Renal oncocytoma natural history, complications and prognosis: Difference between revisions

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==Overview==
==Overview==
[[Prognosis]] of renal oncocytoma is generally excellent.
The median age at the time of [[surgery]] is 62 to 68 years. In 10% to 32% of [[patients]] with renal oncocytoma, coexcitente [[RCC]] are seen. [[Prognosis]] is generally excellent, There are only two cases of [[metastatic]] renal oncocytoma were reported. Since the definite [[diagnosis]] is maintain just after [[surgery]], most of [[patients]] are undergone operation.
==Prognosis==
Prognosis of renal oncocytoma is generally excellent.<ref name="pmid2226597">{{cite journal |vauthors=Lieber MM |title=Renal oncocytoma: prognosis and treatment |journal=[[European Urology]] |volume=18 Suppl 2 |issue= |pages=17–21 |year=1990 |pmid=2226597 |doi= |url=}}</ref>


==Overview==
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==


===Natural History===
===Natural History===
*The median age at the time of [[surgery]] is 62 to 68 years. <ref name="NeuzilletLechevallier2005">{{cite journal|last1=Neuzillet|first1=Yann|last2=Lechevallier|first2=Eric|last3=Andre|first3=March|last4=Daniel|first4=Laurent|last5=Nahon|first5=Olivier|last6=Coulange|first6=Christian|title=Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy|journal=Urology|volume=66|issue=6|year=2005|pages=1181–1185|issn=00904295|doi=10.1016/j.urology.2005.06.001}}</ref>
*The median age at the time of [[surgery]] is 62 to 68 years. <ref name="NeuzilletLechevallier2005">{{cite journal|last1=Neuzillet|first1=Yann|last2=Lechevallier|first2=Eric|last3=Andre|first3=March|last4=Daniel|first4=Laurent|last5=Nahon|first5=Olivier|last6=Coulange|first6=Christian|title=Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy|journal=Urology|volume=66|issue=6|year=2005|pages=1181–1185|issn=00904295|doi=10.1016/j.urology.2005.06.001}}</ref>
 
*In 10% to 32% of [[patients]] with renal oncocytoma, coexcitente [[RCC]] are seen.<ref>{{Cite journal
| author = [[M. R. Licht]], [[A. C. Novick]], [[R. R. Tubbs]], [[E. A. Klein]], [[H. S. Levin]] & [[S. B. Streem]]
| title = Renal oncocytoma: clinical and biological correlates
| journal = [[The Journal of urology]]
| volume = 150
| issue = 5 Pt 1
| pages = 1380–1383
| year = 1993
| month = November
| pmid = 8411404
}}</ref><ref name="DechetBostwick1999">{{cite journal|last1=Dechet|first1=Christopher B.|last2=Bostwick|first2=David G.|last3=Blute|first3=Michael L.|last4=Bryant|first4=Sandra C.|last5=Zincke|first5=Horst|title=RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA|journal=Journal of Urology|volume=162|issue=1|year=1999|pages=40–42|issn=0022-5347|doi=10.1097/00005392-199907000-00010}}</ref>


