Intravenous leiomyomatosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{SI}}
{{SI}}
 
{{CMG}} {{AE}} {{Sonia Sandeep Js}} {{Sahar}}<br>
{{CMG}} '''Associate Editor-In-Chief:''' {{CZ}}; {{Ammu}}
 
{{SK}} Nesidioblastoma, IVLM
{{SK}} Nesidioblastoma, IVLM
==Overview==
==Overview==
Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a [[uterine leiomyoma]]. The etiology of intravenous leiomyomatosis is unclear. Intravenous leiomyomatosis must be differentiated from other diseases such as [[renal malignancies]] and [[sarcoma]]. The median age is 45 years, with patients ranging from 26 to 70 years old. Only females may develop intravenous leiomyomatosis. Common complications of intravenous leiomyomatosis include [[embolization]], recurrence of the tumor, and metastasis. Surgery is the mainstay of therapy for intravenous leiomyomatosis. It can grow in to lymphatics /veins.<ref name="pmid24027407">{{cite journal| author=Mariyappa N, Manikyam UK, Krishnamurthy D, Preeti K, Agarwal Y, Prakar U| title=Intravenous leiomyomatosis. | journal=Niger J Surg | year= 2012 | volume= 18 | issue= 2 | pages= 105-6 | pmid=24027407 | doi=10.4103/1117-6806.103122 | pmc=3762011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24027407  }} </ref>
Intravenous leiomyomatosis is also refered as IVL. Intravenous leiomyomatosis is characterized by the [[extension]] into [[venous]] channels of [[histologically]] [[Leiomyoma|benign smooth muscle tumor]] arising from either the wall of a [[Vessel wall|vessel]] or from a [[uterine leiomyoma]]. The [[etiology]] of intravenous leiomyomatosis is unclear. Intravenous leiomyomatosis must be [[Differentiate|differentiated]] from other [[diseases]] such as [[Renal cell cancer|renal malignancies]] and [[sarcomas]]. The median age is 45 years, with [[patients]] age ranging from 26 to 70 years old. Only [[females]] may develop intravenous leiomyomatosis. Findings on [[CT scan]] [[diagnostic]] of intravenous leiomyomatosis include an irregular [[mass]] exhibiting [[heterogeneous]] enhancement with [[extension]] into adjacent [[veins]]. Findings on an [[ultrasound]] imaging [[diagnostic]] of intravenous Leiomyomatosis include a vascularized [[thrombi]] within the [[pelvic]] [[Vein|veins]] and [[Inferior vena  cava]]. Findings on [[MRI]] [[diagnostic]] of intravenous leiomyomatosis include a leiomyomatous [[lesion]] or a distorted [[uterus]] with projections into [[vasculature]]. [[Surgery]] is the mainstay of therapy for intravenous leiomyomatosis. It can grow into [[lymphatics]] /[[veins]].
 
==Historical Perspective==
==Historical Perspective==
*first described in 1896 German Pathologist Birch-Hirschfeld <ref>{{Cite journal
*Intravenous leiomyomatosis first described in 1896 by German [[Pathologist]] Birch-Hirschfeld.<ref name="pmid11904348">{{cite journal| author=Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC| title=Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case. | journal=Mod Pathol | year= 2002 | volume= 15 | issue= 3 | pages= 351-6 | pmid=11904348 | doi=10.1038/modpathol.3880529 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11904348  }}</ref>
| pmid =
*First case of leiomyo-matosis of [[pelvic]] origin with [[intravascular]] [[extension]] to [[cardiac]] cavities was described in 1907 in Germany by Dürck and Hörmann.<ref name="pmid10788838">{{cite journal |vauthors=Stolf NA, dos Santos GG, Haddad VL |title=Unusual abdominal tumors with intracardiac extension. Two cases with successful surgical resection |journal=Rev Hosp Clin Fac Med Sao Paulo |volume=54 |issue=5 |pages=159–64 |date=1999 |pmid=10788838 |doi= |url=}}</ref>
23563052
==Classification==
}}</ref>
* There is no established system for the [[classification]] of intravenous leiomyomatosis.
*first reported case of leiomyo-matosis of pelvic origin with intravascular extension to cardiac cavities was described in 1907 in Germany by Dürck and Hörmann. <ref><nowiki>https://www.ncbi.nlm.nih.gov/pubmed/23563052</nowiki></ref>
 
