Immune Thrombocytopenia causes: Difference between revisions
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{{ | {{Immune Thrombocytopenia}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{Maryam}} | ||
==Overview== | ==Overview== | ||
Disease name] may be caused by [cause1], [cause2], or [cause3]. | Disease name] may be caused by [cause1], [cause2], or [cause3]. | ||
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OR | OR | ||
Common causes of [disease] include [ | Immune thrombocytopenia has been classified to two groups; Primary or Secondary. Common causes of secondary ITP include [[SLE]], [[antiphospholipid syndrome]], [[infectious disease]] and thyroid disease. There are also some less common cause which include [[Evans syndrome]] and [[lymphoproliferative disease]]. | ||
OR | OR | ||
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==Cause[[inflammatory bowel disease|s]]== | ==Cause[[inflammatory bowel disease|s]]== | ||
* | *Immune thrombocytopenia include primary and secondary. | ||
*The cause of Primary immune thrombocytopenia is unknown. It occurs by autoantibodies binding to platelet surface then captured and destructed by [[macrophages]] in [[spleen]] and [[liver]]. | |||
===Common Causes=== | ===Common Causes=== | ||
Common causes of | Common causes of secondary immune thrombocytopenia may include: | ||
*[[systemic lupus erythematous]] | |||
*[[antiphospholipid syndrome]] | |||
*Thyroid disease ( [[hypothyroidism]], [[hyperthyroidism]], [[immune Thyroid disease]]) | |||
*[[Drug induced thrombocytopenia]] ( such as [[Heparin induced thrombocytopenia]]) | |||
*[[Infectious disease]] ([[Human Immunodeficiency Virus (HIV)|HIV]], [[HCV infection|HCV]], [[Helicobacter pylori]] ) | |||
===Less Common Causes=== | |||
Less common causes of [disease name] include: | |||
*[ | *Evans syndrome ([[immune anemia]] , immune thrombocytopenia and [[immune neutropenia]]) | ||
*[ | *[[Posttransfusion purpura]] ( In caucasian woman within 7 days of blood product transfusion due to developing [[antibody]] against HPA1b [[epitope]].) | ||
*[[Lymphoproliferative disease]] ( [[Chronic lymphocytic leukemia|CLL]] (difficult to distinguish from [[Bone marrow|marrow]] infiltration and [[splenomegaly]]), [[Large granular lymphocytic leukemia]] (clonal sequestration of [[Megakaryocytes|megakaryocytic]].) and [[Hodgkin lymphoma]].)<ref name="CinesLiebman2009">{{cite journal|last1=Cines|first1=Douglas B.|last2=Liebman|first2=Howard|last3=Stasi|first3=Roberto|title=Pathobiology of Secondary Immune Thrombocytopenia|journal=Seminars in Hematology|volume=46|year=2009|pages=S2–S14|issn=00371963|doi=10.1053/j.seminhematol.2008.12.005}}</ref><div style="-moz-column-count:3; column-count:3;"> | |||
==References== | ==References== | ||
Latest revision as of 17:37, 8 February 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Barkhordarian, M.D.[2]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Immune thrombocytopenia has been classified to two groups; Primary or Secondary. Common causes of secondary ITP include SLE, antiphospholipid syndrome, infectious disease and thyroid disease. There are also some less common cause which include Evans syndrome and lymphoproliferative disease.
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
- Immune thrombocytopenia include primary and secondary.
- The cause of Primary immune thrombocytopenia is unknown. It occurs by autoantibodies binding to platelet surface then captured and destructed by macrophages in spleen and liver.
Common Causes
Common causes of secondary immune thrombocytopenia may include:
- systemic lupus erythematous
- antiphospholipid syndrome
- Thyroid disease ( hypothyroidism, hyperthyroidism, immune Thyroid disease)
- Drug induced thrombocytopenia ( such as Heparin induced thrombocytopenia)
- Infectious disease (HIV, HCV, Helicobacter pylori )
Less Common Causes
Less common causes of [disease name] include:
- Evans syndrome (immune anemia , immune thrombocytopenia and immune neutropenia)
- Posttransfusion purpura ( In caucasian woman within 7 days of blood product transfusion due to developing antibody against HPA1b epitope.)
- Lymphoproliferative disease ( CLL (difficult to distinguish from marrow infiltration and splenomegaly), Large granular lymphocytic leukemia (clonal sequestration of megakaryocytic.) and Hodgkin lymphoma.)[1]
References
- ↑ Cines, Douglas B.; Liebman, Howard; Stasi, Roberto (2009). "Pathobiology of Secondary Immune Thrombocytopenia". Seminars in Hematology. 46: S2–S14. doi:10.1053/j.seminhematol.2008.12.005. ISSN 0037-1963.