Epistaxis resident survival guide: Difference between revisions
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! style="padding: 0 5px; font-size: 80%; background: #A8A8A8;" align=center| {{fontcolor|#2B3B44|Epistaxis <BR>Resident Survival Guide}} | ! style="padding: 0 5px; font-size: 80%; background: #A8A8A8;" align="center" |{{fontcolor|#2B3B44|Epistaxis <BR>Resident Survival Guide}} | ||
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! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align=left | [[{{PAGENAME}}#Overview|Overview]] | ! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align="left" |[[{{PAGENAME}}#Overview|Overview]] | ||
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! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align=left | [[{{PAGENAME}}#Causes|Causes]] | ! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align="left" |[[{{PAGENAME}}#Causes|Causes]] | ||
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! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align=left | [[{{PAGENAME}}#Diagnosis|Diagnosis]] | ! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align="left" |[[{{PAGENAME}}#Diagnosis|Diagnosis]] | ||
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! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align=left | [[{{PAGENAME}}#Treatment|Treatment]] | ! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align="left" |[[{{PAGENAME}}#Treatment|Treatment]] | ||
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! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align=left | [[{{PAGENAME}}#Do's|Do's]] | ! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align="left" |[[{{PAGENAME}}#Do's|Do's]] | ||
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! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align=left | [[{{PAGENAME}}#Don'ts|Don'ts]] | ! style="font-size: 80%; padding: 0 5px; background: #DCDCDC; border-radius: 5px 5px 5px 5px;" align="left" |[[{{PAGENAME}}#Don'ts|Don'ts]] | ||
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__NOTOC__ | __NOTOC__ | ||
{{WikiDoc CMG}}; {{AE}} [[User:Amir Bagheri|Amir Behzad Bagheri, M.D.]] | {{WikiDoc CMG}}; {{AE}} [[User:Amir Bagheri|Amir Behzad Bagheri, M.D.]] | ||
{{SK}} Epistaxis approach, An approach to epistaxis, Nose bleeding approach | {{SK}} Epistaxis approach, An approach to epistaxis, Nose bleeding approach | ||
==Overview== | ==Overview== | ||
Epistaxis, also known as | Epistaxis, also known as nose [[bleeding]], is terminology for [[bleeding]] of the nose [[vessels]] that drain from the nostrils (most often) and/or [[nasopharynx]]. Epistaxis often stops easily but can be an ENT emergency, and may be critical if appropriate action does not occur. [[Kiesselbach's plexus]] is the source of most epistaxis. | ||
==Causes== | ==Causes== | ||
Based on the cause and severity of Epistaxis, it can be life-threatening.<ref name="KrulewitzFix2019">{{cite journal|last1=Krulewitz|first1=Neil Alexander|last2=Fix|first2=Megan Leigh|title=Epistaxis|journal=Emergency Medicine Clinics of North America|volume=37|issue=1|year=2019|pages=29–39|issn=07338627|doi=10.1016/j.emc.2018.09.005}}</ref> <ref name="DouglasWormald2007">{{cite journal|last1=Douglas|first1=Richard|last2=Wormald|first2=Peter-John|title=Update on epistaxis|journal=Current Opinion in Otolaryngology & Head and Neck Surgery|volume=15|issue=3|year=2007|pages=180–183|issn=1068-9508|doi=10.1097/MOO.0b013e32814b06ed}}</ref> <ref name="KikidisTsioufis2013">{{cite journal|last1=Kikidis|first1=D.|last2=Tsioufis|first2=K.|last3=Papanikolaou|first3=V.|last4=Zerva|first4=K.|last5=Hantzakos|first5=A.|title=Is epistaxis associated with arterial hypertension? A systematic review of the literature|journal=European Archives of Oto-Rhino-Laryngology|volume=271|issue=2|year=2013|pages=237–243|issn=0937-4477|doi=10.1007/s00405-013-2450-z}}</ref> | |||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
Life-threatening causes of epistaxis include [[conditions]] that may result in death or permanent disability within 24 hours if left untreated. | Life-threatening causes of epistaxis include [[conditions]] that may result in death or permanent disability within 24 hours if left untreated. | ||
* [[Haemophilia]] | |||
* [[Congestive heart failure]] | *[[Haemophilia]] | ||
* [[ITP]] | *[[Congestive heart failure]] | ||
* [[Leukemia]] | *[[ITP]] | ||
*[[Leukemia]] | |||
===Common Causes=== | ===Common Causes=== | ||
There is not enough evidence that [[hypertension]] is a risk factor for [[epistaxis]] | *Local [[trauma]] | ||
*[[Acute sinusitis]] | |||
*[[Allergic rhinitis]] | |||
*[[Anticoagulation]] | |||
*[[Aspirin]] | |||
*[[Rhinitis|Chronic rhinitis]] | |||
*[[Chronic sinusitis]] | |||
*[[Barotrauma]] | |||
*[[Cocaine]] | |||
*[[Common cold]] | |||
*[[Foreign bodies]] | |||
*[[Nose-picking]] | |||
*[[Neoplasia]] | |||
There is not enough evidence that [[hypertension]] is a [[risk factor]] for [[epistaxis]]. The role of lowering [[blood pressure]] to control and prevent [[epistaxis]] remains controversial. | |||
==Diagnosis== | ==Diagnosis== | ||
