Amyloidosis classification: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(5 intermediate revisions by one other user not shown)
Line 2: Line 2:
{{Amyloidosis}}
{{Amyloidosis}}


{{CMG}}{{AE}}{{SHH}}
{{CMG}}{{AE}}{{HK}}{{SHH}}


== Overview ==
== Overview ==
Line 12: Line 12:
{| class="wikitable"
{| class="wikitable"
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Type
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Type
!Abbreviation
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Abbreviation
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Amyloidogenic Protein/Fibril
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Amyloidogenic Protein/Fibril
!Acquired/Inherited
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Acquired/Inherited
!Most Common Organ Involvement
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Most Common Organ Involvement
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated Conditions
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated Conditions
|-
|-
Line 40: Line 40:
** Familial periodic fever syndromes
** Familial periodic fever syndromes
|-
|-
| style="background:#DCDCDC;" |'''Senile systemic amyloidosis'''
| style="background:#DCDCDC;" |'''Senile systemic or wild-type amyloidosis'''
|ATTRwt
|ATTRwt/ATTRvar
|
|
*[[Transthyretin|Wild-type transthyretin (TTR)]]
*[[Transthyretin|Wild-type transthyretin (TTRwt)]]
* Abnormal TTR gene
* Abnormal TTR gene (TTRvar)
|[[Acquired disorder|Acquired]] or [[Hereditary]]
|[[Acquired disorder|Acquired]] (ATTRwt) or [[Hereditary]] (ATTRvar)
|[[Heart]] and [[nerves]] (more common in hereditary type)
|[[Heart]] and [[nerves]] (more common in hereditary type)
|
|
* [[Senile]] [[restrictive cardiomyopathy]]/[[Transthyretin]]-related amyloidosis wild-type
* [[Senile]] [[restrictive cardiomyopathy]]/[[Transthyretin]]-related amyloidosis wild-type
*ATTRwt common in males and exhibits involvement of [[ligaments]] and tenosynovium
*ATTRvar may involve [[eyes]] and [[leptomeninges]]
|-
|-
| style="background:#DCDCDC;" |'''β2-microglobulin-related amyloidosis'''
| style="background:#DCDCDC;" |'''β2-microglobulin related amyloidosis'''
|AH  
|AH  
|
|
Line 59: Line 61:
* Long-term [[hemodialysis]]
* Long-term [[hemodialysis]]
|-
|-
|'''Leucocyte cell–derived chemotaxin 2 related amyloidosis'''
| style="background:#DCDCDC;" |'''Leucocyte cell–derived chemotaxin 2 related amyloidosis'''
|ALect2
|ALect2
|
|
Line 80: Line 82:
* Familial [[polyneuropathy]]/[[cardiomyopathy]]/[[nephropathy]]
* Familial [[polyneuropathy]]/[[cardiomyopathy]]/[[nephropathy]]
|-
|-
|'''Abnormal Apolipoprotein A-I, AII, and AIV related amyloidosis'''
| style="background:#DCDCDC;" |'''Abnormal Apolipoprotein A-I, AII, and AIV related amyloidosis'''
|AApoA-I
|AApoA-I
|
|
Line 89: Line 91:
*[[Testicular]] involvement (possible relation to [[steroidogenic]] tissues)
*[[Testicular]] involvement (possible relation to [[steroidogenic]] tissues)
|-
|-
|'''Lysozyme amyloid related amyloidosis'''
| style="background:#DCDCDC;" |'''Lysozyme amyloid related amyloidosis'''
|ALys
|ALys
|
|
Line 98: Line 100:
*[[Gastrointestinal tract|Gastrointestinal]] involvement
*[[Gastrointestinal tract|Gastrointestinal]] involvement
|-
|-
|'''Gelsolin amyloid related amyloidosis'''
| style="background:#DCDCDC;" |'''Gelsolin related amyloidosis'''
|AGel
|AGel
|
|
Line 107: Line 109:
*[[Cranial nerves|Cranial]] neuropathy
*[[Cranial nerves|Cranial]] neuropathy
|}
|}
===Classification Based on Organ Involvement:<ref name="pmid26719234">{{cite journal |vauthors=Wechalekar AD, Gillmore JD, Hawkins PN |title=Systemic amyloidosis |journal=Lancet |volume=387 |issue=10038 |pages=2641–2654 |date=June 2016 |pmid=26719234 |doi=10.1016/S0140-6736(15)01274-X |url=}}</ref><ref name="pmid27634125">{{cite journal |vauthors=Falk RH, Alexander KM, Liao R, Dorbala S |title=AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy |journal=J. Am. Coll. Cardiol. |volume=68 |issue=12 |pages=1323–41 |date=September 2016 |pmid=27634125 |doi=10.1016/j.jacc.2016.06.053 |url=}}</ref>===
===Classification Based on Organ Involvement:<ref name="pmid26719234">{{cite journal |vauthors=Wechalekar AD, Gillmore JD, Hawkins PN |title=Systemic amyloidosis |journal=Lancet |volume=387 |issue=10038 |pages=2641–2654 |date=June 2016 |pmid=26719234 |doi=10.1016/S0140-6736(15)01274-X |url=}}</ref><ref name="pmid27634125">{{cite journal |vauthors=Falk RH, Alexander KM, Liao R, Dorbala S |title=AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy |journal=J. Am. Coll. Cardiol. |volume=68 |issue=12 |pages=1323–41 |date=September 2016 |pmid=27634125 |doi=10.1016/j.jacc.2016.06.053 |url=}}</ref>===
{| class="wikitable"
{| class="wikitable"
Line 180: Line 183:
{{WS}}
{{WS}}


