Teratoma natural history: Difference between revisions

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Latest revision as of 20:35, 25 November 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]

Overview

The prognosis of teratoma depends on the type of tumor and malignant transformation. Mature teratoma is begnin and has an excellent prognosis compared to immature teratoma which has a favorable prognosis.The 6 year survival rate of patients with mature teratoma is approximately 96%. The overall 5 years survival rate of patient with immature teratoma is 90% and 75% for stage II-IV.Common complications are malignant transformation, rupture, torsion, and hemolytic anemia.

Natural History, Complications, and Prognosis

Natural History

The symptoms of teratoma depends on the locations of the tumors.

Complications

Common complications of teratoma specially ovarian teratoma include:^[1]^[2]^[3]
- Torsion
- Rupture
- Malignant transformation
- Infections
- Autoimmune hemolytic anemia

Prognosis

Mature teratoma has an excellent prognosis.^[4]
The 6 year survival rate of patients with mature teratoma is approximately 96%.^[5]
Immature teratoma has favorable prognosis for stage I and poor for advance stages.^[6]
Immature teratoma has 90%-95% of 5 years of survival rate for stage I and 75 % for stage II-IV.^[6]

References

↑ Park SB, Kim JK, Kim KR, Cho KS (2008). "Imaging findings of complications and unusual manifestations of ovarian teratomas". Radiographics. 28 (4): 969–83. doi:10.1148/rg.284075069. PMID 18635624.
↑ Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994) Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol 84 (1):22-8. PMID: 8008317
↑ Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A (1988). "Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary". Singapore Med J. 29 (1): 30–4. PMID 2841767.
↑ Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL; et al. (2015). "Mature and immature teratoma: A report from the second Italian pediatric study". Pediatr Blood Cancer. 62 (7): 1202–8. doi:10.1002/pbc.25423. PMID 25631333.
↑ Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP; et al. (1998). "Teratomas in infancy and childhood". Med Pediatr Oncol. 31 (1): 8–15. doi:10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID 9607423.
↑ ^6.0 ^6.1 Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience. J Clin Oncol 26 (21):3590-7. DOI:10.1200/JCO.2008.16.0622 PMID: 18541896

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[pmid18635624-1] Park SB, Kim JK, Kim KR, Cho KS (2008). "Imaging findings of complications and unusual manifestations of ovarian teratomas". Radiographics. 28 (4): 969–83. doi:10.1148/rg.284075069. PMID 18635624.

[pmid8008317-2] Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994) Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol 84 (1):22-8. PMID: 8008317

[pmid2841767-3] Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A (1988). "Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary". Singapore Med J. 29 (1): 30–4. PMID 2841767.

[pmid25631333-4] Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL; et al. (2015). "Mature and immature teratoma: A report from the second Italian pediatric study". Pediatr Blood Cancer. 62 (7): 1202–8. doi:10.1002/pbc.25423. PMID 25631333.

[pmid9607423-5] Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP; et al. (1998). "Teratomas in infancy and childhood". Med Pediatr Oncol. 31 (1): 8–15. doi:10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID 9607423.

[pmid18541896-6] 6.0 ^6.1 Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience. J Clin Oncol 26 (21):3590-7. DOI:10.1200/JCO.2008.16.0622 PMID: 18541896

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@@ Line 5: / Line 5: @@
 ==Overview==
-The prognosis of teratoma depends on the type of tumor and malignant transformation. Mature teratoma is begnin and has an excellent prognosis compared to immature teratoma which has a favorable prognosis.The 6 year survival rate of patients with mature teratoma is approximately 96%. The overall 5 years survival rate of patient with immature teratoma is 90% and 75% for stage III and IV.
+The prognosis of teratoma depends on the type of tumor and malignant transformation. Mature teratoma is begnin and has an excellent prognosis compared to immature teratoma which has a favorable prognosis.The 6 year survival rate of patients with mature teratoma is approximately 96%. The overall 5 years survival rate of patient with immature teratoma is 90% and 75% for stage II-IV.Common complications are malignant transformation, rupture, torsion, and hemolytic anemia.
 ==Natural History, Complications, and Prognosis==
 ===Natural History===
-*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
+*The symptoms of teratoma depends on the locations of the tumors.
-*The symptoms of (disease name) typically develop ___ years after exposure to ___.
-*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
 ===Complications===
@@ Line 22: / Line 21: @@
 ===Prognosis===
-*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
+*Mature teratoma has an excellent prognosis.<ref name="pmid25631333">{{cite journal| author=Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL et al.| title=Mature and immature teratoma: A report from the second Italian pediatric study. | journal=Pediatr Blood Cancer | year= 2015 | volume= 62 | issue= 7 | pages= 1202-8 | pmid=25631333 | doi=10.1002/pbc.25423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25631333  }} </ref>
-*Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
+*The 6 year survival rate of patients with mature teratoma is approximately 96%.<ref name="pmid9607423">{{cite journal| author=Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP et al.| title=Teratomas in infancy and childhood. | journal=Med Pediatr Oncol | year= 1998 | volume= 31 | issue= 1 | pages= 8-15 | pmid=9607423 | doi=10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9607423  }} </ref>
-*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
+*Immature teratoma has favorable prognosis for stage I and poor for advance stages.<ref name="pmid18541896">Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18541896 Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience.] ''J Clin Oncol'' 26 (21):3590-7. [http://dx.doi.org/10.1200/JCO.2008.16.0622 DOI:10.1200/JCO.2008.16.0622] PMID: [https://pubmed.gov/18541896 18541896]</ref>
-*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
+*Immature teratoma has 90%-95% of 5 years of survival rate for stage I and 75 % for stage II-IV.<ref name="pmid18541896">Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18541896 Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience.] ''J Clin Oncol'' 26 (21):3590-7. [http://dx.doi.org/10.1200/JCO.2008.16.0622 DOI:10.1200/JCO.2008.16.0622] PMID: [https://pubmed.gov/18541896 18541896]</ref>
-*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
 ==References==