Amyotrophic lateral sclerosis classification: Difference between revisions

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==Classification==
==Classification==


*"Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors.  Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals.
*'''Familial ALS''' accounts for approximately 5%-10% of all ALS cases and is caused due to genetic factors.
*Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component.
*'''Sporadic ALS''' accounts for the remaining 90%-95% of ALS with no known cause.  
*A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam.


==Guamanian ALS==
<br />
There was a high incidence of this rare form of ALS from the 1940s to the 1960's, and during this time, the rates of ALS increased to 50-100 times of its incidence prior to this time. The incidence of Guamanian ALS has dropped significantly since the 1960's, but during it's peak, it killed more than 10% of the native Chamorro people of Guam.
<ref name="pmid30207670">{{cite journal| author=Hulisz D| title=Amyotrophic lateral sclerosis: disease state overview. | journal=Am J Manag Care | year= 2018 | volume= 24 | issue= 15 Suppl | pages= S320-S326 | pmid=30207670 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30207670  }} </ref>
 
===Parkinson's and Alzheimers Association===
Unique to the Guamanian form of ALS, it is associated with the development of [[cognitive]] symptoms similar to those seen in [[Parkinson's disease]] and [[Alzheimer's disease]]. Other forms of ALS tend to only effect the nerves which control the motor function, and do not affect the [[brain]] and the mental function.
 
===Non-filtered Drinking Water===
Researchers believe that there are algae and [[bacteria]] found in large quantities in areas of Guam, that produce powerful [[neurotoxin]]s during particular times of the year. Prior to the 1960's, the drinking water was not filtered, and therefore people may have consumed high amounts of these [[toxins]] and subsequently developed ALS.
 
===Food Toxins===
People in Guam consumed a lot of flour made with the cycad plant, a plant which resembles the palm tree. This plant has nuts and seeds which do contain a powerful neurotoxin. Another source could be the fact that bats in the area consume a lot of the fruit from the cycad plant, and bat meat was consumed by the native people. The incidence of gaumanian ALS dropped as the native people stopped consuming bat meat.
 
===Genetic Susceptibility===
The native persons of Guam have been found to carry mutations in their [[gene]]s which make them more susceptible to Guamanian ALS. Studies done in Chamarro families show specific genes that may be effected, and lead to the development of ALS.


==References==
==References==

Latest revision as of 11:34, 2 July 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]Mohamadmostafa Jahansouz M.D.[3]

Overview

ALS is classified into two sub-groups: Familial ALS and Sporadic ALS.

Classification

  • Familial ALS accounts for approximately 5%-10% of all ALS cases and is caused due to genetic factors.
  • Sporadic ALS accounts for the remaining 90%-95% of ALS with no known cause.


[1]

References

  1. ↑ Hulisz D (2018). "Amyotrophic lateral sclerosis: disease state overview". Am J Manag Care. 24 (15 Suppl): S320–S326. PMID 30207670.

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