Waldenström's macroglobulinemia causes: Difference between revisions
Jump to navigation
Jump to search
Sara Mohsin (talk | contribs) (→Causes) |
Sara Mohsin (talk | contribs) |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The exact cause of Waldenström macroglobulinemia has not been identified; however, the disease has been highly associated with [[somatic]] [[mutations]] in [[MYD88]] and CXR4 genes. In addition, possible | The [[Exact test|exact]] [[Causes|cause]] of [[Waldenström's macroglobulinemia|Waldenstrom's macroglobulinemia]] has not been identified; however, the [[disease]] has been highly-[[Association (statistics)|associated]] with [[somatic]] [[mutations]] in [[MYD88]]<nowiki/>and CXR4 [[genes]]. In addition, less possible common [[Causes|cause]] of the [[disease]] includes ''[[Chromosome abnormality|chromosomal abnormalities]].'' | ||
==Causes== | ==Causes== | ||
=== Genetic Causes === | === Genetic Causes === | ||
*[[ | *[[Waldenström's macroglobulinemia|Waldenstrom's macroglobulinemia]] is most probably [[Causes|caused]] by a [[somatic mutation]] in the [[MYD88]] [[gene]] (seen in 90% of cases) or CXR4 [[gene]] (seen in 30% of [[Case-based reasoning|cases]])<ref name=":0">{{Cite journal | ||
| author = [[Steven P. Treon]], [[Lian Xu]], [[Guang Yang]], [[Yangsheng Zhou]], [[Xia Liu]], [[Yang Cao]], [[Patricia Sheehy]], [[Robert J. Manning]], [[Christopher J. Patterson]], [[Christina Tripsas]], [[Luca Arcaini]], [[Geraldine S. Pinkus]], [[Scott J. Rodig]], [[Aliyah R. Sohani]], [[Nancy Lee Harris]], [[Jason M. Laramie]], [[Donald A. Skifter]], [[Stephen E. Lincoln]] & [[Zachary R. Hunter]] | | author = [[Steven P. Treon]], [[Lian Xu]], [[Guang Yang]], [[Yangsheng Zhou]], [[Xia Liu]], [[Yang Cao]], [[Patricia Sheehy]], [[Robert J. Manning]], [[Christopher J. Patterson]], [[Christina Tripsas]], [[Luca Arcaini]], [[Geraldine S. Pinkus]], [[Scott J. Rodig]], [[Aliyah R. Sohani]], [[Nancy Lee Harris]], [[Jason M. Laramie]], [[Donald A. Skifter]], [[Stephen E. Lincoln]] & [[Zachary R. Hunter]] | ||
| title = MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia | | title = MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia | ||
| Line 33: | Line 33: | ||
=== Less Common Causes === | === Less Common Causes === | ||
Less common [[causes]] of [[lymphoplasmacytic lymphoma]] may include:<ref name="UTDR">{{cite journal |vauthors=Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM |title=Oncogenically active MYD88 mutations in human lymphoma |journal=Nature |volume=470 |issue=7332 |pages=115–9 |year=2011 |pmid=21179087 |doi=10.1038/nature09671 |url=}}</ref><ref>{{Cite journal | Less common [[causes]] of [[lymphoplasmacytic lymphoma|Waldenstrom's macroglobulinemia]] may include:<ref name="UTDR">{{cite journal |vauthors=Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM |title=Oncogenically active MYD88 mutations in human lymphoma |journal=Nature |volume=470 |issue=7332 |pages=115–9 |year=2011 |pmid=21179087 |doi=10.1038/nature09671 |url=}}</ref><ref>{{Cite journal | ||
| author = [[Roelandt F. J. Schop]], [[W. Michael Kuehl]], [[Scott A. Van Wier]], [[Gregory J. Ahmann]], [[Tammy Price-Troska]], [[Richard J. Bailey]], [[Syed M. Jalal]], [[Ying Qi]], [[Robert A. Kyle]], [[Philip R. Greipp]] & [[Rafael Fonseca]] | | author = [[Roelandt F. J. Schop]], [[W. Michael Kuehl]], [[Scott A. Van Wier]], [[Gregory J. Ahmann]], [[Tammy Price-Troska]], [[Richard J. Bailey]], [[Syed M. Jalal]], [[Ying Qi]], [[Robert A. Kyle]], [[Philip R. Greipp]] & [[Rafael Fonseca]] | ||
