Neoplastic meningitis differential diagnosis: Difference between revisions

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==Overview==
==Overview==
Neoplastic meningitis must be differentiated from infections ([[meningitis]], [[Lyme disease]], [[neurocysticercosis]]), neoplastic ([[intracerebral metastasis]], dural metastasis), inflammatory ([[rheumatoid arthritis]], [[multiple sclerosis]], [[polychondritis]]), and granulomatous disorders ([[sarcoidosis]], [[histiocytosis]], [[Wegener's granulomatosis]], [[vasculitis]]).<ref name=ddxmeningitis>Leptomeningitis. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningitis. Accessed on January 21, 2016</ref>
Neoplastic meningitis must be differentiated from infections ([[meningitis]], [[Lyme disease]], [[neurocysticercosis]]), neoplastic ([[intracerebral metastasis]], dural metastasis), inflammatory ([[rheumatoid arthritis]], [[multiple sclerosis]], [[polychondritis]]), and granulomatous disorders ([[sarcoidosis]], [[histiocytosis]], [[Wegener's granulomatosis]], [[vasculitis]]).<ref name="ddxmeningitis">Leptomeningitis. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningitis. Accessed on January 21, 2016</ref>


==Differentiating Neoplastic Meningitis from other Diseases==
==Differentiating Neoplastic Meningitis from other Diseases==
Neoplastic meningitis must be differentiated from:<ref name=ddxmeningitis>Leptomeningitis. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningitis. Accessed on January 21, 2016</ref>
Differential Diagnosis for Neoplastic Meningitis:
 
*[[Meningitis]] from infectious causes - infectious meningitis may to some degree manifest like neoplastic meningitis due to meningeal irritation. This include viral, bacterial, fungal and HIV-associated causes of meningitis.
*[https://www.cedars-sinai.edu/Patients/Health-Conditions/Neurosarcoidosis.aspx Neurosarcoidosis.]
*[https://www.mayoclinic.org/diseases-conditions/vasculitis/symptoms-causes/syc-20363435 Vasculitis] - the generalized nature of vessel involvement in these diseases may, to some extent involve the meninges. [[Vasculitis]] documented to present like neoplastic meningitis include [[Kawasaki disease]], [[Takayasu arteritis]], [[Polyarteritis nodosa]], [[Polyarteritis nodosa|microscopic polyarteritis nodosa]] and [[Granulomatosis with polyangiitis|Wegener granulomatosis]].
*Systemic connective tissue diseases - particularly [[SLE]] and [[Sjögren's syndrome|Sjogren's syndrome]] share some of the manifestation of neoplastic meningitis.
 
Neoplastic meningitis must be differentiated from:<ref name="ddxmeningitis">Leptomeningitis. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningitis. Accessed on January 21, 2016</ref>


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[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
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OR
 
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
 
==Differentiating [Disease name] from other Diseases==
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
 
OR
 
[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].
 
OR
 
As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].
 
===Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]===
 
On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].
{|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! rowspan="4"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Diseases
| colspan="6" rowspan="1"  style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Clinical manifestations'''
! colspan="7" rowspan="2"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Para-clinical findings
| colspan="1" rowspan="4"  style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Gold standard'''
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;|Additional findings
|-
| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Symptoms'''
! colspan="3" rowspan="2"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical examination
|-
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab Findings
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|Histopathology
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 1
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 1
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 3
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 1
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 2
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|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 3
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|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
!Diseases
!Symptom 1
! colspan="1" rowspan="1" |Symptom 2
!Symptom 3
!Physical exam 1
! colspan="1" rowspan="1" |Physical exam 2
!Physical exam 3
!Lab 1
!Lab 2
!Lab 3
!Imaging 1
!Imaging 2
!Imaging 3
!Histopathology
|'''Gold standard'''
!Additional findings
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 4
| style="background: #F5F5F5; padding: 5px;" |
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 5
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 6
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|}


==References==
==References==

Latest revision as of 15:16, 16 August 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Neoplastic meningitis must be differentiated from infections (meningitis, Lyme disease, neurocysticercosis), neoplastic (intracerebral metastasis, dural metastasis), inflammatory (rheumatoid arthritis, multiple sclerosis, polychondritis), and granulomatous disorders (sarcoidosis, histiocytosis, Wegener's granulomatosis, vasculitis).[1]

Differentiating Neoplastic Meningitis from other Diseases

Differential Diagnosis for Neoplastic Meningitis:

Neoplastic meningitis must be differentiated from:[1]

Type of disease Differential diagnoses of neoplastic meningitis

Infections

Neoplastic

Inflammatory disorders

Granulomatous disorders


References

  1. ↑ 1.0 1.1 Leptomeningitis. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningitis. Accessed on January 21, 2016


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