==Pathophysiology==
==Pathophysiology==
* Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a [[uterine leiomyoma]].(<nowiki>PMID 3202247</nowiki>)
*Intravenous leiomyomatosis is characterized by the [[extension]] into [[venous]] channels of [[histologically]] [[Leiomyoma|benign smooth muscle tumors]] arising from either the wall of a [[vessel]] or from a [[uterine leiomyoma]].<ref name="pmid240274072">{{cite journal| author=Mariyappa N, Manikyam UK, Krishnamurthy D, Preeti K, Agarwal Y, Prakar U| title=Intravenous leiomyomatosis. | journal=Niger J Surg | year= 2012 | volume= 18 | issue= 2 | pages= 105-6 | pmid=24027407 | doi=10.4103/1117-6806.103122 | pmc=3762011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24027407  }}</ref>
*Approximately 40% of leiomyomata have cytogenetic abnormalities.
*Approximately 40% of leiomyomata have [[Cytogenetics|cytogenetic]] abnormalities.
*They are benign tumors of uterus that extend to veins system but do not invade the surrounding tissues (<nowiki>PMID 12508249</nowiki>)
*They are [[Tumor|benign tumors]] of [[uterus]] that extend to [[Veins|venous system]] but do not invade the surrounding [[tissues]]. <ref name="pmid12508249">{{cite journal| author=Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC| title=Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24). | journal=Genes Chromosomes Cancer | year= 2003 | volume= 36 | issue= 2 | pages= 205-6 | pmid=12508249 | doi=10.1002/gcc.10159 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12508249 }}</ref>
*They contains receptors to Estrogen and progesterone and hence response to these hormones (<nowiki>PMID 12508249</nowiki>)
*They contains receptors responsive to [[estrogen]] and [[progesterone]] and hence response to these [[hormones]]. <ref name="pmid125082492">{{cite journal| author=Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC| title=Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24). | journal=Genes Chromosomes Cancer | year= 2003 | volume= 36 | issue= 2 | pages= 205-6 | pmid=12508249 | doi=10.1002/gcc.10159 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12508249  }}</ref>
*It is also referred as quasi-malignant behavior due to its speedy spreading behavior. <nowiki>PMID 11904348</nowiki>
*It is also referred as quasi-malignant behavior due to its speedy spreading behavior.<ref name="pmid119043482">{{cite journal| author=Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC| title=Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case. | journal=Mod Pathol | year= 2002 | volume= 15 | issue= 3 | pages= 351-6 | pmid=11904348 | doi=10.1038/modpathol.3880529 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11904348 }}</ref>
* Patients are exclusively female, and the majority are white, [[premenopausal]], and parous.<nowiki>PMID 12649198</nowiki>
*On [[microscopy]] it is seen as [[benign]], well-differentiated [[tumor]] with [[smooth muscle cell]] growing within [[veins]] as worm-like projections.
*Intravenous leiomyomatosis should be considered in young women with cardiac symptoms who have a right atrial mass as well as a pelvic mass or who have previously undergone hysterectomy for leiomyoma uterus with intravenous involvement.(<nowiki>PMID 12508249</nowiki>)
*[[Tumor cell|Tumor cells]] shows bizarre [[nuclear]] [[morphology]] with hyperchromatic multilobated [[nuclei]].
*The [[mitotic]] activity is low, with [[mitotic]] index of less than 1 per 50 high-power fields.
==Causes==
==Causes==
* The etiology of intravenous leiomyomatosis is unclear.<ref>{{Cite web|url=https://pubs.rsna.org/doi/pdf/10.1148/rg.287085095|title=Leiomyomas beyond
* The etiology of intravenous leiomyomatosis is unclear.<ref name="FasihPrasad Shanbhogue2008">{{cite journal|last1=Fasih|first1=Najla|last2=Prasad Shanbhogue|first2=Alampady K.|last3=Macdonald|first3=David B.|last4=Fraser-Hill|first4=Margaret A.|last5=Papadatos|first5=Demetrios|last6=Kielar|first6=Ania Z.|last7=Doherty|first7=Geoffrey P.|last8=Walsh|first8=Cynthia|last9=McInnes|first9=Matthew|last10=Atri|first10=Mostafa|title=Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations|journal=RadioGraphics|volume=28|issue=7|year=2008|pages=1931–1948|issn=0271-5333|doi=10.1148/rg.287085095}}</ref>
the Uterus: Unusual
Locations, Rare
Manifestations1|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
*Only two cytogenetic reports in IVL and both exhibited a karyotype with a der(14)t(12;14)(q15;q24) and two normal copies of chromosome 12 which has close association to  uterine leiomyoma genetics
*
==Differentiating Intravenous Leiomyomatosis from other Diseases==
==Differentiating Intravenous Leiomyomatosis from other Diseases==
*Intravenous leiomyomatosis must be differentiated from other diseases such as:
*Intravenous leiomyomatosis must be [[Differentiate|differentiated]] from other [[conditions]] such as [[intravenous]] [[thrombus]], [[leiomyosarcoma]], right atrial [[myxoma]] and [[thrombosis]] of carcinomas, for example, [[renal cell carcinoma]], [[hepatocellular carcinoma]], and [[adrenocortical carcinoma]].<ref name="LeeKim2011">{{cite journal|last1=Lee|first1=Sak|last2=Kim|first2=Do-Kyun|last3=Narm|first3=Kyoung Shik|last4=Cho|first4=Sang-Ho|title=Pulmonary Artery Embolization of Intravenous Leiomyomatosis Extending into the Right Atrium|journal=The Korean Journal of Thoracic and Cardiovascular Surgery|volume=44|issue=3|year=2011|pages=243–246|issn=2233-601X|doi=10.5090/kjtcs.2011.44.3.243}}</ref><ref name="FasihPrasad Shanbhogue2008">{{cite journal|last1=Fasih|first1=Najla|last2=Prasad Shanbhogue|first2=Alampady K.|last3=Macdonald|first3=David B.|last4=Fraser-Hill|first4=Margaret A.|last5=Papadatos|first5=Demetrios|last6=Kielar|first6=Ania Z.|last7=Doherty|first7=Geoffrey P.|last8=Walsh|first8=Cynthia|last9=McInnes|first9=Matthew|last10=Atri|first10=Mostafa|title=Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations|journal=RadioGraphics|volume=28|issue=7|year=2008|pages=1931–1948|issn=0271-5333|doi=10.1148/rg.287085095}}</ref>
:*Renal malignancies
*For more information on intravenous leiomyomatosis [[differential diagnosis]], please [[Leiomyosarcoma differential diagnosis|click here]].
:*Sarcoma
:*Thrombosis of the intravenous catheter
==Epidemiology and Demographics==
==Epidemiology and Demographics==
*The median age is 45 years, with patients ranging from 26 to 70 years old.
*There is no available data on the exact [[incidence]] of intravenous leiomyomatosis.
*Female are exclusively  affected with intravenous leiomyomatosis.
*The median age at the time of [[diagnosis]]  of IVL is 45 years, with [[patients]] age ranging from 26 to 70 years old. <ref name="pmid7850080">{{cite journal| author=Canzonieri V, D'Amore ES, Bartoloni G, Piazza M, Blandamura S, Carbone A| title=Leiomyomatosis with vascular invasion. A unified pathogenesis regarding leiomyoma with vascular microinvasion, benign metastasizing leiomyoma and intravenous leiomyomatosis. | journal=Virchows Arch | year= 1994 | volume= 425 | issue= 5 | pages= 541-5 | pmid=7850080 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7850080  }}</ref>
 
