Third degree AV block laboratory findings: Difference between revisions

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{{Third degree AV block}}
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{{CMG}}; {{AE}} {{Soroush}} {{RT}}
{{CMG}}; {{AE}} {{Sara.Zand}} {{Soroush}} {{RT}}


==Overview==
==Overview==
Laboratory studies are warranted to diagnose etiologies of secondary heart block such as infections (either bacterial or viral), [[drug toxicity]], and electrolyte abnormalities, and to screen for coincident problems that might either cause or exacerbate a previously presented compensated heart block.
There is not any recommendation about routine laboratory tests in [[patients]] presented with [[bradycardia]] or [[conduction disorder]]. However, in suspicion of the underlying causes of [[bradycardia]] including [[sepsis]], [[rheumatologic disorder]], or [[thyroid disease]] specific tests are warranted.


==Laboratory Findings==
==Laboratory Findings==


 
*Laboratory tests in [[patients]] with [[bradycardia]] or conduction disorder based on the underlying cause may include:
 
* [[Thyroid function test]] in suspicion of [[hypothyroidism]]
* [[Lyme]] titer  in acute [[Lyme]] carditis in a young [[person]] who develops [[atrioventricular block]] in an [[endemic]] area
* [[ Potassium]] level, [[PH]] in [[patients]] with [[renal insufficiency]]
* [[Blood]] [[digoxin]] level in [[patients]] suspected [[digoxin]] overdose
{| class="wikitable"
{| class="wikitable"
|-
|-
| Colspan="1" style="text-align:center; background:LemonChiffon"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
| Colspan="1" style="text-align:center; background:LemonChiffon"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
|-
|-
| Bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''1''' [[Thyroid function tests]], [[Lyme]] titer, [[potassium]], pH)based on clinical suspicion for a potential underlying cause should be tested in [[patients]] with [[bradycardia]]'' ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence C]])<nowiki>"</nowiki>''
| Bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''1''' [[Thyroid function tests]], [[Lyme]] titer, [[potassium]], pH) based on clinical suspicion for a potential underlying cause is recommended in [[patients]] with [[bradycardia]]'' ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence C]])<nowiki>"</nowiki>''
|}
|}
 
<ref name="KusumotoSchoenfeld2019">{{cite journal|last1=Kusumoto|first1=Fred M.|last2=Schoenfeld|first2=Mark H.|last3=Barrett|first3=Coletta|last4=Edgerton|first4=James R.|last5=Ellenbogen|first5=Kenneth A.|last6=Gold|first6=Michael R.|last7=Goldschlager|first7=Nora F.|last8=Hamilton|first8=Robert M.|last9=Joglar|first9=José A.|last10=Kim|first10=Robert J.|last11=Lee|first11=Richard|last12=Marine|first12=Joseph E.|last13=McLeod|first13=Christopher J.|last14=Oken|first14=Keith R.|last15=Patton|first15=Kristen K.|last16=Pellegrini|first16=Cara N.|last17=Selzman|first17=Kimberly A.|last18=Thompson|first18=Annemarie|last19=Varosy|first19=Paul D.|title=2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society|journal=Circulation|volume=140|issue=8|year=2019|issn=0009-7322|doi=10.1161/CIR.0000000000000628}}</ref>
 
 
 
 
 
 
 
 
 
There are plenty of diagnostic laboratory findings associated with [[third degree AV block]]. Laboratory studies are warranted to diagnose etiologies of secondary heart block such as infections (either bacterial or viral), [[drug toxicity]], and electrolyte abnormalities, and to screen for coincident problems that might either cause or exacerbate a previously presented compensated heart block.
 
Primary lab work up of patients with [[third degree AV block]] might include but not limitted to the followings:
 
*[[Complete blood count]] - may reveal [[anemia]] (low RBC count), [[infection]] ([[leukocytosis]] is seen in [[myocarditis]], [[acute rheumatic fever]] and viral infections)
* Differential count
* Serum electrolytes: Particularely [[hyperkalemia]]  and magnesium spescially in selected patients such as those with [[renal insufficiency]]
*[[PT]] and [[aPTT]] may be ordered routinely
* Blood [[Digoxin]] levels should be measured in case of [[digoxin overdose]]
* Myocarditis related studies - HIV serologies, Lyme serology, Chagas serology, enterovirus PCR, adenovirus [[PCR]]
* Peripheral blood smears can aid in the diagnosis of hematological disorders like [[thalassemia major]], [[Hodgkins lymphoma]] etc.,
*In patients with concerning history, toxicological studies for [[digoxin]]-like compounds such as:
:*lily of the valley
:*Oleander
:*Foxglove
:*Bufonidae toads
 
* Cardiac enzyme levels: if history or [[ECG]] findings are suggestive of active coronary artery disease.


==References==
==References==

Latest revision as of 05:33, 2 July 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Soroush Seifirad, M.D.[3] Raviteja Guddeti, M.B.B.S. [4]

Overview

There is not any recommendation about routine laboratory tests in patients presented with bradycardia or conduction disorder. However, in suspicion of the underlying causes of bradycardia including sepsis, rheumatologic disorder, or thyroid disease specific tests are warranted.

Laboratory Findings

Class IIa
"1 Thyroid function tests, Lyme titer, potassium, pH) based on clinical suspicion for a potential underlying cause is recommended in patients with bradycardia (Level of Evidence C)"

[1]

References

  1. Kusumoto, Fred M.; Schoenfeld, Mark H.; Barrett, Coletta; Edgerton, James R.; Ellenbogen, Kenneth A.; Gold, Michael R.; Goldschlager, Nora F.; Hamilton, Robert M.; Joglar, José A.; Kim, Robert J.; Lee, Richard; Marine, Joseph E.; McLeod, Christopher J.; Oken, Keith R.; Patton, Kristen K.; Pellegrini, Cara N.; Selzman, Kimberly A.; Thompson, Annemarie; Varosy, Paul D. (2019). "2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society". Circulation. 140 (8). doi:10.1161/CIR.0000000000000628. ISSN 0009-7322.


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