Platelet activation: Difference between revisions
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New page: {{SI}} {{CMG}} {{EH}} ==Overview== Platelet activation is the process whereby a normally quiescent and round platelet undergoes functional and anatomic changes to sprout long pseudopods... |
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==Overview== | ==Overview== | ||
Platelet activation is the process whereby a normally quiescent and round platelet undergoes functional and anatomic changes | Platelet activation is the process whereby a normally quiescent and round platelet undergoes functional and anatomic changes. These changes include: | ||
#Development of long pseudopods which increase the surface area of the platelet allowing for a greater probability or area for cross linking with [[fibrin strands]] | |||
#Expression [[glycoprotein IIbIIIa]] receptors which will bind [[fibrin]] strands to cross link platelets | |||
#Release [[ADP]] and other platelet activators into the local micro environment. Relase of ADP causes further platelet activation in a positive feedback loop. | |||
Stimulatnts of platelet activation include: | |||
#[[Thrombin]] | |||
#Tethering and binding to [[vWF]] on the endothelial surface at an area of vascular injury | |||
#ADP | |||
{{SIB}} | {{SIB}} | ||
Latest revision as of 13:30, 15 February 2009
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Overview
Platelet activation is the process whereby a normally quiescent and round platelet undergoes functional and anatomic changes. These changes include:
- Development of long pseudopods which increase the surface area of the platelet allowing for a greater probability or area for cross linking with fibrin strands
- Expression glycoprotein IIbIIIa receptors which will bind fibrin strands to cross link platelets
- Release ADP and other platelet activators into the local micro environment. Relase of ADP causes further platelet activation in a positive feedback loop.
Stimulatnts of platelet activation include: