|
|
(94 intermediate revisions by the same user not shown) |
Line 1: |
Line 1: |
| __NOTOC__
| |
| ==COVID-19 associated multi-system inflammatory syndrome in children==
| |
| {{CMG}}; {{AE}} [..]<br>
| |
| {{SK}} ; (MIS-C); (MIS-C) associated with COVID-19; (MIS-C) associated with SARS-CoV-2; Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19); Multisystem Inflammatory Syndrome in Children associated with COVID-19 <br>
| |
|
| |
|
| ==[[COVID-19 associated multi-system inflammatory syndrome in children|Overview]]==
| |
|
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children|Historical Perspective]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children|Classification]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children|Pathophysiology]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children|Causes]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children|Differentiating COVID-19 associated multi-system inflammatory syndrome in children from other diseases]]==
| |
| :COVID-19 associated multi-system inflammatory syndrome in children must be differentiated from other diseases that cause [[rash]] such as [[Kawasaki disease]] and [[toxic shock syndrome]].
| |
| *[[Kawasaki disease]] A patient with fever for 5 or more days and at least 4 clinical signs ([[rash]], bilateral conjunctival injection, more than 1.5 cm of cervical [[lymphadenopathy]], oral mucosal changes and extremity changes) is known to have Kawasaki disease. Typically a patient is less than 5 years of age. <ref name="urlCase Definition | Kawasaki Disease | CDC">{{cite web |url=https://www.cdc.gov/kawasaki/case-definition.html |title=Case Definition | Kawasaki Disease | CDC |format= |work= |accessdate=}}</ref>
| |
|
| |
| *[[toxic shock syndrome]]
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children epidemiology and demographics|Epidemiology and Demographics]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in childrenrisk factors|Risk Factors]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children screening|Screening]]==
| |
|
| |
| ==[[COVID-19 associated multi-system inflammatory syndrome in children natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
| |
|
| |
| ==Diagnosis==
| |
| ==WHO preliminary case definition==
| |
| A preliminary case is a patient 0-19 years of age having a fever for more than three days and at least two of the following findings<ref>[https://www.who.int/news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19| WHO reports multisystem-inflammatory-syndrome in children with COVID-19]</ref>:
| |
|
| |
| *#Rash or bilateral non-purulent conjunctivitis or mucocutaneous inflammation signs (oral, hands or feet).
| |
| *#Hypotension or shock.
| |
| *#Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP),
| |
| *#Evidence of coagulopathy (by PT, PTT, elevated d-Dimers).
| |
| *#Acute gastrointestinal problems (diarrhea, vomiting, or abdominal pain).
| |
| AND
| |
| *Elevated markers of inflammation such as [[ESR]], [[C-reactive protein]], or [[procalcitonin]].
| |
| AND
| |
| *No other obvious microbial cause of inflammation, including bacterial [[sepsis]], staphylococcal or streptococcal shock syndromes.
| |
| AND
| |
| *Evidence of COVID-19 (RT-PCR, antigen test or [[serology]] positive), or likely contact with patients with COVID-19.
| |
| [[COVID-19 associated multi-system inflammatory syndrome in children history and symptoms|History and Symptoms]] | [[COVID-19 associated multi-system inflammatory syndrome in children physical examination|Physical Examination]] | [[COVID-19 associated multi-system inflammatory syndrome in children laboratory findings|Laboratory Findings]] | [[COVID-19 associated multi-system inflammatory syndrome in children electrocardiogram|Electrocardiogram]] |[[COVID-19 associated multi-system inflammatory syndrome in children here chest x ray|Chest X Ray]] | [[COVID-19 associated multi-system inflammatory syndrome in children CT|CT]] | [[COVID-19 associated multi-system inflammatory syndrome in children MRI|MRI]] | [[COVID-19 associated multi-system inflammatory syndrome in children echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[COVID-19 associated multi-system inflammatory syndrome in children other imaging findings|Other Imaging Findings]] | [[COVID-19 associated multi-system inflammatory syndrome in children other diagnostic studies|Other Diagnostic Studies]]
| |
|
| |
| ==Treatment==
| |
| [[COVID-19 associated multi-system inflammatory syndrome in children medical therapy|Medical Therapy]] | [[COVID-19 associated multi-system inflammatory syndrome in children surgery|Surgery]] | [[COVID-19 associated multi-system inflammatory syndrome in children primary prevention|Primary Prevention]] | [[COVID-19 associated multi-system inflammatory syndrome in children secondary prevention|Secondary Prevention]] | [[COVID-19 associated multi-system inflammatory syndrome in children cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[COVID-19 associated multi-system inflammatory syndrome in children future or investigational therapies|Future or Investigational Therapies]]
| |