| title = Waldenstrom macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions | | title = Waldenstrom macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions | ||
| Line 45: | Line 45: | ||
| pmid = 12351413 | | pmid = 12351413 | ||
}}</ref> | }}</ref> | ||
*[[Chromosomal abnormalities]]: to see the list of all [[cytogenetic]] [[abnormalities]], click '''[[Lymphoplasmacytic lymphoma pathophysiology#Cytogenetics|here]]''' | *[[Chromosomal abnormalities]]: to see the list of all [[cytogenetic]] [[abnormalities]], click '''[[Lymphoplasmacytic lymphoma pathophysiology#Cytogenetics|here]]''' | ||
**[[Deletion (genetics)|Deletions]] of 6q23 and 13q14 | **[[Deletion (genetics)|Deletions]] of 6q23 and 13q14 | ||
**[[Gain|Gains]] of 3q13-q28, 6p and 18q | **[[Gain|Gains]] of 3q13-q28, 6p and 18q | ||
Latest revision as of 18:29, 15 August 2019
|
Waldenström's macroglobulinemia Microchapters |
|
Differentiating Waldenström's macroglobulinemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Waldenström's macroglobulinemia causes On the Web |
|
American Roentgen Ray Society Images of Waldenström's macroglobulinemia causes |
|
Directions to Hospitals Treating Waldenström's macroglobulinemia |
|
Risk calculators and risk factors for Waldenström's macroglobulinemia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2], Roukoz A. Karam, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
The exact cause of Waldenstrom's macroglobulinemia has not been identified; however, the disease has been highly-associated with somatic mutations in MYD88and CXR4 genes. In addition, less possible common cause of the disease includes chromosomal abnormalities.
Causes
Genetic Causes
- Waldenstrom's macroglobulinemia is most probably caused by a somatic mutation in the MYD88 gene (seen in 90% of cases) or CXR4 gene (seen in 30% of cases)[1][2]
Less Common Causes
Less common causes of Waldenstrom's macroglobulinemia may include:[3][4]
- Chromosomal abnormalities: to see the list of all cytogenetic abnormalities, click here
References
- ↑ Steven P. Treon, Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Patricia Sheehy, Robert J. Manning, Christopher J. Patterson, Christina Tripsas, Luca Arcaini, Geraldine S. Pinkus, Scott J. Rodig, Aliyah R. Sohani, Nancy Lee Harris, Jason M. Laramie, Donald A. Skifter, Stephen E. Lincoln & Zachary R. Hunter (2012). "MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia". The New England journal of medicine. 367 (9): 826–833. doi:10.1056/NEJMoa1200710. PMID 22931316. Unknown parameter
|month=ignored (help) - ↑ Zachary R. Hunter, Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert J. Manning, Christina Tripsas, Christopher J. Patterson, Patricia Sheehy & Steven P. Treon (2014). "The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis". Blood. 123 (11): 1637–1646. doi:10.1182/blood-2013-09-525808. PMID 24366360. Unknown parameter
|month=ignored (help) - ↑ Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM (2011). "Oncogenically active MYD88 mutations in human lymphoma". Nature. 470 (7332): 115–9. doi:10.1038/nature09671. PMID 21179087.
- ↑ Roelandt F. J. Schop, W. Michael Kuehl, Scott A. Van Wier, Gregory J. Ahmann, Tammy Price-Troska, Richard J. Bailey, Syed M. Jalal, Ying Qi, Robert A. Kyle, Philip R. Greipp & Rafael Fonseca (2002). "Waldenstrom macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions". Blood. 100 (8): 2996–3001. doi:10.1182/blood.V100.8.2996. PMID 12351413. Unknown parameter
|month=ignored (help)