Aortic regurgitation causes: Difference between revisions
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{{Aortic insufficiency}} | {{Aortic insufficiency}} | ||
{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}; [[Varun Kumar]], M.B.B.S.; [[Lakshmi Gopalakrishnan]], M.B.B.S.; {{VR}}; {{USAMA}} | {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}; [[Varun Kumar]], M.B.B.S.; [[Lakshmi Gopalakrishnan]], M.B.B.S.; {{VR}}; {{USAMA}} | ||
==Overview== | ==Overview== | ||
Aortic insufficiency can be an acute illness or a chronic illness and the causes differ depending upon the acuity of the disease. In general, aortic insufficiency is due to abnormalities of the aortic valve itself or the aortic root. Aortic regurgitation secondary to dilation of the ascending aorta has overtaken the valvular aortic disease as the most common cause of aortic regurgitation.It can also occur after surgical valve placement. | Aortic insufficiency can be an acute illness or a chronic illness and the causes differ depending upon the acuity of the disease. In general, aortic insufficiency is due to abnormalities of the aortic valve itself or the aortic root. Aortic regurgitation secondary to dilation of the ascending aorta has overtaken the valvular aortic disease as the most common cause of aortic regurgitation.It can also occur after surgical valve placement. | ||
Line 43: | Line 43: | ||
====Causes Based Upon Abnormalities in the Ascending Aorta==== | ====Causes Based Upon Abnormalities in the Ascending Aorta==== | ||
*[[Ankylosing spondylitis]] <ref name="pmid10">{{cite journal |vauthors=Schmoldt A, Benthe HF, Haberland G, Raffle A, Gray J, MacDonald HR, Ehrhart IC, Parker PE, Weidner WJ, Dabney JM, Scott JB, Haddy FJ, Gatzy JT |title=Digitoxin metabolism by rat liver microsomes |journal=Biochem. Pharmacol. |volume=24 |issue=17 |pages=1639–41 |date=September 1975 |pmid=10 |pmc=5922622 |doi=10.1136/bmj.1.6001.93-a |url=}}</ref> | *[[Ankylosing spondylitis]] <ref name="pmid10">{{cite journal |vauthors=Schmoldt A, Benthe HF, Haberland G, Raffle A, Gray J, MacDonald HR, Ehrhart IC, Parker PE, Weidner WJ, Dabney JM, Scott JB, Haddy FJ, Gatzy JT |title=Digitoxin metabolism by rat liver microsomes |journal=Biochem. Pharmacol. |volume=24 |issue=17 |pages=1639–41 |date=September 1975 |pmid=10 |pmc=5922622 |doi=10.1136/bmj.1.6001.93-a |url=}}</ref> | ||
*[[Aortic dissection]] | *[[Aortic dissection]] <ref name="pmid7925504">{{cite journal| author=Lindroos M, Kupari M, Valvanne J, Strandberg T, Heikkilä J, Tilvis R| title=Factors associated with calcific aortic valve degeneration in the elderly. | journal=Eur Heart J | year= 1994 | volume= 15 | issue= 7 | pages= 865-70 | pmid=7925504 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7925504 }} </ref> | ||
*[[Arteriosclerosis]] | *[[Arteriosclerosis]] <ref name="pmid11359741">{{cite journal| author=Ortlepp JR, Hoffmann R, Ohme F, Lauscher J, Bleckmann F, Hanrath P| title=The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. | journal=Heart | year= 2001 | volume= 85 | issue= 6 | pages= 635-8 | pmid=11359741 | doi= | pmc=PMC1729782 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11359741 }} </ref> | ||
* [[Bechterew's Disease]] | * [[Bechterew's Disease]] <ref name="pmid10">{{cite journal |vauthors=Schmoldt A, Benthe HF, Haberland G, Raffle A, Gray J, MacDonald HR, Ehrhart IC, Parker PE, Weidner WJ, Dabney JM, Scott JB, Haddy FJ, Gatzy JT |title=Digitoxin metabolism by rat liver microsomes |journal=Biochem. Pharmacol. |volume=24 |issue=17 |pages=1639–41 |date=September 1975 |pmid=10 |pmc=5922622 |doi=10.1136/bmj.1.6001.93-a |url=}}</ref> | ||
