑ "ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer". Obstet Gynecol. 106 (2): 413–25. August 2005. PMID 16055605.
↑ Boruta DM, Gehrig PA, Fader AN, Olawaiye AB (October 2009). "Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review". Gynecol. Oncol. 115 (1): 142–153. doi:10.1016/j.ygyno.2009.06.011. PMID 19592079.
↑ Bokhman JV (February 1983). "Two pathogenetic types of endometrial carcinoma". Gynecol. Oncol. 15 (1): 10–7. PMID 6822361.
↑ Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F (November 2010). "Factors associated with Type I and Type II endometrial cancer". Cancer Causes Control. 21 (11): 1851–6. doi:10.1007/s10552-010-9612-8. PMC 2962676. PMID 20628804.
↑ Nordal RR, Thoresen SO (May 1997). "Uterine sarcomas in Norway 1956-1992: incidence, survival and mortality". Eur. J. Cancer. 33 (6): 907–11. PMID 9291814.
↑ Goto A, Takeuchi S, Sugimura K, Maruo T (2002). "Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus". Int. J. Gynecol. Cancer. 12 (4): 354–61. PMID 12144683.
↑ Bell SW, Kempson RL, Hendrickson MR (June 1994). "Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases". Am. J. Surg. Pathol. 18 (6): 535–58. PMID 8179071.
↑ Karpathiou G, Sivridis E, Giatromanolaki A (2010). "Myxoid leiomyosarcoma of the uterus: a diagnostic challenge". Eur. J. Gynaecol. Oncol. 31 (4): 446–8. PMID 20882892.
↑ Stewart EA (April 2015). "Clinical practice. Uterine fibroids". N. Engl. J. Med. 372 (17): 1646–55. doi:10.1056/NEJMcp1411029. PMID 25901428.
↑ Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F (March 2002). "Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas". Am. J. Obstet. Gynecol. 186 (3): 409–15. PMID 11904599.
↑ Omary RA, Vasireddy S, Chrisman HB, Ryu RK, Pereles FS, Carr JC, Resnick SA, Nemcek AA, Vogelzang RL (November 2002). "The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids". J Vasc Interv Radiol. 13 (11): 1149–53. PMID 12427815.
↑ Chaffer CL, San Juan BP, Lim E, Weinberg RA (December 2016). "EMT, cell plasticity and metastasis". Cancer Metastasis Rev. 35 (4): 645–654. doi:10.1007/s10555-016-9648-7. PMID 27878502.
↑ Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD (October 2016). "Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition". Proc. Natl. Acad. Sci. U.S.A. 113 (43): 12238–12243. doi:10.1073/pnas.1614120113. PMC 5087050. PMID 27791010.
↑ Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ (March 2004). "Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome". Int. J. Radiat. Oncol. Biol. Phys. 58 (3): 786–96. doi:10.1016/S0360-3016(03)01561-X. PMID 14967435.
↑ Teo SY, Babagbemi KT, Peters HE, Mortele KJ (July 2008). "Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI". AJR Am J Roentgenol. 191 (1): 278–83. doi:10.2214/AJR.07.3281. PMID 18562759.
↑ "Pap and HPV Testing - National Cancer Institute".
↑ Benedet JL, Bender H, Jones H, Ngan HY, Pecorelli S (August 2000). "FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology". Int J Gynaecol Obstet. 70 (2): 209–62. PMID 11041682.
↑ Kim KR, Peng R, Ro JY, Robboy SJ (August 2004). "A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium". Am. J. Surg. Pathol. 28 (8): 1057–62. PMID 15252313.
↑ Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J (2011). "Diagnosis and management of endometrial polyps: a critical review of the literature". J Minim Invasive Gynecol. 18 (5): 569–81. doi:10.1016/j.jmig.2011.05.018. PMID 21783430.
↑ Emons G, Beckmann MW, Schmidt D, Mallmann P (February 2015). "New WHO Classification of Endometrial Hyperplasias". Geburtshilfe Frauenheilkd. 75 (2): 135–136. doi:10.1055/s-0034-1396256. PMC 4361167. PMID 25797956.
↑ Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D (October 2007). "2006 consensus guidelines for the management of women with abnormal cervical screening tests". J Low Genit Tract Dis. 11 (4): 201–22. doi:10.1097/LGT.0b013e3181585870. PMID 17917566.
↑ Espindola D, Kennedy KA, Fischer EG (December 2007). "Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia". Obstet. Gynecol. Clin. North Am. 34 (4): 717–37, ix. doi:10.1016/j.ogc.2007.09.001. PMID 18061866.
↑ Montgomery BE, Daum GS, Dunton CJ (May 2004). "Endometrial hyperplasia: a review". Obstet Gynecol Surv. 59 (5): 368–78. PMID 15097798.
↑ McElin TW, Bird CC (1974). "Adenomyosis of the uterus". Obstet Gynecol Annu. 3: 425–41. PMID 4608783.
↑ Maheshwari A, Gurunath S, Fatima F, Bhattacharya S (July 2012). "Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes". Hum. Reprod. Update. 18 (4): 374–92. doi:10.1093/humupd/dms006. PMID 22442261.
↑ Byun JY, Kim SE, Choi BG, Ko GY, Jung SE, Choi KH (October 1999). "Diffuse and focal adenomyosis: MR imaging findings". Radiographics. 19 Spec No: S161–70. doi:10.1148/radiographics.19.suppl_1.g99oc03s161. PMID 10517452.
↑ McCausland AM, McCausland VM (2007). "Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention". J Minim Invasive Gynecol. 14 (4): 399–406. doi:10.1016/j.jmig.2007.04.004. PMID 17630156.
↑ U Nayak A, Swarup A, G S J, N S (April 2010). "Hematometra and acute abdomen". J Emerg Trauma Shock. 3 (2): 191–2. doi:10.4103/0974-2700.62117. PMC 2884455. PMID 20606801. Vancouver style error: name (help)
↑ Bakri YN, Berkowitz RS, Khan J, Goldstein DP, von Sinner W, Jabbar FA (March 1994). "Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure". J Reprod Med. 39 (3): 175–8. PMID 8035373.
↑ Lurain JR (December 2010). "Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole". Am. J. Obstet. Gynecol. 203 (6): 531–9. doi:10.1016/j.ajog.2010.06.073. PMID 20728069.
↑ Samama M, van Poelgeest M (September 2011). "Primary malignant lymphoma of the uterus: a case report and review of the literature". Case Rep Oncol. 4 (3): 560–3. doi:10.1159/000334852. PMC 3251245. PMID 22220150.
↑ Shen CJ, Tsai EM, Tsai KB, Wu CH, Hsu SC (March 2007). "Primary T-cell lymphoma of the uterine corpus". Kaohsiung J. Med. Sci. 23 (3): 138–41. doi:10.1016/S1607-551X(09)70388-2. PMID 17389178.
↑ Heeren JH, Croonen AM, Pijnenborg JM (April 2008). "Primary extranodal marginal zone B-cell lymphoma of the female genital tract: a case report and literature review". Int. J. Gynecol. Pathol. 27 (2): 243–6. doi:10.1097/PGP.0b013e3181569a0a. PMID 18317217.