Shown below is an algorithm summarizing the [[diagnosis]] of | Shown below is an algorithm summarizing the [[diagnosis]] of epistaxis according to North America Clinical Practice Guideline.<ref name="KrulewitzFix2019">{{cite journal|last1=Krulewitz|first1=Neil Alexander|last2=Fix|first2=Megan Leigh|title=Epistaxis|journal=Emergency Medicine Clinics of North America|volume=37|issue=1|year=2019|pages=29–39|issn=07338627|doi=10.1016/j.emc.2018.09.005}}</ref> <ref name="TunkelAnne2020">{{cite journal|last1=Tunkel|first1=David E.|last2=Anne|first2=Samantha|last3=Payne|first3=Spencer C.|last4=Ishman|first4=Stacey L.|last5=Rosenfeld|first5=Richard M.|last6=Abramson|first6=Peter J.|last7=Alikhaani|first7=Jacqueline D.|last8=Benoit|first8=Margo McKenna|last9=Bercovitz|first9=Rachel S.|last10=Brown|first10=Michael D.|last11=Chernobilsky|first11=Boris|last12=Feldstein|first12=David A.|last13=Hackell|first13=Jesse M.|last14=Holbrook|first14=Eric H.|last15=Holdsworth|first15=Sarah M.|last16=Lin|first16=Kenneth W.|last17=Lind|first17=Meredith Merz|last18=Poetker|first18=David M.|last19=Riley|first19=Charles A.|last20=Schneider|first20=John S.|last21=Seidman|first21=Michael D.|last22=Vadlamudi|first22=Venu|last23=Valdez|first23=Tulio A.|last24=Nnacheta|first24=Lorraine C.|last25=Monjur|first25=Taskin M.|title=Clinical Practice Guideline: Nosebleed (Epistaxis)|journal=Otolaryngology–Head and Neck Surgery|volume=162|issue=1_suppl|year=2020|pages=S1–S38|issn=0194-5998|doi=10.1177/0194599819890327}}</ref> <ref name="ThorntonMahesh2005">{{cite journal|last1=Thornton|first1=M A.|last2=Mahesh|first2=B N.|last3=Lang|first3=J|title=Posterior Epistaxis: Identification of Common Bleeding Sites|journal=The Laryngoscope|volume=115|issue=4|year=2005|pages=588–590|issn=0023852X|doi=10.1097/01.mlg.0000161365.96685.6c}}</ref> <ref name="ChaabanZhang2016">{{cite journal|last1=Chaaban|first1=Mohamad R.|last2=Zhang|first2=Dong|last3=Resto|first3=Vicente|last4=Goodwin|first4=James S.|title=Demographic, Seasonal, and Geographic Differences in Emergency Department Visits for Epistaxis|journal=Otolaryngology–Head and Neck Surgery|volume=156|issue=1|year=2016|pages=81–86|issn=0194-5998|doi=10.1177/0194599816667295}}</ref> <ref name="ViehwegRoberson2006">{{cite journal|last1=Viehweg|first1=Tate L.|last2=Roberson|first2=John B.|last3=Hudson|first3=J.W.|title=Epistaxis: Diagnosis and Treatment|journal=Journal of Oral and Maxillofacial Surgery|volume=64|issue=3|year=2006|pages=511–518|issn=02782391|doi=10.1016/j.joms.2005.11.031}}</ref> | ||
{{Family tree/start}} | {{Family tree/start}} | ||
{{Family tree | | | | | | | | | | | | A01 | | | | | | | | | | |A01=<div style="float: left; text-align: left; height: | {{Family tree | | | | | | | | | | | | A01 | | | | | | | | | | |A01=<div style="float: left; text-align: left; height: 27em; width: 16em; padding:1em;"> '''Patient with [[Epistaxis]]?'''<br> | ||
---- | ---- | ||
Take a complete medical history <br> ❑ Recurrent bleeding? <br> ❑ Using [[anticoagulant]] or [[antiplatelet]] [[medications]]? <br> ❑ Recent trauma or [[surgery]] <br> ❑ [[Vascular abnormalitie]]s<br> ❑ Family history of [[epistaxis]] <br>❑ [[Allergies]]<br> ❑ [[Cancer]] <br> ❑ Other | Take a complete medical history <br> ❑ Recurrent [[bleeding]]? <br> ❑ Using [[anticoagulant]] or [[antiplatelet]] [[medications]]? <br> ❑ Recent [[trauma]] or [[surgery]] <br> ❑ [[Vascular abnormalitie]]s<br> ❑ Family history of [[epistaxis]] <br>❑ [[Allergies]]<br> ❑ [[Cancer]] <br> ❑ Other underlying [[diseases]] <br> -Check the following labs in severe [[bleeding]] or with possibility of [[coagulopathy]]:<br> | ||
❑ [[CBC]]<br> | ❑ [[CBC]]<br> | ||
❑ [[PT]] | ❑ [[PT]]<br> | ||
❑ [[PTT]]</div>}} | ❑ [[PTT]] | ||
</div>}} | |||
{{Family tree | | | | | | | | | | | | |!| | }} | {{Family tree | | | | | | | | | | | | |!| | }} | ||
{{Family tree | | |,|-|-|-|-|-|-|v|-|-|^|-|-|v|-|-|-|-|-|-|.| | | }} | {{Family tree | | |,|-|-|-|-|-|-|v|-|-|^|-|-|v|-|-|-|-|-|-|.| | | }} | ||
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{{Family tree |boxstyle=background: #FA8072; color: #F8F8FF;| | C01 | | | | | C02 | | | | C03 | | | | | C04 | | | | | | | | | | | | | | | | | | | |C01=<div style="float: left; text-align: left; height: 14em; width: 15em; padding:1em;"> | {{Family tree |boxstyle=background: #FA8072; color: #F8F8FF;| | C01 | | | | | C02 | | | | C03 | | | | | C04 | | | | | | | | | | | | | | | | | | | |C01=<div style="float: left; text-align: left; height: 14em; width: 15em; padding:1em;"> | ||
---- | ---- | ||
'''Trauma is the most cause of epistaxis(17%)<br> ❑ Digital [[trauma]] <br> ❑ [[Facial trauma]] <br> ❑ [[Foreign body]] insertion <br> ❑ [[Septal]] perforation <br> ❑ [[Barotrauma]] <br> ❑ Illicit drugs </div> |C02=<div style="float: left; text-align: left; height: 14em; width: 15em; padding:1em;"> | '''[[Trauma]] is the most frequent [[cause]] of epistaxis(17%)<br> ❑ Digital [[trauma]] <br> ❑ [[Facial trauma]] <br> ❑ [[Foreign body]] insertion <br> ❑ [[Septal]] perforation <br> ❑ [[Barotrauma]] <br> ❑ Illicit drugs </div> |C02=<div style="float: left; text-align: left; height: 14em; width: 15em; padding:1em;"> | ||
---- | ---- | ||
'''❑ Using [[Anticoagulants]] or [[Antiplatelet]] medications<br> ❑ [[ITP]]* <br> ❑ [[von Willebrand disease]] <br> ❑ [[Leukemia]] <br>❑ Other medications | '''❑ Using [[Anticoagulants]] or [[Antiplatelet]] [[medications]]<br> ❑ [[ITP]]* <br> ❑ [[von Willebrand disease]] <br> ❑ [[Leukemia]] <br>❑ Other [[medications]] causing [[coagulopathy]] </div> | C03= <div style="float: left; text-align: left; height: 14em; width: 15em; padding:1em;">''' | ||
