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{{CMG}}; {{AE}} {{S.M.}}
{{CMG}}; {{AE}} {{S.M.}}


[[Microscopic]] [[Features (pattern recognition)|features]] include:


* Non-circumscribed
 
* Highly [[cellular]] with [[Cells (biology)|cells]] having following [[Characteristic function (probability theory)|characteristics]]:
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907  }} </ref>
** Monomorphic
 
** Thin
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]
**[[Spindle cells|Spindly]]
 
** Scant [[eosinophilic]] [[cytoplasm]]
 
** Hyperchromatic [[nuclei]] (resembling [[neurofibroma]])
{|
* Tight storiform [[pattern]] ([[Cells (biology)|cells]] [[Radiating fibers|radiating]] in spokes at right [[Angle|angles]] around a [[central]] [[Point (geometry)|point]] that often contains a [[Blood vessel|vessel]]) [[Infiltration (medical)|infiltrating]] deeply into [[subcutaneous tissue]] and entraping [[fat cells]] to form a [[Characteristic function (probability theory)|characteristic]] honeycomb [[pattern]]
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
*[[Area|Areas]] of [[Fasciculus|fascicular]] [[growth]] (seen in some [[Case-based reasoning|cases]])
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
* The early [[plaque]] stage may lack the particular storiform [[pattern]]
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
* Many non-atypical [[mitotic]] figures may be present
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
* Non-[[Polarization|polarized]], thin [[collagen]]
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
* Mild [[pleomorphism]] (not [[Significant figure|significant]])
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
* Focal [[atypia]]
|-
* May coexist with [[giant cell]] fibroblastoma
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
* Absent or [[rare]] [[histiocytes]]
| style="background:#F5F5F5;" align="center" + | +
* Following [[Cell (biology)|cell]] types are absent:
| style="background:#F5F5F5;" align="center" + | +
**[[Histiocyte]]-like [[Cells (biology)|cells]]
| style="background:#F5F5F5;" align="center" + | +
**[[Foam cells]]
| style="background:#F5F5F5;" align="center" + | +
**[[Giant cells]]
|-
** Other [[inflammatory cells]]
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
* Different '''variants''' include:
| style="background:#F5F5F5;" align="center" + | +
**[[Atrophic]] ([[Depress|depressed]] [[lesion]])
| style="background:#F5F5F5;" align="center" + | +
**[[Collagenous]] (with [[central]] thick [[collagen]] bundles)
| style="background:#F5F5F5;" align="center" + | -
**[[Granular cell]] ([[S100A1|S100]] negative)
| style="background:#F5F5F5;" align="center" + | -
** Myxoid
|-
** Palisading
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
**[[Pigmented lesions|Pigmented]]
| style="background:#F5F5F5;" align="center" + | +
** Sclerosing
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
|-
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|}<br />
 
 
 
 
 
==Reference==
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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