Alcoholic hepatitis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The most frequent [[laboratory findings]] of [[Alcoholic hepatitis]] include [[neutrophilic]] [[leukocytosis]] with [[bandemia]],[[anemia ]],[[AST]]/[[ALT]] [[ratio]] greater than 2, | The most frequent [[laboratory findings]] of [[Alcoholic hepatitis]] include [[neutrophilic]] [[leukocytosis]] with [[bandemia]],[[anemia ]],[[AST]]/[[ALT]] [[ratio]] greater than 2, mild elevation of [[Alkaline Phosphatase]], [[hypoalbuminemia]], [[hyperbilirubinemia]],prolonged [[prothrombin time]], and elevated [[gamma-glutamyl transpeptidase]] level. | ||
== Laboratory Findings== | == Laboratory Findings== | ||
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*** [[AST]]/[[ALT]] ([[alanine aminotransferase]]) [[ratio]] greater than 2 | *** [[AST]]/[[ALT]] ([[alanine aminotransferase]]) [[ratio]] greater than 2 | ||
*** Mild elevation of [[Alkaline Phosphatase]] ([[ALP]]) | *** Mild elevation of [[Alkaline Phosphatase]] ([[ALP]]) | ||
*** [[ALP]] level of more than 500 U/L is suggestive of [[infiltrative]] or [[biliary]] [[obstructive]] disease | *** [[ALP]] level of more than 500 U/L is suggestive of [[infiltrative]] or [[biliary]] [[obstructive]] disease | ||
*** Elevated [[gamma-glutamyl transpeptidase]] ([[GGTP]]) level | *** Elevated [[gamma-glutamyl transpeptidase]] ([[GGTP]]) level | ||
*** [[Hypoalbuminemia]] | *** [[Hypoalbuminemia]] | ||
| Line 28: | Line 28: | ||
*** [[Ferritin]] and [[transferrin]] to exclude [[hemochromatosis]] | *** [[Ferritin]] and [[transferrin]] to exclude [[hemochromatosis]] | ||
*** [[Alpha-fetoprotein]] ([[AFP]]) to exclude [[hepatocellular carcinoma]] ([[HCC]]) | *** [[Alpha-fetoprotein]] ([[AFP]]) to exclude [[hepatocellular carcinoma]] ([[HCC]]) | ||
*According to National Institute on Alcohol Abuse and Alcoholism (NIAAA), [[Alcoholic Hepatitis]] is diagnosed based on following criteria:<ref> {{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK470217/ |title=Alcoholic Hepatitis - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}<ref | *According to National Institute on Alcohol Abuse and Alcoholism (NIAAA), [[Alcoholic Hepatitis]] is diagnosed based on following criteria:<ref> {{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK470217/ |title=Alcoholic Hepatitis - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | ||
** Onset of [[jaundice]] within 60 days of heavy [[alcohol]]consumption >50 g/day for at least of 6 [[months]] | ** Onset of [[jaundice]] within 60 days of heavy [[alcohol]]consumption >50 g/day for at least of 6 [[months]] | ||
** [[Serum bilirubin]] > 3 mg/dL | ** [[Serum bilirubin]] > 3 mg/dL | ||
Latest revision as of 16:10, 2 August 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
The most frequent laboratory findings of Alcoholic hepatitis include neutrophilic leukocytosis with bandemia,anemia ,AST/ALT ratio greater than 2, mild elevation of Alkaline Phosphatase, hypoalbuminemia, hyperbilirubinemia,prolonged prothrombin time, and elevated gamma-glutamyl transpeptidase level.
Laboratory Findings
- The laboratory findings include:[1][2]
- Complete blood count (CBC) shows:
- Neutrophilic leukocytosis with bandemia
- Anemia
- Increased mean corpuscular volume (MCV)
- Thrombocytosis as part of inflammatory process or thrombocytopenia as a result of splenic sequestration
- Liver tests shows:
- Aspartate aminotransferase (AST)level is elevated to 2–6 times the upper limit of normal
- AST/ALT (alanine aminotransferase) ratio greater than 2
- Mild elevation of Alkaline Phosphatase (ALP)
- ALP level of more than 500 U/L is suggestive of infiltrative or biliary obstructive disease
- Elevated gamma-glutamyl transpeptidase (GGTP) level
- Hypoalbuminemia
- Hyperbilirubinemia
- Prolonged prothrombin time (PT)
- The severity of hyperbilirubinemia and coagulopathy are indicative of severity of Alcoholic Hepatitis
- Blood tests in order to exclude other diseases:
- Hepatitis B surface antigen (HBsAg)
- Anti–hepatitis C virus
- Ferritin and transferrin to exclude hemochromatosis
- Alpha-fetoprotein (AFP) to exclude hepatocellular carcinoma (HCC)
- Complete blood count (CBC) shows:
- According to National Institute on Alcohol Abuse and Alcoholism (NIAAA), Alcoholic Hepatitis is diagnosed based on following criteria:[3]
- Onset of jaundice within 60 days of heavy alcoholconsumption >50 g/day for at least of 6 months
- Serum bilirubin > 3 mg/dL
- ASTlevel between 50 U/L to 400 U/L
- AST:ALT ratio of more than 1.5
- No other cause of acute hepatitis
References
- ↑ Amini M, Runyon BA (2010). "Alcoholic hepatitis 2010: a clinician's guide to diagnosis and therapy". World J Gastroenterol. 16 (39): 4905–12. doi:10.3748/wjg.v16.i39.4905. PMC 2957598. PMID 20954276.
- ↑ Chayanupatkul M, Liangpunsakul S (2014). "Alcoholic hepatitis: a comprehensive review of pathogenesis and treatment". World J Gastroenterol. 20 (20): 6279–86. doi:10.3748/wjg.v20.i20.6279. PMC 4033465. PMID 24876748.
- ↑ "Alcoholic Hepatitis - StatPearls - NCBI Bookshelf".