*Female are exclusively  affected with intravenous leiomyomatosis.<ref name="pmid18312983">{{cite journal| author=Poliquin V, Victory R, Vilos GA| title=Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report. | journal=J Minim Invasive Gynecol | year= 2008 | volume= 15 | issue= 2 | pages= 152-60 | pmid=18312983 | doi=10.1016/j.jmig.2007.12.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18312983  }}</ref>
* The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
*Intravenous leiomyomatosis is seen more commonly in white [[females]].<ref name="pmid183129832">{{cite journal| author=Poliquin V, Victory R, Vilos GA| title=Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report. | journal=J Minim Invasive Gynecol | year= 2008 | volume= 15 | issue= 2 | pages= 152-60 | pmid=18312983 | doi=10.1016/j.jmig.2007.12.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18312983  }}</ref>
* In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].
===Age===
*Patients affected are of reproductive age group
*Age from 28 to 76 years (median, 42 years) (DOI: S0368-2315(04)96638-0)
===Gender===
*It is diagnosis only of female
===Race===
*There is no racial predilection forntravenous leiomyomatosis.
 
==Risk Factors==
==Risk Factors==
*Common risk factors in the development of ntravenous leiomyomatosis are age, cytogenetics , and prior history,
*Common [[risk factors]] in the development of intravenous leiomyomatosis are [[age]], [[cytogenetic]] abnormalities , and prior history of [[uterine leiomyoma]], and/or [[hysterectomy]].<ref name="LeitmanKuperstein2008">{{cite journal|last1=Leitman|first1=M.|last2=Kuperstein|first2=R.|last3=Medalion|first3=B.|last4=Stamler|first4=A.|last5=Porat|first5=E.|last6=Rosenblatt|first6=S.|last7=Konen|first7=E.|last8=Krakover|first8=R.|last9=Vered|first9=Z.|title=A highly unusual right atrial mass presented in two women|journal=European Heart Journal - Cardiovascular Imaging|volume=9|issue=6|year=2008|pages=833–834|issn=2047-2412|doi=10.1093/ejechocard/jen173}}</ref>
 