[pmid22217630-1] 1.0 ^1.1 Hippisley-Cox J, Coupland C (2011). "Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm". BMJ. 344: d8009. doi:10.1136/bmj.d8009. PMC 3251328. PMID 22217630.

[pmid16055605-2] "ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer". Obstet Gynecol. 106 (2): 413–25. August 2005. PMID 16055605.

[pmid195920792-3] Boruta DM, Gehrig PA, Fader AN, Olawaiye AB (October 2009). "Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review". Gynecol. Oncol. 115 (1): 142–153. doi:10.1016/j.ygyno.2009.06.011. PMID 19592079.

[pmid6822361-4] Bokhman JV (February 1983). "Two pathogenetic types of endometrial carcinoma". Gynecol. Oncol. 15 (1): 10–7. PMID 6822361.

[pmid20628804-5] Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F (November 2010). "Factors associated with Type I and Type II endometrial cancer". Cancer Causes Control. 21 (11): 1851–6. doi:10.1007/s10552-010-9612-8. PMC 2962676. PMID 20628804.

[pmid9291814-6] Nordal RR, Thoresen SO (May 1997). "Uterine sarcomas in Norway 1956-1992: incidence, survival and mortality". Eur. J. Cancer. 33 (6): 907–11. PMID 9291814.

[pmid12144683-7] Goto A, Takeuchi S, Sugimura K, Maruo T (2002). "Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus". Int. J. Gynecol. Cancer. 12 (4): 354–61. PMID 12144683.

[pmid8179071-8] Bell SW, Kempson RL, Hendrickson MR (June 1994). "Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases". Am. J. Surg. Pathol. 18 (6): 535–58. PMID 8179071.

[pmid20882892-9] Karpathiou G, Sivridis E, Giatromanolaki A (2010). "Myxoid leiomyosarcoma of the uterus: a diagnostic challenge". Eur. J. Gynaecol. Oncol. 31 (4): 446–8. PMID 20882892.

[pmid25901428-10] Stewart EA (April 2015). "Clinical practice. Uterine fibroids". N. Engl. J. Med. 372 (17): 1646–55. doi:10.1056/NEJMcp1411029. PMID 25901428.

[pmid11904599-11] Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F (March 2002). "Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas". Am. J. Obstet. Gynecol. 186 (3): 409–15. PMID 11904599.

[pmid12427815-12] Omary RA, Vasireddy S, Chrisman HB, Ryu RK, Pereles FS, Carr JC, Resnick SA, Nemcek AA, Vogelzang RL (November 2002). "The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids". J Vasc Interv Radiol. 13 (11): 1149–53. PMID 12427815.

[pmid27878502-13] Chaffer CL, San Juan BP, Lim E, Weinberg RA (December 2016). "EMT, cell plasticity and metastasis". Cancer Metastasis Rev. 35 (4): 645–654. doi:10.1007/s10555-016-9648-7. PMID 27878502.

[pmid27791010-14] Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD (October 2016). "Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition". Proc. Natl. Acad. Sci. U.S.A. 113 (43): 12238–12243. doi:10.1073/pnas.1614120113. PMC 5087050. PMID 27791010.

[pmid14967435-15] Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ (March 2004). "Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome". Int. J. Radiat. Oncol. Biol. Phys. 58 (3): 786–96. doi:10.1016/S0360-3016(03)01561-X. PMID 14967435.

[pmid18562759-16] Teo SY, Babagbemi KT, Peters HE, Mortele KJ (July 2008). "Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI". AJR Am J Roentgenol. 191 (1): 278–83. doi:10.2214/AJR.07.3281. PMID 18562759.

[urlPap_and_HPV_Testing_-_National_Cancer_Institute-17] "Pap and HPV Testing - National Cancer Institute".

[pmid11041682-18] Benedet JL, Bender H, Jones H, Ngan HY, Pecorelli S (August 2000). "FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology". Int J Gynaecol Obstet. 70 (2): 209–62. PMID 11041682.

[pmid15252313-19] Kim KR, Peng R, Ro JY, Robboy SJ (August 2004). "A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium". Am. J. Surg. Pathol. 28 (8): 1057–62. PMID 15252313.

[pmid21783430-20] Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J (2011). "Diagnosis and management of endometrial polyps: a critical review of the literature". J Minim Invasive Gynecol. 18 (5): 569–81. doi:10.1016/j.jmig.2011.05.018. PMID 21783430.

[pmid25797956-21] Emons G, Beckmann MW, Schmidt D, Mallmann P (February 2015). "New WHO Classification of Endometrial Hyperplasias". Geburtshilfe Frauenheilkd. 75 (2): 135–136. doi:10.1055/s-0034-1396256. PMC 4361167. PMID 25797956.

[pmid17917566-22] Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D (October 2007). "2006 consensus guidelines for the management of women with abnormal cervical screening tests". J Low Genit Tract Dis. 11 (4): 201–22. doi:10.1097/LGT.0b013e3181585870. PMID 17917566.

[pmid18061866-23] Espindola D, Kennedy KA, Fischer EG (December 2007). "Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia". Obstet. Gynecol. Clin. North Am. 34 (4): 717–37, ix. doi:10.1016/j.ogc.2007.09.001. PMID 18061866.

[pmid15097798-24] Montgomery BE, Daum GS, Dunton CJ (May 2004). "Endometrial hyperplasia: a review". Obstet Gynecol Surv. 59 (5): 368–78. PMID 15097798.

[pmid4608783-25] McElin TW, Bird CC (1974). "Adenomyosis of the uterus". Obstet Gynecol Annu. 3: 425–41. PMID 4608783.