*[[Behcet's syndrome]] | *[[Behcet's syndrome]] | ||
*[[Cystic medial necrosis]] of the [[aorta]] | *[[Cystic medial necrosis]] of the [[aorta]] |
Latest revision as of 04:33, 7 July 2020
Aortic Regurgitation Microchapters |
Diagnosis |
---|
Treatment |
Acute Aortic regurgitation |
Chronic Aortic regurgitation |
Special Scenarios |
Case Studies |
Aortic regurgitation causes On the Web |
American Roentgen Ray Society Images of Aortic regurgitation causes |
Risk calculators and risk factors for Aortic regurgitation causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Varun Kumar, M.B.B.S.; Lakshmi Gopalakrishnan, M.B.B.S.; Vendhan Ramanujam M.B.B.S [3]; Usama Talib, BSc, MD [4]
Overview
Aortic insufficiency can be an acute illness or a chronic illness and the causes differ depending upon the acuity of the disease. In general, aortic insufficiency is due to abnormalities of the aortic valve itself or the aortic root. Aortic regurgitation secondary to dilation of the ascending aorta has overtaken the valvular aortic disease as the most common cause of aortic regurgitation.It can also occur after surgical valve placement.
Aortic regurgitation causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Bicuspid aortic valve[3]
- Senile or degenerative calcific aortic valve disease[3]
- Rheumatic heart disease[4]
- After Valvular Surgery[5]
Causes by Location of the Abnormality
The cause of Aortic Regurgitation by location can be classified as following:[1]
Causes Based Upon Abnormalities in the Aortic Valve
- Bicuspid aortic valve[3]
- Collagen vascular disease
- Senile or degenerative calcific aortic valve disease
- Endocarditis
- Myxomatous aortic valve
- Rheumatic fever[6]
- Rheumatoid arthritis [7]
- Sinus of Valsalva Aneurysm
- Systemic Lupus Erythematosus
- Trauma[8][9]
- Turner's Syndrome
- Ventricular Septal Defect
- Weight loss medications
- Post Aortic Valve Surgery[10]
- Quadricuspid Aortic Valve [11]
Causes Based Upon Abnormalities in the Ascending Aorta
- Ankylosing spondylitis [12]
- Aortic dissection [13]
- Arteriosclerosis [14]
- Bechterew's Disease [12]
- Behcet's syndrome
- Cystic medial necrosis of the aorta
- Ehlers-Danlos Syndrome
- Giant cell arteritis
- Hypertension[15]
- Idiopathic dilation of the ascending aorta
- Marfan syndrome[9]
- Osteogenesis imperfecta
- Polymyalgia Rheumatica
- Pseudoxanthoma Elasticum
- Psoriatic arthritis
- Reiter's syndrome
- Relapsing polychondritis
- Senile aortic ectasia and dilation
- Spondyloarthropathy
- Syphilitic aortitis
- Takayasu arteritis[16]
- Trauma
- Ulcerative colitis
- Whipple's disease
Causes by Organ System
Causes in Alphabetical Order
Causes of Aortic Insufficiency as of Type of Onset
Causes of Acute Aortic Insufficiency
The causes of Acute Aortic Insufficiency include the following:[33][34][35][10]
- Aortic valvuloplasty[10]
- A type A aortic dissection may disrupt the integrity of the valve leaflets causing malcoaptation of the aortic leaflets.[36]
- In bacterial endocarditis the infection can erode the valve and cause a leaflet to become flail, or a vegetation can prevent coaptation of the leaflets.
- Blunt chest trauma can disrupt the supporting apparatus of the aortic valve.
- Myxomatous aortic valve can degenerate, leading to insufficiency.
- Prosthetic valve dysfunction[37]
- Rheumatic fever[6]
- Rupture of a congenitally fenestrated cusp[38]
Causes of Chronic Aortic Insufficiency
The cause of Chronic Aortic Insufficiency include the following:[1][39]
- Ankylosing spondylitis can be associated with inflammation of the aorta (aortitis).[40] The inflammatory process can also involve the septum and cause conduction disease.
