Clobetasone: Difference between revisions

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Clobetasone
Clinical data
Trade names	Eumovate
Synonyms	(8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	topical
ATC code	D07AB01 (WHO) S01BA09 (WHO);
Identifiers
	IUPAC name (1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione;
CAS Number	54063-32-0 ;
PubChem CID	71387;
ChemSpider	64482 ;
UNII	LT69WY1J6D;
KEGG	D07717 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H26ClFO4
Molar mass	408.891 g/mol
3D model (JSmol)	Interactive image;
	SMILES ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C;
	InChI InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1 ; Key:XXIFVOHLGBURIG-OZCCCYNHSA-N ;
(verify)

VisualWikitext

Latest revision as of 19:14, 18 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clobetasone (INN) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.

It is available as clobetasone butyrate under the brand names Eumosone or Eumovate both manufactured by GlaxoSmithKline.

Trimovate also contains Oxytetracycline, an antibiotic, and nystatin, an antifungal.

Uses

In dermatology, topical clobestasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis. In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren's Syndrome. Sjögren's Syndrome is an autoimmune disorder that affects the moisture producing glands of the body causing many symptoms including dry eyes. When compared to other corticosteroid eye drops; clobetasone butyrate showed only minimal rises in intraocular pressure. Increased pressure within the eye can lead to glaucoma.

Adverse effects

Side effects associated with clobetasone cream and ointment include: burning, irritation, itching, thinning of the skin, and changes in skin color.

References

@@ Line 1: / Line 1: @@
-{{drugbox |
+{{Drugbox
-| IUPAC_name = (''8S,9R,10S,13S,14S,16S,17R'')-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-''6H''-cyclopenta[a]phenanthrene-3,11-dione
+| Watchedfields = changed
+| verifiedrevid = 447609987
+| IUPAC_name = (1''R'',2''S'',10''S'',11''S'',13''S'',14''R'',15''S'')-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.0<sup>2,7</sup>.0<sup>11,15</sup>]heptadeca-3,6-diene-5,17-dione
 | image = clobetasone.png
+<!--Clinical data-->
+| tradename = Eumovate
+| Drugs.com = {{drugs.com|CONS|clobetasone}}
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| legal_UK = <!-- GSL         / P       / POM / CD -->
+| legal_US = <!-- OTC                   / Rx-only  -->
+| legal_status =
+| routes_of_administration = topical
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 54063-32-0
 | ATC_prefix = D07
 | ATC_suffix = AB01
-| ATC_supplemental = {{ATC|S01|BA09}}
+| ATC_supplemental =  {{ATC|S01|BA09}}
 | PubChem = 71387
-| DrugBank =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 64482
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = LT69WY1J6D
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07717
+<!--Chemical data-->
 | C=22 | H=26 | Cl=1 | F=1 | O=4
-| molecular_weight = 408.891
+| molecular_weight = 408.891 g/mol
-| bioavailability =
+| smiles = ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C
-| protein_bound =
+| InChI = 1/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
-| metabolism =
+| InChIKey = XXIFVOHLGBURIG-OZCCCYNHBL
-| elimination_half-life =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| excretion =
+| StdInChI = 1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
-| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_US =  <!-- A / B            / C / D / X -->
+| StdInChIKey = XXIFVOHLGBURIG-OZCCCYNHSA-N
-| pregnancy_category =
+| synonyms = (8''S'',9''R'',10''S'',13''S'',14''S'',16''S'',17''R'')-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6''H''-cyclopenta[''a'']phenanthrene-3,11-dione
-| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
-| legal_UK =      <!-- GSL         / P       / POM / CD -->
-| legal_US =      <!-- OTC                   / Rx-only  -->
-| legal_status =
-| routes_of_administration = topical
 }}
-{{EH}}
+__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Clobetasone''' ([[International Nonproprietary Name|INN]]) is a [[corticosteroid]] used in [[dermatology]], for treating such skin inflammation as seen in [[eczema]], [[psoriasis]] and other forms of [[dermatitis]], and [[ophthalmology]].  Topical clobetasone butyrate has shown minimal suppression of the [[Hypothalamic-pituitary-adrenal axis]].
+It is available as clobetasone butyrate under the brand names '''Eumosone''' or '''Eumovate''' both manufactured by [[GlaxoSmithKline]].
-'''Clobetasone''' is a [[corticosteroid]] used in [[dermatology]], for treating such skin inflammation as seen in [[eczema]] and other forms of [[dermatitis]], and [[ophthalmology]].
+'''Trimovate''' also contains [[Oxytetracycline]], an [[antibiotic]], and [[nystatin]], an [[Antifungal medication|antifungal]].
-It is available as clobetasone butyrate under the brand name '''Eumovate''' manufactured by [[GlaxoSmithKline]].
+==Uses==
+In [[dermatology]], topical clobestasone butyrate helps to reduce the itchiness and [[erythema]] associated with [[eczema]] and [[dermatitis]].
+In [[ophthalmology]], clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in [[Sjögren's Syndrome]]. Sjögren's Syndrome is an autoimmune disorder that affects the moisture producing glands of the body causing many symptoms including dry eyes. When compared to other corticosteroid eye drops; clobetasone butyrate showed only minimal rises in intraocular pressure. Increased pressure within the eye can lead to [[glaucoma]].
-{{Corticosteroids}}
+==Adverse effects==
-{{SIB}}
+Side effects associated with clobetasone cream and ointment include: burning, irritation, itching, thinning of the skin, and changes in skin color.
-{{treatment-stub}}
+==References==
+{{Reflist|2}}
 [[Category:Corticosteroids]]
-[[Category:Organohalides]]
+[[Category:Organochlorides]]
-{{WikiDoc Help Menu}}
+[[Category:Organofluorides]]
-{{WS}}
+[[Category:Alcohols]]
+[[Category:Ketones]]
+[[Category:Drug]]