[pmid22442261-26] Maheshwari A, Gurunath S, Fatima F, Bhattacharya S (July 2012). "Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes". Hum. Reprod. Update. 18 (4): 374–92. doi:10.1093/humupd/dms006. PMID 22442261.

[pmid10517452-27] Byun JY, Kim SE, Choi BG, Ko GY, Jung SE, Choi KH (October 1999). "Diffuse and focal adenomyosis: MR imaging findings". Radiographics. 19 Spec No: S161–70. doi:10.1148/radiographics.19.suppl_1.g99oc03s161. PMID 10517452.

[pmid17630156-28] McCausland AM, McCausland VM (2007). "Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention". J Minim Invasive Gynecol. 14 (4): 399–406. doi:10.1016/j.jmig.2007.04.004. PMID 17630156.

[pmid20606801-29] U Nayak A, Swarup A, G S J, N S (April 2010). "Hematometra and acute abdomen". J Emerg Trauma Shock. 3 (2): 191–2. doi:10.4103/0974-2700.62117. PMC 2884455. PMID 20606801. Vancouver style error: name (help)

[pmid8035373-30] Bakri YN, Berkowitz RS, Khan J, Goldstein DP, von Sinner W, Jabbar FA (March 1994). "Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure". J Reprod Med. 39 (3): 175–8. PMID 8035373.

[pmid20728069-31] Lurain JR (December 2010). "Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole". Am. J. Obstet. Gynecol. 203 (6): 531–9. doi:10.1016/j.ajog.2010.06.073. PMID 20728069.

[pmid22220150-32] Samama M, van Poelgeest M (September 2011). "Primary malignant lymphoma of the uterus: a case report and review of the literature". Case Rep Oncol. 4 (3): 560–3. doi:10.1159/000334852. PMC 3251245. PMID 22220150.

[pmid17389178-33] Shen CJ, Tsai EM, Tsai KB, Wu CH, Hsu SC (March 2007). "Primary T-cell lymphoma of the uterine corpus". Kaohsiung J. Med. Sci. 23 (3): 138–41. doi:10.1016/S1607-551X(09)70388-2. PMID 17389178.

[pmid18317217-34] Heeren JH, Croonen AM, Pijnenborg JM (April 2008). "Primary extranodal marginal zone B-cell lymphoma of the female genital tract: a case report and literature review". Int. J. Gynecol. Pathol. 27 (2): 243–6. doi:10.1097/PGP.0b013e3181569a0a. PMID 18317217.

