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{{CMG}}; {{AE}} {{S.M.}}
{{CMG}}; {{AE}} {{S.M.}}


{| class="wikitable"
 
|+Different variants of dermatofibrosarcoma protuberans
 
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Variant subtype}}
<ref name="pmid27261907">{{cite journal| author=Mao Y, Yang D, He J, Krasna MJ| title=Epidemiology of Lung Cancer. | journal=Surg Oncol Clin N Am | year= 2016 | volume= 25 | issue= 3 | pages= 439-45 | pmid=27261907 | doi=10.1016/j.soc.2016.02.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27261907  }} </ref>
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Details}}
 
[[File:Atypical Bcell gif.gif|thumb|200px|none|High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.[https://openi.nlm.nih.gov/detailedresult.php?img=PMC2944189_1752-1947-4-300-2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=17 Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.]]]
 
 
{|
|+'''Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders'''
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Asymptomatic WM
! style="background:#4479BA; color: #FFFFFF;" align="center" + |IgM-Related Disorders
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''[[Pigmented lesions|Pigmented]] dermatofibrosarcoma protuberans (Bednar [[tumor]])'''
! align="center" style="background:#DCDCDC;" + |IgM monoclonal protein
|
| style="background:#F5F5F5;" align="center" + | +
* Contains dark-[[Color|colored]], [[Pigmented lesions|pigmented]] [[Cells (biology)|cells]] known as [[melanin]]-containing [[dendritic cells]]
| style="background:#F5F5F5;" align="center" + | +
*[[Red-Al|Red]] or [[brown]] in [[color]]
| style="background:#F5F5F5;" align="center" + | +
*Comprises of 1%-5% of all DFSP [[Case-based reasoning|cases]]
| style="background:#F5F5F5;" align="center" + | +
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''Myxoid dermatofibrosarcoma protuberans [[tumor]]'''
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
|
| style="background:#F5F5F5;" align="center" + | +
* Contains an [[abnormal]] type of [[connective tissue]] known as myxoid [[stroma]]
| style="background:#F5F5F5;" align="center" + | +
*Uncommon and difficult to [[diagnose]]
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + | -
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''[[Juvenile (organism)|Juvenile]] dermatofibrosarcoma protuberans ([[Giant cell fibroblastoma]])'''
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
|
| style="background:#F5F5F5;" align="center" + | +
* Called as [[Juvenile (organism)|juvenile]] because it typically [[Affect|affects]] [[children]] and [[Adolescent|adolescents]]
| style="background:#F5F5F5;" align="center" + | -
* Contains [[giant cells]] in the [[tumor]]
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + | -
|-
|-
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Fibrosarcoma|Fibrosarcomatous]] (FS) Dermatofibrosarcoma protuberans
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
|
| style="background:#F5F5F5;" align="center" + | +
*[[Appearance|Appears]] as regions [[Lookahead|looking]] familiar to [[fibrosarcoma]] in different types of DFSP
| style="background:#F5F5F5;" align="center" + | -
*More aggressive type of [[soft tissue sarcoma]]
| style="background:#F5F5F5;" align="center" + | -
*More likely to [[metastasize]] than other types of DFSP
| style="background:#F5F5F5;" align="center" + | -
|}
|}<br />
 
 
 
 
 
==Reference==
{{Reflist|2}}

Latest revision as of 18:18, 11 December 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. ↑ Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.
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