==Screening==
*There is insufficient evidence to recommend routine [[screening]] for intravenous leiomyomatosis.
== Natural History, Complications and Prognosis==
== Natural History, Complications and Prognosis==
*The majority of patients with [disease name] remain asymptomatic for [duration/years].
*If left untreated, [[patients]] with intravenous leiomyomatosis may progress to develop [[congestive heart failure]], [[venous]] obstruction, and sudden death.<ref name="pmid284149953">{{cite journal| author=Schäfer HM, Isaak A, Gürke L| title=Case report of an intracaval leiomyomatosis 10 months after complete hysterectomy. | journal=Int J Surg Case Rep | year= 2017 | volume= 35 | issue=  | pages= 1-3 | pmid=28414995 | doi=10.1016/j.ijscr.2017.03.031 | pmc=5394212 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28414995  }}</ref><ref name="FasihPrasad Shanbhogue2008">{{cite journal|last1=Fasih|first1=Najla|last2=Prasad Shanbhogue|first2=Alampady K.|last3=Macdonald|first3=David B.|last4=Fraser-Hill|first4=Margaret A.|last5=Papadatos|first5=Demetrios|last6=Kielar|first6=Ania Z.|last7=Doherty|first7=Geoffrey P.|last8=Walsh|first8=Cynthia|last9=McInnes|first9=Matthew|last10=Atri|first10=Mostafa|title=Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations|journal=RadioGraphics|volume=28|issue=7|year=2008|pages=1931–1948|issn=0271-5333|doi=10.1148/rg.287085095}}</ref><ref name="KocicaVranes2005">{{cite journal|last1=Kocica|first1=Mladen J.|last2=Vranes|first2=Mile R.|last3=Kostic|first3=Dusan|last4=Kostic|first4=Natasa Kovacevic-|last5=Lackovic|first5=Vesna|last6=Mihajlovic|first6=Vesna Bozic-|last7=Velinovic|first7=Milos M.|last8=Mikic|first8=Aleksandar Dj.|last9=Kalezic|first9=Nevena Dimitrijevic-|title=Intravenous leiomyomatosis with extension to the heart: Rare or underestimated?|journal=The Journal of Thoracic and Cardiovascular Surgery|volume=130|issue=6|year=2005|pages=1724–1726|issn=00225223|doi=10.1016/j.jtcvs.2005.08.021}}</ref>
*Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
*Other possible [[complications]] of intravenous leiomyomatosis include [[tumor]] recurrence, and [[metastasis]].<ref name="pmid7465135">{{cite journal |vauthors=Evans AT, Symmonds RE, Gaffey TA |title=Recurrent pelvic intravenous leiomyomatosis |journal=Obstet Gynecol |volume=57 |issue=2 |pages=260–4 |date=February 1981 |pmid=7465135 |doi= |url=}}</ref><ref name="AwonugaRotas2008">{{cite journal|last1=Awonuga|first1=Awoniyi O.|last2=Rotas|first2=Michael|last3=Imudia|first3=Anthony N.|last4=Choi|first4=Christine|last5=Khulpateea|first5=Neekianund|title=Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy|journal=Archives of Gynecology and Obstetrics|volume=278|issue=4|year=2008|pages=373–376|issn=0932-0067|doi=10.1007/s00404-008-0581-z}}</ref>
*If left untreated, [#%] of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
*[[Prognosis]] is generally good.
*Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
*Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with [disease name] is approximately [#%].
*Common complications of intravenous leiomyomatosis include embolization, recurrence of the tumor, and metastasis.
*The tumor is slow growing, and the prognosis is favorable.  
 
*
 
== Diagnosis ==
== Diagnosis ==
===Diagnostic Criteria===
===Diagnostic Criteria===
*The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:
*There is no specific [[diagnostic]] Criteria for intravenous leiomyomatosis.
:*[criterion 1]
*[[Diagnosis]] may be challenging. However, a history of  A history of [[hysterectomy]] or the presence of [[Uterine leiomyoma|uterine leiomyomas]] may be helpful.<ref name="FasihPrasad Shanbhogue2008">{{cite journal|last1=Fasih|first1=Najla|last2=Prasad Shanbhogue|first2=Alampady K.|last3=Macdonald|first3=David B.|last4=Fraser-Hill|first4=Margaret A.|last5=Papadatos|first5=Demetrios|last6=Kielar|first6=Ania Z.|last7=Doherty|first7=Geoffrey P.|last8=Walsh|first8=Cynthia|last9=McInnes|first9=Matthew|last10=Atri|first10=Mostafa|title=Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations|journal=RadioGraphics|volume=28|issue=7|year=2008|pages=1931–1948|issn=0271-5333|doi=10.1148/rg.287085095}}</ref>
:*[criterion 2]
=== History and Symptoms ===
:*[criterion 3]
*[[Patients]] may be asymptomatic or have [[symptoms]] related to [[Uterine leiomyoma|uterine leiomyomas]].<ref name="pmid7820530">{{cite journal| author=Nakayama Y, Kitamura S, Kawachi K, Kawata T, Fukutomi M, Hasegawa J et al.| title=Intravenous leiomyomatosis extending into the right atrium. | journal=Cardiovasc Surg | year= 1994 | volume= 2 | issue= 5 | pages= 642-5 | pmid=7820530 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7820530  }}</ref><ref name="pmid15985146">{{cite journal| author=Moorjani N, Kuo J, Ashley S, Hughes G| title=Intravenous uterine leiomyosarcomatosis with intracardial extension. | journal=J Card Surg | year= 2005 | volume= 20 | issue= 4 | pages= 382-5 | pmid=15985146 | doi=10.1111/j.1540-8191.2005.200476.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15985146  }}</ref><ref name="pmid183129833">{{cite journal| author=Poliquin V, Victory R, Vilos GA| title=Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report. | journal=J Minim Invasive Gynecol | year= 2008 | volume= 15 | issue= 2 | pages= 152-60 | pmid=18312983 | doi=10.1016/j.jmig.2007.12.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18312983  }}</ref>
:*[criterion 4]
*[[Symptoms]] related to [[uterine]] [[leiomyoma]] may include [[abdominal pain]], [[abnormal uterine bleeding]], and [[abdominal distension]].<ref name="pmid19423058">{{cite journal |vauthors=Vaquero ME, Magrina JF, Leslie KO |title=Uterine smooth-muscle tumors with unusual growth patterns |journal=J Minim Invasive Gynecol |volume=16 |issue=3 |pages=263–8 |date=2009 |pmid=19423058 |doi=10.1016/j.jmig.2009.01.013 |url=}}</ref>
*[[Symptoms]] of intravenous Leiomyomatosis due to extension to great [[veins]] or invoving the [[heart]] may include [[dyspnoea]], [[loss of consciousness]], lower extremity [[edema]], [[chest pain]], [[abdominal pain]], and [[fatigue]].
=== Symptoms ===
 
Patients may be asymptomatic or have symptoms of uterine leiomyomas, [[Syncope|syncopal episodes]], and [[dyspnea]] on exertion.
 
