Cowden syndrome surgery: Difference between revisions
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==Overview== | ==Overview== | ||
[[Surgery]] is not the first-line treatment option for [[patients]] with [[cowden syndrome]]. [[Surgery]] is usually reserved for patients with [[facial]] [[papules]]. | [[Surgery]] is not the first-line treatment option for [[patients]] with [[cowden syndrome]]. [[Surgery]] is usually reserved for patients with [[gastrointestinal]] [[polyps]], Dysplastic [[Gangliocytoma|Gangliocytoma and]] [[facial]] [[papules]]. | ||
==Indications== | ==Indications== | ||
*[[Surgery]] is not the first-line treatment option for [[patients]] with [[cowden syndrome]]. [[Surgery]] is usually reserved for patients with the following: | *[[Surgery]] is not the first-line treatment option for [[patients]] with [[cowden syndrome]]. [[Surgery]] is usually reserved for patients with the following: | ||
* '''[[Dysplasia|Dysplastic]] [[Gangliocytoma]]''' | * '''[[Dysplasia|Dysplastic]] [[Gangliocytoma]]:''' | ||
** Keeping in mind about the potential effects of [[hydrocephalus]] like fatal [[herniation]], resection of dysplastic gangliocytoma of the cerebellum should be considered. | ** Keeping in mind about the potential effects of [[hydrocephalus]] like fatal [[herniation]], [[resection]] of [[Dysplasia|dysplastic]] [[gangliocytoma]] of the [[cerebellum]] should be considered.<ref name="RobinsonCohen2006">{{cite journal|last1=Robinson|first1=Shenandoah|last2=Cohen|first2=Alan R.|title=Cowden disease and Lhermitte–Duclos disease: an update|journal=Neurosurgical Focus|volume=20|issue=1|year=2006|pages=1–6|issn=1092-0684|doi=10.3171/foc.2006.20.1.7}}</ref><ref name="ShinagarePatil2009">{{cite journal|last1=Shinagare|first1=Atul B.|last2=Patil|first2=Nirupama K.|last3=Sorte|first3=S. Z.|title=Case 144: Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease)|journal=Radiology|volume=251|issue=1|year=2009|pages=298–303|issn=0033-8419|doi=10.1148/radiol.2511071390}}</ref> | ||
* '''[[Gastrointestinal]] [[polyps]]''' | * '''[[Gastrointestinal]] [[polyps]]:''' | ||
** Patients with [[cowden syndrome]] should consider resection of gastrointestinal polyps endoscopically which includes adenomatous polyps which are risk for developing colon cancer. | ** Patients with [[cowden syndrome]] should consider resection of [[gastrointestinal]] [[polyps]] [[Endoscopic|endoscopically]] which includes [[adenomatous polyps]] which are risk for developing [[colon cancer]].<ref name="pmid23238744">{{cite journal |vauthors=Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C |title=Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program |journal=Clin Transl Gastroenterol |volume=2 |issue= |pages=e5 |date=November 2011 |pmid=23238744 |pmc=3365666 |doi=10.1038/ctg.2011.4 |url=}}</ref><ref name="pmid20600018">{{cite journal |vauthors=Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C |title=Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers |journal=Gastroenterology |volume=139 |issue=6 |pages=1927–33 |date=December 2010 |pmid=20600018 |pmc=3652614 |doi=10.1053/j.gastro.2010.06.061 |url=}}</ref> | ||
** Endoscopic techniques like narrow band imaging should be considered for removing large polyps (≥1 cm). | ** [[Endoscopic]] techniques like narrow band imaging should be considered for removing large [[polyps]] (≥1 cm).<ref name="pmid9869523">{{cite journal |vauthors=Howe JR, Mitros FA, Summers RW |title=The risk of gastrointestinal carcinoma in familial juvenile polyposis |journal=Ann. Surg. Oncol. |volume=5 |issue=8 |pages=751–6 |date=December 1998 |pmid=9869523 |doi= |url=}}</ref> | ||
Facial [[papules]]: | |||
*Chemical peels | * '''Facial [[papules]]:''' | ||
* Laser resurfacing | ** Chemical peels | ||
** [[Laser]] resurfacing | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 15:07, 19 March 2019
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Cowden syndrome Microchapters |
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Cowden syndrome surgery On the Web |
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Risk calculators and risk factors for Cowden syndrome surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Surgery is not the first-line treatment option for patients with cowden syndrome. Surgery is usually reserved for patients with gastrointestinal polyps, Dysplastic Gangliocytoma and facial papules.
Indications
- Surgery is not the first-line treatment option for patients with cowden syndrome. Surgery is usually reserved for patients with the following:
- Dysplastic Gangliocytoma:
- Keeping in mind about the potential effects of hydrocephalus like fatal herniation, resection of dysplastic gangliocytoma of the cerebellum should be considered.[1][2]
- Gastrointestinal polyps:
- Patients with cowden syndrome should consider resection of gastrointestinal polyps endoscopically which includes adenomatous polyps which are risk for developing colon cancer.[3][4]
- Endoscopic techniques like narrow band imaging should be considered for removing large polyps (≥1 cm).[5]
References
- ↑ Robinson, Shenandoah; Cohen, Alan R. (2006). "Cowden disease and Lhermitte–Duclos disease: an update". Neurosurgical Focus. 20 (1): 1–6. doi:10.3171/foc.2006.20.1.7. ISSN 1092-0684.
- ↑ Shinagare, Atul B.; Patil, Nirupama K.; Sorte, S. Z. (2009). "Case 144: Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease)". Radiology. 251 (1): 298–303. doi:10.1148/radiol.2511071390. ISSN 0033-8419.
- ↑ Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C (November 2011). "Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program". Clin Transl Gastroenterol. 2: e5. doi:10.1038/ctg.2011.4. PMC 3365666. PMID 23238744.
- ↑ Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C (December 2010). "Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers". Gastroenterology. 139 (6): 1927–33. doi:10.1053/j.gastro.2010.06.061. PMC 3652614. PMID 20600018.
- ↑ Howe JR, Mitros FA, Summers RW (December 1998). "The risk of gastrointestinal carcinoma in familial juvenile polyposis". Ann. Surg. Oncol. 5 (8): 751–6. PMID 9869523.