Eisenmenger’s syndrome laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
The laboratory findings of patients with Eisenmenger's syndrome include [[erythrocytosis]], [[Iron deficiency anemia|iron deficiency]], increased [[bleeding time]], increased blood [[uric acid]] and [[conjugated bilirubin]] concentrations, as well as mixed [[Respiratory acidosis|respiratory]] and [[metabolic acidosis]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
* [[Erythrocytosis]] | The following may be observed on the laboratory work-up of patients with [[Eisenmenger's syndrome]]<ref name="pmid9556469">{{cite journal| author=Vongpatanasin W, Brickner ME, Hillis LD, Lange RA| title=The Eisenmenger syndrome in adults. | journal=Ann Intern Med | year= 1998 | volume= 128 | issue= 9 | pages= 745-55 | pmid=9556469 | doi=10.7326/0003-4819-128-9-199805010-00008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9556469 }}</ref><ref name="pmid30121863">{{cite journal| author=An HS, Kim GB, Song MK, Bang JS, Lee SY, Bae EJ et al.| title=Eisenmenger Syndrome in Adults: Treatment Pattern and Prognostic Factors in the Advanced Pulmonary Vasodilator Era. | journal=Pediatr Cardiol | year= 2019 | volume= 40 | issue= 1 | pages= 23-28 | pmid=30121863 | doi=10.1007/s00246-018-1956-y | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30121863 }}</ref><ref name="pmid22397941">{{cite journal| author=Diller GP, Alonso-Gonzalez R, Kempny A, Dimopoulos K, Inuzuka R, Giannakoulas G et al.| title=B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy. | journal=Heart | year= 2012 | volume= 98 | issue= 9 | pages= 736-42 | pmid=22397941 | doi=10.1136/heartjnl-2011-301522 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22397941 }}</ref>: | ||
* Iron deficiency | |||
* Increased [[bleeding time]] | *[[Erythrocytosis]] (increased Hb, [[Hematocrit|Hct]], and red blood cell mass) | ||
* Increased uric acid | *[[Iron deficiency anemia|Iron deficiency]] (due to [[phlebotomy]]: reduced serum [[ferritin]] and increased [[iron]] binding capacity) | ||
* ABG: Mixed respiratory and metabolic acidosis. | * Increased [[bleeding time]] (due to [[platelet]] dysfunction) | ||
* Increased blood [[uric acid]] concentrations | |||
*Increased [[conjugated bilirubin]] levels | |||
* ABG: Mixed [[Respiratory acidosis|respiratory]] and [[metabolic acidosis]]. | |||
*[[Brain natriuretic peptide]]: Elevated levels indicate poor [[prognosis]]. | |||
==References== | ==References== | ||
Latest revision as of 04:50, 20 January 2020
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Eisenmenger’s syndrome Microchapters |
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Diagnosis |
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Eisenmenger’s syndrome ACC/AHA Guidelines for Evaluation of Patients |
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Treatment |
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Eisenmenger’s syndrome laboratory tests On the Web |
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American Roentgen Ray Society Images of Eisenmenger’s syndrome laboratory tests |
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Risk calculators and risk factors for Eisenmenger’s syndrome laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]
Overview
The laboratory findings of patients with Eisenmenger's syndrome include erythrocytosis, iron deficiency, increased bleeding time, increased blood uric acid and conjugated bilirubin concentrations, as well as mixed respiratory and metabolic acidosis.
Laboratory Findings
The following may be observed on the laboratory work-up of patients with Eisenmenger's syndrome[1][2][3]:
- Erythrocytosis (increased Hb, Hct, and red blood cell mass)
- Iron deficiency (due to phlebotomy: reduced serum ferritin and increased iron binding capacity)
- Increased bleeding time (due to platelet dysfunction)
- Increased blood uric acid concentrations
- Increased conjugated bilirubin levels
- ABG: Mixed respiratory and metabolic acidosis.
- Brain natriuretic peptide: Elevated levels indicate poor prognosis.
References
- ↑ Vongpatanasin W, Brickner ME, Hillis LD, Lange RA (1998). "The Eisenmenger syndrome in adults". Ann Intern Med. 128 (9): 745–55. doi:10.7326/0003-4819-128-9-199805010-00008. PMID 9556469.
- ↑ An HS, Kim GB, Song MK, Bang JS, Lee SY, Bae EJ; et al. (2019). "Eisenmenger Syndrome in Adults: Treatment Pattern and Prognostic Factors in the Advanced Pulmonary Vasodilator Era". Pediatr Cardiol. 40 (1): 23–28. doi:10.1007/s00246-018-1956-y. PMID 30121863.
- ↑ Diller GP, Alonso-Gonzalez R, Kempny A, Dimopoulos K, Inuzuka R, Giannakoulas G; et al. (2012). "B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy". Heart. 98 (9): 736–42. doi:10.1136/heartjnl-2011-301522. PMID 22397941.