- A type A aortic dissection may disrupt the integrity of the valve leaflets causing malcoaptation of the aortic leaflets.
- Bechterew's disease
- Rarely, in 5% of cases with Behcet disease there is an aortitis that involves the ascending aorta and in some cases the coronary arteries are involved.
- Bicuspid aortic valve is the most common congenital abnormality of the heart. It is the most common cause of isolated aortic insufficiency requiring surgical repair. Bicuspid aortic valve is also associated with inflammation of the aorta (an aortopathy) which may lead to dilation of the aorta and/or aortic dissection that can worsen the aortic insufficiency.[41]
- Cystic medial necrosis of the aorta
- Ehlers-Danlos syndrome
- Giant cell arteritis may also be associated with an aortitis as well as coronary artery disease.[42]
- Hypertension
- Marfan Syndrome
- Myxomatous aortic valve
- Polymyalgia rheumatica
- Pseudoxanthoma elasticum
- Reiter's syndrome
- Rheumatic fever remains a cause of AS in the Middle East, Northern Africa and Asia as well as some immigrant populations in the United States. It is less prevalent in the US than it was in the 20th century. AR occurs as a result of fibrosis of the valve that is associated with thickening and retraction of the leaflets of the aortic valve. This retraction results in regurgitation in the center of the valve. At the same time, there may also be fusion of the aortic leaflets which results in concurrent aortic stenosis. It should be noted that rheumatic disease of the mitral valve is usually present in the same patient.
- Rheumatoid arthritis rarely causes symptomatic AR, but it can cause granulomatous nodules on the aortic leaflets which leads to clinical aortic regurgitation.[43]
- Sinus of valsalva aneurysm
- Syphilis
- Systemic lupus erythematosus can cause AR by tow mechanisms. SLE can cause inflammation and fibrosis of the aortic leaflets leading to their damage and retraction.[44] SLE can also be associated with the development of sterile verrucous vegetations on the valves called Libman-Sacks endocarditis.[45][46]
- Takayasu arteritis can involve the aorta in an aortitis, the aortic valve itself, and the coronary arteries.[47]
- Turner's syndrome
- Ventricular septal defect[48]
- Weight loss medications including fenfluramine and dexfenfluramine (a.k.a. Phen-Fen). These drugs have been associated with degeneration of the aortic valve.
- Whipple disease can involve the aortic valve.[49]
References
- ↑ 1.0 1.1 1.2 Enriquez-Sarano M, Tajik AJ (2004). "Clinical practice. Aortic regurgitation". N Engl J Med. 351 (15): 1539–46. doi:10.1056/NEJMcp030912. PMID 15470217.
- ↑ Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA; et al. (2014). "2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (22): e57–185. doi:10.1016/j.jacc.2014.02.536. PMID 24603191.
- ↑ 3.0 3.1 3.2 Nishimura, RA. (2002). "Cardiology patient pages. Aortic valve disease". Circulation. 106 (7): 770–2. PMID 12176943. Unknown parameter
|month=
ignored (help) - ↑ Bekeredjian, R.; Grayburn, PA. (2005). "Valvular heart disease: aortic regurgitation". Circulation. 112 (1): 125–34. doi:10.1161/CIRCULATIONAHA.104.488825. PMID 15998697. Unknown parameter
|month=
ignored (help) - ↑ Ribeiro HB, Orwat S, Hayek SS, Larose É, Babaliaros V, Dahou A; et al. (2016). "Cardiovascular Magnetic Resonance to Evaluate Aortic Regurgitation After Transcatheter Aortic Valve Replacement". J Am Coll Cardiol. 68 (6): 577–85. doi:10.1016/j.jacc.2016.05.059. PMID 27491900.
