Kawasaki disease causes: Difference between revisions
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{{CMG}}; {{AE}} {{SH}} | {{CMG}}; {{AE}} {{SH}} | ||
==Overview== | ==Overview== | ||
The exact cause of Kawasaki disease has not been identified. The current [[etiology|etiological]] theories center primarily on [[immune system|immunological]] causes for the disease. Much research has been carried out to discover a definitive [[toxin]] or [[antigen]]ic substance, possibly a [[superantigen]], | The exact cause of Kawasaki disease has not been identified. The current [[etiology|etiological]] theories center primarily on [[immune system|immunological]] causes for the disease. Much research has been carried out to discover a definitive [[toxin]] or [[antigen]]ic substance, possibly a [[superantigen]], to be established as the specific cause of the disease. There are several hypotheses for the cause of Kawasaki disease - infectious agents which are thought to induce Kawasaki disease include [[parvovirus]] B19, [[meningococcal]] septicemia, [[adenoviridae|adenovirus]], bacterial toxin–mediated, [[Superantigen|superantigens]], [[cytomegalovirus]], [[Epstein Barr virus|Epstein-Barr virus]], human lymphotropic virus, [[klebsiella pneumoniae]], [[mycoplasma pneumoniae]], [[mite]]-associated bacteria, [[measles]], [[propionibacterium acnes]], [[Human parainfluenza viruses|parainfluenza type 3 virus]], [[rotavirus]] infection, [[Rickettsiae|rickettsia]] species, and [[Tick-borne disease|tick-borne diseases]]. | ||
==Causes== | ==Causes== | ||
*The exact cause of Kawasaki disease has not been identified. | *The exact cause of Kawasaki disease has not been identified. | ||
*The current [[etiology|etiological]] theories center primarily on [[immune system|immunological]] causes for the disease. | *The current [[etiology|etiological]] theories center primarily on [[immune system|immunological]] causes for the disease. | ||
*Studies have failed to discover a definitive [[toxin]] or [[antigen]]ic substance | *Studies have failed to discover a definitive [[toxin]] or [[antigen]]ic substance to be the causative agent. | ||
*An unknown virus may play a role as an inciting factor as well. | *An unknown [[virus]] may play a role as an inciting factor as well. | ||
*There are several | *There are several hypotheses regarding the causality of Kawasaki disease. | ||
*Infectious agents which are thought to induce Kawasaki disease are:<ref name="pmid18448971">{{cite journal |vauthors=Pinna GS, Kafetzis DA, Tselkas OI, Skevaki CL |title=Kawasaki disease: an overview |journal=Curr. Opin. Infect. Dis. |volume=21 |issue=3 |pages=263–70 |date=June 2008 |pmid=18448971 |doi=10.1097/QCO.0b013e3282fbf9cd |url=}}</ref><ref name="pmid9832593">{{cite journal |vauthors=Yanagawa H, Nakamura Y, Yashiro M, Ojima T, Tanihara S, Oki I, Zhang T |title=Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan |journal=Pediatrics |volume=102 |issue=6 |pages=E65 |date=December 1998 |pmid=9832593 |doi= |url=}}</ref><ref name="Sundel2015">{{cite journal|last1=Sundel|first1=Robert P.|title=Kawasaki Disease|journal=Rheumatic Disease Clinics of North America|volume=41|issue=1|year=2015|pages=63–73|issn=0889857X|doi=10.1016/j.rdc.2014.09.010}}</ref> | |||
**[[Parvovirus]] B19 | **[[Parvovirus]] B19 | ||
**[[Meningococcal]] septicemia | **[[Meningococcal]] septicemia | ||
| Line 18: | Line 19: | ||
**[[Cytomegalovirus]] | **[[Cytomegalovirus]] | ||
**[[Epstein Barr virus|Epstein-Barr virus]] | **[[Epstein Barr virus|Epstein-Barr virus]] | ||
**Human lymphotropic virus | **Human lymphotropic virus | ||
**[[Klebsiella pneumoniae]] | **[[Klebsiella pneumoniae]] | ||
**[[Mycoplasma pneumoniae]] | **[[Mycoplasma pneumoniae]] | ||
| Line 25: | Line 26: | ||
**[[Propionibacterium acnes]] | **[[Propionibacterium acnes]] | ||
**[[Human parainfluenza viruses|Parainfluenza type 3 virus]] | **[[Human parainfluenza viruses|Parainfluenza type 3 virus]] | ||
**[[Rotavirus]] | **[[Rotavirus]] | ||
**[[Rickettsiae|Rickettsia]] species | **[[Rickettsiae|Rickettsia]] species | ||
**[[Tick-borne disease|Tick-borne diseases]] | **[[Tick-borne disease|Tick-borne diseases]] | ||
Latest revision as of 20:52, 12 February 2020
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Kawasaki disease Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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American Roentgen Ray Society Images of Kawasaki disease causes |
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Risk calculators and risk factors for Kawasaki disease causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]
Overview
The exact cause of Kawasaki disease has not been identified. The current etiological theories center primarily on immunological causes for the disease. Much research has been carried out to discover a definitive toxin or antigenic substance, possibly a superantigen, to be established as the specific cause of the disease. There are several hypotheses for the cause of Kawasaki disease - infectious agents which are thought to induce Kawasaki disease include parvovirus B19, meningococcal septicemia, adenovirus, bacterial toxin–mediated, superantigens, cytomegalovirus, Epstein-Barr virus, human lymphotropic virus, klebsiella pneumoniae, mycoplasma pneumoniae, mite-associated bacteria, measles, propionibacterium acnes, parainfluenza type 3 virus, rotavirus infection, rickettsia species, and tick-borne diseases.
Causes
- The exact cause of Kawasaki disease has not been identified.
- The current etiological theories center primarily on immunological causes for the disease.
- Studies have failed to discover a definitive toxin or antigenic substance to be the causative agent.
- An unknown virus may play a role as an inciting factor as well.
- There are several hypotheses regarding the causality of Kawasaki disease.
- Infectious agents which are thought to induce Kawasaki disease are:[1][2][3]
- Parvovirus B19
- Meningococcal septicemia
- Adenovirus
- Bacterial toxin–mediated superantigens
- Cytomegalovirus
- Epstein-Barr virus
- Human lymphotropic virus
- Klebsiella pneumoniae
- Mycoplasma pneumoniae
- Mite-associated bacteria
- Measles
- Propionibacterium acnes
- Parainfluenza type 3 virus
- Rotavirus
- Rickettsia species
- Tick-borne diseases
References
- ↑ Pinna GS, Kafetzis DA, Tselkas OI, Skevaki CL (June 2008). "Kawasaki disease: an overview". Curr. Opin. Infect. Dis. 21 (3): 263–70. doi:10.1097/QCO.0b013e3282fbf9cd. PMID 18448971.
- ↑ Yanagawa H, Nakamura Y, Yashiro M, Ojima T, Tanihara S, Oki I, Zhang T (December 1998). "Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan". Pediatrics. 102 (6): E65. PMID 9832593.
- ↑ Sundel, Robert P. (2015). "Kawasaki Disease". Rheumatic Disease Clinics of North America. 41 (1): 63–73. doi:10.1016/j.rdc.2014.09.010. ISSN 0889-857X.