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@@ Line 1: / Line 1: @@
 __NOTOC__
-{{Endometrial cancer}}
+[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Endometrial_cancer]]
-{{CMG}}{{AE}}{{MD}}{{RAK}}
+{{CMG}}; {{AE}} {{Qurrat}}; {{MD}}{{RAK}}
 ==Overview==
-In early stages endometrial cancer must be differentiated from diseases that cause abnormal uterine bleeding and endometrial thickening on  ultrasound, such as [[endometrial hyperplasia]], [[endometrial polyp]] and submucosal uterine [[leiomyoma]]. In advanced stages endometrial cancer must be differentiated from uterine [[sarcoma]] and uterine [[lymphoma]].
+In early stages endometrial cancer must be differentiated from diseases that cause [[abnormal uterine bleeding]] and [[endometrial]] thickening on [[ultrasound]], such as [[endometrial hyperplasia]], [[endometrial polyp]], and submucosal uterine [[leiomyoma]]. In advanced stages endometrial cancer must be differentiated from [[uterine sarcoma]] and uterine [[lymphoma]].
 ==Differentiating Endometrial Cancer From Other Diseases==
-* In early disease, uterine cancer must be differentiated from other diseases causing endometrial thickening:<ref name="pmid22217630">{{cite journal| author=Hippisley-Cox J, Coupland C| title=Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm. | journal=BMJ | year= 2011 | volume= 344 | issue=  | pages= d8009 | pmid=22217630 | doi=10.1136/bmj.d8009 | pmc=3251328 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22217630  }} </ref>
+* In early stages endometrial cancer must be differentiated from diseases that cause [[abnormal uterine bleeding]] and [[endometrial]] thickening on [[ultrasound]], such as [[endometrial hyperplasia]], [[endometrial polyp]], and submucosal uterine [[leiomyoma]]. In advanced stages endometrial cancer must be differentiated from [[uterine sarcoma]] and uterine [[lymphoma]].<ref name="pmid22217630">{{cite journal| author=Hippisley-Cox J, Coupland C| title=Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm. | journal=BMJ | year= 2011 | volume= 344 | issue=  | pages= d8009 | pmid=22217630 | doi=10.1136/bmj.d8009 | pmc=3251328 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22217630  }} </ref>
-:* Benign endometrial proliferation
-:* [[Endometrial hyperplasia]]
-:* [[Endometrial polyp]]
-:* Submucosal uterine [[leiomyoma]]
-*  In advanced disease, uterine cancer must be differentiated from other diseases:<ref name="pmid22217630">{{cite journal| author=Hippisley-Cox J, Coupland C| title=Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm. | journal=BMJ | year= 2011 | volume= 344 | issue=  | pages= d8009 | pmid=22217630 | doi=10.1136/bmj.d8009 | pmc=3251328 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22217630  }} </ref>
-:* [[Uterine sarcoma]]
-::* Endometrial stromal [[sarcoma]] (ESS)
-::* [[Leiomyosarcoma]] of the [[uterus]]
-::* Malignant mixed Mullerian tumour (MMMT) of the uterus
-:* Uterine lymphoma: rare
-::* Primary uterine [[lymphoma]]
-::* Secondary uterine involvement with lymphoma
-:* [[Cervical cancer]] with uterine invasion
-:* Metastasis to the uterus from a non gynecological malignancy: rare
 {|
 |- style="background: #4479BA; color: #FFFFFF; text-align: center;"
-! colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Diseases</small>
+! colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
-| colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''<small>Clinical manifestations</small>'''
+! colspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
-! colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Para-clinical findings</small>
+! colspan="7" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
-| rowspan="4" |<small>'''Pap Smear'''</small>
+! colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
-! rowspan="4" |<small>Histopathology</small>
+|-
-| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''<small>Gold standard</small>'''
+! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Additional findings</small>
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examination
+|-
+! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
+|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
+discomfort
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdomino-pelvic examination
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
 |-
-| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''<small>Symptoms</small>'''
+! align="center" style="background:#DCDCDC;" + |[[Uterine cancer|Endometrial]] [[Uterine cancer|cancer]]<ref name="pmid16055605">{{cite journal |vauthors= |title=ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer |journal=Obstet Gynecol |volume=106 |issue=2 |pages=413–25 |date=August 2005 |pmid=16055605 |doi= |url=}}</ref><ref name="pmid195920792">{{cite journal |vauthors=Boruta DM, Gehrig PA, Fader AN, Olawaiye AB |title=Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review |journal=Gynecol. Oncol. |volume=115 |issue=1 |pages=142–153 |date=October 2009 |pmid=19592079 |doi=10.1016/j.ygyno.2009.06.011 |url=}}</ref><ref name="pmid6822361">{{cite journal |vauthors=Bokhman JV |title=Two pathogenetic types of endometrial carcinoma |journal=Gynecol. Oncol. |volume=15 |issue=1 |pages=10–7 |date=February 1983 |pmid=6822361 |doi= |url=}}</ref><ref name="pmid20628804">{{cite journal |vauthors=Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F |title=Factors associated with Type I and Type II endometrial cancer |journal=Cancer Causes Control |volume=21 |issue=11 |pages=1851–6 |date=November 2010 |pmid=20628804 |pmc=2962676 |doi=10.1007/s10552-010-9612-8 |url=}}</ref>
-! colspan="2" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Physical examination</small>
+| align="left" style="background:#F5F5F5;" + |
+* [[Menorrhagia]]
+* [[Metrorrhagia]] in [[premenopausal]] women
+* Postcoital [[bleeding]]
+* Intermenstrual [[bleeding]]
+| align="center" style="background:#F5F5F5;" + |±
+| align="left" style="background:#F5F5F5;" + |
+* [[Polyuria]] and [[dysuria]] (due to compression)
+* [[Fatigue|Fatigue]]
+* [[Weight loss|Weight loss]]
+| align="left" style="background:#F5F5F5;" + |
+* Enlarged fixed  [[uterus]]
+* [[Vaginal bleeding]]
+* [[Vaginal discharge]]
+* [[Lymphadenopathy]]
+* [[Mesentery|Mesenteric]] nodules ([[metastasis]])
+| align="center" style="background:#F5F5F5;" + |[[Anemia|↓]]
+| align="center" style="background:#F5F5F5;" + |–
+| align="center" style="background:#F5F5F5;" + | +
+| align="left" style="background:#F5F5F5;" + |
+* A thickened [[Endometrium|endometrial]] lining >4mm
+| align="left" style="background:#F5F5F5;" + |
+* [[Endometrium|Endometrial]] thickening
+* [[Lymph node]] involvement
+* Pelvic [[metastasis]]
+| align="left" style="background:#F5F5F5;" + |
+* Atypical glandular cells
+| align="left" style="background:#F5F5F5;" + |[[Malignant|Endometrial malignant cells]]
+* Low grade Type I
+* High grade Type II
+| align="left" style="background:#F5F5F5;" + |
+* [[Biopsy]]
 |-
-! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Lab Findings</small>
+! align="center" style="background:#DCDCDC;" + |[[Uterine sarcoma|Uterine]]
-! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Imaging</small>
