Hepatocellular adenoma history and symptoms: Difference between revisions
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{{CMG}}; {{AE}} {{ZAS}} | {{CMG}}; {{AE}} {{ZAS}} | ||
==Overview== | ==Overview== | ||
Small hepatocellular adenomas are generally [[asymptomatic]]. Typical [[clinical]] manifestations include spontaneous [[rupture]] or [[hemorrhage]] leading to [[acute abdominal pain]] with progression to [[hypotension]] and even death. Patients with hepatocellular | Small hepatocellular adenomas are generally [[asymptomatic]]. Typical [[clinical]] manifestations include spontaneous [[rupture]] or [[hemorrhage]] leading to [[acute abdominal pain]] with progression to [[hypotension]] and even death. [[Patient|Patients]] with hepatocellular adenoma typically have a history of [[Oral contraceptive|oral contraceptive use]] (females) and long term [[anabolic]] [[steroids]] use (males). | ||
== | ==History and Symptoms== | ||
* | |||
=== History === | |||
* [[Patient|Patients]] with hepatocellular adenoma present with history of [[abdominal pain]]/[[Abdominal discomfort|discomfort]]. | |||
* [[Obesity]], being a [[risk factor]], can mask the [[physical examination]] findings of hepatocellular adenoma. | |||
=== Symptoms === | |||
*Small hepatocellular adenomas are generally [[asymptomatic]].<ref name="AgrawalAgarwal2015">{{cite journal|last1=Agrawal|first1=Shefali|last2=Agarwal|first2=Sheela|last3=Arnason|first3=Thomas|last4=Saini|first4=Sanjay|last5=Belghiti|first5=Jacques|title=Management of Hepatocellular Adenoma: Recent Advances|journal=Clinical Gastroenterology and Hepatology|volume=13|issue=7|year=2015|pages=1221–1230|issn=15423565|doi=10.1016/j.cgh.2014.05.023}}</ref><ref>{{Cite journal | |||
| author = [[Massimo Roncalli]], [[Amedeo Sciarra]] & [[Luca Di Tommaso]] | | author = [[Massimo Roncalli]], [[Amedeo Sciarra]] & [[Luca Di Tommaso]] | ||
| title = Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma | | title = Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma | ||
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| pmid = 21481415 | | pmid = 21481415 | ||
}}</ref> | }}</ref> | ||
* [[Abdominal pain]] is the most common presenting [[symptom]] in some [[Patient|patients]], and the pain is usually related to [[Tumor|tumoral]] [[hemorrhage]]. | *[[Abdominal pain]] is the most common presenting [[symptom]] in some [[Patient|patients]], and the [[pain]] is usually related to [[Tumor|tumoral]] [[hemorrhage]]. | ||
* [[Right upper quadrant]] [[Abdomen|abdominal]] fullness or [[discomfort]] is present in 40% of cases due to [[mass]] | *[[Right upper quadrant]] [[Abdomen|abdominal]] fullness or [[discomfort]] is present in 40% of the cases due to [[Mass effect (medicine)|mass effect]]. | ||
* Eventually, spontaneous [[rupture]] or [[hemorrhage]] may occur, leading to [[acute abdominal pain]] with progression to [[hypotension]] and even death. | * Eventually, spontaneous [[rupture]] or [[hemorrhage]] may occur, leading to [[acute abdominal pain]] with progression to [[hypotension]] and even death. | ||
* Patients with hepatocellular | *[[Patients]] with hepatocellular adenoma typically have a history of [[Oral contraceptive|oral contraceptive use]] ([[Female|females]]) and long term [[anabolic]] [[steroids]] use ([[Male|males]]).<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref><ref name="age">Introduction. Hindawi(2015). http://www.hindawi.com/journals/ijh/2013/374170. Accessed on November 2, 2015</ref> | ||
==References== | ==References== | ||
Latest revision as of 21:05, 20 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]
Overview
Small hepatocellular adenomas are generally asymptomatic. Typical clinical manifestations include spontaneous rupture or hemorrhage leading to acute abdominal pain with progression to hypotension and even death. Patients with hepatocellular adenoma typically have a history of oral contraceptive use (females) and long term anabolic steroids use (males).
History and Symptoms
History
- Patients with hepatocellular adenoma present with history of abdominal pain/discomfort.
- Obesity, being a risk factor, can mask the physical examination findings of hepatocellular adenoma.
Symptoms
- Small hepatocellular adenomas are generally asymptomatic.[1][2][3]
- Abdominal pain is the most common presenting symptom in some patients, and the pain is usually related to tumoral hemorrhage.
- Right upper quadrant abdominal fullness or discomfort is present in 40% of the cases due to mass effect.
- Eventually, spontaneous rupture or hemorrhage may occur, leading to acute abdominal pain with progression to hypotension and even death.
- Patients with hepatocellular adenoma typically have a history of oral contraceptive use (females) and long term anabolic steroids use (males).[4][5]
References
- ↑ Agrawal, Shefali; Agarwal, Sheela; Arnason, Thomas; Saini, Sanjay; Belghiti, Jacques (2015). "Management of Hepatocellular Adenoma: Recent Advances". Clinical Gastroenterology and Hepatology. 13 (7): 1221–1230. doi:10.1016/j.cgh.2014.05.023. ISSN 1542-3565.
- ↑ Massimo Roncalli, Amedeo Sciarra & Luca Di Tommaso (2016). "Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma". Clinical and molecular hepatology. 22 (2): 199–211. doi:10.3350/cmh.2016.0101. PMID 27189732. Unknown parameter
|month=ignored (help) - ↑ David Q. Wang, Laurie M. Fiske, Caroline T. Carreras & David A. Weinstein (2011). "Natural history of hepatocellular adenoma formation in glycogen storage disease type I". The Journal of pediatrics. 159 (3): 442–446. doi:10.1016/j.jpeds.2011.02.031. PMID 21481415. Unknown parameter
|month=ignored (help) - ↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ Introduction. Hindawi(2015). http://www.hindawi.com/journals/ijh/2013/374170. Accessed on November 2, 2015