---- | ---- | ||
'''❑ [[HHT]]** <br> ❑ [[Congestive heart failure]] <br> ❑ [[Granulomatosis with polyangitis]] </div> | C04= <div style="float: left; text-align: left; height: 16em; width: 15em; padding:1em;"> '''<span style="color:navy;"></span>'''<br>''' | '''❑ [[HHT]]** <br> ❑ [[Congestive heart failure]] <br> ❑ [[Granulomatosis with polyangitis]] </div> | C04= <div style="float: left; text-align: left; height: 16em; width: 15em; padding:1em;"> '''<span style="color:navy;"></span>'''<br>''' | ||
---- | ---- | ||
'''❑[[Sinusitis]] <br> ❑ [[Allergies]] <br> ❑ [[Septal]] deviation <br> ❑ [[Neoplasia]] in situ <br> ❑ [[Renal failure]] <br> ❑ [[Uremia]] <br> ❑ Hepatic dysfuction <br> ❑ [[Idiopathic]] <br> ❑ [[Infection]]</div>}} | '''❑ [[Sinusitis]] <br> ❑ [[Allergies]] <br> ❑ [[Septal]] deviation <br> ❑ [[Neoplasia]] in situ <br> ❑ [[Renal failure]] <br> ❑ [[Uremia]] <br> ❑ Hepatic dysfuction <br> ❑ [[Idiopathic]] <br> ❑ [[Infection]]</div>}} | ||
{{familytree/end}} | {{familytree/end}} | ||
* [[ITP]] = [[Immune thrombocytopenic purpura]] | *[[ITP]] = [[Immune thrombocytopenic purpura]] | ||
* [[HHT]] = [[Hereditary Hemorrhagic Telangiectasia]] | *[[HHT]] = [[Hereditary Hemorrhagic Telangiectasia]] | ||
{| | {| | ||
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==Treatment== | ==Treatment== | ||
Shown below is an algorithm summarizing the treatment of | Shown below is an algorithm summarizing the treatment of [[epistaxis]] according to The American Academy of [[ENT]] guidelines. <ref name="TunkelAnne2020">{{cite journal|last1=Tunkel|first1=David E.|last2=Anne|first2=Samantha|last3=Payne|first3=Spencer C.|last4=Ishman|first4=Stacey L.|last5=Rosenfeld|first5=Richard M.|last6=Abramson|first6=Peter J.|last7=Alikhaani|first7=Jacqueline D.|last8=Benoit|first8=Margo McKenna|last9=Bercovitz|first9=Rachel S.|last10=Brown|first10=Michael D.|last11=Chernobilsky|first11=Boris|last12=Feldstein|first12=David A.|last13=Hackell|first13=Jesse M.|last14=Holbrook|first14=Eric H.|last15=Holdsworth|first15=Sarah M.|last16=Lin|first16=Kenneth W.|last17=Lind|first17=Meredith Merz|last18=Poetker|first18=David M.|last19=Riley|first19=Charles A.|last20=Schneider|first20=John S.|last21=Seidman|first21=Michael D.|last22=Vadlamudi|first22=Venu|last23=Valdez|first23=Tulio A.|last24=Nnacheta|first24=Lorraine C.|last25=Monjur|first25=Taskin M.|title=Clinical Practice Guideline: Nosebleed (Epistaxis)|journal=Otolaryngology–Head and Neck Surgery|volume=162|issue=1_suppl|year=2020|pages=S1–S38|issn=0194-5998|doi=10.1177/0194599819890327}}</ref> | ||
<ref name="ChaabanZhang2016">{{cite journal|last1=Chaaban|first1=Mohamad R.|last2=Zhang|first2=Dong|last3=Resto|first3=Vicente|last4=Goodwin|first4=James S.|title=Demographic, Seasonal, and Geographic Differences in Emergency Department Visits for Epistaxis|journal=Otolaryngology–Head and Neck Surgery|volume=156|issue=1|year=2016|pages=81–86|issn=0194-5998|doi=10.1177/0194599816667295}}</ref> <ref name="BéquignonTeissier2017">{{cite journal|last1=Béquignon|first1=E|last2=Teissier|first2=N|last3=Gauthier|first3=A|last4=Brugel|first4=L|last5=De Kermadec|first5=H|last6=Coste|first6=A|last7=Prulière-Escabasse|first7=V|title=Emergency Department care of childhood epistaxis|journal=Emergency Medicine Journal|volume=34|issue=8|year=2017|pages=543–548|issn=1472-0205|doi=10.1136/emermed-2015-205528}}</ref> | <ref name="ChaabanZhang2016">{{cite journal|last1=Chaaban|first1=Mohamad R.|last2=Zhang|first2=Dong|last3=Resto|first3=Vicente|last4=Goodwin|first4=James S.|title=Demographic, Seasonal, and Geographic Differences in Emergency Department Visits for Epistaxis|journal=Otolaryngology–Head and Neck Surgery|volume=156|issue=1|year=2016|pages=81–86|issn=0194-5998|doi=10.1177/0194599816667295}}</ref> <ref name="BéquignonTeissier2017">{{cite journal|last1=Béquignon|first1=E|last2=Teissier|first2=N|last3=Gauthier|first3=A|last4=Brugel|first4=L|last5=De Kermadec|first5=H|last6=Coste|first6=A|last7=Prulière-Escabasse|first7=V|title=Emergency Department care of childhood epistaxis|journal=Emergency Medicine Journal|volume=34|issue=8|year=2017|pages=543–548|issn=1472-0205|doi=10.1136/emermed-2015-205528}}</ref> | ||
<ref name="EscabasseBequignon2017">{{cite journal|last1=Escabasse|first1=V.|last2=Bequignon|first2=E.|last3=Vérillaud|first3=B.|last4=Robard|first4=L.|last5=Michel|first5=J.|last6=Malard|first6=O.|last7=Crampette|first7=L.|last8=Malard|first8=O.|last9=Crampette|first9=L.|last10=Achache|first10=M.|last11=Alaoui Lamrani|first11=M.Y.|last12=Ardillon|first12=L.|last13=Babin|first13=E.|last14=Bal Dit Sollier|first14=C.|last15=Bequignon|first15=E.|last16=Borsik|first16=M.|last17=Castillo|first17=L.|last18=Coste|first18=A.|last19=Debry|first19=C.|last20=Dessi|first20=P.|last21=Drouet|first21=L.|last22=Dufour|first22=X.|last23=Dupuis-Girod|first23=S.|last24=Faure|first24=F.|last25=Gallet|first25=P.|last26=Guldman|first26=R.|last27=Houdart|first27=E.|last28=Jankowski|first28=R.|last29=Jegoux|first29=F.|last30=Leble|first30=S.|last31=Michel|first31=J.|last32=Mortuaire|first32=G.|last33=Mouchon|first33=E.|last34=Page|first34=C.|last35=Pruliere Escabasse|first35=V.|last36=Robard|first36=L.|last37=Roux|first37=A.|last38=Saint Maurice|first38=J.P.|last39=Sarlon|first39=G.|last40=Strunski|first40=V.|last41=Trevillot|first41=V.|last42=Verillaud|first42=B.|last43=Vironneau|first43=P.