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__NOTOC__
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{{CMG}}; {{AE}} {{S.M.}}




{{CMG}}; {{AE}} {{S.M.}}


<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907  }} </ref>


[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]




{| class="wikitable"
{|  
|+Different sunscreen recommendations and recommendations' grading according to Canadian Task Force on Preventive Health Care (CTFPHC) GRADE System
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Sunscreen property}}
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Recommendation}}
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Grade of Recommendations}}
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
|-
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[SPF]] ([[Sun Protection Factor]])
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
|
*An [[Idealization|ideal]] [[sunscreen]] should have the following properties:
**[[Broad-spectrum]]
**Both [[UVA radiation|UVA]] & [[UVB radiation|UVB]] [[Filter (chemistry)|filters]]
**Atleast [[SPF]] 30
| rowspan="8" |
*'''[[Strong|Strongly]] recommended'''
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Water]] [[resistance]]
|
*[[Sunscreen]] providing [[water]]-[[resistance]] for 40-80 [[Minute|minutes]] must be worn in following [[conditions]]:
**[[Water]] [[Immersion Therapy|immersion]]
**Excessive [[sweating]]
**Contact with sand
**Physical contact [[Causes|causing]] increased [[skin]] [[friction]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Organic Chemistry|Organic]] vs [[inorganic]] [[sunscreens]]
|
*Whether the components of [[sunscreen]] are [[Organic Chemistry|organic]] or [[inorganic]], the recommended [[sunscreen]] must be [[broad spectrum]] with both [[UVA radiation|UVA]] & [[UVB radiation|UVB]] [[Filter (chemistry)|filters]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Lip]] [[Protecting group|protection]]
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
|
| style="background:#F5F5F5;" align="center" + | +
*Whole [[lip]] should be generously covered by high-[[SPF]] (>/= 30) and reapplication of [[lip]] [[sunscreen]]
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | +
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Sunscreen]] application
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
|
| style="background:#F5F5F5;" align="center" + | +
*[[Sunscreen]] is recommended to be applied according to the following [[Guideline (medical)|guidelines]]:
| style="background:#F5F5F5;" align="center" + | +
**Should be applied liberally (approximately 45 ml) to all the [[Exposure (photography)|exposed]] [[Area|areas]]
| style="background:#F5F5F5;" align="center" + | -
**[[Strong]] reapplication within a [[period]] of 8 hours is [[Mandatory labelling|mandatory]] only after [[Activities of daily living|activities]] that may remove the [[sunscreen]] layer such as [[sweating]], [[swimming]], or [[friction]]
| style="background:#F5F5F5;" align="center" + | -
**Should be applied before any [[sun exposure]] and at least 20 [[Minute|minutes]] before the [[water]] [[Activities of daily living|activities]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Patient education]] on [[sunscreen]]
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
|
| style="background:#F5F5F5;" align="center" + | +
*[[Patients]] should be [[Education|educated]] about the [[Mean|meaning]] of [[SPF]] and its [[Effective method|effectiveness]]
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Sunscreen]] [[Safety film|safety]]
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
|
| style="background:#F5F5F5;" align="center" + | +
*[[Sunscreens]] have a favorable [[RiskMetrics|risk]]-benefit profile, hence, are considered to be safe overall
| style="background:#F5F5F5;" align="center" + | -
*There is still a [[RiskMetrics|risk]] of following [[Fewmets|few]] [[complications]] due to [[sunscreen]] application in some [[People's Solidarity|people]]:
| style="background:#F5F5F5;" align="center" + | -
**[[Photoallergy]] (most common, but quite [[rare]])
| style="background:#F5F5F5;" align="center" + | -
**[[Reproductive]] [[toxicity]]
|}<br />
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Sunscreen]] benefits
|
*[[Prevention (medical)|Prevents]] photoaging
*[[Prevention (medical)|Prevents]] [[melanoma]] and non–[[melanoma]] [[skin cancer]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Sunscreen]] [[Vehicle extrication|vehicle]]
|
*Highest [[SPF]] and [[water]] [[resistance]] properties of [[sunscreen]] can be obtained by [[Usage analysis|using]] a '''[[water]]-in-[[oil]] [[emulsion]]''' [[formulation]] for [[sunscreens]]
| rowspan="2" |
*'''Weakly recommended'''
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Expiration|Expiry]] date
|
*Avoid [[Usage analysis|using]] [[sunscreens]] past their manufacturer-[[Specific activity|specified]] [[Expiration|expiry]] date/recommended [[period]] after opening
*[[Sunscreens]] should be [[Storage (memory)|stored]] at [[normal]] [[room temperature]] in order to ensure their proper [[stability]]
|}
 




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==References==
==Reference==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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