Bipolar disorder electrocardiogram: Difference between revisions
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==Overview== | ==Overview== | ||
There are no ECG findings associated with Bipolar disorder. The use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range.<br /> | There are no ECG findings associated with Bipolar disorder. The use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range. ECG is important before starting lithium or tricyclic antidepressant therapy.<br /> | ||
==Electrocardiogram== | ==Electrocardiogram== | ||
* There are no ECG findings associated with Bipolar disorder. | *There are no ECG findings associated with Bipolar disorder. | ||
* Reduced vagal tone and higher levels of inflammatory biomarkers may distinguish Bipolar disorder from major depression and reveal an underlying pathophysiology of depression involving ANS dysfunction and chronic immune system dys-regulation.<ref name="HageBritton2017">{{cite journal|last1=Hage|first1=Brandon|last2=Britton|first2=Briana|last3=Daniels|first3=David|last4=Heilman|first4=Keri|last5=Porges|first5=Stephen W.|last6=Halaris|first6=Angelos|title=Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression|journal=The World Journal of Biological Psychiatry|volume=20|issue=5|year=2017|pages=359–367|issn=1562-2975|doi=10.1080/15622975.2017.1376113}}</ref> | *Reduced vagal tone and higher levels of inflammatory biomarkers may distinguish Bipolar disorder from major depression and reveal an underlying pathophysiology of depression involving ANS dysfunction and chronic immune system dys-regulation.<ref name="HageBritton2017">{{cite journal|last1=Hage|first1=Brandon|last2=Britton|first2=Briana|last3=Daniels|first3=David|last4=Heilman|first4=Keri|last5=Porges|first5=Stephen W.|last6=Halaris|first6=Angelos|title=Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression|journal=The World Journal of Biological Psychiatry|volume=20|issue=5|year=2017|pages=359–367|issn=1562-2975|doi=10.1080/15622975.2017.1376113}}</ref> | ||
* In the study, patients with bipolar disorder had higher blood levels of inflammation biomarkers than patients with major depression.<ref name="HageBritton20172">{{cite journal|last1=Hage|first1=Brandon|last2=Britton|first2=Briana|last3=Daniels|first3=David|last4=Heilman|first4=Keri|last5=Porges|first5=Stephen W.|last6=Halaris|first6=Angelos|title=Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression|journal=The World Journal of Biological Psychiatry|volume=20|issue=5|year=2017|pages=359–367|issn=1562-2975|doi=10.1080/15622975.2017.1376113}}</ref> | *In the study, patients with bipolar disorder had higher blood levels of inflammation biomarkers than patients with major depression.<ref name="HageBritton20172">{{cite journal|last1=Hage|first1=Brandon|last2=Britton|first2=Briana|last3=Daniels|first3=David|last4=Heilman|first4=Keri|last5=Porges|first5=Stephen W.|last6=Halaris|first6=Angelos|title=Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression|journal=The World Journal of Biological Psychiatry|volume=20|issue=5|year=2017|pages=359–367|issn=1562-2975|doi=10.1080/15622975.2017.1376113}}</ref> | ||
* The use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range.<ref name="AltinbasGuloksuz2014">{{cite journal|last1=Altinbas|first1=Kursat|last2=Guloksuz|first2=Sinan|last3=Caglar|first3=Ilker Murat|last4=Caglar|first4=Fatma Nihan Turhan|last5=Kurt|first5=Erhan|last6=Oral|first6=Esat Timucin|title=Electrocardiography changes in bipolar patients during long-term lithium monotherapy|journal=General Hospital Psychiatry|volume=36|issue=6|year=2014|pages=694–697|issn=01638343|doi=10.1016/j.genhosppsych.2014.07.001}}</ref> | *The use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range. TCA and some of the anti-psychotics, can affect the heart and cause conduction problems. In older patients with bipolar disorder, on lithium or tricyclic antidepressant therapy, ECG is important before starting these medications .<ref name="AltinbasGuloksuz2014">{{cite journal|last1=Altinbas|first1=Kursat|last2=Guloksuz|first2=Sinan|last3=Caglar|first3=Ilker Murat|last4=Caglar|first4=Fatma Nihan Turhan|last5=Kurt|first5=Erhan|last6=Oral|first6=Esat Timucin|title=Electrocardiography changes in bipolar patients during long-term lithium monotherapy|journal=General Hospital Psychiatry|volume=36|issue=6|year=2014|pages=694–697|issn=01638343|doi=10.1016/j.genhosppsych.2014.07.001}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 13:20, 26 July 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nuha Al-Howthi, MD[2]
Overview
There are no ECG findings associated with Bipolar disorder. The use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range. ECG is important before starting lithium or tricyclic antidepressant therapy.
Electrocardiogram
- There are no ECG findings associated with Bipolar disorder.
- Reduced vagal tone and higher levels of inflammatory biomarkers may distinguish Bipolar disorder from major depression and reveal an underlying pathophysiology of depression involving ANS dysfunction and chronic immune system dys-regulation.[1]
- In the study, patients with bipolar disorder had higher blood levels of inflammation biomarkers than patients with major depression.[2]
- The use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range. TCA and some of the anti-psychotics, can affect the heart and cause conduction problems. In older patients with bipolar disorder, on lithium or tricyclic antidepressant therapy, ECG is important before starting these medications .[3]
References
- ↑ Hage, Brandon; Britton, Briana; Daniels, David; Heilman, Keri; Porges, Stephen W.; Halaris, Angelos (2017). "Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression". The World Journal of Biological Psychiatry. 20 (5): 359–367. doi:10.1080/15622975.2017.1376113. ISSN 1562-2975.
- ↑ Hage, Brandon; Britton, Briana; Daniels, David; Heilman, Keri; Porges, Stephen W.; Halaris, Angelos (2017). "Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression". The World Journal of Biological Psychiatry. 20 (5): 359–367. doi:10.1080/15622975.2017.1376113. ISSN 1562-2975.
- ↑ Altinbas, Kursat; Guloksuz, Sinan; Caglar, Ilker Murat; Caglar, Fatma Nihan Turhan; Kurt, Erhan; Oral, Esat Timucin (2014). "Electrocardiography changes in bipolar patients during long-term lithium monotherapy". General Hospital Psychiatry. 36 (6): 694–697. doi:10.1016/j.genhosppsych.2014.07.001. ISSN 0163-8343.