Cancer of unknown primary origin differential diagnosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Cancer of unknown primary origin}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Cancer_of_unknown_primary_origin]]


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}}, {{RAK}}
==Overview==
==Overview==
Cancer of unknown primary is a diagnosis of exclusion; hence, all other differentials in addition to primary tumor location must be ruled out prior to [[Diagnosis WikiDoc|diagnosis]].


==Epidemiology and Demographics==
==Differentiating Cancer of Unknown Primary Origin from Other Diseases==
===Incidence===
*Cancer of unknown primary is a diagnosis of exclusion; hence, all other differentials in addition to primary tumor location must be ruled out prior to [[Diagnosis WikiDoc|diagnosis]].  
*The prevalence of cancer of unknown primary origin is approximately 10 cases per 100,000 individuals worldwide.<ref name="pmid23860528">{{cite journal |vauthors=Urban D, Rao A, Bressel M, Lawrence YR, Mileshkin L |title=Cancer of unknown primary: a population-based analysis of temporal change and socioeconomic disparities |journal=Br. J. Cancer |volume=109 |issue=5 |pages=1318–24 |year=2013 |pmid=23860528 |pmc=3778275 |doi=10.1038/bjc.2013.386 |url=}}</ref><ref name="lonco">Fong T, Govindan R, Morgensztern D. Cancer of unknown primary. J Clin Oncol 2008 ASCO Ann Meet Proc. 2008;26 (15S:22159.</ref>
*Cancer of unknown primary origin must be differentiated from other diseases that cause sudden [[weight-loss]], [[Fatigue (medical)|fatigue]], and [[loss of appetite]], such as:<ref name="pmid19262901">{{cite journal| author=Varadhachary GR| title=Carcinoma of unknown primary origin. | journal=Gastrointest Cancer Res | year= 2007 | volume= 1 | issue= 6 | pages= 229-35 | pmid=19262901 | doi= | pmc=2631214 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19262901 }} </ref>
* Cancer of unknown primary origin is common, and it accounts for 3–5% of all [[Malignant epithelial tumor|malignant epithelial tumors]].<ref name="pmid22414598">{{cite journal| author=Pavlidis N, Pentheroudakis G| title=Cancer of unknown primary site. | journal=Lancet | year= 2012 | volume= 379 | issue= 9824 | pages= 1428-35 | pmid=22414598 | doi=10.1016/S0140-6736(11)61178-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22414598  }} </ref>
:*[[Incidentaloma]]
* Cancer of unknown primary origin is the fourth most common cause of cancer-related death.<ref name="pmid23860528">{{cite journal |vauthors=Urban D, Rao A, Bressel M, Lawrence YR, Mileshkin L |title=Cancer of unknown primary: a population-based analysis of temporal change and socioeconomic disparities |journal=Br. J. Cancer |volume=109 |issue=5 |pages=1318–24 |year=2013 |pmid=23860528 |pmc=3778275 |doi=10.1038/bjc.2013.386 |url=}}</ref>
:*[[Anemia]]
:*[[Tuberculosis]]
===Age===
:*[[Multiple myeloma]]
*Patients of all age groups may develop cancer of unknown primary origin.
*Cancer of unknown primary origin is more commonly observed among adults and elderly patients with a mean age of 59 upon presentation.<ref name="pmid8201389">{{cite journal| author=Abbruzzese JL, Abbruzzese MC, Hess KR, Raber MN, Lenzi R, Frost P| title=Unknown primary carcinoma: natural history and prognostic factors in 657 consecutive patients. | journal=J Clin Oncol | year= 1994 | volume= 12 | issue= 6 | pages= 1272-80 | pmid=8201389 | doi=10.1200/JCO.1994.12.6.1272 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8201389  }} </ref>
 
===Gender===
*Cancer of unknown primary origin affects men and women equally except for [[squamous cell carcinomas]] where males are affected twice as frequently as females.<ref name="pmid8001006">{{cite journal| author=Muir C| title=Cancer of unknown primary site. | journal=Cancer | year= 1995 | volume= 75 | issue= 1 Suppl | pages= 353-6 | pmid=8001006 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8001006 }} </ref>
 
===Race===
*There is no racial predilection to cancer of unknown primary origin.
 
*The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
*In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.


==References==
==References==

Latest revision as of 22:04, 27 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: , Roukoz A. Karam, M.D.[2]

Overview

Cancer of unknown primary is a diagnosis of exclusion; hence, all other differentials in addition to primary tumor location must be ruled out prior to diagnosis.

Differentiating Cancer of Unknown Primary Origin from Other Diseases

  • Cancer of unknown primary is a diagnosis of exclusion; hence, all other differentials in addition to primary tumor location must be ruled out prior to diagnosis.
  • Cancer of unknown primary origin must be differentiated from other diseases that cause sudden weight-loss, fatigue, and loss of appetite, such as:[1]

References

  1. ↑ Varadhachary GR (2007). "Carcinoma of unknown primary origin". Gastrointest Cancer Res. 1 (6): 229–35. PMC 2631214. PMID 19262901.

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