|title=Guidelines of the French Society of Otorhinolaryngology (SFORL). Managing epistaxis under coagulation disorder due to antithrombotic therapy|journal=European Annals of Otorhinolaryngology, Head and Neck Diseases|volume=134|issue=3|year=2017|pages=195–199|issn=18797296|doi=10.1016/j.anorl.2016.10.001}}</ref> | <ref name="EscabasseBequignon2017">{{cite journal|last1=Escabasse|first1=V.|last2=Bequignon|first2=E.|last3=Vérillaud|first3=B.|last4=Robard|first4=L.|last5=Michel|first5=J.|last6=Malard|first6=O.|last7=Crampette|first7=L.|last8=Malard|first8=O.|last9=Crampette|first9=L.|last10=Achache|first10=M.|last11=Alaoui Lamrani|first11=M.Y.|last12=Ardillon|first12=L.|last13=Babin|first13=E.|last14=Bal Dit Sollier|first14=C.|last15=Bequignon|first15=E.|last16=Borsik|first16=M.|last17=Castillo|first17=L.|last18=Coste|first18=A.|last19=Debry|first19=C.|last20=Dessi|first20=P.|last21=Drouet|first21=L.|last22=Dufour|first22=X.|last23=Dupuis-Girod|first23=S.|last24=Faure|first24=F.|last25=Gallet|first25=P.|last26=Guldman|first26=R.|last27=Houdart|first27=E.|last28=Jankowski|first28=R.|last29=Jegoux|first29=F.|last30=Leble|first30=S.|last31=Michel|first31=J.|last32=Mortuaire|first32=G.|last33=Mouchon|first33=E.|last34=Page|first34=C.|last35=Pruliere Escabasse|first35=V.|last36=Robard|first36=L.|last37=Roux|first37=A.|last38=Saint Maurice|first38=J.P.|last39=Sarlon|first39=G.|last40=Strunski|first40=V.|last41=Trevillot|first41=V.|last42=Verillaud|first42=B.|last43=Vironneau|first43=P.|title=Guidelines of the French Society of Otorhinolaryngology (SFORL). Managing epistaxis under coagulation disorder due to antithrombotic therapy|journal=European Annals of Otorhinolaryngology, Head and Neck Diseases|volume=134|issue=3|year=2017|pages=195–199|issn=18797296|doi=10.1016/j.anorl.2016.10.001}}</ref> | ||
{{familytree/start |summary=PE diagnosis Algorithm.}} | {{familytree/start |summary=PE diagnosis Algorithm.}} | ||
{{familytree | | | | | | | | | | A01 | | | | |A01=Patient with [[Epistaxis]] }} | {{familytree | | | | | | | | | | A01 | | | | |A01=[[Patient]] with [[Epistaxis]] }} | ||
{{familytree | | | | | | | | | | |!| | | | | | | }} | {{familytree | | | | | | | | | | |!| | | | | | | }} | ||
{{familytree | | | | | | | | | | A02 | | | | | |A02=First assess '''ABC''' }} | {{familytree | | | | | | | | | | A02 | | | | | |A02=First assess '''ABC'''* }} | ||
{{familytree | | | | | | | | | | |!| | | | | | | }} | {{familytree | | | | | | | | | | |!| | | | | | | }} | ||
{{familytree | | | | | | | | | | A02 | | | | | |A02=Need of [[Immediate Action]]? }} | {{familytree | | | | | | | | | | A02 | | | | | |A02=Need of [[Immediate Action]]? }} | ||
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{{Familytree | | | |!| | | | | | | | | | | | | | |!| }} | {{Familytree | | | |!| | | | | | | | | | | | | | |!| }} | ||
{{familytree | | | |`|-|-|-|-|-|-|-|-|v|-|-|-|-|-|'| | | | }} | {{familytree | | | |`|-|-|-|-|-|-|-|-|v|-|-|-|-|-|'| | | | }} | ||
{{familytree | | | | | | | | | | | | C01 | | | | | | | |C01= [[ | {{familytree | | | | | | | | | | | | C01 | | | | | | | |C01= Active [[Bleeding]] ? }} | ||
{{familytree | | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | }} | {{familytree | | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | }} | ||
{{Familytree | | | | | |!| | | | | | | | | | | | |!| }} | {{Familytree | | | | | |!| | | | | | | | | | | | |!| }} | ||
{{familytree | | | | | D01 | | | | | | | | | | | D02 | |D01=Yes→[[Nasal compression]] for≥5 min| D02=No}} | {{familytree | | | | | D01 | | | | | | | | | | | D02 | |D01=Yes→[[Nasal compression]] for≥5 min| D02=No}} | ||
{{familytree | | | |,|-|^|.| | | | | | | | | | | |!| | | | }} | {{familytree | | | |,|-|^|.| | | | | | | | | | | |!| | | | }} | ||
{{familytree | | E01 | | E02 | | | | | | | | | | |!| | | | | |E01=Bleeding resume|E02=Bleeding Controlled }} | {{familytree | | E01 | | E02 | | | | | | | | | | |!| | | | | |E01=[[Bleeding]] resume|E02=[[Bleeding]] Controlled }} | ||
{{familytree | | | |!| | |`|-|-|-|-|-|-|-|-|-|-| E03 | | | | | |E03=[[Rhinoscopy]] to identify location of bleeding}} | {{familytree | | | |!| | |`|-|-|-|-|-|-|-|-|-|-| E03 | | | | | |E03=[[Rhinoscopy]] to identify location of [[bleeding]]}} | ||
{{familytree | | | |!| | | | | | | | | | | | | | |!| | | | | | }} | {{familytree | | | |!| | | | | | | | | | | | | | |!| | | | | | }} | ||
{{familytree | | | F01 | | | | | | | | | | | | | F02 | | |F01=<div style="float: left; text-align: left; height: 7em; width: 14em; padding:1em;"> '''Risk factor Assessment :'''<br> | {{familytree | | | F01 | | | | | | | | | | | | | F02 | | |F01=<div style="float: left; text-align: left; height: 7em; width: 14em; padding:1em;"> '''Risk factor Assessment :'''<br> | ||
---- | ---- | ||
❑ Assess [[HHT]] <br> ❑ Bilateral bleeding <br> ❑ [[Epistaxis]] history in Family <br> </div>|F02=Bleeding site identified?}} | ❑ Assess [[HHT]] ** <br> ❑ Bilateral [[bleeding]] <br> ❑ [[Epistaxis]] history in Family <br> </div>|F02=[[Bleeding]] site identified?}} | ||
{{familytree | | | |!| | | | | | | | | | | |,|-|-|^|-|-|.| | | }} | {{familytree | | | |!| | | | | | | | | | | |,|-|-|^|-|-|.| | | }} | ||