*Symptoms of intravenous Leiomyomatosis may include the following:
 
:*Dyspnoea
:*Syncope
:*Oedema of the lower extremities
:*Palpitation
:*Fatigue
:*Ascites
:*Jugular vein distension
:*Chest pain
:*Abdominal pain  
:*Asymptomatic
=== Physical Examination ===
=== Physical Examination ===
*Patients with  intravenous Leiomyomatosis usually depends on location and extension which may include as :
*Patients with  intravenous Leiomyomatosis usually depends on location and [[extension]] of the [[tumor]] which may include [[jugular venous distention]], increased pulse rate, shifting dullness in [[abdominal exam]] suggestive of [[ascites]], and [[lower extremity edema]].<ref name="pmid9555121">{{cite journal |vauthors=Andrade LA, Torresan RZ, Sales JF, Vicentini R, De Souza GA |title=Intravenous leiomyomatosis of the uterus. A report of three cases |journal=Pathol. Oncol. Res. |volume=4 |issue=1 |pages=44–7 |date=1998 |pmid=9555121 |doi= |url=}}</ref>
 
<br />
 
# Iliac vein
# Ovarian vein
# Renal vein
# Both iliac and ovarian veins
# Gonadal vein
# Hypogastric vein
# Uterine vein
# Hypohepatic or hepatic vein
# Pelvic vein
#
 
<br />
 
*Physical examination may be remarkable for:
 
:*[finding 1]
:*[finding 2]
:*[finding 3]
:*[finding 4]
:*[finding 5]
:*[finding 6]
 
=== Laboratory Findings ===
=== Laboratory Findings ===
*There are no specific laboratory findings associated with [disease name].
*There are no specific laboratory findings associated with intravenous Leiomyomatosis.
 
=== Electrocardiogram ===
*A  [positive/negative] [test name] is diagnostic of [disease name].
*There are no [[ECG]] findings associated with intravenous Leiomyomatosis.
*An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].
=== X-ray ===
*Other laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
*There are no [[x-ray]] findings associated with intravenous Leiomyomatosis.
=== Echocardiography or Ultrasound ===
===Imaging Findings===
*[[Echocardiography]]/[[ultrasound]] may be helpful in the [[diagnosis]] of intravenous Leiomyomatosis.  
*There are no [imaging study] findings associated with [disease name].
*Findings on an [[ultrasound]] imaging [[diagnostic]] of intravenous Leiomyomatosis include a [[vascularized]] [[thrombi]] within the [[pelvic]] [[veins]] and [[IVC]].<ref name="FasihPrasad Shanbhogue2008">{{cite journal|last1=Fasih|first1=Najla|last2=Prasad Shanbhogue|first2=Alampady K.|last3=Macdonald|first3=David B.|last4=Fraser-Hill|first4=Margaret A.|last5=Papadatos|first5=Demetrios|last6=Kielar|first6=Ania Z.|last7=Doherty|first7=Geoffrey P.|last8=Walsh|first8=Cynthia|last9=McInnes|first9=Matthew|last10=Atri|first10=Mostafa|title=Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations|journal=RadioGraphics|volume=28|issue=7|year=2008|pages=1931–1948|issn=0271-5333|doi=10.1148/rg.287085095}}</ref>
*[[Echocardiography]] may show findings consistent with [[right atrial]] involvement of the [[tumor]].
*[Imaging study 1] is the imaging modality of choice for [disease name].
*Possible findings of IVL on [[echocardiography]] include hyperechoic elongated mobile [[mass]] extending from the [[inferior vena cava]] and an irregular [[lesion]] in the [[right atrium]] and sometimes with protrusion into the [[right ventricle]].<ref name="pmid22340462">{{cite journal |vauthors=Kang LQ, Zhang B, Liu BG, Liu FH |title=Diagnosis of intravenous leiomyomatosis extending to heart with emphasis on magnetic resonance imaging |journal=Chin. Med. J. |volume=125 |issue=1 |pages=33–7 |date=January 2012 |pmid=22340462 |doi= |url=}}</ref>
*On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
=== CT scan ===
*[Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].
*[[Pelvic]] [[CT scan]] may be helpful in the [[diagnosis]] of intravenous leiomyomatosis.<ref name="Xu2013">{{cite journal|last1=Xu|first1=Zhi-Feng|title=Uterine intravenous leiomyomatosis with cardiac extension: Imaging characteristics and literature review|journal=World Journal of Clinical Oncology|volume=4|issue=1|year=2013|pages=25|issn=2218-4333|doi=10.5306/wjco.v4.i1.25}}</ref>
*Findings on [[CT scan]] [[diagnostic]] of intravenous leiomyomatosis include an irregular [[mass]] exhibiting [[heterogeneous]] enhancement with [[extension]] into adjacent [[veins]].
=== Other Diagnostic Studies ===
=== MRI ===
*[Disease name] may also be diagnosed using [diagnostic study name].
*[[Pelvic]] [[MRI]] may be helpful in the [[diagnosis]] of intravenous leiomyomatosis.<ref name="FasihPrasad Shanbhogue2008">{{cite journal|last1=Fasih|first1=Najla|last2=Prasad Shanbhogue|first2=Alampady K.|last3=Macdonald|first3=David B.|last4=Fraser-Hill|first4=Margaret A.|last5=Papadatos|first5=Demetrios|last6=Kielar|first6=Ania Z.|last7=Doherty|first7=Geoffrey P.|last8=Walsh|first8=Cynthia|last9=McInnes|first9=Matthew|last10=Atri|first10=Mostafa|title=Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations|journal=RadioGraphics|volume=28|issue=7|year=2008|pages=1931–1948|issn=0271-5333|doi=10.1148/rg.287085095}}</ref>
*Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
*Findings on [[MRI]] [[diagnostic]] of intravenous leiomyomatosis include a leiomyomatous [[lesion]] or a distorted [[uterus]] with projections into [[vasculature]].
 