{{Amyloidosis}}
ocrinology]]
{{CMG}}; {{AE}} {{SHH}}
 
== Overview ==
 
==Classification==
 
Amyloidosis may be classified based on [[precursor]] of amyloidogenic [[protein]] into different subtypes, include:<ref name="pmid25378951">{{cite journal |vauthors=Real de Asúa D, Costa R, Galván JM, Filigheddu MT, Trujillo D, Cadiñanos J |title=Systemic AA amyloidosis: epidemiology, diagnosis, and management |journal=Clin Epidemiol |volume=6 |issue= |pages=369–77 |date=2014 |pmid=25378951 |pmc=4218891 |doi=10.2147/CLEP.S39981 |url=}}</ref><ref name="pmid24998818">{{cite journal |vauthors=Misumi Y, Ando Y |title=[Classification of amyloidosis] |language=Japanese |journal=Brain Nerve |volume=66 |issue=7 |pages=731–7 |date=July 2014 |pmid=24998818 |doi= |url=}}</ref>
{| class="wikitable"
!Type
!Amyloidogenic protein/ fibril
!Clinical syndrome
|-
|AL
|Light chains of immunoglobulines (most common type)
|Monoclonal gammopathy
|-
|AA
|Serum amyloid A protein
|Chronic inflammatory diseases
|-
|AF
|Mutant transthyretin, A1-apolipoprotein, gelsolin, fibrinogen, etc.
|Familial polyneuropathy/cardiomyopathy/nephropathy
|-
|ATTRwt
|Wild-type transthyretin
|Senile restrictive cardiomyopathy _ Transthyretin-related amyloidosis wild-type
|-
|AH
|ß2-microglobulin
|Long-term hemodialysis
|}
 
== References ==
{{reflist|2}}
 
[[Category:Disease]]
[[Category:Rheumatology]]
[[Category:Cardiology]]
[[Category:Endocrinology]]


{{WH}}
{{WH}}
{{WS}}
{{WS}}

Latest revision as of 21:52, 10 December 2019

Amyloidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

• Primary amyloidosis
• Secondary amyloidosis
• Familial amyloidosis
• Wild-type (senile) amyloidosis
• Cardiac amyloidosis
• Beta-2 microglobulin related amyloidosis
• Gelsolin related amyloidosis
• Lysozyme amyloid related amyloidosis
• Leucocyte cell-derived chemotaxin 2 related amyloidosis
• Fibrinogen A alpha-chain associated amyloidosis

Pathophysiology

Causes

Differentiating Amyloidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Amyloidosis classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Amyloidosis classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Amyloidosis classification

CDC on Amyloidosis classification

Amyloidosis classification in the news

Blogs on Amyloidosis classification

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Amyloidosis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]Shaghayegh Habibi, M.D.[3]

Overview

Amyloidosis may be classified on the basis of type of amyloidogenic protein and associated clinical syndromes into primary (AL) amyloidosis, secondary (AA) amyloidosis, familial (AF) amyloidosis, transthyretin (ATTRwt) amyloidosis and dialysis-associated (AH) amyloidosis. It can also be classified based on extent of organ system involvement.

Classification

Classification Based on Precursor of Amyloidogenic Protein: [1][2]

Type Abbreviation Amyloidogenic Protein/Fibril Acquired/Inherited Most Common Organ Involvement Associated Conditions
Primary amyloidosis AL Acquired Heart and kidneys
Secondary amyloidosis AA Acquired Kidneys (early), heart and liver (late)
Senile systemic or wild-type amyloidosis ATTRwt/ATTRvar Acquired (ATTRwt) or Hereditary (ATTRvar) Heart and nerves (more common in hereditary type)
β2-microglobulin related amyloidosis AH Acquired or Hereditary Nerves (peripheral and autonomic)
Leucocyte cell–derived chemotaxin 2 related amyloidosis ALect2
  • Leucocyte cell–derived chemotaxin 2
 Acquired Kidneys and liver
Fibrinogen A alpha-chain associated amyloidosis AF Hereditary Kidneys and liver
Abnormal Apolipoprotein A-I, AII, and AIV related amyloidosis AApoA-I Hereditary Kidneys, liver and nerves (peripheral)
Lysozyme amyloid related amyloidosis ALys Hereditary Liver and kidneys
Gelsolin related amyloidosis AGel Hereditary Kidneys and nerves (peripheral and cranial)

Classification Based on Organ Involvement:[3][4]

Classification Subtypes Causes Clinical Features
Systemic amyloidosis Primary amyloidosis (AL)
Secondary amyloidosis (AA)
Hereditary amyloidosis
Organ-specific amyloidosis Renal amyloidosis
Cardiac amyloidosis
Hepatic amyloidosis
Amyloid neuropathy
Gastrointestinal amyloidosis

Refrences

  1. ↑ Khoor A, Colby TV (February 2017). "Amyloidosis of the Lung". Arch. Pathol. Lab. Med. 141 (2): 247–254. doi:10.5858/arpa.2016-0102-RA. PMID 28134587.
  2. ↑ Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva M, Sekijima Y, Sipe JD, Westermark P (December 2018). "Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee". Amyloid. 25 (4): 215–219. doi:10.1080/13506129.2018.1549825. PMID 30614283. Vancouver style error: initials (help)
  3. ↑ Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). "Systemic amyloidosis". Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.
  4. ↑ Falk RH, Alexander KM, Liao R, Dorbala S (September 2016). "AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy". J. Am. Coll. Cardiol. 68 (12): 1323–41. doi:10.1016/j.jacc.2016.06.053. PMID 27634125.

Template:WH Template:WS

ocrinology]]

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Amyloidosis_classification&oldid=1591322"