Chronic lymphocytic leukemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Twenty-five to fifty percent of patients with chronic lymphocytic leukemia are usually asymptomatic with incidental absolute lymphocytosis finding on a routine blood examination. The onset of chronic lymphocytic leukemia is insidious and can present with wide range of symptoms. Symptoms of chronic lymphocytic leukemia include lymph node swelling and "B" symptoms including [[fever]], [[weight loss]], [[night sweats]], fatigue and recurrent bleeding. | |||
==History== | ==History== | ||
Although majority of patients with chronic lymphocytic leukemia have non-specific history, a through, detailed history from the patient is necessary. Most of the patients with chronic lymphocytic leukemia are asymptomatic, so they are diagnosed incidentally on a routine blood examination. | |||
==Symptoms== | ==Symptoms== | ||
* Symptoms of chronic lymphocytic leukemia include:<ref name="pmid29540348" /> | * Symptoms of chronic lymphocytic leukemia include:<ref name="pmid29540348" /><ref name="pmid1139039">{{cite journal |vauthors=Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS |title=Clinical staging of chronic lymphocytic leukemia |journal=Blood |volume=46 |issue=2 |pages=219–34 |date=August 1975 |pmid=1139039 |doi= |url=}}</ref><ref name="pmid28102226">{{cite journal |vauthors=Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K |title=Chronic lymphocytic leukaemia |journal=Nat Rev Dis Primers |volume=3 |issue= |pages=16096 |date=January 2017 |pmid=28102226 |pmc=5336551 |doi=10.1038/nrdp.2016.96 |url=}}</ref> | ||
:* Painless lymph node enlargement (50-90%) | :* Painless lymph node enlargement (50-90%) | ||
:* | :* Abdominal pain | ||
:* "B" symptoms (5-10%):<ref name="pmid29540348">{{cite journal |vauthors=Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ |title=iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL |journal=Blood |volume=131 |issue=25 |pages=2745–2760 |date=June 2018 |pmid=29540348 |doi=10.1182/blood-2017-09-806398 |url=}}</ref> | |||
:* B | |||
:** [[Fever]] | :** [[Fever]] | ||
:** Unintentional weight loss | :** Unintentional weight loss | ||
:** [[Muscle wasting]] | :** [[Muscle wasting]] | ||
:** Generalized [[weakness]]/ | :** Generalized [[weakness]]/ fatigue | ||
:** [[Anorexia]] | :** [[Anorexia]] | ||
:** [[Night sweats]] | :** [[Night sweats]] | ||
:* Recurrent [[infection]]s | :* Recurrent [[infection]]s | ||
:* Recurrent [[ bleeding]] | :* Recurrent [[ bleeding]] | ||
:* Skin lesions | :* Skin lesions<ref name="pmid15214899">{{cite journal |vauthors=Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB |title=Cutaneous findings in chronic lymphocytic leukaemia |journal=Br. J. Dermatol. |volume=150 |issue=6 |pages=1129–35 |date=June 2004 |pmid=15214899 |doi=10.1111/j.1365-2133.2004.05982.x |url=}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 15:56, 28 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Raviteja Guddeti, M.B.B.S. [3]
Overview
Twenty-five to fifty percent of patients with chronic lymphocytic leukemia are usually asymptomatic with incidental absolute lymphocytosis finding on a routine blood examination. The onset of chronic lymphocytic leukemia is insidious and can present with wide range of symptoms. Symptoms of chronic lymphocytic leukemia include lymph node swelling and "B" symptoms including fever, weight loss, night sweats, fatigue and recurrent bleeding.
History
Although majority of patients with chronic lymphocytic leukemia have non-specific history, a through, detailed history from the patient is necessary. Most of the patients with chronic lymphocytic leukemia are asymptomatic, so they are diagnosed incidentally on a routine blood examination.
Symptoms
- Painless lymph node enlargement (50-90%)
- Abdominal pain
- "B" symptoms (5-10%):[1]
- Fever
- Unintentional weight loss
- Muscle wasting
- Generalized weakness/ fatigue
- Anorexia
- Night sweats
- Recurrent infections
- Recurrent bleeding
- Skin lesions[4]
References
- ↑ 1.0 1.1 Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.
- ↑ Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (August 1975). "Clinical staging of chronic lymphocytic leukemia". Blood. 46 (2): 219–34. PMID 1139039.
- ↑ Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K (January 2017). "Chronic lymphocytic leukaemia". Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.
- ↑ Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB (June 2004). "Cutaneous findings in chronic lymphocytic leukaemia". Br. J. Dermatol. 150 (6): 1129–35. doi:10.1111/j.1365-2133.2004.05982.x. PMID 15214899.