*The [[tumor]] usually shows low signal intensity similar to that of [[smooth muscle]] on T2-weighted images and low to intermediate signal intensity on T1-weighted images.
*The appearance of the [[lesion]] varies according to its [[smooth muscle cell]] and [[fibrous]] [[tissue]] content.
===Other Imaging Findings===
*There are no other [[imaging]] findings associated with intravenous leiomyomatosis.
===Other Diagnostic Studies===
*There are no other [[diagnostic]] studies associated with intravenous leiomyomatosis.
== Treatment ==
== Treatment ==
=== Medical Therapy ===
=== Medical Therapy ===
*There is no treatment for [disease name]; the mainstay of therapy is supportive care.
*There is no treatment for intravenous leiomyomatosis.
*The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
*[Medical therapy 1] acts by [mechanism of action 1].
*Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
=== Surgery ===
=== Surgery ===
*Surgery is the mainstay of therapy for [disease name].
*[[Surgery]] is the treatment of choice, and complete removal of the [[tumor]] is mandatory.
*[Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
*Recurrences may occur up to 15 years after the primary occurrence in [[patients]] with Incomplete resection of the [[tumor]].<ref name="pmid25743551">{{cite journal| author=Yanagiya A, Yamada O, Nanbu T, Hamada H, Takada J, Matsuura M et al.| title=[One-stage resection of intravenous leiomyomatosis extending into the right atrium]. | journal=Kyobu Geka | year= 2015 | volume= 68 | issue= 3 | pages= 188-91 | pmid=25743551 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25743551  }}</ref>
*[Surgical procedure] can only be performed for patients with [disease stage] [disease name].
*[[Bilateral]] [[oophorectomy]] causes shutdown of hormonal stimulation hence helps preventing recurrence.<ref name="pmid16583249">{{cite journal| author=Castelli P, Caronno R, Piffaretti G, Tozzi M| title=Intravenous uterine leiomyomatosis with right heart extension: successful two-stage surgical removal. | journal=Ann Vasc Surg | year= 2006 | volume= 20 | issue= 3 | pages= 405-7 | pmid=16583249 | doi=10.1007/s10016-006-9024-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16583249  }}</ref>
   
*[[Surgical]] removal can be done in single or staged procedures.<ref name="pmid12694674">{{cite journal| author=Nam MS, Jeon MJ, Kim YT, Kim JW, Park KH, Hong YS| title=Pelvic leiomyomatosis with intracaval and intracardiac extension: a case report and review of the literature. | journal=Gynecol Oncol | year= 2003 | volume= 89 | issue= 1 | pages= 175-80 | pmid=12694674 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12694674 }}</ref>
=== Prevention ===
=== Primary Prevention ===
*There are no primary preventive measures available for [disease name].
*There are no [[Primary prevention|primary preventive]] measures available for IVL.
=== Secondary Prevention ===
*Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
*There are no [[Secondary prevention|secondary preventive]] measures available for IVL.
 
*Once diagnosed and successfully treated, patients with [disease name] are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].  
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Pick One of 28 Approved]]
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==Images==
===Example #1===
The patient presented with S.O.B. one year after hysterectomy for a leiomyomatous uterus.
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Image:Intravascular-extension-leiomyoma-001.jpg|CT in Intravenous leiomyomatosis
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</div>
==Treatment==
*Surgery is the mainstay of therapy for intravenous leiomyomatosis.
==Related Chapters==
*[[Uterine leiomyoma]]
*Benign metastasizing leiomyoma
==References==
{{Reflist|2}}
[[Category:Oncology]]
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[[Category:Gynecology]]
[[Category:Gynecology]]
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Latest revision as of 13:31, 26 November 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Template:Sonia Sandeep Js Sahar Memar Montazerin, M.D.[2]
Synonyms and keywords: Nesidioblastoma, IVLM

