Germ cell tumor classification: Difference between revisions

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! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Types}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Subtypes}}
! style="background: #4479BA; padding: 5px 5px;" colspan=1 | {{fontcolor|#FFFFFF|Signs and Symptoms}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Histopathology}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Lab finding }}
! style="background: #4479BA; padding: 5px 5px;" colspan=1 | {{fontcolor|#FFFFFF| Treatment }}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Prognosis}}
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="3;"|Gonadal'''
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Seminoma
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* Painless [[testicular mass]] with discomfort
* [[Back pain]]
* [[Abdominal discomfort]]
* [[Abdominal mass]].
| style="padding: 5px 5px; background: #F5F5F5;" |Gross: pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface
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* Complete blood count and blood chemistry tests.
* Abnormal serum tumor marker levels ([[LDH]], [[HCG]]).<ref name="Diagnosisoftesticularcancer1" />
* CT: Metastases to the para-aortic, inguinal, or iliac lymph nodes. Visceral metastasis may also be seen.
* Pelvic MRI: may be diagnostic. multinodular tumors of uniform signal intensity
* Hypo- to isointense on T2-weighted images and inhomogenous enhancement on contrast enhanced T1-weighted images.
* Other diagnostic studies for seminoma include [[biopsy]], [[PET|FDG-PET scan]], and [[bone scan]].
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* [[Orchiectomy|Radical inguinal orchiectomy]] is the first treatment for any stage of testicular seminoma. Usually done as diagnostic and therapeutic.
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* Prognosis of seminoma is good for all stages with greater than 90% cure rate.<ref name="progseminomabjhk">Treatment and prognosis of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on March 2, 2016</ref>
* The International Germ Cell Cancer Consensus Group divides seminoma into two prognosis groups: good and intermediate.<ref name="survivalkandprognosisoftesticularcancer">Prognosis and survival for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/prognosis-and-survival/?region=on. Accessed on February 29, 2016</ref>
* Common complications of seminoma include recurrence, lymph node metastasis, distant metastasis, and secondary malignancies.<ref name="Testicularseminomaradiopaediafhg">Testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on March 3, 2016</ref>
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Dysgerminoma
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Germinoma
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="6;" | Extragonadal


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"| Embryonic
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*
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Teratoma
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Extraembryonic
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Coriocarcinoma
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Yolk sac tumor
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<references />

Latest revision as of 14:23, 23 September 2019