Craniopharyngioma natural history, complication and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, majority of patients with craniopharyngioma may progress to develop increased intracranial pressure, blindness and endocrine abnormalities. The prognosis of craniopharyngioma is good with treatment. The 5-year and 10-year survival rates are higher than 90%. | If left untreated, majority of patients with craniopharyngioma may progress to develop [[Intracranial pressure|increased intracranial pressure]], [[blindness]] and [[Endocrine system|endocrine abnormalities]]. The [[prognosis]] of craniopharyngioma is good with treatment. The [[Survival analysis|5-year and 10-year survival rates]] are higher than 90%. | ||
==Natural History== | ==Natural History== | ||
*Craniopharyngiomas are slow growing tumors and symptoms often are present for a year or more before the diagnosis is established.<ref name="pmid28325825">{{cite journal |vauthors=Wijnen M, van den Heuvel-Eibrink MM, Janssen JAMJL, Catsman-Berrevoets CE, Michiels EMC, van Veelen-Vincent MC, Dallenga AHG, van den Berge JH, van Rij CM, van der Lely AJ, Neggers SJCMM |title=Very long-term sequelae of craniopharyngioma |journal=Eur. J. Endocrinol. |volume=176 |issue=6 |pages=755–767 |date=June 2017 |pmid=28325825 |doi=10.1530/EJE-17-0044 |url=}}</ref> | *Craniopharyngiomas are [[Tumors|slow growing tumors]] and symptoms often are present for a year or more before the [[diagnosis]] is established.<ref name="pmid28325825">{{cite journal |vauthors=Wijnen M, van den Heuvel-Eibrink MM, Janssen JAMJL, Catsman-Berrevoets CE, Michiels EMC, van Veelen-Vincent MC, Dallenga AHG, van den Berge JH, van Rij CM, van der Lely AJ, Neggers SJCMM |title=Very long-term sequelae of craniopharyngioma |journal=Eur. J. Endocrinol. |volume=176 |issue=6 |pages=755–767 |date=June 2017 |pmid=28325825 |doi=10.1530/EJE-17-0044 |url=}}</ref> | ||
*Untreated patients can have increased intracranial pressure, visual disturbances and endocrine abnormalities. | *Untreated patients can have [[Intracranial pressure|increased intracranial pressure]], [[Visual system|visual disturbances]] and [[Endocrine system|endocrine abnormalities]]. | ||
==Complications== | ==Complications== | ||
A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. | * A large percentage of patients have [[Hormone|long-term hormone]], [[Visual system|vision]], and [[Nervous system disease|nervous system problems]] after craniopharyngioma is treated. | ||
* [[Tumor]] may reoccur if it is not completely removed.<ref>Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm</ref> | |||
There are complications caused by the | * There are [[Complication (medicine)|complications]] caused by the [[Surgery|radical surgical treatment]] of craniopharyngioma:<ref>Complications. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | ||
*[[ | |||
*[[Surgery|Hypothalamic-sparing surgical techniques]] may result in reduced [[Obesity|postoperative obesity]] without an increase in [[tumor]] [[Recurrence period density entropy|recurrence]].<ref name="pmid24467716">{{cite journal |vauthors=Müller HL |title=Craniopharyngioma |journal=Endocr. Rev. |volume=35 |issue=3 |pages=513–43 |date=June 2014 |pmid=24467716 |doi=10.1210/er.2013-1115 |url=}}</ref> | |||
*[[Hormone replacement therapy]] | *[[Hormone replacement therapy]] | ||
*Severe behavioral problems | *[[Behavioral problems|Severe behavioral problems]] | ||
*[[Blindness]] | *[[Blindness]] | ||
*[[Seizures]] | *[[Seizures]] | ||
*[[Spinal fluid]] leak | *[[Spinal fluid]] leak | ||
*False [[aneurysms]] | *False [[aneurysms]] | ||
*Difficulty with eye movements | *[[Ophthalmic pathology|Difficulty with eye movements]] | ||
*Death from intraoperative [[hemorrhage]], hypothalamic damage, or [[stroke]] (rare) | *Death from [[Intraoperative monitoring|intraoperative]] [[hemorrhage]], [[Hypothalamic|hypothalamic damage]], or [[stroke]] (rare) | ||
==Prognosis== | ==Prognosis== | ||
* Craniopharyngioma is a [[benign]] tumor, the 5-year and 10-year survival rates, regardless of treatment given, are higher than 90%. <ref>Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | * Craniopharyngioma is a [[benign]] tumor, the [[Survival analysis|5-year and 10-year survival rates]], regardless of treatment given, are higher than 90%.<ref>Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | ||