- ↑ 6.0 6.1 6.2 Spagnuolo, M.; Kloth, H.; Taranta, A.; Doyle, E.; Pasternack, B. (1971). "Natural history of rheumatic aortic regurgitation. Criteria predictive of death, congestive heart failure, and angina in young patients". Circulation. 44 (3): 368–80. PMID 4255488. Unknown parameter
|month=
ignored (help) - ↑ Pierpont ME, Basson CT, Benson DW, Gelb BD, Giglia TM, Goldmuntz E; et al. (2007). "Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics". Circulation. 115 (23): 3015–38. doi:10.1161/CIRCULATIONAHA.106.183056. PMID 17519398.
- ↑ Prêtre R, Faidutti B (1993). "Surgical management of aortic valve injury after nonpenetrating trauma". The Annals of Thoracic Surgery. 56 (6): 1426–31. PMID 8267458. Retrieved 2011-03-28. Unknown parameter
|month=
ignored (help) - ↑ 9.0 9.1 Onorati F, De Santo LS, Carozza A, De Feo M, Renzulli A, Cotrufo M (2004). "Marfan syndrome as a predisposing factor for traumatic aortic insufficiency". The Annals of Thoracic Surgery. 77 (6): 2192–4. doi:10.1016/S0003-4975(03)01409-7. PMID 15172299. Retrieved 2011-03-28. Unknown parameter
|month=
ignored (help) - ↑ 10.0 10.1 10.2 Isner JM (1991). "Acute catastrophic complications of balloon aortic valvuloplasty. The Mansfield Scientific Aortic Valvuloplasty Registry Investigators". J Am Coll Cardiol. 17 (6): 1436–44. PMID 2016464.
- ↑ Vasudev R, Shah P, Bikkina M, Shamoon F (2016). "Quadricuspid Aortic Valve: A Rare Congenital Cause of Aortic Insufficiency". J Clin Imaging Sci. 6: 10. doi:10.4103/2156-7514.179417. PMC 4860453. PMID 27195176.
- ↑ 12.0 12.1 Schmoldt A, Benthe HF, Haberland G, Raffle A, Gray J, MacDonald HR, Ehrhart IC, Parker PE, Weidner WJ, Dabney JM, Scott JB, Haddy FJ, Gatzy JT (September 1975). "Digitoxin metabolism by rat liver microsomes". Biochem. Pharmacol. 24 (17): 1639–41. doi:10.1136/bmj.1.6001.93-a. PMC 5922622. PMID 10.
- ↑ Lindroos M, Kupari M, Valvanne J, Strandberg T, Heikkilä J, Tilvis R (1994). "Factors associated with calcific aortic valve degeneration in the elderly". Eur Heart J. 15 (7): 865–70. PMID 7925504.
- ↑ Ortlepp JR, Hoffmann R, Ohme F, Lauscher J, Bleckmann F, Hanrath P (2001). "The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis". Heart. 85 (6): 635–8. PMC 1729782. PMID 11359741.
- ↑ 15.0 15.1 Kim, M.; Roman, MJ.; Cavallini, MC.; Schwartz, JE.; Pickering, TG.; Devereux, RB. (1996). "Effect of hypertension on aortic root size and prevalence of aortic regurgitation". Hypertension. 28 (1): 47–52. PMID 8675263. Unknown parameter
|month=
ignored (help) - ↑ Ferreira TF, Freire M, Teodoro RB (2016). "Difficulties in the differential diagnosis between Takayasu arteritis and rheumatic fever: case report". Rev Bras Reumatol Engl Ed. 56 (1): 90–2. doi:10.1016/j.rbre.2015.07.001. PMID 27267341.
- ↑ Pereira, AM.; van Thiel, SW.; Lindner, JR.; Roelfsema, F.; van der Wall, EE.; Morreau, H.; Smit, JW.; Romijn, JA.; Bax, JJ. (2004). "Increased prevalence of regurgitant valvular heart disease in acromegaly". J Clin Endocrinol Metab. 89 (1): 71–5. PMID 14715829. Unknown parameter
|month=
ignored (help) - ↑ Palazzi C, D' Angelo S, Lubrano E, Olivieri I. Aortic involvement in ankylosing spondylitis. Clin Exp Rheumatol. May-Jun 2008;26(3 Suppl 49):S131-4.
