Rhabdomyolysis overview: Difference between revisions
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==Overview== | ==Overview== | ||
Rhabdomyolysis is | [[Rhabdomyolysis]] is a [[syndrome]] characterized by [[skeletal muscle]] [[necrosis]] and the release of intracellular [[muscle]] contents, such as [[myoglobin]] and [[electrolytes]], into the blood [[circulation]].<ref name="pmidPMID: 17909702">{{cite journal| author=Bagley WH, Yang H, Shah KH| title=Rhabdomyolysis. | journal=Intern Emerg Med | year= 2007 | volume= 2 | issue= 3 | pages= 210-8 | pmid=PMID: 17909702 | doi=10.1007/s11739-007-0060-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17909702 }} </ref> | ||
==Causes== | ==Causes== | ||
The causes can be divided into 3 categories:<ref name="pmidPMID: 7078398">{{cite journal| author=Gabow PA, Kaehny WD, Kelleher SP| title=The spectrum of rhabdomyolysis. | journal=Medicine (Baltimore) | year= 1982 | volume= 61 | issue= 3 | pages= 141-52 | pmid=PMID: 7078398 | doi=10.1097/00005792-198205000-00002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7078398 }} </ref><ref name="pmidPMID: 16267412">{{cite journal| author=Melli G, Chaudhry V, Cornblath DR| title=Rhabdomyolysis: an evaluation of 475 hospitalized patients. | journal=Medicine (Baltimore) | year= 2005 | volume= 84 | issue= 6 | pages= 377-85 | pmid=PMID: 16267412 | doi=10.1097/01.md.0000188565.48918.41 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16267412 }} </ref><ref name="pmidPMID: 25829882">{{cite journal| author=Torres PA, Helmstetter JA, Kaye AM, Kaye AD| title=Rhabdomyolysis: pathogenesis, diagnosis, and treatment. | journal=Ochsner J | year= 2015 | volume= 15 | issue= 1 | pages= 58-69 | pmid=PMID: 25829882 | doi= | pmc=4365849 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25829882 }} </ref> | |||
* Traumatic or muscle compression. | |||
* Nontraumatic exertional. | |||
* Nontraumatic non-exertional. | |||
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{{familytree | | | | | | | | A01 |A01=Causes of Rhabdomyolysis}} | |||
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{{familytree | | | B01 | | | | | | | | B02 | | |B01=Traumatic|B02=Atraumatic}} | |||
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{{familytree | | | C01 | | | | | | |C02| |C03| | |C01=C01|C02=C02|C03=C03}} | |||
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==Diagnosis== | ==Diagnosis== |
Latest revision as of 16:01, 9 June 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayesha Javid, MBBS[2]
Overview
Rhabdomyolysis is a syndrome characterized by skeletal muscle necrosis and the release of intracellular muscle contents, such as myoglobin and electrolytes, into the blood circulation.[1]
Causes
The causes can be divided into 3 categories:[2][3][4]
- Traumatic or muscle compression.
- Nontraumatic exertional.
- Nontraumatic non-exertional.
Causes of Rhabdomyolysis | |||||||||||||||||||||||||||||||||||||||
Traumatic | Atraumatic | ||||||||||||||||||||||||||||||||||||||
C01 | C02 | C03 | |||||||||||||||||||||||||||||||||||||
Diagnosis
Physical Examination
A physical usually reveals no abnormalities, but there may be tenderness, weakness, or atrophy.
Electrocardiogram
The EKG can show non specific ST T wave changes and T wave inversions. Despite the very high level of CK, the criteria for MI requires a 5% MB index (may vary by assay and gender).
References
- ↑ Bagley WH, Yang H, Shah KH (2007). "Rhabdomyolysis". Intern Emerg Med. 2 (3): 210–8. doi:10.1007/s11739-007-0060-8. PMID 17909702 PMID: 17909702 Check
|pmid=
value (help). - ↑ Gabow PA, Kaehny WD, Kelleher SP (1982). "The spectrum of rhabdomyolysis". Medicine (Baltimore). 61 (3): 141–52. doi:10.1097/00005792-198205000-00002. PMID 7078398 PMID: 7078398 Check
|pmid=
value (help). - ↑ Melli G, Chaudhry V, Cornblath DR (2005). "Rhabdomyolysis: an evaluation of 475 hospitalized patients". Medicine (Baltimore). 84 (6): 377–85. doi:10.1097/01.md.0000188565.48918.41. PMID 16267412 PMID: 16267412 Check
|pmid=
value (help). - ↑ Torres PA, Helmstetter JA, Kaye AM, Kaye AD (2015). "Rhabdomyolysis: pathogenesis, diagnosis, and treatment". Ochsner J. 15 (1): 58–69. PMC 4365849. PMID 25829882 PMID: 25829882 Check
|pmid=
value (help).