+[[Leiomyosarcoma|leiomyosarcoma]]<ref name="pmid9291814">{{cite journal |vauthors=Nordal RR, Thoresen SO |title=Uterine sarcomas in Norway 1956-1992: incidence, survival and mortality |journal=Eur. J. Cancer |volume=33 |issue=6 |pages=907–11 |date=May 1997 |pmid=9291814 |doi= |url=}}</ref><ref name="pmid12144683">{{cite journal |vauthors=Goto A, Takeuchi S, Sugimura K, Maruo T |title=Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus |journal=Int. J. Gynecol. Cancer |volume=12 |issue=4 |pages=354–61 |date=2002 |pmid=12144683 |doi= |url=}}</ref><ref name="pmid8179071">{{cite journal |vauthors=Bell SW, Kempson RL, Hendrickson MR |title=Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases |journal=Am. J. Surg. Pathol. |volume=18 |issue=6 |pages=535–58 |date=June 1994 |pmid=8179071 |doi= |url=}}</ref><ref name="pmid20882892">{{cite journal |vauthors=Karpathiou G, Sivridis E, Giatromanolaki A |title=Myxoid leiomyosarcoma of the uterus: a diagnostic challenge |journal=Eur. J. Gynaecol. Oncol. |volume=31 |issue=4 |pages=446–8 |date=2010 |pmid=20882892 |doi= |url=}}</ref>
+| align="left" style="background:#F5F5F5;" + |
+* May have [[menorrhagia]]
+* Intermenstrual [[bleeding]]
+| align="center" style="background:#F5F5F5;" + |±
+| align="left" style="background:#F5F5F5;" + |
+* [[Abdominal pain]]
+* [[Urinary system|Urinary]] symptoms
+* [[Abdominal distension]]
+* Asymptomatic
+| align="left" style="background:#F5F5F5;" + |
+* [[Abdominal distension]]
+* Enlarged or normal sized [[uterus]]
+* [[Lymphadenopathy]]
+| align="center" style="background:#F5F5F5;" + |↓
+| align="center" style="background:#F5F5F5;" + |–
+| align="center" style="background:#F5F5F5;" + | +
+| align="left" style="background:#F5F5F5;" + |
+* [[Uterus|Uterine]] mass
+* [[Lymph node]] metastases
+| align="left" style="background:#F5F5F5;" + |
+* Shows details of [[Uterus|uterine]] mass boundaries, extent and spread
+| align="left" style="background:#F5F5F5;" + |
+* Negative
+| align="left" style="background:#F5F5F5;" + |
+* Epithiloid shaped [[Smooth muscle|smooth muscle cells]] showing:
+:* High [[mitotic index]]
+:* [[Atypia|Cellular atypia]]
+:* [[Coagulative necrosis]]
+* Two variants of [[leiomyosarcoma]]:
+:* [[Leiomyosarcoma|Epithelioid leiomyosarcoma]]
+:* Myxoid [[leiomyosarcoma]]  (bland features)
+| align="left" style="background:#F5F5F5;" + |
+* [[Biopsy]]
 |-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Vaginal </small><small>leeding</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
-! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Pelvic P</small><small>ain</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Abdominal D</small><small>istention</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Other</small>
+discomfort
-<small>symptoms</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Pelvic M</small><small>ass</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
-! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Abdominal D</small><small>istension</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Hb</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>CEA-19</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>Ultrasound</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |<small>MRI</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>[[Uterine cancer|Uterine]]</small> <small>[[Uterine cancer|cancer]]</small>
+! align="center" style="background:#DCDCDC;" + |[[Uterine leiomyoma]]<ref name="pmid25901428">{{cite journal |vauthors=Stewart EA |title=Clinical practice. Uterine fibroids |journal=N. Engl. J. Med. |volume=372 |issue=17 |pages=1646–55 |date=April 2015 |pmid=25901428 |doi=10.1056/NEJMcp1411029 |url=}}</ref><ref name="pmid11904599">{{cite journal |vauthors=Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F |title=Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=3 |pages=409–15 |date=March 2002 |pmid=11904599 |doi= |url=}}</ref><ref name="pmid12427815">{{cite journal |vauthors=Omary RA, Vasireddy S, Chrisman HB, Ryu RK, Pereles FS, Carr JC, Resnick SA, Nemcek AA, Vogelzang RL |title=The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids |journal=J Vasc Interv Radiol |volume=13 |issue=11 |pages=1149–53 |date=November 2002 |pmid=12427815 |doi= |url=}}</ref>
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* May have [[menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* May have intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Asymptomatic
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+* [[Dysmenorrhea]] (most common symptoms)
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Infertility]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Obstetric]] complications
-| style="background: #F5F5F5; padding: 5px;" |
+* Obstructive symptoms (due to compression)
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Dyspareunia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Torsion or degeneration
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Enlarged mobile [[uterus]]
+* Irregular contour
+* Large fibroid uteri may cause [[abdominal distention]]
+| align="center" style="background:#F5F5F5;" + |↓ or Nl
+| align="center" style="background:#F5F5F5;" + |–
+| align="center" style="background:#F5F5F5;" + |–
+| align="left" style="background:#F5F5F5;" + |
+* [[Transvaginal ultrasound]] shows:
+:* Hypoechoic, well-circumscribed round masses
+:* Location of [[fibroid]]: Submucosal, intramural, subserosal, and cervical fibroids
+| align="left" style="background:#F5F5F5;" + |
+* "Popcorn" calcification in the [[fibroid]] (degeneration)
+* Differentiaites between [[leiomyomas]], [[adenomyosis]] and [[adenomyomas]]
+| align="left" style="background:#F5F5F5;" + |
+* Normal
+| align="left" style="background:#F5F5F5;" + |
+* Normal appearing bundle of epithiloid shape [[smooth muscle cells]] with normal mitotic index
+| align="left" style="background:#F5F5F5;" + |
+* Imaging and histologic analysis
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Uterine sarcoma|<small>Uterine</small>]]
+! align="center" style="background:#DCDCDC;" + |Uterine carcinosarcomas (Malignant mixed mullerian tumour (MMMT) of the [[uterus]])<ref name="pmid27878502">{{cite journal |vauthors=Chaffer CL, San Juan BP, Lim E, Weinberg RA |title=EMT, cell plasticity and metastasis |journal=Cancer Metastasis Rev. |volume=35 |issue=4 |pages=645–654 |date=December 2016 |pmid=27878502 |doi=10.1007/s10555-016-9648-7 |url=}}</ref><ref name="pmid27791010">{{cite journal |vauthors=Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD |title=Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=113 |issue=43 |pages=12238–12243 |date=October 2016 |pmid=27791010 |pmc=5087050 |doi=10.1073/pnas.1614120113 |url=}}</ref><ref name="pmid14967435">{{cite journal |vauthors=Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ |title=Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=58 |issue=3 |pages=786–96 |date=March 2004 |pmid=14967435 |doi=10.1016/S0360-3016(03)01561-X |url=}}</ref><ref name="pmid18562759">{{cite journal |vauthors=Teo SY, Babagbemi KT, Peters HE, Mortele KJ |title=Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI |journal=AJR Am J Roentgenol |volume=191 |issue=1 |pages=278–83 |date=July 2008 |pmid=18562759 |doi=10.2214/AJR.07.3281 |url=}}</ref>
-[[Uterine sarcoma|<small>sarcoma</small>]]
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* May have [[menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* May have intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |±
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Classical triad:
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Pain]]
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+** [[Bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+** Rapidly enlarging [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Enlarged [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Pelvic mass]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Mass protruding through the [[cervical os]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Involvement of the [[cervix]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |↓