- ↑ Stiles, GL.; Friesinger, GC. (1980). "Bacterial endocarditis with aortic regurgitation: implications of embolism". South Med J. 73 (5): 582–6. PMID 7375973. Unknown parameter
|month=
ignored (help) - ↑ Roberts, WC.; Vowels, TJ.; Ko, JM. (2012). "Natural history of adults with congenitally malformed aortic valves (unicuspid or bicuspid)". Medicine (Baltimore). 91 (6): 287–308. doi:10.1097/MD.0b013e3182764b84. PMID 23117850. Unknown parameter
|month=
ignored (help) - ↑ Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (2007). "Dopamine agonists and the risk of cardiac-valve regurgitation". The New England Journal of Medicine. 356 (1): 29–38. doi:10.1056/NEJMoa062222. PMID 17202453. Retrieved 2011-03-28. Unknown parameter
|month=
ignored (help) - ↑ Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL (2000). "Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications". Circulation. 102 (23): 2836–41. PMID 11104741. Retrieved 2011-03-28. Unknown parameter
|month=
ignored (help) - ↑ Waller EA, Kaplan J, Heckman MG (2005). "Valvular heart disease in patients taking pergolide". Mayo Clinic Proceedings. Mayo Clinic. 80 (8): 1016–20. PMID 16092580. Retrieved 2011-03-28. Unknown parameter
|month=
ignored (help) - ↑ Wunderlich, C.; Schulze, MR.; Strasser, RH. (2005). "Severe aortic regurgitation in Ehlers-Danlos syndrome type IV". Heart. 91 (1): 126. doi:10.1136/hrt.2004.035097. PMID 15604357. Unknown parameter
|month=
ignored (help) - ↑ 25.0 25.1 Jollis, JG.; Landolfo, CK.; Kisslo, J.; Constantine, GD.; Davis, KD.; Ryan, T. (2000). "Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities". Circulation. 101 (17): 2071–7. PMID 10790349. Unknown parameter
|month=
ignored (help) - ↑ Brown, OR.; DeMots, H.; Kloster, FE.; Roberts, A.; Menashe, VD.; Beals, RK. (1975). "Aortic root dilatation and mitral valve prolapse in Marfan's syndrome: an ECHOCARDIOgraphic study". Circulation. 52 (4): 651–7. PMID 1157278. Unknown parameter
|month=
ignored (help) - ↑ Lamanna, A.; Fayers, T.; Clarke, S.; Parsonage, W. (2013). "Valvular and aortic diseases in osteogenesis imperfecta". Heart Lung Circ. 22 (10): 801–10. doi:10.1016/j.hlc.2013.05.640. PMID 23791715. Unknown parameter
|month=
ignored (help) - ↑ Mullenix, PS.; Parsa, CJ.; Mackensen, GB.; Jollis, JG.; Harrison, JK.; Hughes, GC. (2008). "Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitation". J Heart Valve Dis. 17 (6): 666–9. PMID 19137799. Unknown parameter
|month=
ignored (help) - ↑ COFFMAN, JD.; SOMMERS, SC. (1959). "Familial pseudoxanthoma elasticum and valvular heart disease". Circulation. 19 (2): 242–50. PMID 13629785. Unknown parameter
|month=
ignored (help) - ↑ Levine, AJ.; Dimitri, WR.; Bonser, RS. (1999). "Aortic regurgitation in rheumatoid arthritis necessitating aortic valve replacement". Eur J Cardiothorac Surg. 15 (2): 213–4. PMID 10219558. Unknown parameter
|month=
ignored (help) - ↑ Aizawa, H.; Hasegawa, A.; Arai, M.; Naganuma, F.; Hatori, M.; Kanda, T.; Suzuki, T.; Murata, K.; Satoh, Y. (1998). "Bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis". Intern Med. 37 (1): 56–9. PMID 9510401. Unknown parameter
|month=
ignored (help) - ↑ Miyashita, T.; Abe, Y.; Kato, Y.; Nakagawa, E.; Komatsu, R.; Hattori, K.; Shibata, T.; Yoshioka, K.; Naruko, T. (2010). "Aortic aneurysm with severe aortic regurgitation in a patient with systemic lupus erythematosus". Intern Med. 49 (20): 2263–6. PMID 20962447.
