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{| class="wikitable"
 
|+Different variants of dermatofibrosarcoma protuberans
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907  }} </ref>
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Variant subtype}}
 
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Details}}
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]
 
 
{|
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''[[Pigmented lesions|Pigmented]] dermatofibrosarcoma protuberans (Bednar [[tumor]])'''
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
|
| style="background:#F5F5F5;" align="center" + | +
* Contains dark-colored, pigmented cells known as melanin-containing dendritic cells
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | +
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''Myxoid dermatofibrosarcoma protuberans [[tumor]]'''
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
|
| style="background:#F5F5F5;" align="center" + | +
* Contains an abnormal type of [[connective tissue]] known as myxoid stroma
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''[[Juvenile (organism)|Juvenile]] dermatofibrosarcoma protuberans ([[Giant cell fibroblastoma]])'''
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
|
| style="background:#F5F5F5;" align="center" + | +
* Called as juvenile because it usually affects children and adolescents
| style="background:#F5F5F5;" align="center" + | -
* Contains giant cells in the tumor
| style="background:#F5F5F5;" align="center" + | +
|}
| style="background:#F5F5F5;" align="center" + | -
|-
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|}<br />
 








==References==
==Reference==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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