+| align="center" style="background:#F5F5F5;" + |–
+| align="center" style="background:#F5F5F5;" + | +
+| align="left" style="background:#F5F5F5;" + |
+* Enlarged [[uterine]] cavity
+* Hyperechoic mass in [[uterus]] and [[cervix]]
+| align="left" style="background:#F5F5F5;" + |
+* Heterogenous bulky polypoid mass with intense enhancement
+| align="left" style="background:#F5F5F5;" + |
+| align="left" style="background:#F5F5F5;" + |
+* Biphasic:
+:* High grade carcinomatous ([[epithelial]]) contents
+:* Stromal sarcomatous ([[connective tissue]])
+| align="left" style="background:#F5F5F5;" + |
+* [[Biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Lymphoma|<small>Uterine</small>]]
+! align="center" style="background:#DCDCDC;" + |[[Cervical cancer]]<ref name="urlPap and HPV Testing - National Cancer Institute">{{cite web |url=https://www.cancer.gov/types/cervical/pap-hpv-testing-fact-sheet |title=Pap and HPV Testing - National Cancer Institute |format= |work= |accessdate=}}</ref><ref name="pmid11041682">{{cite journal |vauthors=Benedet JL, Bender H, Jones H, Ngan HY, Pecorelli S |title=FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology |journal=Int J Gynaecol Obstet |volume=70 |issue=2 |pages=209–62 |date=August 2000 |pmid=11041682 |doi= |url=}}</ref>
-[[Lymphoma|<small>lymphoma</small>]]
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Postcoital [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Vaginal]] passage of [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |±
-| style="background: #F5F5F5; padding: 5px;" |
+Pressure-related [[bowel]] and [[bladder]] symptoms
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+| align="left" style="background:#F5F5F5;" + |
+* Copious malodorous [[vaginal discharge]]
-<small>or</small>
+* [[Hematuria]]
+| align="left" style="background:#F5F5F5;" + |
-<small>N</small>
+* Enlarged [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Concomitant [[cervical]] lesions
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal distention]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |↓
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |±
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* To evaluate [[tumor]] size, extent and parametrial invasion
+* Usually not needed for diagnosis
+| align="left" style="background:#F5F5F5;" + |
+* To evaluate tumor size, local extent and staging
+| align="left" style="background:#F5F5F5;" + |
+* [[Squamous cell carcinoma]]
+:* Low-grade squamous intraepithelial lesions (LSILs)
+:* High-grade squamous intraepithelial lesions (HSILs)
+* [[Adenocarcinoma]]
+:* Atypical glandular cells (AGC)
+:* Endocervical adenocarcinoma in situ (AIS)
+| align="left" style="background:#F5F5F5;" + |
+* [[Squamous cell carcinoma]]
+* [[Adenocarcinoma]]
+* Adenosquamous cervical tumors
+| align="left" style="background:#F5F5F5;" + |
+* [[Colposcopy]] and [[biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Uterine</small> <small>[[leiomyoma]]</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
-| style="background: #F5F5F5; padding: 5px;" |
+discomfort
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
-<small>or</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
-<small>N</small>
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Malignant</small> <small>mixed</small><small>Mullerian</small>
+! align="center" style="background:#DCDCDC;" + |[[Metastasis]]
+| align="left" style="background:#F5F5F5;" + |
-<small>tumour</small>
+* [[Menorrhagia]]
+* Intermenstrual [[bleeding]]
-<small>(MMMT)</small>
+| align="center" style="background:#F5F5F5;" + |±
+| align="left" style="background:#F5F5F5;" + |
-<small>of the uterus</small>
+* Asymptomatic
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Obstetric]] complications
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Dysmenorrhea]] (most common symptoms)
-| style="background: #F5F5F5; padding: 5px;" |
+* Obstructive symptoms (due to [[urinary bladder]] and [[bowel]] compression)
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Dyspareunia]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Enlarged [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+* [[Abdominal distention]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |↓
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Enlarged [[uterine]] cavity
-| style="background: #F5F5F5; padding: 5px;" |
+* Hyperechoic mass in [[uterus]] and [[cervix]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
+* Shows involvement of [[uterus]], [[lymph nodes]], parmetrial area, and surrounding area
+| align="left" style="background:#F5F5F5;" + |
+* Normal
+* May show malignant [[metastatic cells]]
+| align="left" style="background:#F5F5F5;" + |
+* Not recommended
+* It may show the [[malignant]] cells of the primary site
+| align="left" style="background:#F5F5F5;" + |
+* [[Biopsy]] and [[histopathology]] analysis of the primary site of the [[tumor]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>[[Cervical cancer|Cervical]]</small> <small>[[Cervical cancer|cancer]]</small><small>with</small>
+! align="center" style="background:#DCDCDC;" + |[[Endometrial polyp]]<ref name="pmid15252313">{{cite journal |vauthors=Kim KR, Peng R, Ro JY, Robboy SJ |title=A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium |journal=Am. J. Surg. Pathol. |volume=28 |issue=8 |pages=1057–62 |date=August 2004 |pmid=15252313 |doi= |url=}}</ref><ref name="pmid21783430">{{cite journal |vauthors=Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J |title=Diagnosis and management of endometrial polyps: a critical review of the literature |journal=J Minim Invasive Gynecol |volume=18 |issue=5 |pages=569–81 |date=2011 |pmid=21783430 |doi=10.1016/j.jmig.2011.05.018 |url=}}</ref>
+| align="left" style="background:#F5F5F5;" + |
-<small>uterine</small>
+* [[Menorrhagia]]
+* Intermenstrual [[bleeding]]
-<small>invasion</small>
+* Postmenopausal [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Asymptomatic
-| style="background: #F5F5F5; padding: 5px;" |
+* Endometrial polyp prolapses (visible on speculum examination protruding through [[cervical os]])
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Normal sized [[uterus]] with smooth surface
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+| align="center" style="background:#F5F5F5;" + |↓
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | + or Nl
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Incidentally found on [[pelvic ultrasound]] (most common)
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* MRI will show [[polyp]] size and dimension in detail
-| style="background: #F5F5F5; padding: 5px;" |
+* Not required for [[diagnosis]]
+| align="left" style="background:#F5F5F5;" + |
+* Normal
+| align="left" style="background:#F5F5F5;" + |
+* Localized hyperplastic growth of [[endometrial glands]] and [[stroma]] around a [[vessel]]
+| align="left" style="background:#F5F5F5;" + |
+* [[Imaging]]
+* Histologic evaluation
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>[[Metastasis]]</small> <small>to the uterus</small><small>from a non gynaecologcial</small>