{{familytree | | | | G01 | | | | | | | | G03 | | | | | G04 | | | | |G01=[[Rhinoscopy]] to identify location of [[bleeding]]| G03=<div style="float: left; text-align: left; height: 7em; width: 14em; padding:1em;"> '''Yes→ Three options:'''<br> | {{familytree | | | | G01 | | | | | | | | G03 | | | | | G04 | | | | |G01=[[Rhinoscopy]] to identify location of [[bleeding]]| G03=<div style="float: left; text-align: left; height: 7em; width: 14em; padding:1em;"> '''Yes→ Three options:'''<br> | ||
Line 124: | Line 124: | ||
❑ 1= [[Lubricant]]s <br> ❑ 2= Topical [[vasoconstrictor]]s <br> ❑ 3= Nasal [[cautery]] </div>| G04=No}} | ❑ 1= [[Lubricant]]s <br> ❑ 2= Topical [[vasoconstrictor]]s <br> ❑ 3= Nasal [[cautery]] </div>| G04=No}} | ||
{{familytree | | | |,|^|-|-|-|.| | | | | |!| | | | | | |!| | | }} | {{familytree | | | |,|^|-|-|-|.| | | | | |!| | | | | | |!| | | }} | ||
{{familytree | | | H01 | | | H02 | | | | H03 | | | | | |!| | | |H01=Bleeding site Identified|H02=Bleeding site not identified| H03=Decision for Nausal [[Cautery]]? | H04= }} | {{familytree | | | H01 | | | H02 | | | | H03 | | | | | |!| | | |H01=Bleeding site Identified|H02=[[Bleeding]] site not identified| H03=Decision for Nausal [[Cautery]]? | H04= }} | ||
{{familytree | | | |!| | | | |!| | | |,|-|^|.| | | | | |!| | | | }} | {{familytree | | | |!| | | | |!| | | |,|-|^|.| | | | | |!| | | | }} | ||
{{familytree | | | I01 | | | |!| | | I02 | | I03 | | | |!| | | |I01=[[ | {{familytree | | | I01 | | | |!| | | I02 | | I03 | | | |!| | | |I01=[[Anesthesia]] [[bleeding]] site and limit Nasal [[cautery]] to site|I02=Yes→ [[Anesthesia]] [[bleeding]] site and limit Nasal [[Cautery]] to site | I03=No | I04= }} | ||
{{familytree | |,|-|^|-|.| | |!| | | |!| | | |!| | | | |!| | |}} | {{familytree | |,|-|^|-|.| | |!| | | |!| | | |!| | | | |!| | |}} | ||
{{familytree | J01 | | J02 | |!| | | |`|-|-|-|^|-|-|-| J03 | | |J01= [[Bleeding]] controlled|J02= [[Bleeding]] resume|J03=[[Rist factor]] assessment}} | {{familytree | J01 | | J02 | |!| | | |`|-|-|-|^|-|-|-| J03 | | |J01= [[Bleeding]] controlled|J02= [[Bleeding]] resume|J03=[[Rist factor]] assessment}} | ||
{{familytree | |!| | | |!| | |!| | | | | | | | | | | | |!| | | | | |}} | {{familytree | |!| | | |!| | |!| | | | | | | | | | | | |!| | | | | |}} | ||
{{familytree | |!| | | |`|-|-| K02 | | | | | | | | | | K03 | |K01=K01|K02=Suspected [[Bleeding]] site [[HHT]]** or | {{familytree | |!| | | |`|-|-| K02 | | | | | | | | | | K03 | |K01=K01|K02=Suspected [[Bleeding]] site [[HHT]] ** or on [[anticoagulant]]s?| K03=[[Patient]] education and [[prevention]] }} | ||
{{Familytree | |!| | | | | |,|-|-|^|-|-|.| | | | | | | |!| }} | {{Familytree | |!| | | | | |,|-|-|^|-|-|.| | | | | | | |!| }} | ||
{{Familytree | |!| | | | | E01 | | | | E02 | | | | | | E03 | | | | | |E01=NO→[[Non absorbable]] or [[Absorbable packing]](Preferred in children)| E02=Yes→[[Absorbable packing]]| E03=Outcome Assesment}} | {{Familytree | |!| | | | | E01 | | | | E02 | | | | | | E03 | | | | | |E01=NO→[[Non absorbable]] or [[Absorbable packing]](Preferred in children)| E02=Yes→[[Absorbable packing]]| E03=Outcome Assesment}} | ||
Line 139: | Line 139: | ||
{{Familytree | |!| | | | | G01 | | | G02 | | | | | | | |G01= [[Bleeding]] controlled| G02= [[Bleeding]] resume}} | {{Familytree | |!| | | | | G01 | | | G02 | | | | | | | |G01= [[Bleeding]] controlled| G02= [[Bleeding]] resume}} | ||
{{Familytree | |!| | | | | |!| | |,|-|^|-|-|-|.| | | | | }} | {{Familytree | |!| | | | | |!| | |,|-|^|-|-|-|.| | | | | }} | ||
{{Familytree | |!| | | | | |!| | | H03 | | | H02 | | | | | | | |H01=| H02=Patient '''doesn't use''' [[anticoagulant]] or [[antiplatelet]] medications | H03=Patient use [[anticoagulant]] or [[antiplatelet]] medications }} | {{Familytree | |!| | | | | |!| | | H03 | | | H02 | | | | | | | |H01=| H02=[[Patient]] '''doesn't use''' [[anticoagulant]] or [[antiplatelet]] [[medications]] | H03=[[Patient]] use [[anticoagulant]] or [[antiplatelet]] [[medications]] }} | ||
{{Familytree | |`|-| H01 |-|'| | |!| | | | | |!| | H01=Patient Education and [[prevention]] }} | {{Familytree | |`|-| H01 |-|'| | |!| | | | | |!| | H01=[[Patient]] Education and [[prevention]] }} | ||
{{Familytree | | | | |!| | | | | | I03 | | | |!| | |I01=I01| I02=I02| I03=[[Life treatening]] Nose [[bleeding]] ?}} | {{Familytree | | | | |!| | | | | | I03 | | | |!| | |I01=I01| I02=I02| I03=[[Life treatening]] Nose [[bleeding]] ?}} | ||
{{Familytree | | | | B01 | | | |,|-|^|-|.| | |!| | | B01=Outcome Assement }} | {{Familytree | | | | B01 | | | |,|-|^|-|.| | |!| | | B01=Outcome Assement }} | ||
{{Familytree | | | | |! | {{Familytree | | | | |!| | | | J02 | | J03 | |!| |J01=| J02=Yes→ Evaluate need for or risk of discontinuation [[Anti-Coag]]/[[Anti-Platelet]] medications | J03=No }} | ||
{{Familytree | | | | A01 | | |,|-|^|.| | |!| |!| | | | A01=Discharge }} | {{Familytree | | | | A01 | | |,|-|^|.| | |!| |!| | | | A01=Discharge }} | ||
{{Familytree | | | | | | | | K02 | | K03 |!| |!| | | |K01=K01| K02= [[Bleeding]] controled| K03= [[Bleeding]] resume }} | {{Familytree | | | | | | | | K02 | | K03 |!| |!| | | |K01=K01| K02= [[Bleeding]] controled| K03= [[Bleeding]] resume }} | ||
Line 151: | Line 151: | ||
{{Familytree | | | | | | | | |!| | | | | E02 | | | |E01=E01| E02=Appropriate intervention which may include [[embolization]], [[Surgery]], Additional [[Nasal packing]] or [[Cautery]]}} | {{Familytree | | | | | | | | |!| | | | | E02 | | | |E01=E01| E02=Appropriate intervention which may include [[embolization]], [[Surgery]], Additional [[Nasal packing]] or [[Cautery]]}} | ||