* Patients can have a permanent cure if the tumor can be completely removed with [[surgery]] or treated with high doses of [[radiation]].<ref>Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm</ref> | * Patients can have a permanent cure if the tumor can be completely removed with [[surgery]] or treated with high doses of [[radiation]].<ref>Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm</ref> | ||
* The outlook depends on whether or not the tumor can be removed by surgery. | * The outlook depends on whether or not the tumor can be removed by [[surgery]]. | ||
*The neurological deficits and hormonal imbalances caused by the tumor and the treatment | *The [[Neurological disorders|neurological deficits]] and [[Hormone replacement therapy|hormonal imbalances]] caused by the [[tumor]] and the treatment the patient’s general health. | ||
* Recent research has demonstrated [[malignant | * [[Research|Recent research]] has demonstrated [[malignant|malignant tendency of craniopharyngiomas]]. | ||
* These malignant craniopharyngiomas are very rare | * These [[malignant]] craniopharyngiomas are very rare but are associated with [[Prognosis|poor prognosis]].<ref name="ReferenceA">{{cite journal|last1=Sofela|first1=AA|last2=Hettige|first2=S|last3=Curran|first3=O|last4=Bassi|first4=S|title=Malignant transformation in craniopharyngiomas.|journal=Neurosurgery|date=Sep 2014|volume=75|issue=3|pages=306–14; discussion 314|pmid=24978859|doi=10.1227/NEU.0000000000000380}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 15:22, 26 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]
Overview
If left untreated, majority of patients with craniopharyngioma may progress to develop increased intracranial pressure, blindness and endocrine abnormalities. The prognosis of craniopharyngioma is good with treatment. The 5-year and 10-year survival rates are higher than 90%.
Natural History
- Craniopharyngiomas are slow growing tumors and symptoms often are present for a year or more before the diagnosis is established.[1]
- Untreated patients can have increased intracranial pressure, visual disturbances and endocrine abnormalities.
Complications
- A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated.
- Tumor may reoccur if it is not completely removed.[2]
- There are complications caused by the radical surgical treatment of craniopharyngioma:[3]
- Hypothalamic-sparing surgical techniques may result in reduced postoperative obesity without an increase in tumor recurrence.[4]
- Hormone replacement therapy
- Severe behavioral problems
- Blindness
- Seizures
- Spinal fluid leak
- False aneurysms
- Difficulty with eye movements
- Death from intraoperative hemorrhage, hypothalamic damage, or stroke (rare)
Prognosis
- Craniopharyngioma is a benign tumor, the 5-year and 10-year survival rates, regardless of treatment given, are higher than 90%.[5]
- Patients can have a permanent cure if the tumor can be completely removed with surgery or treated with high doses of radiation.[6]
- The outlook depends on whether or not the tumor can be removed by surgery.
- The neurological deficits and hormonal imbalances caused by the tumor and the treatment the patient’s general health.
- Recent research has demonstrated malignant tendency of craniopharyngiomas.
- These malignant craniopharyngiomas are very rare but are associated with poor prognosis.[7]
References
- ↑ Wijnen M, van den Heuvel-Eibrink MM, Janssen J, Catsman-Berrevoets CE, Michiels E, van Veelen-Vincent MC, Dallenga A, van den Berge JH, van Rij CM, van der Lely AJ, Neggers S (June 2017). "Very long-term sequelae of craniopharyngioma". Eur. J. Endocrinol. 176 (6): 755–767. doi:10.1530/EJE-17-0044. PMID 28325825. Vancouver style error: initials (help)
- ↑ Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- ↑ Complications. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Müller HL (June 2014). "Craniopharyngioma". Endocr. Rev. 35 (3): 513–43. doi:10.1210/er.2013-1115. PMID 24467716.
- ↑ Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- ↑ Sofela, AA; Hettige, S; Curran, O; Bassi, S (Sep 2014). "Malignant transformation in craniopharyngiomas". Neurosurgery. 75 (3): 306–14, discussion 314. doi:10.1227/NEU.0000000000000380. PMID 24978859.