+! align="center" style="background:#DCDCDC;" + |[[Endometrial hyperplasia]]<ref name="pmid25797956">{{cite journal |vauthors=Emons G, Beckmann MW, Schmidt D, Mallmann P |title=New WHO Classification of Endometrial Hyperplasias |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=2 |pages=135–136 |date=February 2015 |pmid=25797956 |pmc=4361167 |doi=10.1055/s-0034-1396256 |url=}}</ref><ref name="pmid17917566">{{cite journal |vauthors=Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D |title=2006 consensus guidelines for the management of women with abnormal cervical screening tests |journal=J Low Genit Tract Dis |volume=11 |issue=4 |pages=201–22 |date=October 2007 |pmid=17917566 |doi=10.1097/LGT.0b013e3181585870 |url=}}</ref><ref name="pmid18061866">{{cite journal |vauthors=Espindola D, Kennedy KA, Fischer EG |title=Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia |journal=Obstet. Gynecol. Clin. North Am. |volume=34 |issue=4 |pages=717–37, ix |date=December 2007 |pmid=18061866 |doi=10.1016/j.ogc.2007.09.001 |url=}}</ref><ref name="pmid15097798">{{cite journal |vauthors=Montgomery BE, Daum GS, Dunton CJ |title=Endometrial hyperplasia: a review |journal=Obstet Gynecol Surv |volume=59 |issue=5 |pages=368–78 |date=May 2004 |pmid=15097798 |doi= |url=}}</ref>
+| align="left" style="background:#F5F5F5;" + |
-<small>malignancy</small>
+* [[Menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Postmenopausal [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Asymptomatic
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+* Normal sized [[uterus with smooth surface]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |↓
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Determines [[endometrial]] thickness
-| style="background: #F5F5F5; padding: 5px;" |
+* Rules out other abnormalities
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
+* Thick [[endometrial]] lining
+| align="left" style="background:#F5F5F5;" + |
+* Abnormal glandular or [[endometrial]] cells on [[pap smear]]
+| align="left" style="background:#F5F5F5;" + |
+* Non-neoplastic changes:
+:* Disordered [[endometrial]] growth
+:* Benign hyperplasia
+:* Simple hyperplasia
+:* Complex hyperplasia without atypia
+* Precancerous changes:
+:* Endometrial intraepithelial [[neoplasms]]
+:* Atypical complex hyperplasia
+| align="left" style="background:#F5F5F5;" + |
+* [[Endometrial]] sampling
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometrial polyp|<small>Endometrial</small>]]
+! align="center" style="background:#DCDCDC;" + |[[Adenomyosis|Uterine adenomyosis]]<ref name="pmid4608783">{{cite journal |vauthors=McElin TW, Bird CC |title=Adenomyosis of the uterus |journal=Obstet Gynecol Annu |volume=3 |issue= |pages=425–41 |date=1974 |pmid=4608783 |doi= |url=}}</ref><ref name="pmid22442261">{{cite journal |vauthors=Maheshwari A, Gurunath S, Fatima F, Bhattacharya S |title=Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes |journal=Hum. Reprod. Update |volume=18 |issue=4 |pages=374–92 |date=July 2012 |pmid=22442261 |doi=10.1093/humupd/dms006 |url=}}</ref><ref name="pmid10517452">{{cite journal |vauthors=Byun JY, Kim SE, Choi BG, Ko GY, Jung SE, Choi KH |title=Diffuse and focal adenomyosis: MR imaging findings |journal=Radiographics |volume=19 Spec No |issue= |pages=S161–70 |date=October 1999 |pmid=10517452 |doi=10.1148/radiographics.19.suppl_1.g99oc03s161 |url=}}</ref>
-[[Endometrial polyp|<small>polyp</small>]]
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |±
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Dysmenorrhea]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Subfertility
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Diffusely enlarged tender boggy [[uterus]] with smooth surface
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+* [[Uterus]] may develop masses
+| align="center" style="background:#F5F5F5;" + |↓
-<small>or</small>
+| align="center" style="background:#F5F5F5;" + |–
+| align="center" style="background:#F5F5F5;" + | +
-<small>N</small>
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Snow storm appearance in diffuse adenomyosis
-| style="background: #F5F5F5; padding: 5px;" |
+* Shows a [[uterine mass]] in case of [[adenoma]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Identifies diffuse or focal [[adenomyosis]] from [[leiomyoma]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Mostly normal may show glandular cells in [[cervical]] [[cytology]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
+* [[Endometrial]] glands in [[myometrium]] of [[uterus]]
+| align="left" style="background:#F5F5F5;" + |
+* [[Imaging]]
+* [[Histologic]] diagnosis
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometrial hyperplasia|<small>Endometrial</small>]]
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
-[[Endometrial hyperplasia|<small>hyperplasia</small>]]
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
-| style="background: #F5F5F5; padding: 5px;" |
+discomfort
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
-| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>[[Fetus]]</small>
+! align="center" style="background:#DCDCDC;" + |[[Hematometra]] ([[blood]] within the [[uterine]] cavity)
-| style="background: #F5F5F5; padding: 5px;" |
+<ref name="pmid17630156">{{cite journal |vauthors=McCausland AM, McCausland VM |title=Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention |journal=J Minim Invasive Gynecol |volume=14 |issue=4 |pages=399–406 |date=2007 |pmid=17630156 |doi=10.1016/j.jmig.2007.04.004 |url=}}</ref><ref name="pmid20606801">{{cite journal |vauthors=U Nayak A, Swarup A, G S J, N S |title=Hematometra and acute abdomen |journal=J Emerg Trauma Shock |volume=3 |issue=2 |pages=191–2 |date=April 2010 |pmid=20606801 |pmc=2884455 |doi=10.4103/0974-2700.62117 |url=}}</ref>
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+Cramping cyclic [[pain]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Dysmenorrhea]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Amenorrhea]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Hypotension]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Vasovagal syncope]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Firm and enlarged [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Adenaxal [[tenderness]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Pelvic examination]] may be restricted due to [[pain]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |↓
+| align="center" style="background:#F5F5F5;" + |–
+| align="center" style="background:#F5F5F5;" + |–
+| align="left" style="background:#F5F5F5;" + |
+* Echogenic fluid in the [[uterine]] cavity occluding [[cervical os]]
+| align="left" style="background:#F5F5F5;" + |
+* Not required
+| align="left" style="background:#F5F5F5;" + |
+* Normal
+| align="left" style="background:#F5F5F5;" + |
+* [[Biopsy]] is not required for diagnosis
+| align="left" style="background:#F5F5F5;" + |
+* [[Ultrasound]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Adenomyoma|<small>Uterine</small>]]
+! align="center" style="background:#DCDCDC;" + |[[Gestational trophoblastic disease]]<ref name="pmid8035373">{{cite journal |vauthors=Bakri YN, Berkowitz RS, Khan J, Goldstein DP, von Sinner W, Jabbar FA |title=Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure |journal=J Reprod Med |volume=39 |issue=3 |pages=175–8 |date=March 1994 |pmid=8035373 |doi= |url=}}</ref><ref name="pmid20728069">{{cite journal |vauthors=Lurain JR |title=Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole |journal=Am. J. Obstet. Gynecol. |volume=203 |issue=6 |pages=531–9 |date=December 2010 |pmid=20728069 |doi=10.1016/j.ajog.2010.06.073 |url=}}</ref>
-[[Adenomyoma|<small>adenomyoma</small>]]
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* May have [[menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* May have intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Pulmonary]] [[metastasis]]:
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Dyspnea]]
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Chest pain]]
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Cough]]
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Hemoptysis]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Vaginal]] [[metastasis]]:
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Vaginal bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+** Purulent [[vaginal discharge]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Central nervous system]] metastasis:
-| style="background: #F5F5F5; padding: 5px;" |
+** Asymptomatic
+** Neurologic signs
+| align="left" style="background:#F5F5F5;" + |
+* Irregularly sized boggy enlarged [[uterus]]
+* [[Adnexal]] fullness
+* [[Abdominal distention]]
+| align="center" style="background:#F5F5F5;" + |↓
+| align="center" style="background:#F5F5F5;" + |±
+| align="center" style="background:#F5F5F5;" + | +
+| align="left" style="background:#F5F5F5;" + |
+* Dilated grape like structures
+* Diffuse hydropic swelling
+* Multiples echoes
+* Cystic spaces invading [[edometrium]] and [[myometrium]] (in case of invasive disease)
+| align="left" style="background:#F5F5F5;" + |
+* MRI defines the extent of primary lesion, invasion and distant [[metastasis]]
+| align="left" style="background:#F5F5F5;" + |
+* Trophoblastic cells
+| align="left" style="background:#F5F5F5;" + |
+* Dilated grape like villous structures
+* Invasive [[malignant]] lesions
+| align="left" style="background:#F5F5F5;" + |
+* Imaging
+* Histologic diagnosis
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Hematometra|<small>Hematometra</small>]]
+! align="center" style="background:#DCDCDC;" + |[[Abortion|Incomplete abortion]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Vaginal bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal pain]]/cramps
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Enlarges [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal distention]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |N/↓
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |±
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +↓
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Uterus]] shows [[fetus]] with absent [[cardiac activity]] in lower part of [[uterus]]
+| align="left" style="background:#F5F5F5;" + |
+* Not required for the diagnosis
+| align="left" style="background:#F5F5F5;" + |
+* Not required for the diagnosis
+| align="left" style="background:#F5F5F5;" + |
+* Suction [[biopsy]] and [[histology]] shows [[fetal]] and [[placental tissues]]
+| align="left" style="background:#F5F5F5;" + |
+* Imaging
+* Histologic diagnosis
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Hematometra|<small></small>]]
+! align="center" style="background:#DCDCDC;" + |[[Pregnancy]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Absent menstrual cycle
-| style="background: #F5F5F5; padding: 5px;" |
+* May have intermenstrual [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Nausea]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Fatigue]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* Enlarged gravid [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal distention]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |–
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
+* [[Fetus]] inside [[uterine]] cavity
+| align="left" style="background:#F5F5F5;" + |
+* Not needed once [[ultrasound]] determines [[pregnancy]]
+| align="left" style="background:#F5F5F5;" + |
+* Normal or may show cervical cells
+| align="left" style="background:#F5F5F5;" + |
+* Not needed once [[ultrasound]] determines [[pregnancy]]
+| align="left" style="background:#F5F5F5;" + |
+* [[Transvaginal ultrasound]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Hematometra|<small></small>]]
+! align="center" style="background:#DCDCDC;" + |Uterine [[lymphoma]]<ref name="pmid22217630" /><ref name="pmid22220150">{{cite journal |vauthors=Samama M, van Poelgeest M |title=Primary malignant lymphoma of the uterus: a case report and review of the literature |journal=Case Rep Oncol |volume=4 |issue=3 |pages=560–3 |date=September 2011 |pmid=22220150 |pmc=3251245 |doi=10.1159/000334852 |url=}}</ref><ref name="pmid17389178">{{cite journal |vauthors=Shen CJ, Tsai EM, Tsai KB, Wu CH, Hsu SC |title=Primary T-cell lymphoma of the uterine corpus |journal=Kaohsiung J. Med. Sci. |volume=23 |issue=3 |pages=138–41 |date=March 2007 |pmid=17389178 |doi=10.1016/S1607-551X(09)70388-2 |url=}}</ref><ref name="pmid18317217">{{cite journal |vauthors=Heeren JH, Croonen AM, Pijnenborg JM |title=Primary extranodal marginal zone B-cell lymphoma of the female genital tract: a case report and literature review |journal=Int. J. Gynecol. Pathol. |volume=27 |issue=2 |pages=243–6 |date=April 2008 |pmid=18317217 |doi=10.1097/PGP.0b013e3181569a0a |url=}}</ref>
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |
+* Abnormal [[uterine bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+** Post-coital bleeding
-| style="background: #F5F5F5; padding: 5px;" |
+** Intermenstrual bleeding
-| style="background: #F5F5F5; padding: 5px;" |
+** [[Postmenopausal bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + | +
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Urinary bladder|Bladder]] obstruction
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal pain]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="left" style="background:#F5F5F5;" + |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal distension]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal mass]] protruding into [[abdomen]]
-| style="background: #F5F5F5; padding: 5px;" |
+| align="center" style="background:#F5F5F5;" + |↓
+| align="center" style="background:#F5F5F5;" + | -
+| align="center" style="background:#F5F5F5;" + | -
+| align="left" style="background:#F5F5F5;" + |
+*Show [[Pelvic masses|pelvic mass]]
+| align="left" style="background:#F5F5F5;" + |
+* Shows [[Pelvic masses|pelvic mass]] , its extent in the [[uterus]], and involvement of surrounding [[lymph nodes]]
+| align="left" style="background:#F5F5F5;" + |
+* May show [[Malignant|malignant cells]] mostly non-specific
+| align="left" style="background:#F5F5F5;" + |
+* [[Histology]] may show [[Lymphoma|primary malignant lymphomas]]
+* [[Non-Hodgkin lymphoma|Non-Hodgkin lymphomas]], [[Diffuse large B cell lymphoma|diffuse large B-cell lymphomas]] (most common)
+| align="left" style="background:#F5F5F5;" + |
+*[[Laparoscopy]] and [[biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Hematometra|<small></small>]]
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
-| style="background: #F5F5F5; padding: 5px;" |
+discomfort
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
-| style="background: #F5F5F5; padding: 5px;" |
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
-| style="background: #F5F5F5; padding: 5px;" |
 |-
 |}
@@ Line 325: / Line 533: @@
 {{reflist|2}}
-[[Category:Disease]]
+[[Category:Up-To-Date]]
-[[Category:Types of cancer]]
+[[Category:Medicine]]
-[[Category:Gynecology]]
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}
- [[Category:Up-To-Date]]
 [[Category:Oncology]]
-[[Category:Medicine]]
 [[Category:Gynecology]]
 [[Category:Surgery]]
+[[Category:Emergency medicine]]
+[[Category:Differential diagnosis]]

Endometrial cancer differential diagnosis: Difference between revisions

Latest revision as of 21:34, 29 July 2020

Overview

Differentiating Endometrial Cancer From Other Diseases

References

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