Hepatopulmonary syndrome surgery: Difference between revisions
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{{Hepatopulmonary syndrome}} | {{Hepatopulmonary syndrome}} | ||
{{CMG}}; {{AE}} {{Soroush}} | {{CMG}}; {{AE}} {{Soroush}} | ||
==Overview== | |||
[[Surgery]] is the mainstay of treatment for hepatopulmonary syndrome. [[Liver transplantation|Orthotopic liver transplantation]] is the only available treatment for patients with hepatopulmonary syndrome. | |||
==Indications== | |||
*There are a number of indications for liver transplantation in cirrhosis divided to relative and absolute indications. | |||
*Among them, severe cardiac and/or pulmonary diseases and severe pulmonary hypertension (mPAP >45 mm Hg) is an absolute indication. | |||
*Plenty of patients who develop HPS are already candied for liver transplantation. | |||
==Surgery== | |||
*[[Surgery]] is the mainstay of treatment for hepatopulmonary syndrome. | |||
*[[Liver transplantation|Orthotopic liver transplantation]] is the only available treatment for patients with hepatopulmonary syndrome. | |||
<ref name="pmid15828054">Swanson KL, Wiesner RH, Krowka MJ (2005) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=15828054 Natural history of hepatopulmonary syndrome: Impact of liver transplantation.] ''Hepatology'' 41 (5):1122-9. [http://dx.doi.org/10.1002/hep.20658 DOI:10.1002/hep.20658] PMID: [https://pubmed.gov/15828054 15828054]</ref><ref name="pmid24142412">Nayyar D, Man HS, Granton J, Gupta S (2014) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=24142412 Defining and characterizing severe hypoxemia after liver transplantation in hepatopulmonary syndrome.] ''Liver Transpl'' 20 (2):182-90. [http://dx.doi.org/10.1002/lt.23776 DOI:10.1002/lt.23776] PMID: [https://pubmed.gov/24142412 24142412]</ref> | |||
<ref name="pmid25649047">Nayyar D, Man HS, Granton J, Lilly LB, Gupta S (2015) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=25649047 Proposed management algorithm for severe hypoxemia after liver transplantation in the hepatopulmonary syndrome.] ''Am J Transplant'' 15 (4):903-13. [http://dx.doi.org/10.1111/ajt.13177 DOI:10.1111/ajt.13177] PMID: [https://pubmed.gov/25649047 25649047]</ref><ref name="pmid24757662">Park TJ, Ahn KS, Kim YH, Kim H, Park UJ, Kim HT et al. (2014) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=24757662 Improved severe hepatopulmonary syndrome after liver transplantation in an adolescent with end-stage liver disease secondary to biliary atresia.] ''Clin Mol Hepatol'' 20 (1):76-80. [http://dx.doi.org/10.3350/cmh.2014.20.1.76 DOI:10.3350/cmh.2014.20.1.76] PMID: [https://pubmed.gov/24757662 24757662]</ref> | |||
<ref name="pmid10096527">Egawa H, Kasahara M, Inomata Y, Uemoto S, Asonuma K, Fujita S et al. (1999) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=10096527 Long-term outcome of living related liver transplantation for patients with intrapulmonary shunting and strategy for complications.] ''Transplantation'' 67 (5):712-7. PMID: [https://pubmed.gov/10096527 10096527]</ref><ref name="pmid18509123">Rodríguez-Roisin R, Krowka MJ (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18509123 Hepatopulmonary syndrome--a liver-induced lung vascular disorder.] ''N Engl J Med'' 358 (22):2378-87. [http://dx.doi.org/10.1056/NEJMra0707185 DOI:10.1056/NEJMra0707185] PMID: [https://pubmed.gov/18509123 18509123]</ref> | |||
<ref name="pmid11003635">Fallon MB, Abrams GA (2000) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=11003635 Pulmonary dysfunction in chronic liver disease.] ''Hepatology'' 32 (4 Pt 1):859-65. [http://dx.doi.org/10.1053/jhep.2000.7519 DOI:10.1053/jhep.2000.7519] PMID: [https://pubmed.gov/11003635 11003635]</ref><ref name="pmid14762853">Krowka MJ, Mandell MS, Ramsay MA, Kawut SM, Fallon MB, Manzarbeitia C et al. (2004) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=14762853 Hepatopulmonary syndrome and portopulmonary hypertension: a report of the multicenter liver transplant database.] ''Liver Transpl'' 10 (2):174-82. [http://dx.doi.org/10.1002/lt.20016 DOI:10.1002/lt.20016] PMID: [https://pubmed.gov/14762853 14762853]</ref><ref name="pmid891282">Kennedy TC, Knudson RJ (1977) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=891282 Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis.] ''Chest'' 72 (3):305-9. [http://dx.doi.org/10.1378/chest.72.3.305 DOI:10.1378/chest.72.3.305] PMID: [https://pubmed.gov/891282 891282]</ref><ref name="pmid27326810">Krowka MJ, Fallon MB, Kawut SM, Fuhrmann V, Heimbach JK, Ramsay MA et al. (2016) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27326810 International Liver Transplant Society Practice Guidelines: Diagnosis and Management of Hepatopulmonary Syndrome and Portopulmonary Hypertension.] ''Transplantation'' 100 (7):1440-52. [http://dx.doi.org/10.1097/TP.0000000000001229 DOI:10.1097/TP.0000000000001229] PMID: [https://pubmed.gov/27326810 27326810]</ref> | |||
==Complications== | |||
*Severe post-transplant hypoxemia and subsequent prolonged mechanical ventilation | |||
*Post-operative infections | |||
*Anastomotic bile duct leaks due to delayed wound healing because of hypoxemia | |||
*Post-operative portal vein and hepatic artery thrombosis due to polycythemia induced by chronic hypoxemia | |||
*Post-transplant HPS recurrence because of graft dysfunction | |||
*Progressive pulmonary hypertension | |||
==References== | |||
{{Reflist|2}} | |||
{{WH}} | |||
{{WS}} | |||
[[Category:Surgery]] | |||
[[Category:Medicine]] | |||
[[Category:Pulmonology]] | |||
[[Category:Cardiology]] | |||
[[Category:Gastroentrology]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 18:04, 6 September 2019
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Hepatopulmonary syndrome Microchapters |
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Differentiating Hepatopulmonary syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatopulmonary syndrome surgery On the Web |
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American Roentgen Ray Society Images of Hepatopulmonary syndrome surgery |
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Risk calculators and risk factors for Hepatopulmonary syndrome surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]
Overview
Surgery is the mainstay of treatment for hepatopulmonary syndrome. Orthotopic liver transplantation is the only available treatment for patients with hepatopulmonary syndrome.