- ↑ Stout KK, Verrier ED (2009). "Acute valvular regurgitation". Circulation. 119 (25): 3232–41. doi:10.1161/CIRCULATIONAHA.108.782292. PMID 19564568.
- ↑ Mokadam NA, Stout KK, Verrier ED (2011). "Management of acute regurgitation in left-sided cardiac valves". Tex Heart Inst J. 38 (1): 9–19. PMC 3060740. PMID 21423463.
- ↑ Blaszyk H, Witkiewicz AJ, Edwards WD (1999). "Acute aortic regurgitation due to spontaneous rupture of a fenestrated cusp: report in a 65-year-old man and review of seven additional cases". Cardiovasc Pathol. 8 (4): 213–6. PMID 10724525.
- ↑ Lai, DT.; Miller, DC.; Mitchell, RS.; Oyer, PE.; Moore, KA.; Robbins, RC.; Shumway, NE.; Reitz, BA. (2003). "Acute type A aortic dissection complicated by aortic regurgitation: composite valve graft versus separate valve graft versus conservative valve repair". J Thorac Cardiovasc Surg. 126 (6): 1978–86. doi:10.1016/S0022. PMID 14688716. Unknown parameter
|month=
ignored (help) - ↑ Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther. Feb 2008;6(2):235-48.
- ↑ Stout, KK.; Verrier, ED. (2009). "Acute valvular regurgitation". Circulation. 119 (25): 3232–41. doi:10.1161/CIRCULATIONAHA.108.782292. PMID 19564568. Unknown parameter
|month=
ignored (help) - ↑ Devlin WH, Petrusha J, Briesmiester K, Montgomery D, Starling MR (1999). "Impact of vascular adaptation to chronic aortic regurgitation on left ventricular performance". Circulation. 99 (8): 1027–33. PMID 10051296.
- ↑ Palazzi C, D' Angelo S, Lubrano E, Olivieri I. Aortic involvement in ankylosing spondylitis. Clin Exp Rheumatol. May-Jun 2008;26(3 Suppl 49):S131-4.
- ↑ Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther. Feb 2008;6(2):235-48.
- ↑ Eberhardt RT, Dhadly M. Giant cell arteritis: diagnosis, management, and cardiovascular implications. Cardiol Rev. Mar-Apr 2007;15(2):55-61.
- ↑ Chand EM, Freant LJ, Rubin JW. Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol. Nov-Dec 1999;8(6):333-8.
- ↑ Jain D, Halushka MK. Cardiac pathology of systemic lupus erythematosus. J Clin Pathol. Jul 2009;62(7):584-92.
- ↑ Moyssakis I, Tektonidou MG, Vasilliou VA, Samarkos M, Votteas V, Moutsopoulos HM. Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution. Am J Med. Jul 2007;120(7):636-42.
- ↑ Lee JL, Naguwa SM, Cheema GS, Gershwin ME. Revisiting Libman-Sacks endocarditis: a historical review and update. Clin Rev Allergy Immunol. Jun 2009;36(2-3):126-30.
- ↑ Adachi O, Saiki Y, Akasaka J, Oda K, Iguchi A, Tabayashi K. Surgical management of aortic regurgitation associated with takayasu arteritis and other forms of aortitis. Ann Thorac Surg. Dec 2007;84(6):1950-3.
- ↑ Schmaltz, AA.; Schaefer, M.; Hentrich, F.; Neudorf, U.; Brecher, AM.; Asfour, B.; Urban, AE. (2004). "[Ventricular septal defect and aortic regurgitation-pathophysiological aspects and therapeutic consequences]". Z Kardiol. 93 (3): 194–200. doi:10.1007/s00392-004-0015-2. PMID 15024586. Unknown parameter
|month=
ignored (help) - ↑ Jeserich M, Ihling C, Holubarsch C. Aortic valve endocarditis with Whipple disease. Ann Intern Med. Jun 1 1997;126(11):920.
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