Failure to thrive pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
*The most common cause of failure to thrive is inadequate calorie intake. <ref name="pmid8298353">{{cite journal| author=Marcovitch H| title=Failure to thrive. | journal=BMJ | year= 1994 | volume= 308 | issue= 6920 | pages= 35-8 | pmid=8298353 | doi=10.1136/bmj.308.6920.35 | pmc=2539114 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8298353 }} </ref> | *The most common cause of failure to thrive is inadequate calorie intake. <ref name="pmid8298353">{{cite journal| author=Marcovitch H| title=Failure to thrive. | journal=BMJ | year= 1994 | volume= 308 | issue= 6920 | pages= 35-8 | pmid=8298353 | doi=10.1136/bmj.308.6920.35 | pmc=2539114 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8298353 }} </ref> | ||
* This may be secondary to psychological causes, poor environmental status, poor calorie absorption and underlying medical conditions that cause excessive energy expenditure. | * This may be secondary to psychological causes, poor environmental status, poor calorie absorption and underlying medical conditions that cause excessive energy expenditure. <ref name="pmid27353148">{{cite journal| author=Goh LH, How CH, Ng KH| title=Failure to thrive in babies and toddlers. | journal=Singapore Med J | year= 2016 | volume= 57 | issue= 6 | pages= 287-91 | pmid=27353148 | doi=10.11622/smedj.2016102 | pmc=4971446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27353148 }} </ref> | ||
*The pathophysiology of failure to thrive is a culmination of environmental, psychological, pathological and nutritional factors. | *The pathophysiology of failure to thrive is a culmination of environmental, psychological, pathological and nutritional factors. | ||
*In terms of the pathophysiology, failure to thrive is a contributing rather than an exclusive cause of the patient’s over all condition. | *In terms of the pathophysiology, failure to thrive is a contributing rather than an exclusive cause of the patient’s over all condition. | ||
**A healthy, disease free, stressor-free, clean environment should be maintained for adequate growth of the child. Absence of this contributes to failure to thrive. | **A healthy, disease free, stressor-free, clean environment should be maintained for adequate growth of the child. Absence of this contributes to failure to thrive. <ref name="pmid13678136">{{cite journal| author=Krugman SD, Dubowitz H| title=Failure to thrive. | journal=Am Fam Physician | year= 2003 | volume= 68 | issue= 5 | pages= 879-84 | pmid=13678136 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13678136 }} </ref> | ||
**Increased parental conflict, decreased discipline where feeding techniques are concerned, poor education, separation, emotional deprivation, use of alcohol, tobacco or illicit drugs are psychological contributors to failure to thrive. | **Increased parental conflict, decreased discipline where feeding techniques are concerned, poor education, separation, emotional deprivation, use of alcohol, tobacco or illicit drugs are psychological contributors to failure to thrive. | ||
*It is beyond the scope of this page to explain the pathophysiology of every organic cause. | *It is beyond the scope of this page to explain the pathophysiology of every organic cause.<ref name="pmid23604606">{{cite journal| author=Nangia S, Tiwari S| title=Failure to thrive. | journal=Indian J Pediatr | year= 2013 | volume= 80 | issue= 7 | pages= 585-9 | pmid=23604606 | doi=10.1007/s12098-013-1003-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23604606 }} </ref> | ||
*However, malabsorption syndromes, cystic fibrosis, pancreatic insufficiency, malignancies, congenital heart disease, immunodeficiencies causing recurrent infections, intestinal obstructions and chronic respiratory disease are some common organic pathologies that cause either impaired calorie absorption or increased calorie demand. | *However, malabsorption syndromes, cystic fibrosis, pancreatic insufficiency, malignancies, congenital heart disease, immunodeficiencies causing recurrent infections, intestinal obstructions and chronic respiratory disease are some common organic pathologies that cause either impaired calorie absorption or increased calorie demand. | ||
*But irrespective of the cause, all patients have one thing in common, a treatment strategy which is based on calorie catch up growth and a subsequent prolonged follow up period. | *But irrespective of the cause, all patients have one thing in common, a treatment strategy which is based on calorie catch up growth and a subsequent prolonged follow up period. | ||
Latest revision as of 01:31, 24 September 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akash Daswaney, M.B.B.S[2]
Overview
The most common cause of failure to thrive is inadequate calorie intake. This may be secondary to psychological causes, poor environmental status, poor calorie absorption and underlying medical conditions that cause excessive energy expenditure.
Pathophysiology
- The most common cause of failure to thrive is inadequate calorie intake. [1]
- This may be secondary to psychological causes, poor environmental status, poor calorie absorption and underlying medical conditions that cause excessive energy expenditure. [2]
- The pathophysiology of failure to thrive is a culmination of environmental, psychological, pathological and nutritional factors.
- In terms of the pathophysiology, failure to thrive is a contributing rather than an exclusive cause of the patient’s over all condition.
- A healthy, disease free, stressor-free, clean environment should be maintained for adequate growth of the child. Absence of this contributes to failure to thrive. [3]
- Increased parental conflict, decreased discipline where feeding techniques are concerned, poor education, separation, emotional deprivation, use of alcohol, tobacco or illicit drugs are psychological contributors to failure to thrive.
- It is beyond the scope of this page to explain the pathophysiology of every organic cause.[4]
- However, malabsorption syndromes, cystic fibrosis, pancreatic insufficiency, malignancies, congenital heart disease, immunodeficiencies causing recurrent infections, intestinal obstructions and chronic respiratory disease are some common organic pathologies that cause either impaired calorie absorption or increased calorie demand.
- But irrespective of the cause, all patients have one thing in common, a treatment strategy which is based on calorie catch up growth and a subsequent prolonged follow up period.
- It is a learning process for the parents and emotions may get the better of them initially. Slow, apathetic babies may be ignored whereas voraciously feeding small for gestational ages may be handled aggressively as they are anxiety/tension provoking.
References
- ↑ Marcovitch H (1994). "Failure to thrive". BMJ. 308 (6920): 35–8. doi:10.1136/bmj.308.6920.35. PMC 2539114. PMID 8298353.
- ↑ Goh LH, How CH, Ng KH (2016). "Failure to thrive in babies and toddlers". Singapore Med J. 57 (6): 287–91. doi:10.11622/smedj.2016102. PMC 4971446. PMID 27353148.
- ↑ Krugman SD, Dubowitz H (2003). "Failure to thrive". Am Fam Physician. 68 (5): 879–84. PMID 13678136.
- ↑ Nangia S, Tiwari S (2013). "Failure to thrive". Indian J Pediatr. 80 (7): 585–9. doi:10.1007/s12098-013-1003-1. PMID 23604606.