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| __NOTOC__
| | [[Syncope]] is classified into three types: |
| | | * [[Cardiac]] |
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| | * [[Neurogenic]] |
| ! colspan="2" style="background:#DCDCDC;" align="center" + |Diagnostic algorithm for Infantile onset glyogen storage disease type II
| | * [[Vasovagal syncope|vasovagal]] |
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| *On [[microscopic]] [[histopathological]] analysis, [[carotid body]] [[tumor]] composed of:
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| **The chief or [[paraganglionic]] cells composing the predominant part of the [[tumor]] and contain [[eosinophilic]] granular materials and oval or round nuclei.<ref name="PatetsiosGable2002">{{cite journal|last1=Patetsios|first1=Peter|last2=Gable|first2=Dennis R.|last3=Garrett|first3=Wilson V.|last4=Lamont|first4=Jeffrey P.|last5=Kuhn|first5=Joseph A.|last6=Shutze|first6=William P.|last7=Kourlis|first7=Harry|last8=Grimsley|first8=Bradley|last9=Pearl|first9=Gregory J.|last10=Smith|first10=Bertram L.|last11=Talkington|first11=C.M.|last12=Thompson|first12=Jesse E.|title=Management of Carotid Body Paragangliomas and Review of a 30-year Experience|journal=Annals of Vascular Surgery|volume=16|issue=3|year=2002|pages=331–338|issn=08905096|doi=10.1007/s10016-001-0106-8}}</ref>
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| **The supporting or sustentacular cells responsible for the [[chemoreceptor]] activity of the [[carotid body]]
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| *The characteristic finding of this [[tumor]] is:
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| :*Chief cells Arranged in distinctive pattern called [[cell]] balls (zellballen)
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| :*Separated by fibrovascular stroma and surrounded by [[sustentacular]] cells
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| :*The [[cytoplasm]] is [[pale]] and diffuse with occasional presence of the [[eosinophilic]] [[granules]].<ref>{{cite book | last = Bibbo | first = Marluce | title = Comprehensive cytopathology | publisher = Saunders/Elsevier | location = Philadelphia, PA | year = 2008 | isbn = 978-1-4160-4208-2 }}</ref>
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| :*The nuclei are round to spindle shape.
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| *The [[tumor]] is highly [[vascular]].
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| *Although there is no well-accepted [[histologic]] criteria for the [[diagnosis]] of [[malignant]] [[tumors]], worrisome [[histologic]] features include:<ref name="WienekeSmith2009">{{cite journal|last1=Wieneke|first1=Jacqueline A.|last2=Smith|first2=Alice|title=Paraganglioma: Carotid Body Tumor|journal=Head and Neck Pathology|volume=3|issue=4|year=2009|pages=303–306|issn=1936-055X|doi=10.1007/s12105-009-0130-5}}</ref>
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| **[[Necrosis]]
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| **Extensive [[vascular]] or capsular [[invasion]] | |
| **Increased [[mitotic]] activity | |
| **Atypical [[mitotic]] figures
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| {| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;"
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| | align="center" style="background: #4479BA;" | {{fontcolor|#FFF|''' Features on Gross Pathology'''}}
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| | align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Image'''}}
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| |Characteristic findings of [[carotid body]] [[tumor]], include:<ref name="WienekeSmith2009">{{cite journal|last1=Wieneke|first1=Jacqueline A.|last2=Smith|first2=Alice|title=Paraganglioma: Carotid Body Tumor|journal=Head and Neck Pathology|volume=3|issue=4|year=2009|pages=303–306|issn=1936-055X|doi=10.1007/s12105-009-0130-5}}</ref>
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| **Well-circumscribed with psudocapsule
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| **The size of the [[tumor]] varies greatly and it may be as large as 10 cm
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| **The cutting surface is solid with a smooth, rubbery texture||
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| |[[File:Carotid body tumor.jpg|thumb|300px|Contributed by Paweł Kuźniar in wikimedia.commons]]
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| {{Family tree/start}}
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| {{Family tree | | | | | | | | | | | | A01 | | | |A01= Patient with carotid body tumor}}
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| {{Family tree | | | | | | | | | | | | |!| | | | | }}
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| {{Family tree | | | | | | | | | | | | B01 | | | |B01= History, Physical examination, and evaluation of cnotralateral side}}
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| {{Family tree | | | | | | | | | |,|-|-|^|-|-|.| | }}
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| {{Family tree | | | | | | | | | C01 | | | | C02 |C01= Patients with age < 50 years<br>Patients with multiple paraganglioma<br>Patients with a positive family history| C02= The rest of the patients}}
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| {{Family tree | | | | | | | | | |!| | | | }}
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| {{Family tree | | | | | | | | | D01 | | | | | |D01= SDHD genetic testing}}
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| {{Family tree | | | | | |,|-|-|-|^|-|-|.| | }}
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| {{Family tree | | | | | E01 | | | | | E02 |E01= Presence of SDHD mutation |E02= Absence of SDHD mutation}}
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| {{Family tree | | | | | |!| | | | | | |!| | | | | }}
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| {{Family tree | | | | | |!| | | | | | F01 | | | |F01= SDHC and SDHB genetic testing}}
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| {{Family tree | | | | | |!| | | |,|-|-|^|-|-|.| | }}
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| {{Family tree | | | | | |!| | | G01 | | | | G02 |G01= Presence of SDHC/B mutation |G02= Absence of SDHC/B mutation}}
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| {{Family tree | | | | | |!| | | |!| | }}
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| {{familytree | | | | | | H02 |-|'| | | |H02=All the relatives should be evaluated for the presence of paragnaglioma}}
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| {{Family tree | | | | | | |!| | | | }}
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| {{Family tree | | | | | | I01 | | | |I01= whole-body 18F-dihydroxyphenylalanine (F-DOPA) positron emission tomography to assess the presence of other paragangliomas}}
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| {{Family tree | | | |,|-|-|^|-|-|.| |}}
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| {{Family tree | | | J01 | | | | J02 |J01= Presence of other paraganglioma |J02= Absence of other paraganglioma}}
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| {{Family tree | | | |!| | | | | |!| | | }}
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| {{Family tree | | | K01 | | | | K02 |K01= 24-hour urine catecholamines and MRI for biochemical screening|K02=surveillance screening every 5 years}}
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| {{Family tree/end}}
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