Traumatic brain injury laboratory findings: Difference between revisions
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Laboratory findings have little to no utility of diagnostic importance to the TBI. They may however, be useful, in case patient needs emergent surgery. | Laboratory findings have little to no utility of diagnostic importance to the TBI. They may however, be useful, in case patient needs emergent surgery. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
One of the rare but very interesting finding that one can see in laboratory evaluation would be hyponatremia. An elevated intracranial pressure can induce natriuresis and lead to hyponatremia in very rare cases. But otherwise, the important laboratory investigations to get complete blood count, comprehensive metabolic panel, PT/INR and PTT in case patient needs emergent surgery. CSF analysis is not done in clinical practice, as a lumbar puncture carries higher risk of herniation and the analysis itself is not particularly useful. But you can see the following abnormal findings in the CSF<ref name="pmid21171922">{{cite journal| author=Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK| title=Blood-based diagnostics of traumatic brain injuries. | journal=Expert Rev Mol Diagn | year= 2011 | volume= 11 | issue= 1 | pages= 65-78 | pmid=21171922 | doi=10.1586/erm.10.104 | pmc=3063529 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21171922 }} </ref> | One of the rare but very interesting finding that one can see in laboratory evaluation would be [[hyponatremia]]. An elevated intracranial pressure can induce natriuresis and lead to hyponatremia in very rare cases. But otherwise, the important laboratory investigations to get [[complete blood count]], [[comprehensive metabolic panel]], [[PT/INR]] and [[PTT]] in case patient needs emergent surgery. [[CSF]] analysis is not done in clinical practice, as a [[lumbar puncture]] carries higher risk of herniation and the analysis itself is not particularly useful. But you can see the following abnormal findings in the CSF<ref name="pmid21171922">{{cite journal| author=Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK| title=Blood-based diagnostics of traumatic brain injuries. | journal=Expert Rev Mol Diagn | year= 2011 | volume= 11 | issue= 1 | pages= 65-78 | pmid=21171922 | doi=10.1586/erm.10.104 | pmc=3063529 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21171922 }} </ref> | ||
*Spectrin breakdown product (SBDP)120 and SBDP145 | *Spectrin breakdown product (SBDP)120 and SBDP145 | ||
*Ubiquitin C-terminal hydrolase-L1 (UCH-L1) | *Ubiquitin C-terminal hydrolase-L1 (UCH-L1) | ||
*Glial fibrillary acidic protein (GFAP) | *Glial fibrillary acidic protein (GFAP) | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 01:36, 15 December 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Joanna Ekabua, M.D. [2] Deekshitha Manney, M.D.[[3]]
Overview
Laboratory findings have little to no utility of diagnostic importance to the TBI. They may however, be useful, in case patient needs emergent surgery.
Laboratory Findings
One of the rare but very interesting finding that one can see in laboratory evaluation would be hyponatremia. An elevated intracranial pressure can induce natriuresis and lead to hyponatremia in very rare cases. But otherwise, the important laboratory investigations to get complete blood count, comprehensive metabolic panel, PT/INR and PTT in case patient needs emergent surgery. CSF analysis is not done in clinical practice, as a lumbar puncture carries higher risk of herniation and the analysis itself is not particularly useful. But you can see the following abnormal findings in the CSF[1]
- Spectrin breakdown product (SBDP)120 and SBDP145
- Ubiquitin C-terminal hydrolase-L1 (UCH-L1)
- Glial fibrillary acidic protein (GFAP)
References
- ↑ Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK (2011). "Blood-based diagnostics of traumatic brain injuries". Expert Rev Mol Diagn. 11 (1): 65–78. doi:10.1586/erm.10.104. PMC 3063529. PMID 21171922.