Overview

Intravenous leiomyomatosis is also refered as IVL. Intravenous leiomyomatosis is characterized by the extension into venous channels of histologically benign smooth muscle tumor arising from either the wall of a vessel or from a uterine leiomyoma. The etiology of intravenous leiomyomatosis is unclear. Intravenous leiomyomatosis must be differentiated from other diseases such as renal malignancies and sarcomas. The median age is 45 years, with patients age ranging from 26 to 70 years old. Only females may develop intravenous leiomyomatosis. Findings on CT scan diagnostic of intravenous leiomyomatosis include an irregular mass exhibiting heterogeneous enhancement with extension into adjacent veins. Findings on an ultrasound imaging diagnostic of intravenous Leiomyomatosis include a vascularized thrombi within the pelvic veins and Inferior vena cava. Findings on MRI diagnostic of intravenous leiomyomatosis include a leiomyomatous lesion or a distorted uterus with projections into vasculature. Surgery is the mainstay of therapy for intravenous leiomyomatosis. It can grow into lymphatics /veins.

Historical Perspective

Classification

  • There is no established system for the classification of intravenous leiomyomatosis.

Pathophysiology

Causes

  • The etiology of intravenous leiomyomatosis is unclear.[7]

Differentiating Intravenous Leiomyomatosis from other Diseases

Epidemiology and Demographics

  • There is no available data on the exact incidence of intravenous leiomyomatosis.
  • The median age at the time of diagnosis of IVL is 45 years, with patients age ranging from 26 to 70 years old. [9]
  • Female are exclusively affected with intravenous leiomyomatosis.[10]
  • Intravenous leiomyomatosis is seen more commonly in white females.[11]

Risk Factors

Screening

  • There is insufficient evidence to recommend routine screening for intravenous leiomyomatosis.

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

  • There are no specific laboratory findings associated with intravenous Leiomyomatosis.

Electrocardiogram

  • There are no ECG findings associated with intravenous Leiomyomatosis.

X-ray

  • There are no x-ray findings associated with intravenous Leiomyomatosis.

Echocardiography or Ultrasound

CT scan

MRI

Other Imaging Findings

  • There are no other imaging findings associated with intravenous leiomyomatosis.

Other Diagnostic Studies

  • There are no other diagnostic studies associated with intravenous leiomyomatosis.

Treatment

Medical Therapy

  • There is no treatment for intravenous leiomyomatosis.

Surgery

  • Surgery is the treatment of choice, and complete removal of the tumor is mandatory.
  • Recurrences may occur up to 15 years after the primary occurrence in patients with Incomplete resection of the tumor.[24]
  • Bilateral oophorectomy causes shutdown of hormonal stimulation hence helps preventing recurrence.[25]
  • Surgical removal can be done in single or staged procedures.[26]

