|
|
| (30 intermediate revisions by 6 users not shown) |
| Line 1: |
Line 1: |
| {{Infobox_Disease |
| | #REDIRECT[[Gestational trophoblastic neoplasia]] |
| Name = {{PAGENAME}} |
| |
| Image = |
| |
| Caption = |
| |
| DiseasesDB = 2602 |
| |
| ICD10 = {{ICD10|C|58||c|51}} |
| |
| ICD9 = {{ICD9|181}} |
| |
| ICDO = 9100-9101 |
| |
| OMIM = |
| |
| MedlinePlus = |
| |
| eMedicineSubj = |
| |
| eMedicineTopic = |
| |
| MeshID = D002822 |
| |
| }}
| |
| {{SI}}
| |
| {{CMG}}
| |
| __NOTOC__
| |
| {{Editor Help}}
| |
| | |
| ==Overview==
| |
| '''Choriocarcinoma''' is a malignant and aggressive [[cancer]] of the [[placenta]]. It is characterized by '''early hematogenous spread''' to the lungs. It belongs to the far end of the spectrum of [[gestational trophoblastic diseases]] (GTD).
| |
| | |
| ==Classification of GTDs==
| |
| Broadly, gestational trophoblastic diseases can be classified in the following:
| |
| | |
| 1. [[Hydatidiform Mole]]
| |
| :a. Complete Mole
| |
| :b. Partial Mole
| |
| 2. Invasive Mole<br>
| |
| | |
| 3. Choriocarcinoma
| |
| | |
| 4. Placental site trophoblastic tumor
| |
| | |
| == Etiology/Epidemiology ==
| |
| It is preceded by:
| |
| * [[hydatidiform mole]] (50% of cases)
| |
| * Spontaneous abortion (20%of cases)
| |
| * [[ectopic pregnancy]] (2% of cases)
| |
| * normal term pregnancy (20-30% of cases)
| |
| | |
| ==Symptoms/Signs/Labs==
| |
| * increased quantitative [[human chorionic gonadotropin|β-hCG]] levels
| |
| * [[vaginal bleeding]]
| |
| * [[shortness of breath]]
| |
| * [[hemoptysis]] (coughing up blood)
| |
| * [[chest pain]]
| |
| * [[chest X-ray]] shows multiple infiltrates of various shapes in both lungs
| |
| * presents in males as a [[testicular_cancer|testicular neoplasm]]
| |
| | |
| ==Pathology==
| |
| On [[light microscopy]], there is malignant [[trophoblast]]ic proliferation without hydropic villi.
| |
| | |
| ==Treatment==
| |
| Choriocarcinoma is one of the tumors that is most sensitive to [[chemotherapy]]. The cure rate, even for metastatic choriocarcinoma, is around 90-95%. Virtually everyone without metastases can be cured however metastatic disease to the kidneys and/or brain is usually fatal. Chemotherapy regimen include EMACO ([[etoposide]], [[methotrexate]], [[actinomycin D]], [[cyclosphosphamide]] and [[oncovin]]).
| |
| | |
| [[Hysterectomy]] (surgical removal of the uterus) can also be offered to patients > 40 years of age or those desiring sterilization. It may be required for those with severe infection and uncontrolled bleeding.
| |
| | |
| ==External Links==
| |
| *[http://www.mymolarpregnancy.com MyMolarPregnancy.com] Support group, information, links and personal stories for women with molar pregnancies at mymolarpregnancy.com
| |
| *{{Chorus|00976}}
| |
| | |
| {{Soft tissue tumors and sarcomas}}
| |
| {{SIB}}
| |
| [[Category:Gynecology]]
| |
| [[Category:Types of cancer]]
| |
| [[Category:Oncology]]
| |
| | |
| | |
| {{WikiDoc Help Menu}}
| |
| {{WikiDoc Sources}}
| |