Extranodal NK-T-cell lymphoma causes: Difference between revisions

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{{CMG}}; {{AE}} {{RG}}
{{CMG}}; {{AE}} {{RG}}
==Overview==
==Overview==
Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.P53 overexpresion has assosiation with poor prognosis.
Extranodal NK/T-cell lymphoma is caused by transition mutation of [[p53]]. [[P53]] overexpresion has assosiation with poor prognosis.
==Causes==
==Causes==
===Life-threatening Causes===
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common.
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
*[Cause] is a life-threatening cause of [disease].
===Common Causes===
===Common Causes===
Common causes of [disease name] may include:
Common causes of extranodal NK-T cell lymphoma may include:<ref name="HarabuchiTakahara2019">{{cite journal|last1=Harabuchi|first1=Yasuaki|last2=Takahara|first2=Miki|last3=Kishibe|first3=Kan|last4=Nagato|first4=Toshihiro|last5=Kumai|first5=Takumi|title=Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress|journal=Frontiers in Pediatrics|volume=7|year=2019|issn=2296-2360|doi=10.3389/fped.2019.00141}}</ref>
*[Cause1]
*[Cause2]
*[Cause3]
 
 
OR
 


*[Disease name] is caused by an infection with [pathogen name].
*presence of Epstein-Barr virus ([[EBV]])-DNA and [[EBV]]-[[oncogenic]] proteins, and [[EBV]]
*[Pathogen name] is caused by [pathogen name].


===Less Common Causes===
*transition mutation of [[p53]].
Less common causes of [disease name] include:
*[[P53]] overexertion association with poor prognosis.
*[Cause1]
*[Cause2]
*[Cause3]


=== Genetic causes: ===
=== Genetic causes: ===
* Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.<ref name="AozasaTakakuwa2008">{{cite journal|last1=Aozasa|first1=Katsuyuki|last2=Takakuwa|first2=Tetsuya|last3=Hongyo|first3=Tadashi|last4=Yang|first4=Woo-Ick|title=Nasal NK/T-cell lymphoma: epidemiology and pathogenesis|journal=International Journal of Hematology|volume=87|issue=2|year=2008|pages=110–117|issn=0925-5710|doi=10.1007/s12185-008-0021-7}}</ref>
* Extranodal NK/T-cell lymphoma is caused by transition [[mutation]] of [[p53]].<ref name="AozasaTakakuwa2008">{{cite journal|last1=Aozasa|first1=Katsuyuki|last2=Takakuwa|first2=Tetsuya|last3=Hongyo|first3=Tadashi|last4=Yang|first4=Woo-Ick|title=Nasal NK/T-cell lymphoma: epidemiology and pathogenesis|journal=International Journal of Hematology|volume=87|issue=2|year=2008|pages=110–117|issn=0925-5710|doi=10.1007/s12185-008-0021-7}}</ref>
* Genetic instability of micro satellites was not found in cases with the disease.<ref name="pmid8069852">{{cite journal| author=Greenblatt MS, Bennett WP, Hollstein M, Harris CC| title=Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. | journal=Cancer Res | year= 1994 | volume= 54 | issue= 18 | pages= 4855-78 | pmid=8069852 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8069852  }}</ref>
* Genetic instability of micro satellites was not found in cases with the disease.<ref name="pmid8069852">{{cite journal| author=Greenblatt MS, Bennett WP, Hollstein M, Harris CC| title=Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. | journal=Cancer Res | year= 1994 | volume= 54 | issue= 18 | pages= 4855-78 | pmid=8069852 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8069852  }}</ref>
* P53 overexpresion has assosiation with poor prognosis.
*[[P53]] overexertion has association with poor [[prognosis]].


===Causes by Organ System===
===Causes by Organ System===
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| EBV infection
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| P53 mutation
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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List the causes of the disease in alphabetical order:
List the causes of the disease in alphabetical order:
<div style="-moz-column-count:3; column-count:3;">
<div style="-moz-column-count:3; column-count:3;">
* Cause 1
*[[EBV]] infection
* Cause 2
*[[P53]] gene mutation
* Cause 3
* Cause 4
* Cause 5
* Cause 6
* Cause 7
* Cause 8
* Cause 9
* Cause 10
</div>
</div>


Latest revision as of 13:21, 28 October 2019

Extranodal NK-T-cell lymphoma Microchapters

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Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

Extranodal NK/T-cell lymphoma is caused by transition mutation of p53. P53 overexpresion has assosiation with poor prognosis.

Causes

Common Causes

Common causes of extranodal NK-T cell lymphoma may include:[1]

  • transition mutation of p53.
  • P53 overexertion association with poor prognosis.

Genetic causes:

  • Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.[2]
  • Genetic instability of micro satellites was not found in cases with the disease.[3]
  • P53 overexertion has association with poor prognosis.

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease EBV infection
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic P53 mutation
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes


Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

  • EBV infection
  • P53 gene mutation

References

  1. ↑ Harabuchi, Yasuaki; Takahara, Miki; Kishibe, Kan; Nagato, Toshihiro; Kumai, Takumi (2019). "Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00141. ISSN 2296-2360.
  2. ↑ Aozasa, Katsuyuki; Takakuwa, Tetsuya; Hongyo, Tadashi; Yang, Woo-Ick (2008). "Nasal NK/T-cell lymphoma: epidemiology and pathogenesis". International Journal of Hematology. 87 (2): 110–117. doi:10.1007/s12185-008-0021-7. ISSN 0925-5710.
  3. ↑ Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994). "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis". Cancer Res. 54 (18): 4855–78. PMID 8069852.


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