{{Familytree | | | | | | | | |!| | | | | |!| | | | | | | }} | {{Familytree | | | | | | | | |!| | | | | |!| | | | | | | }} | ||
{{Familytree | | | | | | | | |`|-|-|-|-| F01 |-|-| F02 |-|-| F03 | | | |F01=Patient Education and [[Prevention]]| F02=Outcome Assesment| F03=Discharge}} | {{Familytree | | | | | | | | |`|-|-|-|-| F01 |-|-| F02 |-|-| F03 | | | |F01=[[Patient]] Education and [[Prevention]]| F02=Outcome Assesment| F03=Discharge}} | ||
{{familytree/end}} | {{familytree/end}} | ||
* [[ABC]]= [[Airway, Breathing, Circulation]] | *'''[[ABC]]'''= [[Airway]], [[Breathing]], [[Circulation]] | ||
* [[HHT]]= [[Hereditary Hemorrhagic | *[[HHT]] = [[Hereditary Hemorrhagic Telangiectasia]] | ||
{| | {| | ||
! colspan="2" style="background:#DCDCDC;" align="center" + |This algorithm developed and modified according to Epistaxis of Emergency Medicine Clinics of North America and Clinical Practice Nosebleed (Epistaxis) Guideline. This guideline was published in the January 2020 issue of the American Academy of Otolaryngology-Head and Neck Surgery. | ! colspan="2" style="background:#DCDCDC;" align="center" + |This algorithm developed and modified according to Epistaxis of Emergency Medicine Clinics of North America and Clinical Practice Nosebleed (Epistaxis) Guideline. This guideline was published in the January 2020 issue of the American Academy of Otolaryngology-Head and Neck Surgery. | ||
|- | |- | ||
|} | |} | ||
==Do's== | ==Do's== | ||
* [[Absorbable]] packs are preferred in children because the removal of the [[nonabsorbable]] pack is difficult. | *Assess '''[[ABC]]''' <ref name="TunkelAnne2020">{{cite journal|last1=Tunkel|first1=David E.|last2=Anne|first2=Samantha|last3=Payne|first3=Spencer C.|last4=Ishman|first4=Stacey L.|last5=Rosenfeld|first5=Richard M.|last6=Abramson|first6=Peter J.|last7=Alikhaani|first7=Jacqueline D.|last8=Benoit|first8=Margo McKenna|last9=Bercovitz|first9=Rachel S.|last10=Brown|first10=Michael D.|last11=Chernobilsky|first11=Boris|last12=Feldstein|first12=David A.|last13=Hackell|first13=Jesse M.|last14=Holbrook|first14=Eric H.|last15=Holdsworth|first15=Sarah M.|last16=Lin|first16=Kenneth W.|last17=Lind|first17=Meredith Merz|last18=Poetker|first18=David M.|last19=Riley|first19=Charles A.|last20=Schneider|first20=John S.|last21=Seidman|first21=Michael D.|last22=Vadlamudi|first22=Venu|last23=Valdez|first23=Tulio A.|last24=Nnacheta|first24=Lorraine C.|last25=Monjur|first25=Taskin M.|title=Clinical Practice Guideline: Nosebleed (Epistaxis)|journal=Otolaryngology–Head and Neck Surgery|volume=162|issue=1_suppl|year=2020|pages=S1–S38|issn=0194-5998|doi=10.1177/0194599819890327}}</ref> | ||
* Before [[Nasal]] [[cautery]] [[anesthetize]] the [[bleeding]] area and limit [[cauterization]] just to the [[bleeding]] site. | |||
* Remove [[blood clot]]s before [[rhinoscopy]]. | *[[Absorbable]] packs are preferred in children because the removal of the [[nonabsorbable]] pack is difficult. | ||
* Educate patients and their [[caregiver]]s about [[preventive method]]s for [[epistaxis]]. | *Before [[Nasal]] [[cautery]] [[anesthetize]] the [[bleeding]] area and limit [[cauterization]] just to the [[bleeding]] site. | ||
*Remove [[blood clot]]s before [[rhinoscopy]]. | |||
*Educate [[patients]] and their [[caregiver]]s about [[preventive method]]s for [[epistaxis]]. | |||
==Don'ts== | ==Don'ts== | ||
* Give additional | *Discontinue [[anticoagulant]] medications or reverse [[anticoagulation]] before cost-benefit assessment.<ref name="TunkelAnne2020">{{cite journal|last1=Tunkel|first1=David E.|last2=Anne|first2=Samantha|last3=Payne|first3=Spencer C.|last4=Ishman|first4=Stacey L.|last5=Rosenfeld|first5=Richard M.|last6=Abramson|first6=Peter J.|last7=Alikhaani|first7=Jacqueline D.|last8=Benoit|first8=Margo McKenna|last9=Bercovitz|first9=Rachel S.|last10=Brown|first10=Michael D.|last11=Chernobilsky|first11=Boris|last12=Feldstein|first12=David A.|last13=Hackell|first13=Jesse M.|last14=Holbrook|first14=Eric H.|last15=Holdsworth|first15=Sarah M.|last16=Lin|first16=Kenneth W.|last17=Lind|first17=Meredith Merz|last18=Poetker|first18=David M.|last19=Riley|first19=Charles A.|last20=Schneider|first20=John S.|last21=Seidman|first21=Michael D.|last22=Vadlamudi|first22=Venu|last23=Valdez|first23=Tulio A.|last24=Nnacheta|first24=Lorraine C.|last25=Monjur|first25=Taskin M.|title=Clinical Practice Guideline: Nosebleed (Epistaxis)|journal=Otolaryngology–Head and Neck Surgery|volume=162|issue=1_suppl|year=2020|pages=S1–S38|issn=0194-5998|doi=10.1177/0194599819890327}}</ref> | ||
* After nasal [[packing]] don't educate the patient or caregiver about nasal [[packing]] sustenance. | |||
*Give additional dose of [[anticoagulant]] in active [[bleeding]]. | |||
*After nasal [[packing]] don't educate the [[patient]] or caregiver about nasal [[packing]] sustenance. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Resident survival guide]] | [[Category:Resident survival guide]] | ||
[[Category:Up-To-Date]] |
Latest revision as of 23:06, 27 October 2020
Epistaxis Resident Survival Guide |
---|
Overview |
Causes |
Diagnosis |
Treatment |
Do's |
Don'ts |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amir Behzad Bagheri, M.D.
Synonyms and keywords: Epistaxis approach, An approach to epistaxis, Nose bleeding approach
Overview
