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| {{drugbox
| | #REDIRECT [[Alprostadil]] |
| | IUPAC_name = 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] heptanoic acid
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| | image = Alprostadil.svg
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| | CAS_number = 745-65-3
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| | ATC_prefix = C01
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| | ATC_suffix = EA01
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| | ATC_supplemental = {{ATC|G04|BE01}}
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| | PubChem = 149351
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| | DrugBank = APRD00785
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| | C=20 | H=34 | O=5
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| | molecular_weight = 354.481 g/mol
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| | bioavailability =
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| | protein_bound =
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| | metabolism =
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| | elimination_half-life =
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| | excretion =
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = <!-- A / B / C / D / X -->
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| | pregnancy_category =
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| | legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
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| | legal_UK = <!-- GSL / P / POM / CD -->
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| | legal_US = <!-- OTC / Rx-only -->
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| | legal_status =
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| | routes_of_administration =
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| }}
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| {{SI}}
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| {{CMG}}
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| __NOTOC__
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| {{Editor Help}}
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| ==Overview==
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| '''Alprostadil''' is the pharmaceutical name for [[prostaglandin]] E<sub>1</sub>. It is used as a drug in the treatment of [[erectile dysfunction]] and has [[vasodilatory]] properties.<ref name=dorlands>{{Dorlands|a_26|12123006}}</ref>
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| ==Sexual dysfunction==
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| Aprostidil is sold in the United States under the brand name Muse.<ref>[http://www.drugdigest.org/DD/DVH/Uses/0,3915,550749|Muse,00.html Muse].</ref> It is also sold as Caverject and Edex.
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| Muse delivers alprostadil as a penile [[suppository]], inserted into the urethra, at least ten minutes before the erection will be needed. Caverject and Edex are similarly fast-acting, but are actually injected directly into the [[corpus cavernosum penis|corpus cavernosum of the penis]].
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| This drug is reputed to work for erectile dysfunction for 30 to 60 minutes.
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| This drug, following on the coattails of [[Viagra]], has failed to achieve comparable above-ground market share in the United States, perhaps in part because of the invasive means of delivery.
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| NexMed is developing transdermal forumulations—Alprox-TD(R) for men with erectile dysfunction and Femprox(R) for female sexual arousal disorder. Alprox-TD(R) has been selling in China and in Hong Kong since October 2001 and April 2002, respectively.
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| Two Phase III studies have been completed for this product, and the Company is seeking regulatory approval in the U.S., Canada and Europe.
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| <ref name=nexm>{{cite web
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| | title=NEXM: Dutton Sees Strong Speculative Buy and 12-Month Price Double
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| | url=http://www.tradingmarkets.com/.site/news/Stock%20News/722371/
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| | author=Fain Hughes
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| | date=2007-10-29
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| | accessdate=2007-11-01}}</ref>
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| == Other uses==
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| Aprostadil is also used in maintaining a [[patent ductus arteriosus]] in the [[fetus]]. This is primarily useful when there is threat of premature closure of the ductus arteriosus.<ref name=dorlands />
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| ==References==
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| <references/>
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| <br>
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| {{Urologicals}}
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| {{Prostaglandins}}
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| {{SIB}}
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| [[Category:Prostaglandins]]
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| [[es:Alprostadil]] | |
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