Rift valley fever laboratory findings: Difference between revisions
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{{CMG}}{{AE}} {{AAH}} | {{CMG}}{{AE}} {{AAH}} | ||
==Overview== | ==Overview== | ||
Laboratory investigations are required for diagnosis of [[Rift valley fever]] and to observe [[hemoglobin]], [[bilirubin]] and blood [[coagulation]] profiles. | |||
==Lab Findings== | ==Lab Findings== | ||
*The main purpose is to detect the virus in the blood, which can be accomplished by a few tests. | *The main purpose is to detect the virus in the blood, which can be accomplished by a few tests. | ||
*[[Reverse transcription polymerase chain reaction|RT-PCR]] (reverse transcriptase-polymerase chain reaction) and [[Enzyme linked immunosorbent assay (ELISA)|ELISA test]] (for [[Antigen|antigen]] detection) may be used during the initial phase of the illness. | *[[Reverse transcription polymerase chain reaction|RT-PCR]] (reverse transcriptase-polymerase chain reaction) and [[Enzyme linked immunosorbent assay (ELISA)|ELISA test]] (for [[Antigen|antigen]] detection) may be used during the initial phase of the illness.<ref>Hartman A. Rift Valley Fever. Clin Lab Med. 2017;37(2):285-301. doi:10.1016/j.cll.2017.01.004</ref> | ||
*[[Immunoglobulin M|IgM]] Antibodies : Once the viral load decreases in the blood, IgM antibody tests are helpful in detecting the presence of ongoing [[Infection|infection]]. | *[[Immunoglobulin M|IgM]] Antibodies : Once the viral load decreases in the blood, IgM antibody tests are helpful in detecting the presence of ongoing [[Infection|infection]]. | ||
*[[Immunoglobulin G|IgG]] Antibodies : In recovered cases, testing for IgG antibodies aid in identifying cases who may have had a recent episode of RVF. | *[[Immunoglobulin G|IgG]] Antibodies : In recovered cases, testing for IgG antibodies aid in identifying cases who may have had a recent episode of RVF. | ||
Latest revision as of 16:01, 17 July 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Aakash Hans, MD[2]
Overview
Laboratory investigations are required for diagnosis of Rift valley fever and to observe hemoglobin, bilirubin and blood coagulation profiles.
Lab Findings
- The main purpose is to detect the virus in the blood, which can be accomplished by a few tests.
- RT-PCR (reverse transcriptase-polymerase chain reaction) and ELISA test (for antigen detection) may be used during the initial phase of the illness.[1]
- IgM Antibodies : Once the viral load decreases in the blood, IgM antibody tests are helpful in detecting the presence of ongoing infection.
- IgG Antibodies : In recovered cases, testing for IgG antibodies aid in identifying cases who may have had a recent episode of RVF.
- In majority of cases, lab findings will not be significant for anything else except fever and low blood pressure.
- Low hemoglobin levels, raised bilirubin levels along with deranged blood coagulation profile and decreased platelet counts are seen in hemorrhagic RVF.
- Increased leukocytes in CSF along with presence of viral load in CSF would indicate encephalitis or meningitis due to RVF.
References
- ↑ Hartman A. Rift Valley Fever. Clin Lab Med. 2017;37(2):285-301. doi:10.1016/j.cll.2017.01.004