Acute lymphoblastic leukemia diagnostic study of choice: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy. | The diagnostic study of choice for acute lymphoblastic lymphoma is [[bone marrow biopsy]]. | ||
==Diagnostic study of choice== | ==Diagnostic study of choice== | ||
*The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy | *The diagnostic study of choice for acute lymphoblastic lymphoma is [[bone marrow biopsy]].<ref name="pmid12163052">{{cite journal |vauthors=Thomas X, Le QH, Danaïla C, Lhéritier V, Ffrench M |title=Bone marrow biopsy in adult acute lymphoblastic leukemia: morphological characteristics and contribution to the study of prognostic factors |journal=Leuk. Res. |volume=26 |issue=10 |pages=909–18 |date=October 2002 |pmid=12163052 |doi= |url=}}</ref><ref name="pmid10889907">{{cite journal |vauthors=Kröber SM, Greschniok A, Kaiserling E, Horny HP |title=Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens |journal=MP, Mol. Pathol. |volume=53 |issue=2 |pages=83–7 |date=April 2000 |pmid=10889907 |pmc=1186910 |doi= |url=}}</ref> | ||
*A bone marrow biopsy must show 20% or greater blasts of lymphoid immunophenotype<ref name="pmid25408859">{{cite journal| author=Chiaretti S, Zini G, Bassan R| title=Diagnosis and subclassification of acute lymphoblastic leukemia. | journal=Mediterr J Hematol Infect Dis | year= 2014 | volume= 6 | issue= 1 | pages= e2014073 | pmid=25408859 | doi=10.4084/MJHID.2014.073 | pmc=4235437 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25408859 }} </ref> | *A [[bone marrow biopsy]] must show 20% or greater blasts of [[lymphoid]] [[immunophenotype]]<ref name="pmid25408859">{{cite journal| author=Chiaretti S, Zini G, Bassan R| title=Diagnosis and subclassification of acute lymphoblastic leukemia. | journal=Mediterr J Hematol Infect Dis | year= 2014 | volume= 6 | issue= 1 | pages= e2014073 | pmid=25408859 | doi=10.4084/MJHID.2014.073 | pmc=4235437 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25408859 }} </ref> | ||
*This diagnostic criteria is very similar to that of acute myeloid leukemia.<ref name="pmid28665419">{{cite journal| author=Terwilliger T, Abdul-Hay M| title=Acute lymphoblastic leukemia: a comprehensive review and 2017 update. | journal=Blood Cancer J | year= 2017 | volume= 7 | issue= 6 | pages= e577 | pmid=28665419 | doi=10.1038/bcj.2017.53 | pmc=5520400 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28665419 }} </ref> | *This diagnostic criteria is very similar to that of [[acute myeloid leukemia]].<ref name="pmid28665419">{{cite journal| author=Terwilliger T, Abdul-Hay M| title=Acute lymphoblastic leukemia: a comprehensive review and 2017 update. | journal=Blood Cancer J | year= 2017 | volume= 7 | issue= 6 | pages= e577 | pmid=28665419 | doi=10.1038/bcj.2017.53 | pmc=5520400 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28665419 }} </ref> | ||
===== Diagnostic results ===== | ===== Diagnostic results ===== | ||
On [[bone marrow biopsy]] the following result is a confirmation of acute lymphoblastic leukemia: | |||
*Lymphoblast | *[[Lymphoblast]] | ||
===== Sequence of Diagnostic Studies ===== | ===== Sequence of Diagnostic Studies ===== | ||
The various investigations must be performed in the following order: | The various investigations must be performed in the following order: | ||
*CBC | *[[CBC]] | ||
*Histopathological microscopy | *[[Histopathological|Histopathological microscopy]] | ||
*Bone marrow biopsy | *[[Bone marrow biopsy]] | ||
*Flow cytometry | *[[Flow cytometry]] | ||
*Immunohistochemistry | *[[Immunohistochemistry]] | ||
*PCR | *[[Polymerase chain reaction|PCR]] | ||
*FISH | *[[Fluorescence in situ hybridization|FISH]] | ||
==References== | ==References== | ||
Latest revision as of 22:58, 13 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Shyam Patel [2]
Overview
The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy.
Diagnostic study of choice
- The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy.[1][2]
- A bone marrow biopsy must show 20% or greater blasts of lymphoid immunophenotype[3]
- This diagnostic criteria is very similar to that of acute myeloid leukemia.[4]
Diagnostic results
On bone marrow biopsy the following result is a confirmation of acute lymphoblastic leukemia:
Sequence of Diagnostic Studies
The various investigations must be performed in the following order:
References
- ↑ Thomas X, Le QH, Danaïla C, Lhéritier V, Ffrench M (October 2002). "Bone marrow biopsy in adult acute lymphoblastic leukemia: morphological characteristics and contribution to the study of prognostic factors". Leuk. Res. 26 (10): 909–18. PMID 12163052.
- ↑ Kröber SM, Greschniok A, Kaiserling E, Horny HP (April 2000). "Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens". MP, Mol. Pathol. 53 (2): 83–7. PMC 1186910. PMID 10889907.
- ↑ Chiaretti S, Zini G, Bassan R (2014). "Diagnosis and subclassification of acute lymphoblastic leukemia". Mediterr J Hematol Infect Dis. 6 (1): e2014073. doi:10.4084/MJHID.2014.073. PMC 4235437. PMID 25408859.
- ↑ Terwilliger T, Abdul-Hay M (2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.