Myelofibrosis: Difference between revisions

	Myelofibrosis Microchapters
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Diagnostic Study of Choice
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Latest revision as of 06:34, 28 July 2020

For patient information, click here

Template:DiseaseDisorder infobox

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]; Mohamad Alkateb, MBBCh [3]; Sujit Routray, M.D. [4]

Synonyms and keywords: Agnogenic myeloid metaplasia; AMM; Myeloid metaplasia; Myeloid metaplasia, NOS; Myelofibrosis with myeloid metaplasia; MMM; Assmann's disease; Chronic granulocytic-megakaryocytic myelosis; Chronic granulocytic megakaryocytic myelosis; Megakaryocytic myelosclerosis; Chronic idiopathic myelofibrosis; CIMF; Heuck-Assmann disease; Idiopathic myelofibrosis; Primary myelofibrosis; PMF; Prefibrotic primary myelofibrosis; Secondary myelofibrosis; Myelosclerosis; Osteomyelofibrosis; Osteomyelosclerosis; Myeloproliferative disorder

Diagnosis

Treatment

Case Studies

Case # 1

Related chapters

Myelophthisic anemia

@@ Line 1: / Line 1: @@
+__NOTOC__
+'''For patient information, click [[Myelofibrosis (patient information)|here]]'''
 {{DiseaseDisorder infobox |
    Name           = Myelofibrosis |
-  ICD10          = {{ICD10|C|94|5|c|81}}, {{ICD10|D|47|1|d|37}} |
-  ICD9           = {{ICD9|289.89}} |
    Image          = Myelofibrosis micro.jpg|
-   Caption        = Bone marrow: Myelofibrosis: High mag H&E excellent example of myelofibrosis. <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small> |
+   Caption        = Bone marrow: Myelofibrosis: High mag HandE excellent example of myelofibrosis. <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small> |
-  ICDO           = 9932, 9961 |
-  OMIM           = |
-  DiseasesDB     = 8616 |
-  MedlinePlus    = |
-  eMedicineSubj  = |
-  eMedicineTopic = |
-  MeshID          = D009191 |
 }}
-{{Search infobox}}
+{{Myelofibrosis}}
-{{CMG}}
+{{CMG}} {{AE}} {{Sab}}; {{MJK}}; {{SR}}
+{{SK}} Agnogenic myeloid metaplasia; AMM; Myeloid metaplasia; Myeloid metaplasia, NOS; Myelofibrosis with myeloid metaplasia; MMM; Assmann's disease; Chronic granulocytic-megakaryocytic myelosis; Chronic granulocytic megakaryocytic myelosis; Megakaryocytic myelosclerosis; Chronic idiopathic myelofibrosis; CIMF; Heuck-Assmann disease; Idiopathic myelofibrosis; Primary myelofibrosis; PMF; Prefibrotic primary myelofibrosis; Secondary myelofibrosis; Myelosclerosis; Osteomyelofibrosis; Osteomyelosclerosis; Myeloproliferative disorder
+==[[Myelofibrosis overview|Overview]]==
+==[[Myelofibrosis historical perspective|Historical Perspective]]==
-{{EH}}
+==[[Myelofibrosis classification|Classification]]==
-==Overview==
+==[[Myelofibrosis pathophysiology|Pathophysiology]]==
-'''Myelofibrosis with myeloid metaplasia''', also known as '''agnogenic myeloid metaplasia''', '''chronic idiopathic myelofibrosis''', and '''primary myelofibrosis''',<ref>Older terms include "myelofibrosis with myeloid metaplasia" and "agnogenic myeloid metaplasia". The [[World Health Organization]] utilizes the name "chronic idiopathic myelofibrosis", while the International Working Group on Myelofibrosis Research and Treatment calls the disease "primary myelofibrosis".</ref> was first described in 1879 and is currently classified as a [[myeloproliferative disease]] caused by the growth and proliferation of an abnormal [[bone marrow]] stem cell, resulting in the [[fibrosis|replacement of the bone marrow with fibrous connective tissue]]. An eponym for the disease is Heuck-Assmann disease, or Assmann's Disease.
