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{{CMG}}; {{AE}} {{S.M.}}
{{CMG}}; {{AE}} {{S.M.}}


*Immunhistochemical staining of dermatofibrosarcoma protuberans shows:
 
**Positive staining for:
 
***CD34 (strong in 95%)
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907 }} </ref>
***Vimentin
 
***Focal actin
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]
***ApoD<ref name="pmid15252314">{{cite journal| author=West RB, Harvell J, Linn SC, Liu CL, Prapong W, Hernandez-Boussard T et al.| title=Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans. | journal=Am J Surg Pathol | year= 2004 | volume= 28 | issue= 8 | pages= 1063-9 | pmid=15252314 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15252314 }} </ref><ref name="pmid17885669">{{cite journal| author=Lisovsky M, Hoang MP, Dresser KA, Kapur P, Bhawan J, Mahalingam M| title=Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. | journal=Mod Pathol | year= 2008 | volume= 21 | issue= 1 | pages= 31-8 | pmid=17885669 | doi=10.1038/modpathol.3800971 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17885669  }} </ref><ref name="pmid20062007">{{cite journal| author=Bandarchi B, Ma L, Marginean C, Hafezi S, Zubovits J, Rasty G| title=D2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans. | journal=Mod Pathol | year= 2010 | volume= 23 | issue= 3 | pages= 434-8 | pmid=20062007 | doi=10.1038/modpathol.2009.176 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20062007  }} </ref>
 
***bcl2
 
***NKI-C3<ref name="pmid1553911">{{cite journal| author=Ma CK, Zarbo RJ, Gown AM| title=Immunohistochemical characterization of atypical fibroxanthoma and dermatofibrosarcoma protuberans. | journal=Am J Clin Pathol | year= 1992 | volume= 97 | issue= 4 | pages= 478-83 | pmid=1553911 | doi=10.1093/ajcp/97.4.478 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1553911  }} </ref>
{|  
***CD99<ref name="pmid18201229">{{cite journal| author=Diwan AH, Skelton HG, Horenstein MG, Kelly DR, Barrett TL, Bussian AH et al.| title=Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity. | journal=J Cutan Pathol | year= 2008 | volume= 35 | issue= 7 | pages= 647-50 | pmid=18201229 | doi=10.1111/j.1600-0560.2007.00872.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18201229  }} </ref>
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
***Nestin
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
***Tenascin
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
***CD163
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
***Factor XIIIa
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
***CD10
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
**Negative staining for:
|-
***Factor XIIIa (usually)
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
***Keratin
| style="background:#F5F5F5;" align="center" + | +
***EMA
| style="background:#F5F5F5;" align="center" + | +
***S100
| style="background:#F5F5F5;" align="center" + | +
***HMB45
| style="background:#F5F5F5;" align="center" + | +
***Desmin
|-
***CD117<ref name="pmid17944726">{{cite journal| author=Labonte S, Hanna W, Bandarchi-Chamkhaleh B| title=A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma. | journal=J Cutan Pathol | year= 2007 | volume= 34 | issue= 11 | pages= 857-60 | pmid=17944726 | doi=10.1111/j.1600-0560.2007.00731.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17944726  }} </ref>
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|-
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
|-
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|}<br />
 
 
 
 
 
==Reference==
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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