Oligodendroglioma other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies for oligodendroglioma include [[biopsy]] (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and [[ | Other [[Diagnostic study of choice|diagnostic studies]] for [[oligodendroglioma]] include [[biopsy]] ([[homogeneous]], [[Compact tissue|compact]], rounded [[Cells (biology)|cells]] with [[Distinctive feature|distinct]] [[Borderline|borders]] and clear [[cytoplasm]] surrounding a [[dense]] [[central]] [[nucleus]] and [[Perinuclear space|perinuclear]] [[Halo (medicine)|halo]]) and [[Fish|fluorescent in-situ hybridization (FISH) technique]] ([[Deletion (genetics)|deletions]] of [[Chromosome 1|chromosome 1p]] and [[Chromosome 19|19q]]). | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
*Biopsy may be performed to help confirm the diagnosis of oligodendroglioma. | *[[Biopsy]] may be [[Performance status|performed]] to help [[Confirmatory factor analysis|confirm]] the [[diagnosis]] of [[oligodendroglioma]]. | ||
*On [[biopsy]], oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance.<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885 }} </ref> | *On [[biopsy]], [[oligodendroglioma]] is characterized by [[homogeneous]], [[Compact tissue|compact]], rounded [[Cell (biology)|cells]] with [[Distinctive feature|distinct]] borders and clear [[cytoplasm]] surrounding a [[dense]] [[central]] [[nucleus]] and [[Perinuclear space|perinuclear]] [[Halo (medicine)|halo]], giving it the characteristic “''fried [[Egg (biology)|egg]]''” [[appearance|appearance.]]<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885 }} </ref> | ||
*Biopsy may be done at the time of [[surgical resection]] of oligodendroglioma. | *[[Biopsy]] may be done at the [[Time series|time]] of [[surgical resection]] of [[oligodendroglioma]]. | ||
*Biopsy may be of two types: [[ | *[[Biopsy]] may be of two types: | ||
*Indications for [[ | **Open [[biopsy]] | ||
**[[stereotactic|Stereotactic biopsy]] | |||
*[[Indications and usage|Indications]] for open [[biopsy]] and [[stereotactic|stereotactic biopsy]] are described below:<ref name="pmid15509821">{{cite journal| author=Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 18 | pages= 1875-82 | pmid=15509821 | doi=10.1056/NEJMcpc049025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15509821 }} </ref> | |||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align="center" | {| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align="center" | ||
|+ | |+ | ||
'''Indications for different types of biopsies''' | |||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Type of biopsy}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Type of biopsy}} | ||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Indications}} | ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Indications}} | ||
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[[craniotomy|Open biopsy]] | [[craniotomy|Open biopsy]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Surgically resectable masses | *[[Surgery|Surgically]] [[Resection|resectable]] [[Mass|masses]] | ||
*Lesions in accessible and relatively | *[[Lesions]] in [[Accessible image|accessible]] and [[Relatively compact|relatively]] “[[Silent News|silent]]” [[Area|areas]] of the [[brain]] or in [[Area|areas]] of the [[brain]] with a mild [[Post operative complications|postoperative]] [[Neurological|neurologic]] deficit | ||
*Appearance consistent with [[tumor]] on the [[MRI]] | *[[Appearance]] consistent with [[tumor]] on the [[MRI]] | ||
*Large [[tumors]] exerting mass effect | *Large [[tumors]] exerting [[mass effect]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | ||
[[Stereotactic|Stereotactic biopsy]] | [[Stereotactic|Stereotactic biopsy]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Deep-seated [[tumor]] that is not amenable to resection | *Deep-seated [[tumor]] that is not amenable to [[resection]] | ||
*Lesions in which the radiological and clinical findings are ambiguous | *[[Lesions]] in which the [[radiological]] and [[clinical]] findings are ambiguous | ||
*Diffuse or multiple lesions | *[[Diffuse]] or multiple [[lesions]] | ||
*Appearance that suggests a [[lymphoma]], which would not require resection | *[[Appearance]] that [[Suggestion|suggests]] a [[lymphoma]], which would not require [[resection]] | ||
*Change in the appearance of a previously diagnosed or treated [[tumor]] | *[[Change detection|Change]] in the [[appearance]] of a previously [[Diagnose|diagnosed]] or [[Treatments|treated]] [[tumor]] | ||
*Assessment of tumor after treatment (to distinguish between [[radiation|radiation necrosis]] and tumor recurrence) | *[[Assessment and Plan|Assessment]] of [[tumor]] after [[Treatments|treatment]] (to distinguish between [[radiation|radiation necrosis]] and [[tumor]] [[Recurrence plot|recurrence]]) | ||
|} | |} | ||
===Fluorescent in-situ hybridization (FISH) technique=== | ===Fluorescent in-situ hybridization (FISH) technique=== | ||
*[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]] | *[[FISH]] demonstrates [[Deletion (genetics)|deletions]] of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q.]]<ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref> | ||
==References== | ==References== | ||
Latest revision as of 21:03, 4 June 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]
Overview
Other diagnostic studies for oligodendroglioma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).
Other Diagnostic Studies
Biopsy
- Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.
- On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.[1]
- Biopsy may be done at the time of surgical resection of oligodendroglioma.
- Biopsy may be of two types:
- Indications for open biopsy and stereotactic biopsy are described below:[2]
| Type of biopsy | Indications |
|---|---|
| |
|
Fluorescent in-situ hybridization (FISH) technique
- FISH demonstrates deletions of chromosome 1p and 19q.[3]
References
- ↑ Wesseling P, van den Bent M, Perry A (2015). "Oligodendroglioma: pathology, molecular mechanisms and markers". Acta Neuropathol. 129 (6): 809–27. doi:10.1007/s00401-015-1424-1. PMC 4436696. PMID 25943885.
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 9 October, 2015 Check date values in:
|accessdate=(help)