===Prognosis===
===Prognosis===
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  | pmid = 9255250
  | pmid = 9255250
}}</ref>
}}</ref>
*Since the definite [[diagnosis]] is maintain just after [[surgery]], most of [[patients]] are undergone operation.<ref>{{Cite journal
*Since the definite [[diagnosis]] is maintain just after [[surgery]], most of [[patients]] are undergone operation.<ref>{{Cite journal
  | author = [[Leo Romis]], [[Luca Cindolo]], [[Jean Jacques Patard]], [[Giovanni Messina]], [[Vincenzo Altieri]], [[Laurent Salomon]], [[Claude Clement Abbou]], [[Dominique Chopin]], [[Bernard Lobel]] & [[Alexandre de La Taille]]
  | author = [[Leo Romis]], [[Luca Cindolo]], [[Jean Jacques Patard]], [[Giovanni Messina]], [[Vincenzo Altieri]], [[Laurent Salomon]], [[Claude Clement Abbou]], [[Dominique Chopin]], [[Bernard Lobel]] & [[Alexandre de La Taille]]
Line 57: Line 54:
  | pmid = 3901483
  | pmid = 3901483
}}</ref>
}}</ref>
Renal oncocytoma is regarded as a benign neoplasia. Although some malignant oncocytomas with local organ invasion and metastases have been described in early reports,20,8,105,4 those cases examined could be confused with eosinophilic variants of chromophobe RCC, because Hale’s colloidal iron stain and electron microscopy were not applied.106 However, despite the strict histological criteria, two oncocytomas that caused liver metastasis confirmed by needle biopsy or metastatic (liver and bone) death have been reported.6 Unfortunately, no genetic material from such cases was available for analysis to confirm the original histological diagnosis.
Today, the vast majority of oncocytomas are operated upon. There are several reasons for this policy. First, definitive preoperative diagnosis is not, at present, possible. As such, the differential diagnosis of RCC cannot be excluded. Furthermore, as was discussed previously, oncocytoma and RCC may exist concomitantly. Second, the natural evolution of renal oncocytomas is not known. There are not many articles in the English literature that address the issue of nonoperative management of oncocytomas [70,78,79]. Romis et al. made a retrospective review of patients with oncocytoma and their management. One patient out of 32 with oncocytoma was not operated because he had a previous contralateral nephrectomy for nephrolithiasis. This patient was diagnosed with percutaneous biopsy of the renal tumor. In order to avoid hemodialysis, he was followed with ultrasound (US) and CT scans for 30 months. The tumor was 6 cm in diameter and stable throughout the follow-up period [70]. Neuzillet et al. retrospectively analyzed 15 cases of asymptomatic oncocytomas in their institute, diagnosed by percutaneous core biopsy. The authors decided to monitor the patients with Doppler ultrasound or CT scans for the first 6 month after the diagnosis, and biannually thereafter. Mean follow-up time was 40.1 months. Four patients were operated upon during the follow-up period because of fast tumor growth (mean growth rate 2.4 cm/y).
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category: Primary care]]

Latest revision as of 23:57, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2] Shanshan Cen, M.D. [3]

Overview

The median age at the time of surgery is 62 to 68 years. In 10% to 32% of patients with renal oncocytoma, coexcitente RCC are seen. Prognosis is generally excellent, There are only two cases of metastatic renal oncocytoma were reported. Since the definite diagnosis is maintain just after surgery, most of patients are undergone operation.

Natural History, Complications, and Prognosis

Natural History

  • The median age at the time of surgery is 62 to 68 years. [1]
  • In 10% to 32% of patients with renal oncocytoma, coexcitente RCC are seen.[2][3]

Prognosis

References

  1. ↑ 1.0 1.1 Neuzillet, Yann; Lechevallier, Eric; Andre, March; Daniel, Laurent; Nahon, Olivier; Coulange, Christian (2005). "Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy". Urology. 66 (6): 1181–1185. doi:10.1016/j.urology.2005.06.001. ISSN 0090-4295.
  2. ↑ M. R. Licht, A. C. Novick, R. R. Tubbs, E. A. Klein, H. S. Levin & S. B. Streem (1993). "Renal oncocytoma: clinical and biological correlates". The Journal of urology. 150 (5 Pt 1): 1380–1383. PMID 8411404. Unknown parameter |month= ignored (help)
  3. ↑ Dechet, Christopher B.; Bostwick, David G.; Blute, Michael L.; Bryant, Sandra C.; Zincke, Horst (1999). "RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA". Journal of Urology. 162 (1): 40–42. doi:10.1097/00005392-199907000-00010. ISSN 0022-5347.
  4. ↑ Lieber MM (1990). "Renal oncocytoma: prognosis and treatment". European Urology. 18 Suppl 2: 17–21. PMID 2226597.
  5. ↑ B. Perez-Ordonez, G. Hamed, S. Campbell, R. A. Erlandson, P. Russo, P. B. Gaudin & V. E. Reuter (1997). "Renal oncocytoma: a clinicopathologic study of 70 cases". The American journal of surgical pathology. 21 (8): 871–883. PMID 9255250. Unknown parameter |month= ignored (help)
  6. ↑ Leo Romis, Luca Cindolo, Jean Jacques Patard, Giovanni Messina, Vincenzo Altieri, Laurent Salomon, Claude Clement Abbou, Dominique Chopin, Bernard Lobel & Alexandre de La Taille (2004). "Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database". European urology. 45 (1): 53–57. PMID 14667516. Unknown parameter |month= ignored (help)
  7. ↑ D. B. Spring, R. C. Ulirsch, W. R. Starke & S. Jr Brown (1985). "Renal oncocytoma followed for eighteen years without resection". Urology. 26 (4): 389–392. PMID 3901483. Unknown parameter |month= ignored (help)

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