T-cell lymphoma: Difference between revisions
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==Overview== | ==Overview== | ||
T-cell lymphoma describes several different types of [[Non-Hodgkin lymphoma]] affecting [[T cell]]s or [[Natural killer cell]]s ([[NK-cells]]), also | T-cell lymphoma describes several different types of [[Non-Hodgkin lymphoma]] affecting [[T cell]]s or [[Natural killer cell]]s ([[NK-cells]]), also known as a NK/T-cell lymphoma. Any organ that has [[lymphatic tissue]] may develop a lymphoma, including the [[spleen]], [[thymus]], [[adenoids]], [[tonsils]], [[digestive tract]] and [[bone marrow]]. Characteristically, they may present as fast (aggressive) or slow (indolent) growing lymphomas. | ||
Lymphomas are named after the precursor cell from which it developed. A [[peripheral T-cell lymphomas]] include lymphomas which arise from mature T-cells (after maturation in the [[thymus]]), in contrast with immature T-cell lymphomas, the [[lymphoblastic lymphoma]]. | Lymphomas are named after the [[precursor]] cell from which it developed. A [[peripheral T-cell lymphomas]] include lymphomas which arise from mature T-cells (after [[maturation]] in the [[thymus]]), in contrast with immature T-cell lymphomas, the [[lymphoblastic lymphoma]]. | ||
==Classification== | ==Classification== | ||
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Sézary syndrome]] | | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Sézary syndrome]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Primary cutaneous CD30 T-cell lymphoproliferative disorders | | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Primary cutaneous CD30 T-cell [[lymphoproliferative disorders]] | ||
*Lymphomatoid papulosis | *Lymphomatoid papulosis | ||
*Primary cutaneous anaplastic large cell lymphoma | *Primary cutaneous anaplastic large cell lymphoma | ||
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Angioimmunoblastic T-cell lymphoma]] | | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Angioimmunoblastic T-cell lymphoma]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Follicular T-cell lymphoma | | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Follicular lymphoma|Follicular T-cell lymphoma]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Nodal peripheral T-cell lymphoma with TFH phenotype | | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Nodal peripheral T-cell lymphoma with TFH phenotype | ||
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Breast implant associated anaplastic large-cell lymphoma | | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Breast implant associated anaplastic large-cell lymphoma | ||
|} | |} | ||
==References== | |||
{{Reflist|2}} | |||
Latest revision as of 15:06, 6 March 2019
For patient information click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
T-cell lymphoma describes several different types of Non-Hodgkin lymphoma affecting T cells or Natural killer cells (NK-cells), also known as a NK/T-cell lymphoma. Any organ that has lymphatic tissue may develop a lymphoma, including the spleen, thymus, adenoids, tonsils, digestive tract and bone marrow. Characteristically, they may present as fast (aggressive) or slow (indolent) growing lymphomas.
Lymphomas are named after the precursor cell from which it developed. A peripheral T-cell lymphomas include lymphomas which arise from mature T-cells (after maturation in the thymus), in contrast with immature T-cell lymphomas, the lymphoblastic lymphoma.
Classification
T-cell lymphomas may be classified according to updated WHO classification into 2 subtypes:[1]
| T-cell and putative NK-cell neoplasms |
|---|
| Precursor T-cell neoplasm |
| Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) |
| Peripheral T-cell and NK-cell neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells |
| Aggressive NK-cell leukemia |
| Systemic EBV positive T-cell lymphoma of childhood |
| Hydroa vacciniforme like lymphoproliferative disorder |
| Adult T-cell leukemia/lymphoma |
| Extranodal T/NK-cell lymphoma, nasal type |
| Enteropathy associated intestinal T-cell lymphoma |
| Monomorphic epitheliotropic intestinal T-cell lymphoma |
| Indolent T-cell lymphoproliferative disorder of the GI tract |
| Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
Primary cutaneous CD30 T-cell lymphoproliferative disorders
|
| Primary cutaneous gamma delta T-cell lymphoma
Primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma Primary cutaneous acral CD8 T-cell lymphoma Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder |
| Peripheral T-cell lymphoma, NOS *
Peripheral T-cell lymphoma, not otherwise characterized |
| Angioimmunoblastic T-cell lymphoma |
| Follicular T-cell lymphoma |
| Nodal peripheral T-cell lymphoma with TFH phenotype |
Anaplastic large cell lymphoma
|
| Breast implant associated anaplastic large-cell lymphoma |
References
- ↑ Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.