Tetralogy of fallot causes: Difference between revisions
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{{Tetralogy of fallot}} | {{Tetralogy of fallot}} | ||
{{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh| Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | {{CMG}}; '''Associate Editors-In-Chief:''' {{Fs}}, [[Priyamvada Singh| Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | ||
==Overview== | ==Overview== | ||
Common causes of tetralogy of Fallot may include: [[Alcoholism]] in the mother, [[diabetes]], [[pregnancy]] after the age of 40, [[rubella]] or other [[viral]] illnesses during [[pregnancy]], [[phenylketonuria]] ([[PKU]]) in the mother, [[fetal hydantoin syndrome]], and [[Fetus|fetal]] [[carbamazepine]] [[syndrome]]. | |||
==Causes== | ==Causes== | ||
=== Common Causes === | === Common Causes === | ||
Common causes of tetralogy of Fallot may include: | |||
*[[Alcoholism]] in the mother | *[[Alcoholism]] in the mother | ||
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=== Less Common Causes === | === Less Common Causes === | ||
Less common causes of tetralogy of Fallot may include: | |||
* [[Clomifene]] | * [[Clomifene]] | ||
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=== Genetic Causes === | === Genetic Causes === | ||
Genetic causes of tetralogy of Fallot may include: | |||
* There is a high [[incidence]] of [[chromosomal disorder]]s in children with tetralogy of Fallot.<ref>Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.</ref><ref>Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.</ref> | * There is a high [[incidence]] of [[chromosomal disorder]]s in children with tetralogy of Fallot.<ref>Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.</ref><ref>Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.</ref> | ||
Latest revision as of 01:43, 23 February 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Fahimeh Shojaei, M.D., Priyamvada Singh, M.B.B.S. [2], Keri Shafer, M.D. [3]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]
Overview
Common causes of tetralogy of Fallot may include: Alcoholism in the mother, diabetes, pregnancy after the age of 40, rubella or other viral illnesses during pregnancy, phenylketonuria (PKU) in the mother, fetal hydantoin syndrome, and fetal carbamazepine syndrome.
Causes
Common Causes
Common causes of tetralogy of Fallot may include:
- Alcoholism in the mother
- Diabetes
- Pregnancy after the age of 40
- Rubella or other viral illnesses during pregnancy
- Phenylketonuria (PKU) in the mother
- Fetal hydantoin syndrome
- Fetal carbamazepine syndrome
Less Common Causes
Less common causes of tetralogy of Fallot may include:
- Clomifene
- Poor nutrition during pregnancy
Genetic Causes
Genetic causes of tetralogy of Fallot may include:
- There is a high incidence of chromosomal disorders in children with tetralogy of Fallot.[1][2]
- Tetralogy of Fallot is associated with:
- Down syndrome
- DiGeorge syndrome (a 22q11.2 deletion, a condition associated with heart defects, hypocalcemia, and immune deficiency) A gene polymorphism at the methylenetetrahydrofolate reductase (MTHFR) region has been associated with tetralogy of Fallot.
References
- ↑ Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.
- ↑ Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.