Epistaxis, also known as nose bleeding, is terminology for bleeding of the nose vessels that drain from the nostrils (most often) and/or nasopharynx. Epistaxis often stops easily but can be an ENT emergency, and may be critical if appropriate action does not occur. Kiesselbach's plexus is the source of most epistaxis.
Causes
Based on the cause and severity of Epistaxis, it can be life-threatening.[1] [2] [3]
Life Threatening Causes
Life-threatening causes of epistaxis include conditions that may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Local trauma
- Acute sinusitis
- Allergic rhinitis
- Anticoagulation
- Aspirin
- Chronic rhinitis
- Chronic sinusitis
- Barotrauma
- Cocaine
- Common cold
- Foreign bodies
- Nose-picking
- Neoplasia
There is not enough evidence that hypertension is a risk factor for epistaxis. The role of lowering blood pressure to control and prevent epistaxis remains controversial.
Diagnosis
Shown below is an algorithm summarizing the diagnosis of epistaxis according to North America Clinical Practice Guideline.[1] [4] [5] [6] [7]
Patient with Epistaxis? Take a complete medical history | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Trauma | Coagulopathy | Vascular abnormalities | Others | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Trauma is the most frequent cause of epistaxis(17%) ❑ Digital trauma ❑ Facial trauma ❑ Foreign body insertion ❑ Septal perforation ❑ Barotrauma ❑ Illicit drugs | ❑ Using Anticoagulants or Antiplatelet medications ❑ ITP* ❑ von Willebrand disease ❑ Leukemia ❑ Other medications causing coagulopathy | ❑ Sinusitis ❑ Allergies ❑ Septal deviation ❑ Neoplasia in situ ❑ Renal failure ❑ Uremia ❑ Hepatic dysfuction ❑ Idiopathic ❑ Infection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
This algorithm developed and modified according to Epistaxis of Emergency Medicine Clinics of North America and Clinical Practice Nosebleed (Epistaxis) Guideline. This guideline was published in the January 2020 issue of the American Academy of Otolaryngology-Head and Neck Surgery. |
---|
Treatment
Shown below is an algorithm summarizing the treatment of epistaxis according to The American Academy of ENT guidelines. [4] [6] [8] [9]
Patient with Epistaxis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
First assess ABC* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Need of Immediate Action? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
No | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Active Bleeding ? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Yes→Nasal compression for≥5 min | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Bleeding resume | Bleeding Controlled | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rhinoscopy to identify location of bleeding | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Bleeding site identified? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rhinoscopy to identify location of bleeding | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Bleeding site Identified | Bleeding site not identified | Decision for Nausal Cautery? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Anesthesia bleeding site and limit Nasal cautery to site | Yes→ Anesthesia bleeding site and limit Nasal Cautery to site | No | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Bleeding controlled | Bleeding resume | Rist factor assessment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Suspected Bleeding site HHT ** or on anticoagulants? | Patient education and prevention | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NO→Non absorbable or Absorbable packing(Preferred in children) | Yes→Absorbable packing | Outcome Assesment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nasal packing education | Discharge | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Bleeding controlled | Bleeding resume | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Patient use anticoagulant or antiplatelet medications | Patient doesn't use anticoagulant or antiplatelet medications | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Patient Education and prevention | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Life treatening Nose bleeding ? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Outcome Assement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Yes→ Evaluate need for or risk of discontinuation Anti-Coag/Anti-Platelet medications | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Discharge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Bleeding controled | Bleeding resume | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Evaluate candidency for embolization or surgical arterial ligation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Appropriate intervention which may include embolization, Surgery, Additional Nasal packing or Cautery | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Patient Education and Prevention | Outcome Assesment | Discharge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
This algorithm developed and modified according to Epistaxis of Emergency Medicine Clinics of North America and Clinical Practice Nosebleed (Epistaxis) Guideline. This guideline was published in the January 2020 issue of the American Academy of Otolaryngology-Head and Neck Surgery. |
---|
Do's
- Absorbable packs are preferred in children because the removal of the nonabsorbable pack is difficult.