+==[[Myelofibrosis causes|Causes]]==
-==Presentation==
+==[[Myelofibrosis differential diagnosis|Differentiating Myelofibrosis from other Diseases]]==
-The [[bone marrow]] is replaced by collagen fibrosis, impairing the patient's ability to generate new blood cells resulting in a progressive anemia. It is usually reactive following other [[myeloproliferative disorders]], such as [[polycythemia rubra vera]] or [[essential thrombocytosis]]. Extramedullary hematopoeisis occurs as the haemopoetic cells migrate away from the bone marrow, to the liver and spleen. Patients often have [[hepatosplenomegaly]] and [[poikilocytosis]]. The mean survival is 5 years and causes of death include infection, bleeding, organ failure, portal hypertension, and leukemic transformation.
-==Diagnosis==
+==[[Myelofibrosis epidemiology and demographics|Epidemiology and Demographics]]==
-Diagnosis is based upon:
-# Normochromic normocytic anaemia
-# Red cell poikilocytosis on blood film (tear drop RBCs)
-# JAK 2 mutation on Val 617 Phe locus in 50%
-# Raised lactate dehydrogenase
-# Raised neutrophil alkaline phosphatase score
-# Bone marrow biopsy may show increased cellularity and fibrosis
-==Diagnostic Findings==
+==[[Myelofibrosis risk factors|Risk Factors]]==
-===MRI===
+==[[Myelofibrosis screening|Screening]]==
-([http://www.radswiki.net Images courtesy of RadsWiki])
+==[[Myelofibrosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-<gallery>
+==Diagnosis==
-Image:Myelofibrosis_MRI_001.jpg
+[[Myelofibrosis diagnostic study of choice|Diagnostic Study of Choice]] | [[Myelofibrosis history and symptoms|History and Symptoms]] | [[Myelofibrosis physical examination|Physical Examination]] | [[Myelofibrosis laboratory tests|Laboratory Findings]] | [[Myelofibrosis electrocardiogram|Electrocardiogram]] | [[Myelofibrosis x ray|X Ray]] | [[Myelofibrosis CT|CT]] | [[Myelofibrosis MRI|MRI]] | [[Myelofibrosis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Myelofibrosis other imaging findings|Other Imaging Findings]] | [[Myelofibrosis other diagnostic studies|Other Diagnostic Studies]]
-Image:Myelofibrosis_MRI_002.jpg
-</gallery>
-<gallery>
+==Treatment==
-Image:Myelofibrosis_MRI_003.jpg
+[[Myelofibrosis medical therapy|Medical Therapy]] | [[Myelofibrosis surgery|Surgery]] | [[Myelofibrosis primary prevention|Primary Prevention]] | [[Myelofibrosis secondary prevention|Secondary Prevention]] | [[Myelofibrosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Myelofibrosis future or investigational therapies|Future or Investigational Therapies]]
-Image:Myelofibrosis_MRI_004.jpg
-</gallery>
-== References ==
+==Case Studies==
-{{reflist}}
+[[Myelofibrosis case study one|Case # 1]]
-<br>
-{{Hematology}}
-{{Hematological malignancy histology}}
-{{SIB}}
+==Related chapters==
+* [[Myelophthisic anemia]]
+[[Category:Medicine]]
 [[Category:Hematology]]
 [[Category:Oncology]]
+[[Category:Neurology]]
-[[bn:মজ্জাকাঠিন্য]]
+[[Category:Neurosurgery]]
-[[de:Osteomyelofibrose]]
+[[Category:Up-To-Date]]
-[[fr:Splénomégalie myéloïde]]
-[[it:Mielofibrosi]]
-[[pl:Mielofibroza]]
-{{WH}}
-{{WS}}