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{{Infobox_gene}}
'''Beta-centractin''' is a [[protein]] that in [[human]]s is encoded by the ''ACTR1B'' [[gene]].<ref name="pmid7696711">{{cite journal | vauthors = Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI | title = Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins | journal = Mol Biol Cell | volume = 5 | issue = 12 | pages = 1301–10 |date=May 1995 | pmid = 7696711 | pmc = 301159 | doi =  10.1091/mbc.5.12.1301}}</ref><ref name="pmid10343100">{{cite journal | vauthors = Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI | title = Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization | journal = Cytogenet Cell Genet | volume = 84 | issue = 1–2 | pages = 48–9 |date=Jun 1999 | pmid = 10343100 | pmc =  | doi =10.1159/000015211  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120| accessdate = }}</ref>
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{{PBB Summary
| section_title =
| summary_text = This gene encodes a 42.3 [[Atomic mass unit|kD]] subunit of [[dynactin]], a [[macromolecular]] complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both [[microtubules]] and [[cytoplasmic dynein]]. It is involved in a diverse array of [[cell (biology)|cell]]ular functions, including [[Endoplasmic reticulum|ER]]-to-[[Golgi apparatus|Golgi]] transport, the [[centripetal]] movement of [[lysosomes]] and [[endosomes]], [[spindle apparatus|spindle]] formation, [[chromosome]] movement, [[Cell nucleus|nuclear positioning]], and [[axonogenesis]]. This subunit, like [[ACTR1A]], is an actin-related protein. These two proteins are of equal length and share 90% [[amino acid]] identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.<ref name="entrez"/>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further reading
| citations =
*{{cite journal  | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Eckley DM, Schroer TA |title=Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1 |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2645–54 |year= 2004 |pmid= 12857853 |doi= 10.1091/mbc.E03-01-0049  | pmc=165665 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 |display-authors=etal}}
*{{cite journal  | vauthors=Adams MD, Dubnick M, Kerlavage AR |title=Sequence identification of 2,375 human brain genes |journal=Nature |volume=355 |issue= 6361 |pages= 632–4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0 |display-authors=etal}}
}}
{{refend}}
==External links==
* {{UCSC genome browser|ACTR1B}}
* {{UCSC gene details|ACTR1B}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{DEFAULTSORT:Actr1b}}
{{GNF_Protein_box
[[Category:Human proteins]]
| image = 
 
| image_source = 
| PDB =
| Name = ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
| HGNCid = 168
| Symbol = ACTR1B
| AltSymbols =; ARP1
| OMIM = 605144
| ECnumber = 
| Homologene = 21173
| MGIid = 1917446
| GeneAtlas_image1 = PBB_GE_ACTR1A_200720_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ACTR1A_200721_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ACTR1A_gnf1h07451_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}  
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005869 |text = dynactin complex}}
| Process = {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10120
    | Hs_Ensembl = ENSG00000115073
    | Hs_RefseqProtein = NP_005735
    | Hs_RefseqmRNA = NM_005736
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 97638863
    | Hs_GenLoc_end = 97646815
    | Hs_Uniprot = P42025
    | Mm_EntrezGene = 226977
    | Mm_Ensembl = ENSMUSG00000037351
    | Mm_RefseqmRNA =
    | Mm_RefseqProtein =
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 36756047
    | Mm_GenLoc_end = 36766769
    | Mm_Uniprot = Q8R5C5
  }}
}}
'''ARP1 actin-related protein 1 homolog B, centractin beta (yeast)''', also known as '''ACTR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120| accessdate = }}</ref>


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{{gene-2-stub}}
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.<ref name="entrez">{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120| accessdate = }}</ref>
}}

Latest revision as of 17:46, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[1][2][3]

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[3]

References

  1. ↑ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.
  2. ↑ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100.
  3. ↑ 3.0 3.1 "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".

Further reading

External links


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