Primary Prevention

Secondary Prevention

References

  1. ↑ Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC (2002). "Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case". Mod Pathol. 15 (3): 351–6. doi:10.1038/modpathol.3880529. PMID 11904348.
  2. ↑ Stolf NA, dos Santos GG, Haddad VL (1999). "Unusual abdominal tumors with intracardiac extension. Two cases with successful surgical resection". Rev Hosp Clin Fac Med Sao Paulo. 54 (5): 159–64. PMID 10788838.
  3. ↑ Mariyappa N, Manikyam UK, Krishnamurthy D, Preeti K, Agarwal Y, Prakar U (2012). "Intravenous leiomyomatosis". Niger J Surg. 18 (2): 105–6. doi:10.4103/1117-6806.103122. PMC 3762011. PMID 24027407.
  4. ↑ Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC (2003). "Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)". Genes Chromosomes Cancer. 36 (2): 205–6. doi:10.1002/gcc.10159. PMID 12508249.
  5. ↑ Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC (2003). "Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)". Genes Chromosomes Cancer. 36 (2): 205–6. doi:10.1002/gcc.10159. PMID 12508249.
  6. ↑ Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC (2002). "Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case". Mod Pathol. 15 (3): 351–6. doi:10.1038/modpathol.3880529. PMID 11904348.
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Fasih, Najla; Prasad Shanbhogue, Alampady K.; Macdonald, David B.; Fraser-Hill, Margaret A.; Papadatos, Demetrios; Kielar, Ania Z.; Doherty, Geoffrey P.; Walsh, Cynthia; McInnes, Matthew; Atri, Mostafa (2008). "Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations". RadioGraphics. 28 (7): 1931–1948. doi:10.1148/rg.287085095. ISSN 0271-5333.
  8. ↑ Lee, Sak; Kim, Do-Kyun; Narm, Kyoung Shik; Cho, Sang-Ho (2011). "Pulmonary Artery Embolization of Intravenous Leiomyomatosis Extending into the Right Atrium". The Korean Journal of Thoracic and Cardiovascular Surgery. 44 (3): 243–246. doi:10.5090/kjtcs.2011.44.3.243. ISSN 2233-601X.
  9. ↑ Canzonieri V, D'Amore ES, Bartoloni G, Piazza M, Blandamura S, Carbone A (1994). "Leiomyomatosis with vascular invasion. A unified pathogenesis regarding leiomyoma with vascular microinvasion, benign metastasizing leiomyoma and intravenous leiomyomatosis". Virchows Arch. 425 (5): 541–5. PMID 7850080.
  10. ↑ Poliquin V, Victory R, Vilos GA (2008). "Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report". J Minim Invasive Gynecol. 15 (2): 152–60. doi:10.1016/j.jmig.2007.12.009. PMID 18312983.
  11. ↑ Poliquin V, Victory R, Vilos GA (2008). "Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report". J Minim Invasive Gynecol. 15 (2): 152–60. doi:10.1016/j.jmig.2007.12.009. PMID 18312983.
  12. ↑ Leitman, M.; Kuperstein, R.; Medalion, B.; Stamler, A.; Porat, E.; Rosenblatt, S.; Konen, E.; Krakover, R.; Vered, Z. (2008). "A highly unusual right atrial mass presented in two women". European Heart Journal - Cardiovascular Imaging. 9 (6): 833–834. doi:10.1093/ejechocard/jen173. ISSN 2047-2412.
  13. ↑ Schäfer HM, Isaak A, Gürke L (2017). "Case report of an intracaval leiomyomatosis 10 months after complete hysterectomy". Int J Surg Case Rep. 35: 1–3. doi:10.1016/j.ijscr.2017.03.031. PMC 5394212. PMID 28414995.
  14. ↑ Kocica, Mladen J.; Vranes, Mile R.; Kostic, Dusan; Kostic, Natasa Kovacevic-; Lackovic, Vesna; Mihajlovic, Vesna Bozic-; Velinovic, Milos M.; Mikic, Aleksandar Dj.; Kalezic, Nevena Dimitrijevic- (2005). "Intravenous leiomyomatosis with extension to the heart: Rare or underestimated?". The Journal of Thoracic and Cardiovascular Surgery. 130 (6): 1724–1726. doi:10.1016/j.jtcvs.2005.08.021. ISSN 0022-5223.
  15. ↑ Evans AT, Symmonds RE, Gaffey TA (February 1981). "Recurrent pelvic intravenous leiomyomatosis". Obstet Gynecol. 57 (2): 260–4. PMID 7465135.
  16. ↑ Awonuga, Awoniyi O.; Rotas, Michael; Imudia, Anthony N.; Choi, Christine; Khulpateea, Neekianund (2008). "Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy". Archives of Gynecology and Obstetrics. 278 (4): 373–376. doi:10.1007/s00404-008-0581-z. ISSN 0932-0067.
  17. ↑ Nakayama Y, Kitamura S, Kawachi K, Kawata T, Fukutomi M, Hasegawa J; et al. (1994). "Intravenous leiomyomatosis extending into the right atrium". Cardiovasc Surg. 2 (5): 642–5. PMID 7820530.
  18. ↑ Moorjani N, Kuo J, Ashley S, Hughes G (2005). "Intravenous uterine leiomyosarcomatosis with intracardial extension". J Card Surg. 20 (4): 382–5. doi:10.1111/j.1540-8191.2005.200476.x. PMID 15985146.
  19. ↑ Poliquin V, Victory R, Vilos GA (2008). "Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report". J Minim Invasive Gynecol. 15 (2): 152–60. doi:10.1016/j.jmig.2007.12.009. PMID 18312983.
  20. ↑ Vaquero ME, Magrina JF, Leslie KO (2009). "Uterine smooth-muscle tumors with unusual growth patterns". J Minim Invasive Gynecol. 16 (3): 263–8. doi:10.1016/j.jmig.2009.01.013. PMID 19423058.
  21. ↑ Andrade LA, Torresan RZ, Sales JF, Vicentini R, De Souza GA (1998). "Intravenous leiomyomatosis of the uterus. A report of three cases". Pathol. Oncol. Res. 4 (1): 44–7. PMID 9555121.
  22. ↑ Kang LQ, Zhang B, Liu BG, Liu FH (January 2012). "Diagnosis of intravenous leiomyomatosis extending to heart with emphasis on magnetic resonance imaging". Chin. Med. J. 125 (1): 33–7. PMID 22340462.
  23. ↑ Xu, Zhi-Feng (2013). "Uterine intravenous leiomyomatosis with cardiac extension: Imaging characteristics and literature review". World Journal of Clinical Oncology. 4 (1): 25. doi:10.5306/wjco.v4.i1.25. ISSN 2218-4333.
  24. ↑ Yanagiya A, Yamada O, Nanbu T, Hamada H, Takada J, Matsuura M; et al. (2015). "[One-stage resection of intravenous leiomyomatosis extending into the right atrium]". Kyobu Geka. 68 (3): 188–91. PMID 25743551.
  25. ↑ Castelli P, Caronno R, Piffaretti G, Tozzi M (2006). "Intravenous uterine leiomyomatosis with right heart extension: successful two-stage surgical removal". Ann Vasc Surg. 20 (3): 405–7. doi:10.1007/s10016-006-9024-0. PMID 16583249.
  26. ↑ Nam MS, Jeon MJ, Kim YT, Kim JW, Park KH, Hong YS (2003). "Pelvic leiomyomatosis with intracaval and intracardiac extension: a case report and review of the literature". Gynecol Oncol. 89 (1): 175–80. PMID 12694674.

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