Indications
- There are a number of indications for liver transplantation in cirrhosis divided to relative and absolute indications.
- Among them, severe cardiac and/or pulmonary diseases and severe pulmonary hypertension (mPAP >45 mm Hg) is an absolute indication.
- Plenty of patients who develop HPS are already candied for liver transplantation.
Surgery
- Surgery is the mainstay of treatment for hepatopulmonary syndrome.
- Orthotopic liver transplantation is the only available treatment for patients with hepatopulmonary syndrome.
[1][2] [3][4] [5][6] [7][8][9][10]
Complications
- Severe post-transplant hypoxemia and subsequent prolonged mechanical ventilation
- Post-operative infections
- Anastomotic bile duct leaks due to delayed wound healing because of hypoxemia
- Post-operative portal vein and hepatic artery thrombosis due to polycythemia induced by chronic hypoxemia
- Post-transplant HPS recurrence because of graft dysfunction
- Progressive pulmonary hypertension
References
- ↑ Swanson KL, Wiesner RH, Krowka MJ (2005) Natural history of hepatopulmonary syndrome: Impact of liver transplantation. Hepatology 41 (5):1122-9. DOI:10.1002/hep.20658 PMID: 15828054
- ↑ Nayyar D, Man HS, Granton J, Gupta S (2014) Defining and characterizing severe hypoxemia after liver transplantation in hepatopulmonary syndrome. Liver Transpl 20 (2):182-90. DOI:10.1002/lt.23776 PMID: 24142412
- ↑ Nayyar D, Man HS, Granton J, Lilly LB, Gupta S (2015) Proposed management algorithm for severe hypoxemia after liver transplantation in the hepatopulmonary syndrome. Am J Transplant 15 (4):903-13. DOI:10.1111/ajt.13177 PMID: 25649047
- ↑ Park TJ, Ahn KS, Kim YH, Kim H, Park UJ, Kim HT et al. (2014) Improved severe hepatopulmonary syndrome after liver transplantation in an adolescent with end-stage liver disease secondary to biliary atresia. Clin Mol Hepatol 20 (1):76-80. DOI:10.3350/cmh.2014.20.1.76 PMID: 24757662
- ↑ Egawa H, Kasahara M, Inomata Y, Uemoto S, Asonuma K, Fujita S et al. (1999) Long-term outcome of living related liver transplantation for patients with intrapulmonary shunting and strategy for complications. Transplantation 67 (5):712-7. PMID: 10096527
- ↑ Rodríguez-Roisin R, Krowka MJ (2008) Hepatopulmonary syndrome--a liver-induced lung vascular disorder. N Engl J Med 358 (22):2378-87. DOI:10.1056/NEJMra0707185 PMID: 18509123
- ↑ Fallon MB, Abrams GA (2000) Pulmonary dysfunction in chronic liver disease. Hepatology 32 (4 Pt 1):859-65. DOI:10.1053/jhep.2000.7519 PMID: 11003635
- ↑ Krowka MJ, Mandell MS, Ramsay MA, Kawut SM, Fallon MB, Manzarbeitia C et al. (2004) Hepatopulmonary syndrome and portopulmonary hypertension: a report of the multicenter liver transplant database. Liver Transpl 10 (2):174-82. DOI:10.1002/lt.20016 PMID: 14762853
- ↑ Kennedy TC, Knudson RJ (1977) Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis. Chest 72 (3):305-9. DOI:10.1378/chest.72.3.305 PMID: 891282
- ↑ Krowka MJ, Fallon MB, Kawut SM, Fuhrmann V, Heimbach JK, Ramsay MA et al. (2016) International Liver Transplant Society Practice Guidelines: Diagnosis and Management of Hepatopulmonary Syndrome and Portopulmonary Hypertension. Transplantation 100 (7):1440-52. DOI:10.1097/TP.0000000000001229 PMID: 27326810