Primary ciliary dyskinesia screening: Difference between revisions
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==Overview== | ==Overview== | ||
There is insufficient evidence to recommend routine screening for [ | There is insufficient [[evidence]] to recommend routine [[screening]] for primary ciliary dyskinesia, however patients with persistent [[sinusitis]], [[rhinitis]], and no known [[etiology]] should be screened by [[Nitric oxide|nasal nitric oxide test]], low levels of nasal [[nitric oxide]] is diagnostic of primary ciliary dyskinesia and should prompt further testing with [[biopsy]] and ciliary beat pattern(CBP). | ||
==Screening== | ==Screening== | ||
There is insufficient evidence to recommend routine screening for [ | There is insufficient evidence to recommend routine [[screening]] for [[primary ciliary dyskinesia]], however patients with persistent [[sinusitis]], [[rhinitis]], and no known [[etiology]] should be screened by nasal [[nitric oxide]] test, low levels of nasal [[nitric oxide]] is [[diagnostic]] of primary ciliary dyskinesia and should prompt further testing with [[biopsy]] and ciliary beat pattern(CBP). | ||
*Nasal nitric oxide test is more reliable in children above 5 years old and in adults because of difficult techniques and interpretation. | |||
*Saccharine test is performed to assess transport in the nose and [[mucociliary clearance]].<ref name="pmid/10.1080/01913120590951220">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=/10.1080/01913120590951220 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Latest revision as of 12:48, 23 September 2021
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Primary ciliary dyskinesia Microchapters |
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Differentiating Primary ciliary dyskinesia from other Diseases |
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Primary ciliary dyskinesia screening On the Web |
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Risk calculators and risk factors for Primary ciliary dyskinesia screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]
Overview
There is insufficient evidence to recommend routine screening for primary ciliary dyskinesia, however patients with persistent sinusitis, rhinitis, and no known etiology should be screened by nasal nitric oxide test, low levels of nasal nitric oxide is diagnostic of primary ciliary dyskinesia and should prompt further testing with biopsy and ciliary beat pattern(CBP).
Screening
There is insufficient evidence to recommend routine screening for primary ciliary dyskinesia, however patients with persistent sinusitis, rhinitis, and no known etiology should be screened by nasal nitric oxide test, low levels of nasal nitric oxide is diagnostic of primary ciliary dyskinesia and should prompt further testing with biopsy and ciliary beat pattern(CBP).
- Nasal nitric oxide test is more reliable in children above 5 years old and in adults because of difficult techniques and interpretation.
- Saccharine test is performed to assess transport in the nose and mucociliary clearance.[1]
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID /10.1080/01913120590951220 Check
|pmid=value (help).