- Before Nasal cautery anesthetize the bleeding area and limit cauterization just to the bleeding site.
- Remove blood clots before rhinoscopy.
- Educate patients and their caregivers about preventive methods for epistaxis.
Don'ts
- Discontinue anticoagulant medications or reverse anticoagulation before cost-benefit assessment.[4]
- Give additional dose of anticoagulant in active bleeding.
- After nasal packing don't educate the patient or caregiver about nasal packing sustenance.
References
- ↑ 1.0 1.1 Krulewitz, Neil Alexander; Fix, Megan Leigh (2019). "Epistaxis". Emergency Medicine Clinics of North America. 37 (1): 29–39. doi:10.1016/j.emc.2018.09.005. ISSN 0733-8627.
- ↑ Douglas, Richard; Wormald, Peter-John (2007). "Update on epistaxis". Current Opinion in Otolaryngology & Head and Neck Surgery. 15 (3): 180–183. doi:10.1097/MOO.0b013e32814b06ed. ISSN 1068-9508.
- ↑ Kikidis, D.; Tsioufis, K.; Papanikolaou, V.; Zerva, K.; Hantzakos, A. (2013). "Is epistaxis associated with arterial hypertension? A systematic review of the literature". European Archives of Oto-Rhino-Laryngology. 271 (2): 237–243. doi:10.1007/s00405-013-2450-z. ISSN 0937-4477.
- ↑ 4.0 4.1 4.2 4.3 Tunkel, David E.; Anne, Samantha; Payne, Spencer C.; Ishman, Stacey L.; Rosenfeld, Richard M.; Abramson, Peter J.; Alikhaani, Jacqueline D.; Benoit, Margo McKenna; Bercovitz, Rachel S.; Brown, Michael D.; Chernobilsky, Boris; Feldstein, David A.; Hackell, Jesse M.; Holbrook, Eric H.; Holdsworth, Sarah M.; Lin, Kenneth W.; Lind, Meredith Merz; Poetker, David M.; Riley, Charles A.; Schneider, John S.; Seidman, Michael D.; Vadlamudi, Venu; Valdez, Tulio A.; Nnacheta, Lorraine C.; Monjur, Taskin M. (2020). "Clinical Practice Guideline: Nosebleed (Epistaxis)". Otolaryngology–Head and Neck Surgery. 162 (1_suppl): S1–S38. doi:10.1177/0194599819890327. ISSN 0194-5998.
- ↑ Thornton, M A.; Mahesh, B N.; Lang, J (2005). "Posterior Epistaxis: Identification of Common Bleeding Sites". The Laryngoscope. 115 (4): 588–590. doi:10.1097/01.mlg.0000161365.96685.6c. ISSN 0023-852X.
- ↑ 6.0 6.1 Chaaban, Mohamad R.; Zhang, Dong; Resto, Vicente; Goodwin, James S. (2016). "Demographic, Seasonal, and Geographic Differences in Emergency Department Visits for Epistaxis". Otolaryngology–Head and Neck Surgery. 156 (1): 81–86. doi:10.1177/0194599816667295. ISSN 0194-5998.
- ↑ Viehweg, Tate L.; Roberson, John B.; Hudson, J.W. (2006). "Epistaxis: Diagnosis and Treatment". Journal of Oral and Maxillofacial Surgery. 64 (3): 511–518. doi:10.1016/j.joms.2005.11.031. ISSN 0278-2391.
- ↑ Béquignon, E; Teissier, N; Gauthier, A; Brugel, L; De Kermadec, H; Coste, A; Prulière-Escabasse, V (2017). "Emergency Department care of childhood epistaxis". Emergency Medicine Journal. 34 (8): 543–548. doi:10.1136/emermed-2015-205528. ISSN 1472-0205.
- ↑ Escabasse, V.; Bequignon, E.; Vérillaud, B.; Robard, L.; Michel, J.; Malard, O.; Crampette, L.; Malard, O.; Crampette, L.; Achache, M.; Alaoui Lamrani, M.Y.; Ardillon, L.; Babin, E.; Bal Dit Sollier, C.; Bequignon, E.; Borsik, M.; Castillo, L.; Coste, A.; Debry, C.; Dessi, P.; Drouet, L.; Dufour, X.; Dupuis-Girod, S.; Faure, F.; Gallet, P.; Guldman, R.; Houdart, E.; Jankowski, R.; Jegoux, F.; Leble, S.; Michel, J.; Mortuaire, G.; Mouchon, E.; Page, C.; Pruliere Escabasse, V.; Robard, L.; Roux, A.; Saint Maurice, J.P.; Sarlon, G.; Strunski, V.; Trevillot, V.; Verillaud, B.; Vironneau, P. (2017). "Guidelines of the French Society of Otorhinolaryngology (SFORL). Managing epistaxis under coagulation disorder due to antithrombotic therapy". European Annals of Otorhinolaryngology, Head and Neck Diseases. 134 (3): 195–199. doi:10.1016/j.anorl.2016.10.001. ISSN 1879-7296.